| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doaa A Ghareeb, Sofia Khalil, Hani S Hafez, Jürgen Bajorath, Hany E A Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A El-Demellaw. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-11-20. PMID:26576191. |
these changes were significantly correlated with decreased insulin degrading enzyme (ide) and beta-amyloid40 (aβ 40) and increased beta-amyloid42 (aβ 42) in the hippocampal region. |
2015-11-20 |
2023-08-13 |
rat |
| John Kealy, Rachel Bennett, John P Lowr. Real-time effects of insulin-induced hypoglycaemia on hippocampal glucose and oxygen. Brain research. vol 1598. 2015-11-17. PMID:25511995. |
the effect of an acute administration of insulin on hippocampal function has been described in terms of behavioural deficits but its effect on hippocampal oxygen and glucose is unclear. |
2015-11-17 |
2023-08-13 |
rat |
| John Kealy, Rachel Bennett, John P Lowr. Real-time effects of insulin-induced hypoglycaemia on hippocampal glucose and oxygen. Brain research. vol 1598. 2015-11-17. PMID:25511995. |
insulin administration produced a significant decrease in hippocampal glucose along with a significant increase in hippocampal oxygen. |
2015-11-17 |
2023-08-13 |
rat |
| Oliver Takach, Trevor B Gill, Michael A Silverma. Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25543463. |
modulation of insulin signaling rescues bdnf transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons. |
2015-11-12 |
2023-08-13 |
mouse |
| Marco Mainardi, Salvatore Fusco, Claudio Grass. Modulation of hippocampal neural plasticity by glucose-related signaling. Neural plasticity. vol 2015. 2015-11-04. PMID:25977822. |
in this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-i, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus, which is a key area for learning and memory. |
2015-11-04 |
2023-08-13 |
Not clear |
| Lina Ma, Zhimin Shao, Rong Wang, Zhiwei Zhao, Wen Dong, Jingshuang Zhang, Xu Zhang, Shuli Sheng, Zhijuan Ji, Jingyan Zhan. Rosiglitazone improves learning and memory ability in rats with type 2 diabetes through the insulin signaling pathway. The American journal of the medical sciences. vol 350. issue 2. 2015-10-13. PMID:25973687. |
western blot and immunohistochemistry were also used to detect changes in proteins involved in the insulin signal transduction pathway, such as the insulin receptor, insulin receptor substrate-1, protein kinase b, phosphorylated camp response element-binding protein and b-cell lymphoma 2, in the hippocampus of the rats. |
2015-10-13 |
2023-08-13 |
rat |
| Carlos Alberto Yasin Wayhs, Caroline Paula Mescka, Gilian Guerreiro, Tarsila Barros Moraes, Carlos Eduardo Diaz Jacques, Andrea Pereira Rosa, Marcelo Kneib Ferri, Maurício Schüler Nin, Carlos Severo Dutra-Filho, Helena Maria Tannhauser Barros, Carmen Regla Varga. Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. Cell biochemistry and function. vol 32. issue 8. 2015-10-05. PMID:25431174. |
considering that diabetic rats and mice present higher depressive-like behaviour when submitted to the forced swimming test and that treatment with insulin and/or clonazepam is able to reverse the behavioural changes of the diabetic rats, the present work investigated the antioxidant status, specifically total antioxidant reactivity and antioxidant potential of insulin and clonazepam, as well as the effect of this drugs upon protein oxidative damage and reactive species formation in cortex, hippocampus and striatum from diabetic rats submitted to forced swimming test. |
2015-10-05 |
2023-08-13 |
mouse |
| Carlos Alberto Yasin Wayhs, Caroline Paula Mescka, Gilian Guerreiro, Tarsila Barros Moraes, Carlos Eduardo Diaz Jacques, Andrea Pereira Rosa, Marcelo Kneib Ferri, Maurício Schüler Nin, Carlos Severo Dutra-Filho, Helena Maria Tannhauser Barros, Carmen Regla Varga. Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. Cell biochemistry and function. vol 32. issue 8. 2015-10-05. PMID:25431174. |
moreover, data obtained in this study allowed to demonstrate through different parameters such as protein carbonyl content, 2'7'-dichlorofluorescein oxidation, catalase, superoxide dismutase, glutathione peroxidase assay, total radical-trapping antioxidant potential and total antioxidant reactivity that there is oxidative stress in cortex, hippocampus and striatum from diabetic rats under depressive-like behaviour and highlight the insulin and/or clonazepam effect in these different brain areas, restoring antioxidant status and protein damage. |
2015-10-05 |
2023-08-13 |
mouse |
| Jan Detka, Anna Kurek, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewsk. Elevated brain glucose and glycogen concentrations in an animal model of depression. Neuroendocrinology. vol 100. issue 2-3. 2015-10-02. PMID:25300940. |
the aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations in the hippocampus and frontal cortex in a prenatal stress rat model of depression. |
2015-10-02 |
2023-08-13 |
rat |
