| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tristano Pancani, Katie L Anderson, Lawrence D Brewer, Inga Kadish, Chris DeMoll, Philip W Landfield, Eric M Blalock, Nada M Porter, Olivier Thibaul. Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiology of aging. vol 34. issue 8. 2013-11-04. PMID:23545425. |
young and mid-aged animals were maintained on control or hfd for 4.5 months, and peripheral metabolic variables, cognitive function, and electrophysiological responses to insulin in the hippocampus were measured. |
2013-11-04 |
2023-08-12 |
rat |
| Rachael Lennox, David W Porter, Peter R Flatt, Victor A Gaul. (Val(8))GLP-1-Glu-PAL: a GLP-1 agonist that improves hippocampal neurogenesis, glucose homeostasis, and β-cell function in high-fat-fed mice. ChemMedChem. vol 8. issue 4. 2013-09-17. PMID:23138973. |
these data demonstrate that (val(8))glp-1-glu-pal is a long-acting glp-1 peptide that significantly improves hippocampal neurogenesis, glucose homeostasis, and insulin secretion in high-fat-fed mice. |
2013-09-17 |
2023-08-12 |
mouse |
| Zhi-Gang Yao, Yu Liu, Ling Zhang, Lan Huang, Chun-Mei Ma, Yan-Feng Xu, Hua Zhu, Chuan Qi. Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus. Cellular and molecular neurobiology. vol 32. issue 8. 2013-09-13. PMID:22733364. |
co-location of hdac2 and insulin signaling components in the adult mouse hippocampus. |
2013-09-13 |
2023-08-12 |
mouse |
| Zhi-Gang Yao, Yu Liu, Ling Zhang, Lan Huang, Chun-Mei Ma, Yan-Feng Xu, Hua Zhu, Chuan Qi. Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus. Cellular and molecular neurobiology. vol 32. issue 8. 2013-09-13. PMID:22733364. |
here, we are concerned about whether hdac2 was co-located with insulin signaling components in postsynaptic glutamatergic neurons (psgns) of the adult mouse hippocampus using double immunofluorescence staining. |
2013-09-13 |
2023-08-12 |
mouse |
| Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in β-amyloid-infused rats. The Journal of nutrition. vol 143. issue 7. 2013-08-26. PMID:23719224. |
the ad-c group exhibited greater hippocampal β-amyloid deposition, which was not detected in the c group, and attenuated hippocampal insulin signaling. |
2013-08-26 |
2023-08-12 |
rat |
| Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in β-amyloid-infused rats. The Journal of nutrition. vol 143. issue 7. 2013-08-26. PMID:23719224. |
yuzu treatment prevented β-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in ad-c rats. |
2013-08-26 |
2023-08-12 |
rat |
| H-S Moon, F Dincer, C S Mantzoro. Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice. Diabetologia. vol 56. issue 3. 2013-08-19. PMID:23224631. |
both leptin and insulin sensitivity have been linked with pathophysiological processes involving the central nervous system in general, and the hippocampus in particular, but the role of leptin in hippocampal neurogenesis has not yet been elucidated. |
2013-08-19 |
2023-08-12 |
mouse |
| H-S Moon, F Dincer, C S Mantzoro. Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice. Diabetologia. vol 56. issue 3. 2013-08-19. PMID:23224631. |
also, no previous studies have evaluated whether amylin or the endogenous insulin sensitiser adiponectin interact with leptin to alter hippocampal neurogenesis in mouse hippocampal neuronal (hn) cells or investigated the role of leptin, amylin or adiponectin signalling in mouse hn cells. |
2013-08-19 |
2023-08-12 |
mouse |
| Gregory A Moy, Ewan C McNa. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF. Physiology & behavior. vol 109. 2013-08-12. PMID:23220362. |
caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (bdnf) seen in high-fat-fed animals. |
2013-08-12 |
2023-08-12 |
rat |
| Akiko Sheala Shingo, Tomomichi Kanabayashi, Shozo Kito, Toshio Muras. Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats. Behavioural brain research. vol 241. 2013-07-01. PMID:23238038. |
we previously demonstrated that intracerebroventricular streptozotocin (stz-icv) injection induced cognitive dysfunction and led to decreased expression levels of phospho-cyclic amp responsive element binding protein (pcreb), akt, and insulin degrading enzyme (ide) and increased amyloid beta (ab) deposition in the hippocampus. |
2013-07-01 |
2023-08-12 |
rat |
| Akiko Sheala Shingo, Tomomichi Kanabayashi, Shozo Kito, Toshio Muras. Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats. Behavioural brain research. vol 241. 2013-07-01. PMID:23238038. |
