| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuejin Cao, Hanrong Xu, Weixi Feng, Dongyuan Su, Ming Xia. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage. Brain research bulletin. vol 143. 2019-09-30. PMID:30347264. |
ldclns increased total and phosphorylated tau protein levels in the hippocampus of both genotype mice, but increased hippocampal amyloid beta 1-40 and 1-42 levels only in aqp4 null mice, with up-regulation of beta-site amyloid precursor protein-cleaving enzyme 1 and down-regulation of insulin degrading enzyme. |
2019-09-30 |
2023-08-13 |
mouse |
| Fernanda Crunfli, Caio Henrique Mazucanti, Ruan Carlos Macêdo de Moraes, Andressa Pereira Costa, Alice Cristina Rodrigues, Cristoforo Scavone, Andréa da Silva Torrã. NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30149447. |
we observed that stz injection causes cognitive impairment in the animals, a temporal variation of the insulin signaling-related proteins and apoptosis cell death in the hippocampus. |
2019-08-26 |
2023-08-13 |
rat |
| Shantala A Hari Dass, Kathryn McCracken, Irina Pokhvisneva, Lawrence M Chen, Elika Garg, Thao T T Nguyen, Zihan Wang, Barbara Barth, Moein Yaqubi, Lisa M McEwen, Julie L MacIsaac, Josie Diorio, Michael S Kobor, Kieran J O'Donnell, Michael J Meaney, Patricia P Silveir. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. vol 42. 2019-08-20. PMID:30922963. |
we propose a novel, biologically informed genetic score reflecting the mesocorticolimbic and hippocampal insulin receptor-related gene networks, and investigate if it predicts endophenotypes (impulsivity, cognitive ability) in community samples of children, and psychopathology (addiction, dementia) in adults. |
2019-08-20 |
2023-08-13 |
Not clear |
| Zahra Abbasnejad, Behzad Nasseri, Homeira Zardooz, Rasoul Ghasem. Time-course study of high fat diet induced alterations in spatial memory, hippocampal JNK, P38, ERK and Akt activity. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30552557. |
to test how duration of hfd consumption affect hippocampal mapks and insulin signaling activity and animal's cognitive function, rats were fed with hfd for different lengths (up to 6 months) and after each point spatial memory performances of animals was tested, then the peripheral indices of insulin resistance and hippocampal mapks and insulin signaling activity was evaluated. |
2019-08-13 |
2023-08-13 |
rat |
| Zahra Abbasnejad, Behzad Nasseri, Homeira Zardooz, Rasoul Ghasem. Time-course study of high fat diet induced alterations in spatial memory, hippocampal JNK, P38, ERK and Akt activity. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30552557. |
results showed that while different time courses of hfd, up to 6 months, did not bring about significant spatial memory impairment, meanwhile the peripheral insulin sensitivity as well as hippocampal insulin and mapks signaling showed significant fluctuations during the different time courses of high fat diet regime. |
2019-08-13 |
2023-08-13 |
rat |
| Eugenio Barone, Antonella Tramutola, Francesca Triani, Silvio Calcagnini, Fabio Di Domenico, Cristian Ripoli, Silvana Gaetani, Claudio Grassi, D Allan Butterfield, Tommaso Cassano, Marzia Perluig. Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30073505. |
we show that ini improves insulin signaling activation in the hippocampus and cortex of adult and aged 3×tg-ad mice by ameliorating bvr-a activation. |
2019-08-06 |
2023-08-13 |
mouse |
| Akram Sadeghi, Ebrahim Esfandiary, Javad Hami, Hossein Khanahmad, Zahra Hejazi, Mohammad Mardani, Shahnaz Razav. The effects of maternal diabetes and insulin treatment on neurogenesis in the developing hippocampus of male rats. Journal of chemical neuroanatomy. vol 91. 2019-07-29. PMID:29578075. |
the effects of maternal diabetes and insulin treatment on neurogenesis in the developing hippocampus of male rats. |
2019-07-29 |
2023-08-13 |
rat |
| Akram Sadeghi, Ebrahim Esfandiary, Javad Hami, Hossein Khanahmad, Zahra Hejazi, Mohammad Mardani, Shahnaz Razav. The effects of maternal diabetes and insulin treatment on neurogenesis in the developing hippocampus of male rats. Journal of chemical neuroanatomy. vol 91. 2019-07-29. PMID:29578075. |
this study aimed to investigate the effect of maternal diabetes and insulin treatment on the expression and distribution pattern of neun and dcx as two important markers of neurogenesis paradigm in developing rat hippocampus. |
2019-07-29 |
2023-08-13 |
rat |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
in this study, an experimental model of type 2 diabetes mellitus (t2dm) was established by injecting sprague dawley (sd) rats with streptozocin (stz), so as to compare the learning and memory ability, hippocampal neurons pathological changes, beta amyloid protein (a beta) content, degree of tau protein phosphorylation, blood glucose and insulin level. |
2019-07-23 |
2023-08-13 |
