| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yua. Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. Toxicology. 2022-04-30. PMID:35489422. |
chronic exposure of bisphenol-a impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. |
2022-04-30 |
2023-08-13 |
mouse |
| Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yua. Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. Toxicology. 2022-04-30. PMID:35489422. |
hence, the purpose of the actual study was to consider the impacts of bpa exposure on cognitive function and insulin signaling pathway in the hippocampus of male offspring mice. |
2022-04-30 |
2023-08-13 |
mouse |
| Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yua. Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. Toxicology. 2022-04-30. PMID:35489422. |
the behavioral tests, blood sugar level, histological observation, transcriptome sequencing, glucose transporter 4 (glut4), and hippocampal insulin signaling pathway were checked for the male offspring mice at 13 weeks of age (pnd91). |
2022-04-30 |
2023-08-13 |
mouse |
| Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yua. Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. Toxicology. 2022-04-30. PMID:35489422. |
our data indicated that bpa exposure impaired cognitive function, disrupted the hippocampal regular cell arrangement, increased blood glucose levels, disturbed the insulin signaling pathway including phosphorylated insulin receptor substrate1 (p-irs1), protein kinase b (p-akt), and glycogen synthase kinase 3β (p-gsk3β). |
2022-04-30 |
2023-08-13 |
mouse |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
we observed memory impairment, aβ aggregation, tau hyper-phosphorylation, neuroinflammation, insulin signaling dys-regulation, and down-regulation of mir-26a, mir-124, mir-29a, mir-181b, mir-125b, mir-132, and mir-146a in the hippocampus of aβo-exposed rats 21 days after aβo injection. |
2022-04-27 |
2023-08-13 |
rat |
| Seong-Hyun Kim, Sang-Seo Park, Chang-Ju Kim, Tae-Woon Ki. Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice. Journal of exercise rehabilitation. vol 18. issue 1. 2022-03-31. PMID:35356135. |
exercise with 40-hz light flicker improves hippocampal insulin signaling in alzheimer disease mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Zeinab Rafiee, Alba M García-Serrano, João M N Duart. Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334949. |
on the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. |
2022-03-26 |
2023-08-13 |
Not clear |
| Ting Zhang, Min Jung Kim, Min Ju Kim, Xuangao Wu, Hye Jeong Yang, Heng Yuan, Shaokai Huang, Sun Myung Yoon, Keun-Nam Kim, Sunmin Par. Long-Term Effect of Porcine Brain Enzyme Hydrolysate Intake on Scopolamine-Induced Memory Impairment in Rats. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328781. |
in parallel with systemic insulin resistance, decreased cholesterol and increased glycogen contents in the hippocampus in the medium-pbeh and high-pbeh represented reduced brain insulin resistance. |
2022-03-25 |
2023-08-13 |
human |
| Kenneth D Carr, Sydney P Weine. Effects of Nucleus Accumbens Insulin Inactivation on Microstructure of Licking for Glucose and Saccharin in Male and Female Rats. Physiology & behavior. 2022-03-05. PMID:35247443. |
functional studies of brain insulin signaling have focused predominantly on hypothalamic regulation of appetite and hippocampal regulation of learning. |
2022-03-05 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
however, the regulation of irisin in the hippocampus of streptozotocin (stz)-induced memory impairment and its relation to insulin signalling remain to be investigated. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
hippocampal tissues were used to assess expression of fndc5/irisin, bdnf and proteins related to insulin signalling, in addition to β-amyloid peptide and phosphorylated tau protein levels. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
exercise and carnosine intake almost normalized hippocampal fndc5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved bdnf and insulin signalling proteins, with corresponding mitigated cognitive impairments. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
in both interventions, enhancement of hippocampal fndc5/irisin and insulin signalling may be involved in mediating these neuroprotective effects. |
2022-01-29 |
2023-08-13 |
rat |
| Dayea Kim, Yeon Suk Jo, Han-Seul Jo, Sungwon Bae, Yang Woo Kwon, Yong-Seok Oh, Jong Hyuk Yoo. Comparative Phosphoproteomics of Neuro-2a Cells under Insulin Resistance Reveals New Molecular Signatures of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055191. |
insulin in the brain is a well-known critical factor in neuro-development and regulation of adult neurogenesis in the hippocampus. |
2022-01-21 |
2023-08-13 |
mouse |
| N A Alfaris, G M Alshammari, J Z Altamimi, D H Aljabryn, R I Alagal, H Aldera, M A Alkhateeb, M A Yahy. Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss in rats by stimulating Nrf2 and nuclear factor-κB, and activating insulin receptor substrate/PI3K/Akt axis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 72. issue 4. 2022-01-06. PMID:34987124. |
also, the hippocampus was used to measure markers of oxidative stress, inflammation, and insulin signaling. |
2022-01-06 |
2023-08-13 |
rat |
| N A Alfaris, G M Alshammari, J Z Altamimi, D H Aljabryn, R I Alagal, H Aldera, M A Alkhateeb, M A Yahy. Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss in rats by stimulating Nrf2 and nuclear factor-κB, and activating insulin receptor substrate/PI3K/Akt axis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 72. issue 4. 2022-01-06. PMID:34987124. |
concomitantly, ea increased rats' weekly weights gain and fasting plasma insulin levels and reduced the hippocampal levels of tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6) and plasma glucose levels in diabetic rats. |
2022-01-06 |
2023-08-13 |
rat |
| Oh-Hoon Kwon, Yoon Young Cho, Jung Hee Lee, Sungkwon Chun. O-GlcNAcylation Inhibits Endocytosis of Amyloid Precursor Protein by Decreasing Its Localization in Lipid Raft Microdomains. Membranes. vol 11. issue 12. 2021-12-23. PMID:34940409. |
to investigate the relationship between app o-glcnacylation and app endocytosis, we tested the effects of insulin on neuroblastoma sh-sy5y cells overexpressing app and bace1, and cultured rat hippocampal neurons. |
2021-12-23 |
2023-08-13 |
rat |
| Sandra Sánchez-Sarasúa, María Meseguer-Beltrán, Cristina García-Díaz, Maria Teresa Beltrán-Bretones, Nisrin ElMlili, Ana María Sánchez-Pére. IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis. Molecular and cellular neurosciences. 2021-12-23. PMID:34942345. |
in this work, we performed a comparative study of irs1 and irs2, together with the igf1 (igf1r) and insulin (ir) receptor expression in the hippocampus and prefrontal cortex during development. |
2021-12-23 |
2023-08-13 |
rat |
| Alexis M Stranaha. Visceral adiposity, inflammation, and hippocampal function in obesity. Neuropharmacology. 2021-12-13. PMID:34902347. |
while gaps in knowledge persist related to insulin insensitivity and cognitive impairment in obesity, several recent studies suggest that cells of the neurovascular unit contribute to hippocampal synaptic dysfunction, and this review interprets those findings in the context of progressive metabolic dysfunction in the cns. |
2021-12-13 |
2023-08-13 |
Not clear |
| Alexis M Stranaha. Visceral adiposity, inflammation, and hippocampal function in obesity. Neuropharmacology. 2021-12-13. PMID:34902347. |
the picture emerging from these studies, while incomplete, implicates pro-inflammatory cytokines, insulin resistance, and hyperglycemia in various stages of obesity-induced hippocampal dysfunction. |
2021-12-13 |
2023-08-13 |
Not clear |