| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninc. Spatial dynamics of the insulin receptor in living neurons. Journal of neurochemistry. vol 156. issue 1. 2021-04-12. PMID:31886886. |
it has been proposed that hippocampal insulin signaling is important for memory, that brain insulin signaling is deficient in alzheimer's disease, and that intranasal insulin treatment improves cognition, but the mechanisms remain unclear and do not seem to involve increased glucose uptake by neurons. |
2021-04-12 |
2023-08-13 |
rat |
| Leela Paladugu, Abeer Gharaibeh, Nivya Kolli, Cameron Learman, Tia C Hall, Lixin Li, Julien Rossignol, Panchanan Maiti, Gary L Dunba. Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-07. PMID:33467075. |
the extent of neurodegeneration, aβ plaque load, and key proteins associated with the insulin signaling pathways were measured using western blot and neuroinflammation (via immunohistological assays) in the cortical and hippocampal regions of the brain were assessed following a series of behavioral tests used to measure cognitive function after lir or vehicle treatments. |
2021-04-07 |
2023-08-13 |
mouse |
| Catrina Sims-Robinson, Anna Bakeman, Elizabeth Bruno, Samuel Jackson, Rebecca Glasser, Geoffrey G Murphy, Eva L Feldma. Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life. PloS one. vol 11. issue 9. 2021-04-05. PMID:27676071. |
to investigate the long-term impact of a hfd on hippocampal insulin signaling and memory, c57bl6 mice were placed into one of three groups based on the diet: a standard diet (control), a hfd, or a hfd for 16 weeks and then the standard diet for 8 weeks (hf16). |
2021-04-05 |
2023-08-13 |
mouse |
| Catrina Sims-Robinson, Anna Bakeman, Elizabeth Bruno, Samuel Jackson, Rebecca Glasser, Geoffrey G Murphy, Eva L Feldma. Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life. PloS one. vol 11. issue 9. 2021-04-05. PMID:27676071. |
hfd-induced impairments in glucose tolerance and hippocampal insulin signaling occurred concurrently with deficits in both short- and long-term memory. |
2021-04-05 |
2023-08-13 |
mouse |
| Austin M Reilly, Andy P Tsai, Peter B Lin, Aaron C Ericsson, Adrian L Oblak, Hongxia Re. Metabolic Defects Caused by High-Fat Diet Modify Disease Risk through Inflammatory and Amyloidogenic Pathways in a Mouse Model of Alzheimer's Disease. Nutrients. vol 12. issue 10. 2021-03-31. PMID:33003412. |
collectively, our results showed that 5xfad mice were more susceptible to hfd-induced metabolic dysregulation and suggest that targeting metabolic dysfunctions can ameliorate ad symptoms via effects on insulin signaling and neuroinflammation in the hippocampus. |
2021-03-31 |
2023-08-13 |
mouse |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
insulin resistance or dysfunction of insulin signaling is a universal feature of t2d, the main culprit for altered glucose metabolism and its interdependence on cell death pathways, forming the basis of linking t2d with ad as it may exacerbate aβ accumulation, tau hyperphosphorylation and devastates glucose transportation, energy metabolism, hippocampal framework and promulgate inflammatory pathways. |
2021-03-29 |
2023-08-13 |
Not clear |
| Amira M Abo-Youssef, Waleed A Khallaf, Mahmoud M Khattab, Basim A S Messih. The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32450287. |
furthermore, it improved cognitive impairment and suppressed hippocampal amyloidogenic markers including amyloid-beta level, phosphorylated tau protein and beta site amyloid precursor protein cleaving enzyme 1 expression, while elevated levels of insulin degrading enzyme and recovered permeability of blood brain barrier (bbb). |
2021-03-29 |
2023-08-13 |
rat |
| Shu Peng, Jin Yang, Yufeng Wang, Yang Fan, Feng Tang, Changyue Hou, Juming Yu, Xiaoming Wang, Guohui Jian. Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy. Brain research. vol 1726. 2021-03-29. PMID:31557476. |
in this study we show that low-dose intranasal insulin inhibited kainic acid (ka)- or pentylenetetrazole (ptz)-induced acute seizures and reduced epileptic discharge activities in mice, potentially by alleviating the increase in seizure-induced glutamate in the hippocampus. |
2021-03-29 |
2023-08-13 |
mouse |
| Shu Peng, Jin Yang, Yufeng Wang, Yang Fan, Feng Tang, Changyue Hou, Juming Yu, Xiaoming Wang, Guohui Jian. Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy. Brain research. vol 1726. 2021-03-29. PMID:31557476. |
meanwhile, intranasal insulin increased gaba levels and the activities of hippocampal theta, which may affect the excitability of the hippocampus. |
2021-03-29 |
2023-08-13 |
mouse |
| Qin Sun, Tingxin Li, Yamei Li, Lingling Wei, Min Zhang, Shaoping Den. Bactericidal/Permeability-Increasing Protein Improves Cognitive Impairment in Diabetic Mice Frontiers in physiology. vol 11. 2021-03-03. PMID:33643054. |