human |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
the results showed that the sagacious confucius' pillow elixir could improve the learning and memory ability of stz injected rats, reduce the level of a beta content both in hippocampus and serum, effectively reduce tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. |
2019-07-23 |
2023-08-13 |
human |
| Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M A Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltune. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice. Neurobiology of aging. vol 75. 2019-07-11. PMID:30554086. |
intranasal insulin activates akt2 signaling pathway in the hippocampus of wild-type but not in app/ps1 alzheimer model mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Jung Hyun Lee, Jordan B Jahrling, Larry Denner, Kelly T Dinele. Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29710715. |
in the brain, insulin manages glucose metabolism in regions such as the hippocampus and plays a key role in directly regulating erk, a kinase required for the type of memory compromised in early alzheimer's disease (ad). |
2019-06-11 |
2023-08-13 |
human |
| Yusuf Hussain, Sunil K Jain, Puneet K Samaiy. Short-term westernized (HFFD) diet fed in adolescent rats: Effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. Behavioural brain research. vol 361. 2019-06-04. PMID:30584898. |
short-term westernized (hffd) diet fed in adolescent rats: effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. |
2019-06-04 |
2023-08-13 |
rat |
| Yusuf Hussain, Sunil K Jain, Puneet K Samaiy. Short-term westernized (HFFD) diet fed in adolescent rats: Effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. Behavioural brain research. vol 361. 2019-06-04. PMID:30584898. |
insres induced hippocampal insulin signaling has serious consequence on hampered sensorimotor, cognitive performance and long term potentiation accompained to neuronal cell death in hippocampus. |
2019-06-04 |
2023-08-13 |
rat |
| Yusuf Hussain, Sunil K Jain, Puneet K Samaiy. Short-term westernized (HFFD) diet fed in adolescent rats: Effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. Behavioural brain research. vol 361. 2019-06-04. PMID:30584898. |
therefore, we investigated a one-week hffd model to augment the state of insres along with a single sub-diabetogenic dose of stz (45 mg/kg i.p) to produce a hampered hippocampal insulin signaling associated with frank hyperglycemia and other biochemical and neurobehavioral alterations in young rats. |
2019-06-04 |
2023-08-13 |
rat |
| Yusuf Hussain, Sunil K Jain, Puneet K Samaiy. Short-term westernized (HFFD) diet fed in adolescent rats: Effect on glucose homeostasis, hippocampal insulin signaling, apoptosis and related cognitive and recognition memory function. Behavioural brain research. vol 361. 2019-06-04. PMID:30584898. |
whereas, we observed a decrease in hippocampal insulin signaling and translocation of glucose transporter type 4 (glut4) to neuronal membrane. |
2019-06-04 |
2023-08-13 |
rat |
| Shaojun Yun, Yanli Wu, Ruiyan Niu, Cuiping Feng, Jundong Wan. Effects of lead exposure on brain glucose metabolism and insulin signaling pathway in the hippocampus of rats. Toxicology letters. vol 310. 2019-05-28. PMID:30980912. |
effects of lead exposure on brain glucose metabolism and insulin signaling pathway in the hippocampus of rats. |
2019-05-28 |
2023-08-13 |
rat |
| Shaojun Yun, Yanli Wu, Ruiyan Niu, Cuiping Feng, Jundong Wan. Effects of lead exposure on brain glucose metabolism and insulin signaling pathway in the hippocampus of rats. Toxicology letters. vol 310. 2019-05-28. PMID:30980912. |
then, the weight of the rats; brain pb content; brain glucose levels; activities of hexokinase, fructose-6-phosphate kinase, pyruvate kinase, glucose-6-phosphate dehydrogenase; expression of genes related to the insulin signaling pathway; as well as the gene and protein expression of glucose transporter (glut)-1 and glut-3 in the hippocampus were evaluated. |
2019-05-28 |
2023-08-13 |
rat |
| Sunmin Park, Da Sol Kim, Suna Kang, Hyun Jin Ki. The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. Nutrition research (New York, N.Y.). vol 60. 2019-05-24. PMID:30527255. |
the combination of luteolin and l-theanine improved alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. |
2019-05-24 |
2023-08-13 |
rat |
| Sunmin Park, Da Sol Kim, Suna Kang, Hyun Jin Ki. The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. Nutrition research (New York, N.Y.). vol 60. 2019-05-24. PMID:30527255. |
ad-luth improved memory function, as determined by water maze and passive avoidance tests, by potentiating the hippocampal insulin signaling and reducing inflammation: luteolin mainly potentiated insulin signaling via the pakt➔pgsk➔ptau pathway, and l-theanine primarily reduced tumor necrosis factor-α. |
2019-05-24 |
2023-08-13 |
rat |