| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue-Peng Bian, Rui-Fang Ji, Bei-Bei Liu, Jing-Yun Hu, Ming-Ming Li, Xiang-Li Xue, Shu-Jie Lo. [Aerobic exercise reduces the expression of pyroptosis-related proteins and inflammatory factors in hippocampus of mice with insulin resistance]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820308. |
the aim of the present study was to observe the expression of pyroptosis- and inflammation-related proteins in the hippocampus of mice with insulin resistance (ir) after aerobic exercise, and to explore the possible mechanism of exercise to improve ir. |
2020-09-24 |
2023-08-13 |
mouse |
| Akram Sadeghi, Hadi Asghari, Javad Hami, Mina Mohasel Roodi, Hamideh Mostafaee, Mohammad Karimipour, Mohamadreza Namavar, Faezeh Idoo. Volumetric investigation of the hippocampus in rat offspring due to diabetes in pregnancy-A stereological study. Journal of chemical neuroanatomy. vol 101. 2020-09-22. PMID:31442582. |
this study was designed to investigate the effects of maternal diabetes during the pregnancy period and insulin therapy on the neuronal density and the volume of different subfields of the hippocampus in rat offspring at postnatal day 14 (p14). |
2020-09-22 |
2023-08-13 |
rat |
| Adrián Martín-Segura, Tariq Ahmed, Álvaro Casadomé-Perales, Irene Palomares-Perez, Ernest Palomer, Axelle Kerstens, Sebastian Munck, Detlef Balschun, Carlos G Dott. Age-associated cholesterol reduction triggers brain insulin resistance by facilitating ligand-independent receptor activation and pathway desensitization. Aging cell. vol 18. issue 3. 2020-09-14. PMID:30884121. |
using long-term depression (ltd) induced by application of insulin to hippocampal slices as a read-out, we found that the decline in insulin function during aging could be monitored as a progressive impairment of insulin-ltd. |
2020-09-14 |
2023-08-13 |
mouse |
| Balaji Krishnan, Hanaa S Sallam, Batbayar Tumurbataar, Salvatore Saieva, Da'Marcus Baymon, Demidmaa Tuvdendorj, Maria-Adelaide Micci, Nicola Abate, Giulio Taglialatel. Amelioration of hippocampal dysfunction by adipose tissue-targeted stem cell transplantation in a mouse model of type 2 diabetes. Journal of neurochemistry. vol 153. issue 1. 2020-08-31. PMID:31730234. |
we recently confirmed altered lipid composition, down-regulation of insulin receptor expression and impaired basal synaptic transmission in the hippocampus of our transgenic murine model of adipocyte insulin resistance (atenpp1-tg). |
2020-08-31 |
2023-08-13 |
mouse |
| Yan-Jun Wu, Kai-Hui Wu, Rong Jiang, Yi-Ying Wang, Min Luo, Qing-Qian Xia, Cheng-Lin Tang, Shu-Juan Zhu, Hua-Jun Shen. [Effect of electroacupuncture on the expression of insulin signal pathway related proteins in hippocampus in mice with Alzheimer's disease]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 5. 2020-08-19. PMID:32394659. |
[effect of electroacupuncture on the expression of insulin signal pathway related proteins in hippocampus in mice with alzheimer's disease]. |
2020-08-19 |
2023-08-13 |
mouse |
| Yan-Jun Wu, Kai-Hui Wu, Rong Jiang, Yi-Ying Wang, Min Luo, Qing-Qian Xia, Cheng-Lin Tang, Shu-Juan Zhu, Hua-Jun Shen. [Effect of electroacupuncture on the expression of insulin signal pathway related proteins in hippocampus in mice with Alzheimer's disease]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 5. 2020-08-19. PMID:32394659. |
to observe the effect of electroacupuncture (ea) on the expression of insulin phosphatidylinositol-3 kinase/glycogen synthetase kinase-3α (pi3k/gsk3α) signal pathway related proteins in the hippocampus in mice with alzheimer's disease (ad), and to explore the regulatory mechanism of ea on improving the pathological characteristics of ad. |
2020-08-19 |
2023-08-13 |
mouse |
| Ewan C McNay, Jiah Pearson-Lear. GluT4: A central player in hippocampal memory and brain insulin resistance. Experimental neurology. vol 323. 2020-07-21. PMID:31614121. |
glut4: a central player in hippocampal memory and brain insulin resistance. |
2020-07-21 |
2023-08-13 |
Not clear |
| Ewan C McNay, Jiah Pearson-Lear. GluT4: A central player in hippocampal memory and brain insulin resistance. Experimental neurology. vol 323. 2020-07-21. PMID:31614121. |
insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. |
2020-07-21 |
2023-08-13 |
Not clear |
| Ewan C McNay, Jiah Pearson-Lear. GluT4: A central player in hippocampal memory and brain insulin resistance. Experimental neurology. vol 323. 2020-07-21. PMID:31614121. |
several lines of research converge to suggest that the insulin-responsive glucose transporter glut4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance. |
2020-07-21 |
2023-08-13 |
Not clear |
