| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven E Arnold, Irwin Lucki, Bethany R Brookshire, Gregory C Carlson, Caroline A Browne, Hala Kazi, Sookhee Bang, Bo-Ran Choi, Yong Chen, Mary F McMullen, Sangwon F Ki. High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of disease. vol 67. 2015-01-06. PMID:24686304. |
to ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17days or a moderate high fat diet (hfd, 45% kcal by fat) for 8weeks and examined changes in brain insulin signaling responses, hippocampal synaptodendritic protein expression, and spatial working memory. |
2015-01-06 |
2023-08-12 |
mouse |
| Steven E Arnold, Irwin Lucki, Bethany R Brookshire, Gregory C Carlson, Caroline A Browne, Hala Kazi, Sookhee Bang, Bo-Ran Choi, Yong Chen, Mary F McMullen, Sangwon F Ki. High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of disease. vol 67. 2015-01-06. PMID:24686304. |
hfd mouse hippocampus exhibited increased expression of serine-phosphorylated insulin receptor substrate 1 (irs1-ps(616)), a marker of insulin resistance, as well as decreased expression of psd-95, a scaffolding protein enriched in post-synaptic densities, and synaptopodin, an actin-associated protein enriched in spine apparatuses. |
2015-01-06 |
2023-08-12 |
mouse |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Iraj Jafari Anarkooli, Hossein Barzegar Ganji, Maryam Pourheida. The protective effects of insulin and natural honey against hippocampal cell death in streptozotocin-induced diabetic rats. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24745031. |
the protective effects of insulin and natural honey against hippocampal cell death in streptozotocin-induced diabetic rats. |
2014-10-28 |
2023-08-13 |
rat |
| Iraj Jafari Anarkooli, Hossein Barzegar Ganji, Maryam Pourheida. The protective effects of insulin and natural honey against hippocampal cell death in streptozotocin-induced diabetic rats. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24745031. |
we investigated the effects of insulin and honey as antioxidants to prevent the hippocampal cell death in streptozotocin-induced diabetic rats. |
2014-10-28 |
2023-08-13 |
rat |
| Iraj Jafari Anarkooli, Hossein Barzegar Ganji, Maryam Pourheida. The protective effects of insulin and natural honey against hippocampal cell death in streptozotocin-induced diabetic rats. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24745031. |
cell viability assessment showed significantly lower number of living cells in group d than in group c. besides, the mean number of living cells was significantly higher in group i, h, and i + h compared to group d. therefore, it can be concluded that the treatment of the diabetic rats with insulin, honey, and a combination of insulin and honey can prevent neuronal cell death in different hippocampal areas of the studied samples. |
2014-10-28 |
2023-08-13 |
rat |
| Tracy J Dixon-Salazar, Lawrence Fourgeaud, Carolyn M Tyler, Julianna R Poole, Joseph J Park, Lisa M Boulange. MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 35. 2014-10-17. PMID:25164678. |
we find that genetically reducing cell surface mhci levels increases synapse density selectively in regions of the hippocampus where insulin receptors are expressed, and occludes the neuronal insulin response by de-repressing insulin receptor signaling. |
2014-10-17 |
2023-08-13 |
mouse |
| Xiao-Hui Chang, Li-Na Liang, Li-Bin Zhan, Xiao-Guang Lu, Xiang Shi, Xin Qi, Zhao-Lan Feng, Mei-Juan Wu, Hua Sui, Lu-Ping Zheng, Fu-Liang Zhang, Jie Sun, Chang-Chuan Bai, Nan Li, Guo-Zhu Ha. The effect of Chinese Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline. BMC complementary and alternative medicine. vol 13. 2014-10-06. PMID:23829668. |
to investigate the effects of treatment with multi component chinese medicine jinzhida (jzd) on behavioral deficits in diabetes-associated cognitive decline (dacd) rats and verify our hypothesis that jzd treatment improves cognitive function by suppressing the endoplasmic reticulum stress (ers) and improving insulin signaling transduction in the rats' hippocampus. |
2014-10-06 |
2023-08-12 |
rat |
| Rahul Agrawal, Yumei Zhuang, Bethany P Cummings, Kimber L Stanhope, James L Graham, Peter J Havel, Fernando Gomez-Pinill. Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24840661. |
there was a decrease in hippocampal insulin receptor signaling in the hippocampus, which correlated with peripheral insulin resistance index along the course of diabetes onset (r=-0.56, p<0.01). |
2014-09-25 |
2023-08-13 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
new insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. |
2014-08-18 |
2023-08-12 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
the reduction of insulin levels in hippocampal areas is associated with alzheimer's disease. |
2014-08-18 |
2023-08-12 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
after confirming the expression of insulin mrna and proinsulin in rat brain, we visualized and analyzed the motion of insulin secretion in rat hippocampal neurons using ph-sensitive green fluorescent protein (phluorin) fused to the insulin. |
2014-08-18 |
2023-08-12 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
these results demonstrate that synthesized insulin is secreted from rat hippocampal and cortical neuron's dense-core vesicles, and that activation of gsk-3β in aβ(1-42)-induced alzheimer's model hippocampal neurons decreases the insulin synthesis. |
2014-08-18 |
2023-08-12 |
rat |
| Thomas H Sanderson, Gargi Mahapatra, Petr Pecina, Qinqin Ji, Kebing Yu, Christopher Sinkler, Ashwathy Varughese, Rita Kumar, Melissa J Bukowski, Renee N Tousignant, Arthur R Salomon, Icksoo Lee, Maik Hütteman. Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment. PloS one. vol 8. issue 11. 2014-08-08. PMID:24223835. |
using an animal model of global brain ischemia, we found a ∼50% decrease in neuronal death in the ca1 hippocampal region with post-ischemic insulin administration. |
2014-08-08 |
2023-08-12 |
rat |
| Qiyi Chen, Wenkui Yu, Jiangliang Shi, Juanhong Shen, Tao Gao, Juanjuan Zhang, Fengchan Xi, Jieshou Li, Ning L. Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats. Journal of inflammation (London, England). vol 11. 2014-08-05. PMID:25093012. |
after 6 hours of insulin therapy, we found that the cytokine concentrations notably decreased and oxidative stress injuries in the cortex, hypothalamus, and hippocampus were alleviated in septic rats. |
2014-08-05 |
2023-08-13 |
rat |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. |
2014-07-21 |
2023-08-12 |
rat |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
systemic insulin resistance resulting from long-term hffd feeding has detrimental consequences on cognitive performance, neurogenesis, and long-term potentiation establishment, accompanied by neuronal alterations in the hippocampus. |
2014-07-21 |
2023-08-12 |
rat |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
therefore, we investigated whether short-term hffd feeding produced hippocampal insulin signaling alterations associated with neuronal changes in the hippocampus. |
2014-07-21 |
2023-08-12 |
rat |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
our results show that 7 days of hffd feeding induce obesity and insres, associated with the following alterations in the hippocampus: (1) a decreased insulin signaling; (2) a decreased hippocampal weight; (3) a reduction in dendritic arborization in ca1 and microtubule-associated protein 2 (map-2) levels; (4) a decreased dendritic spine number in ca1 and synaptophysin content, along with an increase in tau phosphorylation; and finally, (5) an increase in reactive astrocyte associated with microglial changes. |
2014-07-21 |
2023-08-12 |
rat |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
to our knowledge, this is the first report addressing hippocampal insulin signaling, as well as morphologic, structural, and functional modifications due to short-term hffd feeding in the rat. |
2014-07-21 |
2023-08-12 |
rat |