hfd mice following lps treatment showed significantly increased serum levels of tumor necrosis factor-α (tnf-α), interleukin (il)-1β, and il-6, and expressions of bcl-2-associated x protein (bax) and aβ but decreased expression of bcl-2 in hippocampal tissues, as well as enhanced fasting blood glucose, plasma insulin, glucose tolerance, insulin tolerance, cell apoptosis, aggravated hippocampal tissue injury and, ultimately, cognitive impairment. |
2021-03-03 |
2023-08-13 |
mouse |
| Nanduri R Prabhakar, Ying-Jie Peng, Jayasri Nandur. Hypoxia-inducible factors and obstructive sleep apnea. The Journal of clinical investigation. vol 130. issue 10. 2021-02-25. PMID:32730232. |
we also discuss how increased ros generation by hif-1 contributes to ih-induced insulin resistance and t2d as well as disrupted nmda receptor signaling in the hippocampus, resulting in cognitive decline. |
2021-02-25 |
2023-08-13 |
Not clear |
| Jiayuan Chen, Li Gao, Yao Zhang, Ya Su, Zheng Kong, Dongqing Wang, Ming Ya. Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:33029835. |
acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. |
2021-02-23 |
2023-08-13 |
Not clear |
| Jiayuan Chen, Li Gao, Yao Zhang, Ya Su, Zheng Kong, Dongqing Wang, Ming Ya. Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:33029835. |
the primary focus of the current study was to examine the effect of acteoside on insulin, glucose transport, and energy metabolism in the hippocampal area of the brain. |
2021-02-23 |
2023-08-13 |
Not clear |
| Jiayuan Chen, Li Gao, Yao Zhang, Ya Su, Zheng Kong, Dongqing Wang, Ming Ya. Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:33029835. |
the acteoside induced increase in the protein expression of glucose transporters (glu t1, glu t3, and glu t4), glucose, and insulin levels in the hippocampus for maintaining normal learning and memory function were demonstrated by western blot. |
2021-02-23 |
2023-08-13 |
Not clear |
| Hilaree N Frazier, Adam O Ghoweri, Emily Sudkamp, Eleanor S Johnson, Katie L Anderson, Grant Fox, Keomany Vatthanaphone, Mengfan Xia, Ruei-Lung Lin, Kendra E Hargis-Staggs, Nada M Porter, James R Pauly, Eric M Blalock, Olivier Thibaul. Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 6. 2021-01-29. PMID:31180116. |
autoradiography results showed that long-term treatment reduced insulin binding in the thalamus but not the hippocampus. |
2021-01-29 |
2023-08-13 |
rat |
| Hilaree N Frazier, Adam O Ghoweri, Emily Sudkamp, Eleanor S Johnson, Katie L Anderson, Grant Fox, Keomany Vatthanaphone, Mengfan Xia, Ruei-Lung Lin, Kendra E Hargis-Staggs, Nada M Porter, James R Pauly, Eric M Blalock, Olivier Thibaul. Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 6. 2021-01-29. PMID:31180116. |
results from hippocampal immunofluorescence revealed age-related decreases in insulin immunoreactivity that were partially offset by intranasal administration. |
2021-01-29 |
2023-08-13 |
rat |
| Hilaree N Frazier, Adam O Ghoweri, Emily Sudkamp, Eleanor S Johnson, Katie L Anderson, Grant Fox, Keomany Vatthanaphone, Mengfan Xia, Ruei-Lung Lin, Kendra E Hargis-Staggs, Nada M Porter, James R Pauly, Eric M Blalock, Olivier Thibaul. Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 6. 2021-01-29. PMID:31180116. |
microarray analyses highlighted numerous insulin-sensitive genes, suggesting insulin aspart was able to enter the brain and alter hippocampal rna expression patterns including those associated with tumor suppression. |
2021-01-29 |
2023-08-13 |
rat |
| Ansab Akhtar, Sangeeta Pilkhwal Sa. Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease. Neurochemistry international. vol 135. 2021-01-25. PMID:32092326. |
insulin and its downstream signaling molecules are located majorly in the regions of cortex and hippocampus. |
2021-01-25 |
2023-08-13 |
Not clear |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. |
2021-01-22 |
2023-08-13 |
rat |
| Napatsorn Saiyasit, Titikorn Chunchai, Dillon Prus, Kanokphong Suparan, Pansa Pittayapong, Nattayaporn Apaijai, Wasana Pratchayasakul, Jirapas Sripetchwandee, Nipon Chattipakorn M D Ph D, Siriporn C Chattipakor. Gut dysbiosis develops before metabolic disturbance and cognitive decline in high-fat diet-induced obese condition. Nutrition (Burbank, Los Angeles County, Calif.). vol 69. 2020-12-23. PMID:31580986. |
therefore, the aim of this study was to test the hypothesis that gut dysbiosis, peripheral inflammation, and peripheral insulin resistance occur before the brain inflammatory response, hippocampal synaptic dysplasticity, oxidative stress, apoptosis, and cognitive impairment in hfd-fed rats. |
2020-12-23 |
2023-08-13 |
rat |