| Paula Bortoluzzi Canteiro, Daniel Casagrande Antero, Natalia Dos Santos Tramontin, Kellen Ugioni Simon, Carolini Mendes, Maria Eduarda Anastácio Borges Correa, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function. Brain research bulletin. vol 149. 2020-07-20. PMID:31002914. |
whereas the levels of brain-derived neurotrophic factor and beta-nerve growth factor in the hippocampus were not altered by lps, they were decreased in the cortex by insulin. |
2020-07-20 |
2023-08-13 |
rat |
| Paula Bortoluzzi Canteiro, Daniel Casagrande Antero, Natalia Dos Santos Tramontin, Kellen Ugioni Simon, Carolini Mendes, Maria Eduarda Anastácio Borges Correa, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function. Brain research bulletin. vol 149. 2020-07-20. PMID:31002914. |
the il-1β and tnf-α levels were increased in the cortex and hippocampus following exposure to lps, but insulin reversed these effects. |
2020-07-20 |
2023-08-13 |
rat |
| Chelsea M Griffith, Lauren N Macklin, Yan Cai, Andrew A Sharp, Xiao-Xin Yan, Lawrence P Reagan, April D Strader, Gregory M Rose, Peter R Patryl. Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30775979. |
impaired glucose tolerance and reduced plasma insulin precede decreased akt phosphorylation and glut3 translocation in the hippocampus of old 3xtg-ad mice. |
2020-07-14 |
2023-08-13 |
mouse |
| Chelsea M Griffith, Lauren N Macklin, Yan Cai, Andrew A Sharp, Xiao-Xin Yan, Lawrence P Reagan, April D Strader, Gregory M Rose, Peter R Patryl. Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30775979. |
additionally, we examined for altered insulin signaling in the hippocampus. |
2020-07-14 |
2023-08-13 |
mouse |
| Boe-Hyun Kim, Jennifer Kelschenbach, Alejandra Borjabad, Eran Hadas, Hongxia He, Mary Jane Potash, Michael T Nedelcovych, Rana Rais, Norman J Haughey, Justin C McArthur, Barbara S Slusher, David J Volsk. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. AIDS (London, England). vol 33. issue 6. 2020-06-04. PMID:30946151. |
intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of hiv-associated neurocognitive disorders in ecohiv-infected mice. |
2020-06-04 |
2023-08-13 |
mouse |
| Anand Kamal Sachdeva, Ravinder Naik Dharavath, Kanwaljit Chopr. Time-response studies on development of cognitive deficits in an experimental model of insulin resistance. Clinical nutrition (Edinburgh, Scotland). vol 38. issue 3. 2020-06-01. PMID:30037709. |
chronic fructose feeding results in hippocampal insulin resistance. |
2020-06-01 |
2023-08-13 |
rat |
| Kaiwu He, Lulin Nie, Qiang Zhou, Shafiq Ur Rahman, Jianjun Liu, Xifei Yang, Shupeng L. Proteomic Profiles of the Early Mitochondrial Changes in APP/PS1 and ApoE4 Transgenic Mice Models of Alzheimer's Disease. Journal of proteome research. vol 18. issue 6. 2020-05-27. PMID:31055927. |
taken together, our study exposed the changes of hippocampal protein expression profiles at the early stage of app/ps1 and apoe4 knockin mice, and the change of insulin signaling and mitochondrial electron transport chain may be the key molecular processes involved in ad progression. |
2020-05-27 |
2023-08-13 |
mouse |
| Gregory N Ruegsegger, Shankarappa Manjunatha, Priska Summer, Srinivas Gopala, Piotr Zabeilski, Surendra Dasari, Patrick M Vanderboom, Ian R Lanza, Katherine A Klaus, K Sreekumaran Nai. Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2020-05-11. PMID:30676773. |
we show that insulin deficiency in streptozotocin-induced diabetic mice decreased mitochondrial atp production and/or citrate synthase and cytochrome oxidase activities in the cerebrum, hypothalamus, and hippocampus. |
2020-05-11 |
2023-08-13 |
mouse |
| Caio H Mazucanti, Elisa M Kawamoto, Mark P Mattson, Cristoforo Scavone, Simonetta Camandol. Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 8. 2020-05-08. PMID:29493420. |
here, we show that cultured hippocampal neurons respond to insulin and glutamate stimulation by elevating klotho protein levels. |
2020-05-08 |
2023-08-13 |
Not clear |
| Wenqi Gao, Wei Wang, Jing Zhang, Pengyi Deng, Jun Hu, Jian Yang, Zhifang Den. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31201726. |
furthermore, markers of oxidative stress, mitochondrial function, autophagy, and insulin resistance were measured in the hippocampal tissue. |
2020-04-30 |
2023-08-13 |
mouse |
| Wenqi Gao, Wei Wang, Jing Zhang, Pengyi Deng, Jun Hu, Jian Yang, Zhifang Den. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31201726. |
the depressive-like behaviors presented in the obese mice were accompanied by remarkably excessive reactive oxygen species (ros) production and oxidative stress, damaged mitochondrial function, imbalanced autophagy, and enhanced insulin resistance in the hippocampus. |
2020-04-30 |
2023-08-13 |
mouse |