| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Mal-Soon Shin, Tae-Woon Ki. Exercise Alleviates Cognitive Functions by Enhancing Hippocampal Insulin Signaling and Neuroplasticity in High-Fat Diet-Induced Obesity. Nutrients. vol 11. issue 7. 2020-01-09. PMID:31311133. |
exercise alleviates cognitive functions by enhancing hippocampal insulin signaling and neuroplasticity in high-fat diet-induced obesity. |
2020-01-09 |
2023-08-13 |
mouse |
| Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Mal-Soon Shin, Tae-Woon Ki. Exercise Alleviates Cognitive Functions by Enhancing Hippocampal Insulin Signaling and Neuroplasticity in High-Fat Diet-Induced Obesity. Nutrients. vol 11. issue 7. 2020-01-09. PMID:31311133. |
we investigated whether the decline in cognitive function caused by a hfd could be improved through exercise by examining insulin signaling pathways and neuroplasticity in the hippocampus. |
2020-01-09 |
2023-08-13 |
mouse |
| Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Mal-Soon Shin, Tae-Woon Ki. Exercise Alleviates Cognitive Functions by Enhancing Hippocampal Insulin Signaling and Neuroplasticity in High-Fat Diet-Induced Obesity. Nutrients. vol 11. issue 7. 2020-01-09. PMID:31311133. |
in addition, the hfd group showed a decrease in insulin signaling and neuroplasticity in the hippocampus and the dentate gyrus and increased cognitive function impairment, which were reversed by physical exercise. |
2020-01-09 |
2023-08-13 |
mouse |
| Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Mal-Soon Shin, Tae-Woon Ki. Exercise Alleviates Cognitive Functions by Enhancing Hippocampal Insulin Signaling and Neuroplasticity in High-Fat Diet-Induced Obesity. Nutrients. vol 11. issue 7. 2020-01-09. PMID:31311133. |
overall, our findings indicate that physical exercise may act as a non-pharmacologic method that protects against cognitive dysfunction caused by obesity by improving hippocampal insulin signaling and neuroplasticity. |
2020-01-09 |
2023-08-13 |
mouse |
| Vanessa Russo, Patrizio Candeloro, Natalia Malara, Gerardo Perozziello, Michelangelo Iannone, Miriam Scicchitano, Rocco Mollace, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Valeria M Morittu, Santo Gratteri, Ernesto Palma, Carolina Muscoli, Enzo Di Fabrizio, Vincenzo Mollac. Key Role of Cytochrome C for Apoptosis Detection Using Raman Microimaging in an Animal Model of Brain Ischemia with Insulin Treatment. Applied spectroscopy. vol 73. issue 10. 2019-12-30. PMID:31219322. |
intracerebroventricular microinfusion of insulin significantly prevents the apoptosis of ca3 hippocampal neurons. |
2019-12-30 |
2023-08-13 |
Not clear |
| Ana Babic Perhoc, Jelena Osmanovic Barilar, Ana Knezovic, Vladimir Farkas, Robert Bagaric, Alfred Svarc, Edna Grünblatt, Peter Riederer, Melita Salkovic-Petrisi. Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice. Neuropharmacology. vol 148. 2019-12-27. PMID:30571958. |
improvement of reduced grooming behavior and normalization in reduced plasma insulin levels were seen only in 5m+2m tg2576 mice while in 10m+2m tg2576 mice oral galactose induced metabolic exacerbation at the level of plasma insulin, glp-1 homeostasis and glucose intolerance, and additionally increased hippocampal saβ1-42 level, decreased ir expression and increased gsk-3β activity. |
2019-12-27 |
2023-08-13 |
mouse |
| Men Su, Kambiz Naderi, Nathalie Samson, Ihsen Youssef, Livia Fülöp, Zsolt Bozso, Serge Laroche, Benoit Delatour, Sabrina Davi. Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30684218. |
over 35 weeks, this induced classic signs of t2d (hyperglycemia and insulin dysfunction) and a modest, but stable deficit in spatial recognition memory, with very little long-term modification of proteins in or associated with ir/pi3k/akt signalling in ca1 of the hippocampus. |
2019-12-17 |
2023-08-13 |
human |
| Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blu. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiology of disease. vol 125. 2019-12-16. PMID:30665005. |
using electrophysiological and biochemical evaluations, we surprisingly observed that, at a time when tau pathology and cognitive deficits are overt and obvious, the hippocampus of thy-tau22 mice exhibits enhanced response to insulin. |
2019-12-16 |
2023-08-13 |
mouse |
| Christopher Powe. Neurologic disease in feline immunodeficiency virus infection: disease mechanisms and therapeutic interventions for NeuroAIDS. Journal of neurovirology. vol 24. issue 2. 2019-11-25. PMID:29247305. |
in insulin also reduced neuroinflammation and protected neurons in the hippocampus, striatum, and neocortex of fiv-infected animals. |
2019-11-25 |
2023-08-13 |
human |
| Dmitry Petrov, Ignacio Pedrós, Gonzalo Artiach, Francesc X Sureda, Emma Barroso, Mercè Pallàs, Gemma Casadesús, Carlos Beas-Zarate, Eva Carro, Isidro Ferrer, Manuel Vazquez-Carrera, Jaume Folch, Antoni Camin. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochimica et biophysica acta. vol 1852. issue 9. 2019-11-20. PMID:26003667. |
high-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to alzheimer disease pathology in rodents. |
2019-11-20 |
2023-08-13 |
mouse |