| Erika Calvo-Ochoa, Clorinda Aria. Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models. Diabetes/metabolism research and reviews. vol 31. issue 1. 2015-10-01. PMID:24464982. |
cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and alzheimer's disease: studies in animal models. |
2015-10-01 |
2023-08-12 |
Not clear |
| Ted M Hsu, Vaibhav R Konanur, Lilly Taing, Ryan Usui, Brandon D Kayser, Michael I Goran, Scott E Kanosk. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus. vol 25. issue 2. 2015-09-16. PMID:25242636. |
protein expression of pro-inflammatory cytokines (interleukin 6, interleukin 1β) was increased in the dorsal hippocampus for the adolescent hfcs-55 group relative to controls with no significant effect in the sucrose group, whereas liver interleukin 1β and plasma insulin levels were elevated for both adolescent-exposed sugar groups. |
2015-09-16 |
2023-08-13 |
rat |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ana Vasiljevi\\xc4\\x87, Gordana Mati\\xc4\\x8. The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats. Nutritional neuroscience. vol 18. issue 2. 2015-08-28. PMID:24257416.' |
the impact of different fructose loads on insulin sensitivity, inflammation, and psa-ncam-mediated plasticity in the hippocampus of fructose-fed male rats. |
2015-08-28 |
2023-08-12 |
rat |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ana Vasiljevi\\xc4\\x87, Gordana Mati\\xc4\\x8. The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats. Nutritional neuroscience. vol 18. issue 2. 2015-08-28. PMID:24257416.' |
fructose-induced hippocampal dysfunction may arise from insulin resistance and inflammation, and from concomitant changes in plasticity-related presynaptic proteins. |
2015-08-28 |
2023-08-12 |
rat |
| b' Ana Djordjevic, Biljana Bursa\\xc4\\x87, Nata\\xc5\\xa1a Veli\\xc4\\x8dkovi\\xc4\\x87, Ana Vasiljevi\\xc4\\x87, Gordana Mati\\xc4\\x8. The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats. Nutritional neuroscience. vol 18. issue 2. 2015-08-28. PMID:24257416.' |
we hypothesized that long-term access to fructose (10% and 60% solutions over a period of 9 weeks) affects insulin sensitivity, hippocampal inflammation, and synaptic plasticity in male wistar rats. |
2015-08-28 |
2023-08-12 |
rat |
| Linda Adzovic, Ashley E Lynn, Heather M D'Angelo, Alexis M Crockett, Roxanne M Kaercher, Sarah E Royer, Sarah C Hopp, Gary L Wen. Erratum to: Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. Journal of neuroinflammation. vol 12. 2015-08-18. PMID:26248591. |
erratum to: insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. |
2015-08-18 |
2023-08-13 |
Not clear |
| Fangfang Fang, Donglong Chen, Pan Yu, Wenyi Qian, Jing Zhou, Jingli Liu, Rong Gao, Jun Wang, Hang Xia. Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice. General and comparative endocrinology. vol 212. 2015-08-04. PMID:25637671. |
our results revealed that bpa significantly increased peripheral plasma insulin levels, and decreased the insulin signals including phosphorylated insulin receptor (p-ir), phosphorylated insulin receptor substrate 1 (p-irs1), phosphorylated protein kinase b (p-akt), phosphorylated glycogen synthase kinase 3β (p-gsk3β) and phosphorylated extracellular regulated protein kinases (p-erk1/2) in the brain, though insulin expression in both hippocampus and profrontal cortex was increased. |
2015-08-04 |
2023-08-13 |
mouse |
| Rachael Lennox, Peter R Flatt, Victor A Gaul. Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice. Peptides. vol 61. 2015-07-29. PMID:25195184. |
this study examines actions within the hippocampus following chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition. |
2015-07-29 |
2023-08-13 |
mouse |
| Akiko Sheala Shingo, Ronald F Mervis, Tomomichi Kanabayashi, Shozo Kito, Toshio Muras. The dendrites of granule cell layer neurons are the primary injury sites in the "Brain Diabetes" rat. Behavioural brain research. vol 280. 2015-07-24. PMID:25476563. |
immunohistochemical studies of the hippocampal formations of these animals have revealed significant changes in cerebral insulin signalling pathways, as well as marked increases of amyloid beta (ab) deposition. |
2015-07-24 |
2023-08-13 |
rat |
| Hongwei Wang, Qing Ye, Yan Huang, Huiying Liao, Haifen Huang, Yong Yo. [Effect of rehabilitation training on insulin-resistance and hippocampus amyloid-beta peptide in rats with vascular dementia]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 38. issue 11. 2015-07-17. PMID:24316935. |
to investigate the effect of rehabilitation training on insulin-resistance and insulin degrading enzyme (ide) in the hippocampus in rats with vascular dementia. |
2015-07-17 |
2023-08-12 |
rat |
| Ewan McNa. Your Brain on Insulin: From Heresy to Dogma. Perspectives on psychological science : a journal of the Association for Psychological Science. vol 9. issue 1. 2015-07-17. PMID:26173246. |
as our ability to measure metabolic and molecular changes in the brain has improved, the hippocampus in particular has been revealed as a primary target for insulin. |
2015-07-17 |
2023-08-13 |
Not clear |