| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kellen Ugioni Simon, Elias Wiggers Neto, Natalia Dos Santos Tramontin, Paula Bortoluzzi Canteiro, Barbara da Costa Pereira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. Peptides. vol 123. 2020-12-10. PMID:31639435. |
intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. |
2020-12-10 |
2023-08-13 |
mouse |
| Kellen Ugioni Simon, Elias Wiggers Neto, Natalia Dos Santos Tramontin, Paula Bortoluzzi Canteiro, Barbara da Costa Pereira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. Peptides. vol 123. 2020-12-10. PMID:31639435. |
in the hippocampus, in insulin significantly decreased the bdnf level. |
2020-12-10 |
2023-08-13 |
mouse |
| Kellen Ugioni Simon, Elias Wiggers Neto, Natalia Dos Santos Tramontin, Paula Bortoluzzi Canteiro, Barbara da Costa Pereira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. Peptides. vol 123. 2020-12-10. PMID:31639435. |
lps significantly increased the interleukin (il)-6 levels in the cortex, while in insulin significantly decreased its levels in the hippocampus. |
2020-12-10 |
2023-08-13 |
mouse |
| Kellen Ugioni Simon, Elias Wiggers Neto, Natalia Dos Santos Tramontin, Paula Bortoluzzi Canteiro, Barbara da Costa Pereira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. Peptides. vol 123. 2020-12-10. PMID:31639435. |
the tumor necrosis factor-α levels were significantly decreased by in insulin both in the cortex and hippocampus. |
2020-12-10 |
2023-08-13 |
mouse |
| Kellen Ugioni Simon, Elias Wiggers Neto, Natalia Dos Santos Tramontin, Paula Bortoluzzi Canteiro, Barbara da Costa Pereira, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model. Peptides. vol 123. 2020-12-10. PMID:31639435. |
lps significantly increased the antioxidant enzyme activity both in the cortex and hippocampus, whereas in insulin significantly increased the activity of both superoxide dismutase and catalase in the hippocampus and that of catalase in the cortex. |
2020-12-10 |
2023-08-13 |
mouse |
| Zhen Jin, Kyung Eun Kim, Hyun Joo Shin, Eun Ae Jeong, Kyung-Ah Park, Jong Youl Lee, Hyeong Seok An, Eun Bee Choi, Jae Hun Jeong, Woori Kwak, Gu Seob Ro. Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob/ob Mice. Journal of neuropathology and experimental neurology. vol 79. issue 5. 2020-12-04. PMID:32296847. |
here, we investigated whether lcn2-mediated signaling promotes neurodegeneration in the hippocampus of leptin-deficient ob/ob mice, which are characterized by obesity, insulin resistance, systemic inflammation, and neuroinflammation. |
2020-12-04 |
2023-08-13 |
mouse |
| Katarzyna Głombik, Jan Detka, Joanna Góralska, Anna Kurek, Bogdan Solnica, Bogusława Budziszewsk. Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes. Neurotoxicity research. vol 37. issue 2. 2020-11-12. PMID:31782099. |
in the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of glut4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished glp-1r, which could cause neurodegenerative changes in the hippocampus. |
2020-11-12 |
2023-08-13 |
rat |
| Elizabeth M Rhea, Surabhi Nirkhe, Steven Nguyen, Sarah Pemberton, Theo K Bammler, Richard Beyer, Michael L Niehoff, John E Morley, Susan A Farr, William A Bank. Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice. Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31561374. |
using the samp8 mouse model of ad, we investigated the impact of inl insulin on protein and gene expression in brain regions including the olfactory bulb, hypothalamus, and hippocampus. |
2020-11-06 |
2023-08-13 |
mouse |
| Elizabeth M Rhea, Surabhi Nirkhe, Steven Nguyen, Sarah Pemberton, Theo K Bammler, Richard Beyer, Michael L Niehoff, John E Morley, Susan A Farr, William A Bank. Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice. Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31561374. |
however, we did find the expression of genes present in the hippocampus involved in other pathways, especially those related to inflammation, were altered due to age and with a dose of inl insulin previously shown to improve cognition. |
2020-11-06 |
2023-08-13 |
mouse |
| Arianna Mazzoli, Maria Stefania Spagnuolo, Cristina Gatto, Martina Nazzaro, Rosa Cancelliere, Raffaella Crescenzo, Susanna Iossa, Luisa Ciglian. Adipose Tissue and Brain Metabolic Responses to Western Diet-Is There a Similarity between the Two? International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991770. |