| Hiranya Pintana, Pongpan Tanajak, Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Titikorn Chunchai, Pattarapong Satjaritanun, Linlada Leelarphat, Nipon Chattipakorn, Siriporn C Chattipakor. Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats. The British journal of nutrition. 2019-11-20. PMID:27852331. |
however, the effects of er or the combination with vildagliptin on brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function in obese insulin-resistant rats have never been investigated. |
2019-11-20 |
2023-08-13 |
rat |
| Hiranya Pintana, Pongpan Tanajak, Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Titikorn Chunchai, Pattarapong Satjaritanun, Linlada Leelarphat, Nipon Chattipakorn, Siriporn C Chattipakor. Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats. The British journal of nutrition. 2019-11-20. PMID:27852331. |
we hypothesised that er with ddp-4 inhibitor exerts better efficacy than er alone in improving cognition in obese insulin-resistant male rats by restoring brain insulin sensitivity, brain mitochondrial function and hippocampal synaptic plasticity. |
2019-11-20 |
2023-08-13 |
rat |
| Hiranya Pintana, Pongpan Tanajak, Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Titikorn Chunchai, Pattarapong Satjaritanun, Linlada Leelarphat, Nipon Chattipakorn, Siriporn C Chattipakor. Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats. The British journal of nutrition. 2019-11-20. PMID:27852331. |
at the end of the treatment, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity and brain mitochondrial function were determined. |
2019-11-20 |
2023-08-13 |
rat |
| Hiranya Pintana, Pongpan Tanajak, Wasana Pratchayasakul, Piangkwan Sa-Nguanmoo, Titikorn Chunchai, Pattarapong Satjaritanun, Linlada Leelarphat, Nipon Chattipakorn, Siriporn C Chattipakor. Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats. The British journal of nutrition. 2019-11-20. PMID:27852331. |
although hfd-fed rats treated with er and er plus vildagliptin showed restored peripheral insulin sensitivity and improved lipid profiles, only er plus vildagliptin rats had restored brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function. |
2019-11-20 |
2023-08-13 |
rat |
| Véronica Rougeon, Marie-Pierre Moisan, Nicole Barthe, Marie-Christine Beauvieux, Jean-Christophe Helbling, Véronique Pallet, Nathalie Marissal-Arvy, Pascal Bara. Diabetes and Insulin Injection Modalities: Effects on Hepatic and Hippocampal Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Juvenile Diabetic Male Rats. Frontiers in endocrinology. vol 8. 2019-11-20. PMID:28458655. |
diabetes and insulin injection modalities: effects on hepatic and hippocampal expression of 11β-hydroxysteroid dehydrogenase type 1 in juvenile diabetic male rats. |
2019-11-20 |
2023-08-13 |
rat |
| Ramavat Ravindhar Naik, Praveen Kumar Munipally, Turlapati Nagaraj. Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats. Cardiovascular & hematological agents in medicinal chemistry. 2019-11-20. PMID:29076435. |
andrographolide (2.5 mg/kg b.w) was administered orally to diabetic rats and glibenclamide (25mg/kg b.w) as control for 30 days to assess its effects on blood glucose, insulin, insulin resistance and antioxidant profiles such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation in various regions of brain namely hypothalamus, cerebellum, hippocampus and brain cerebral cortex. |
2019-11-20 |
2023-08-13 |
rat |
| Anna Kurek, Katarzyna Głombik, Jan Detka, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewsk. Regulators of glucocorticoid receptor function in an animal model of depression and obesity. Journal of neuroendocrinology. 2019-11-20. PMID:29524264. |
the decrease in mr density in the hippocampus and increased plasma insulin level seemed to be the most significant changes observed in the model of the co-occurrence of depression and obesity, which could limit the neuroprotective effects associated with the activation of mr and be a marker of peripheral insulin resistance, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Sujeong Park, Steven Hyun Seung Lee, Won Il Lee, Rachelle Choi, Seong Who Kim, Ha-Na Woo, Heuiran Le. MicroRNA expression profiling of adult hippocampal neural stem cells upon cell death reveals an autophagic cell death-like pattern. Biochemical and biophysical research communications. vol 509. issue 3. 2019-11-04. PMID:30612732. |
adult hippocampal neural (hcn) stem cells promptly undergo irreversible autophagic cell death (acd) if deprived of insulin in culture. |
2019-11-04 |
2023-08-13 |
rat |
| Erin R Hascup, Sarah O Broderick, Mary K Russell, Yimin Fang, Andrzej Bartke, Heather A Boger, Kevin N Hascu. Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice. Journal of neurochemistry. vol 148. issue 2. 2019-10-28. PMID:30472734. |
diet-induced insulin resistance elevates hippocampal glutamate as well as vglut1 and gfap expression in aβpp/ps1 mice. |
2019-10-28 |
2023-08-13 |
mouse |
| Noriyasu Kamei, Nobuyuki Okada, Takamasa Ikeda, Hayoung Choi, Yui Fujiwara, Haruka Okumura, Mariko Takeda-Morishit. Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30518944. |
the activation of hippocampal insulin signaling after the simultaneous nose-to-brain delivery of exendin-4 and an adequate level of insulin were confirmed by analyzing the phosphorylation of akt. |
2019-10-21 |
2023-08-13 |
mouse |