in the present study, we aimed to investigate whether treatment with an insulin analogue could prevent stz-induced cognitive decline by reducing or eliminating these changes in the hippocampus. |
2013-07-01 |
2023-08-12 |
rat |
| Antoine Leboucher, Cyril Laurent, Francisco-José Fernandez-Gomez, Sylvie Burnouf, Laetitia Troquier, Sabiha Eddarkaoui, Dominique Demeyer, Raphaëlle Caillierez, Nadège Zommer, Emmanuelle Vallez, Kadiombo Bantubungi, Christophe Breton, Pascal Pigny, Valérie Buée-Scherrer, Bart Staels, Malika Hamdane, Anne Tailleux, Luc Buée, David Blu. Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice. Diabetes. vol 62. issue 5. 2013-06-28. PMID:23250356. |
further, pathological worsening occurred while hippocampal insulin signaling was upregulated. |
2013-06-28 |
2023-08-12 |
mouse |
| Heather Kenna, Fumiko Hoeft, Ryan Kelley, Tonita Wroolie, Bevin DeMuth, Allan Reiss, Natalie Rasgo. Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22770543. |
subjects were dichotomized relative to fasting plasma insulin levels (i.e., > 8 μiu/ml [n = 10] and < 8 μiu/ml [n = 10]), and functional connectivity analysis contrasted their respective blood oxygen level-dependent signal correlation between dmn and hippocampal regions. |
2013-05-24 |
2023-08-12 |
human |
| Yaso Emmanuel, Lowri E Cochlin, Damian J Tyler, Celeste A de Jager, A David Smith, Kieran Clark. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain and behavior. vol 3. issue 2. 2013-03-28. PMID:23533158. |
human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. |
2013-03-28 |
2023-08-12 |
human |
| Yaso Emmanuel, Lowri E Cochlin, Damian J Tyler, Celeste A de Jager, A David Smith, Kieran Clark. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain and behavior. vol 3. issue 2. 2013-03-28. PMID:23533158. |
however, it is now known that components of the insulin-mediated glucose uptake pathway, including neuronal insulin synthesis and the insulin-dependent glucose transporter glut4, are present in brain tissue, particularly in the hippocampus. |
2013-03-28 |
2023-08-12 |
human |
| Yaso Emmanuel, Lowri E Cochlin, Damian J Tyler, Celeste A de Jager, A David Smith, Kieran Clark. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain and behavior. vol 3. issue 2. 2013-03-28. PMID:23533158. |
there is considerable recent evidence that insulin signaling is crucial to optimal hippocampal function. |
2013-03-28 |
2023-08-12 |
human |
| Yaso Emmanuel, Lowri E Cochlin, Damian J Tyler, Celeste A de Jager, A David Smith, Kieran Clark. Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain and behavior. vol 3. issue 2. 2013-03-28. PMID:23533158. |
we studied hippocampal high-energy phosphate metabolism in eight healthy volunteers, using a lipid infusion protocol to inhibit insulin signaling. |
2013-03-28 |
2023-08-12 |
human |
| Xin Liu, Yi-Na Zhang, Li-Hong Jiang, Zong-Yan Ten. [Study of the correlation about IGF-I receptor and β-amyloid in Alzheimer's disease]. Zhonghua yi xue za zhi. vol 92. issue 15. 2013-03-20. PMID:22781651. |
to detect the expression of igf-i receptor in the hippocampus neuron of rat treated by aβ(1-42), and thus from the receptor level explore the disorder of central nervous insulin signaling and the possible molecular mechanism of alzheimer disease. |
2013-03-20 |
2023-08-12 |
rat |
| Ewan C McNay, Leslie A Sandusky, Jiah Pearson-Lear. Hippocampal insulin microinjection and in vivo microdialysis during spatial memory testing. Journal of visualized experiments : JoVE. issue 71. 2013-03-17. PMID:23354340. |
hippocampal insulin microinjection and in vivo microdialysis during spatial memory testing. |
2013-03-17 |
2023-08-12 |
Not clear |
| Ewan C McNay, Leslie A Sandusky, Jiah Pearson-Lear. Hippocampal insulin microinjection and in vivo microdialysis during spatial memory testing. Journal of visualized experiments : JoVE. issue 71. 2013-03-17. PMID:23354340. |
this technique is especially useful when combined with tasks designed to rely on specific brain regions and/or acute pharmacological manipulation; for example, hippocampal measurements during a spatial working memory task (spontaneous alternation) show a dip in extracellular glucose and rise in lactate that are suggestive of enhanced glycolysis, and intrahippocampal insulin administration both improves memory and increases hippocampal glycolysis. |
2013-03-17 |
2023-08-12 |
Not clear |