specific cyto/adipokines (tumor necrosis factor alpha (tnf-α), adiponectin), critical obesity-inflammatory markers (haptoglobin, lipocalin), and insulin signaling or survival protein network (insulin receptor substrate 1 (irs), akt, erk) were quantified in epididymal white adipose tissue (e-wat), hippocampus, and frontal cortex. |
2020-11-05 |
2023-08-13 |
rat |
| Tsan-Ju Chen, Shun-Sheng Chen, Dean-Chuan Wang, Hui-Shan Hun. High-fat diet reduces novelty-induced expression of activity-regulated cytoskeleton-associated protein. Journal of cellular physiology. vol 235. issue 2. 2020-10-16. PMID:31264208. |
accordingly, it is suggested that following hfd feeding, the reduction in novelty-induced arc protein expression in animal's hippocampus is probably related to a suppressed activation of the pi3k/akt/p70s6k pathway due to the existence of brain insulin resistance. |
2020-10-16 |
2023-08-13 |
mouse |
| Whitney Franklin, Balaji Krishnan, Giulio Taglialatel. Chronic synaptic insulin resistance after traumatic brain injury abolishes insulin protection from amyloid beta and tau oligomer-induced synaptic dysfunction. Scientific reports. vol 9. issue 1. 2020-10-15. PMID:31160730. |
we detected acute and chronic decreases in insulin responsiveness in isolated hippocampal synaptosomes after tbi. |
2020-10-15 |
2023-08-13 |
rat |
| Sunmin Park, Ting Zhang, Xuangao Wu, Jing Yi Qi. Ketone production by ketogenic diet and by intermittent fasting has different effects on the gut microbiota and disease progression in an Alzheimer's disease rat model. Journal of clinical biochemistry and nutrition. vol 67. issue 2. 2020-10-13. PMID:33041517. |
hippocampal insulin signaling (pakt→pgsk-3β) was potentiated and ptau was attenuated in ad-imf and ad-cho much more than ad-con. |
2020-10-13 |
2023-08-13 |
rat |
| Shize Li, Nini Wang, Jiyu Lou, Xiaoman Zhan. Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Experimental and therapeutic medicine. vol 9. issue 6. 2020-10-01. PMID:26136993. |
the aim of this study was to investigate the expression of β-site app-cleaving enzyme 1 (bace1) in the hippocampal tissue of an insulin-resistant rat model, and thereby explore the roles of bace1 and insulin resistance (ir) in the pathogenesis of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
rat |
| Ping Sun, Gabriela Ortega, Yan Tan, Qian Hua, Peter F Riederer, Jürgen Deckert, Angelika G Schmitt-Böhre. Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867451. |
streptozotocin impairs proliferation and differentiation of adult hippocampal neural stem cells rats intracerebroventricularily (icv) treated with streptozotocin (stz), shown to generate an insulin resistant brain state, were used as an animal model for the sporadic form of alzheimer's disease (sad). |
2020-10-01 |
2023-08-13 |
rat |
| Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasem. Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. EXCLI journal. vol 17. 2020-10-01. PMID:30233281. |
investigating the role of p38, jnk and erk in lps induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. |
2020-10-01 |
2023-08-13 |
rat |
| Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasem. Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. EXCLI journal. vol 17. 2020-10-01. PMID:30233281. |
given that inflammatory mediators are shown to interfere with insulin signaling pathway in different cell types, the present work aimed to investigate whether neuro-inflammation induced memory loss is associated with hippocampal ir and whether insulin treatment protects against this ir. |
2020-10-01 |
2023-08-13 |
rat |
| Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasem. Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. EXCLI journal. vol 17. 2020-10-01. PMID:30233281. |
the outcomes indicated that while lps induced memory loss and hippocampal ir (shown by elevated irs1 and decreased akt phosphorylation), insulin treatment nullified these effects. |
2020-10-01 |
2023-08-13 |
rat |
| Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkool. Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomedical reports. vol 10. issue 1. 2020-10-01. PMID:30588303. |
antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. |
2020-10-01 |
2023-08-13 |
rat |
| Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkool. Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomedical reports. vol 10. issue 1. 2020-10-01. PMID:30588303. |
in the present study the antioxidant and neuroprotective effects of insulin and lycopene on passive avoidance memory, total antioxidant capacity (tac), malondialdehyde activity (mda) and prevention of apoptosis in the hippocampus streptozotocin-induced diabetic rats were examined. |
2020-10-01 |
2023-08-13 |
rat |