| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariia Shypshyna, Oksana Kolesnyk, Svitlana Fedulova, Nickolai Veselovsk. Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. Frontiers in cellular neuroscience. vol 17. 2023-04-07. PMID:37025701. |
insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. |
2023-04-07 |
2023-08-14 |
Not clear |
| Mariia Shypshyna, Oksana Kolesnyk, Svitlana Fedulova, Nickolai Veselovsk. Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. Frontiers in cellular neuroscience. vol 17. 2023-04-07. PMID:37025701. |
here we used the whole cell patch-clamp recording of evoked glutamatergic excitatory postsynaptic currents (eepscs) and the method of local extracellular electrical stimulation of a single presynaptic axon to investigate the effect of insulin (100 nm) on the paired-pulse plasticity at glutamatergic synapses of cultured hippocampal neurons under hypoinsulinemia. |
2023-04-07 |
2023-08-14 |
Not clear |
| Mariia Shypshyna, Oksana Kolesnyk, Svitlana Fedulova, Nickolai Veselovsk. Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. Frontiers in cellular neuroscience. vol 17. 2023-04-07. PMID:37025701. |
our data indicate that under normoinsulinemia additional insulin enhances the paired-pulse facilitation (ppf) of eepscs in hippocampal neurons by stimulating the glutamate release in their synapses. |
2023-04-07 |
2023-08-14 |
Not clear |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| M Omidi-Shahsavandi, P Yaghmaei, S Ahmadian, A Ebrahim-Habib. Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-03-01. PMID:36856252. |
in vivo bilateral injection of fibrils formed by incubation of insulin in the presence or absence of silibinin and trans-chalcone or insulin fibrils plus the compounds in rats' hippocampus was performed to obtain ad characteristics. |
2023-03-01 |
2023-08-14 |
rat |
| Ana Knezovic, Stjepan Budisa, Ana Babic Perhoc, Jan Homolak, Jelena Osmanovic Barila. From Determining Brain Insulin Resistance in a Sporadic Alzheimer's Disease Model to Exploring the Region-Dependent Effect of Intranasal Insulin. Molecular neurobiology. 2023-01-03. PMID:36596966. |
central changes found after ins in stz-icv rats suggest hippocampal and cortical insulin sensitivity. |
2023-01-03 |
2023-08-14 |
rat |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the ir/irs1/akt/gsk3β/β-catenin signaling pathway. |
2022-12-31 |
2023-08-14 |
mouse |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
thirdly, several pathological research has also shown that beta-amyloid plaques, hyperphosphorylated tau protein, and brain shrinkage, particularly in the hippocampus, are shared brain lesions between insulin and alzheimer's disease. in light of this, type 2 diabetes mellitus may be viewed as a liability for dementia and alzheimer's disease. |
2022-12-12 |
2023-08-14 |
human |
| Pinar Bayram, Deniz Billur, Sule Kizil, Hasan Caliskan, Belgin Ca. Alterations in hippocampal neurogenesis and hippocampal insulin signaling pathway in rat with metabolic syndrome. Iranian journal of basic medical sciences. vol 25. issue 11. 2022-12-07. PMID:36474571. |
alterations in hippocampal neurogenesis and hippocampal insulin signaling pathway in rat with metabolic syndrome. |
2022-12-07 |
2023-08-14 |
rat |
| Pinar Bayram, Deniz Billur, Sule Kizil, Hasan Caliskan, Belgin Ca. Alterations in hippocampal neurogenesis and hippocampal insulin signaling pathway in rat with metabolic syndrome. Iranian journal of basic medical sciences. vol 25. issue 11. 2022-12-07. PMID:36474571. |
we aimed to examine the level of hippocampal neurogenesis, and assess learning and anxiety and the level of some proteins involving insulin signaling pathways in rats with metabolic syndrome (mets); and to reveal the relationship among them. |
2022-12-07 |
2023-08-14 |
rat |
| Masoomeh Mohammadi, Ali Haeri Rohani, Parichehr Yaghmaei, Hedayat Sahrae. Prenatal Stress-induced Spatial Memory Deficit in a Sex-specific Manner in Mice: A Possible Involvement of Hippocampal Insulin Resistance. Basic and clinical neuroscience. vol 13. issue 3. 2022-12-02. PMID:36457886. |
prenatal stress-induced spatial memory deficit in a sex-specific manner in mice: a possible involvement of hippocampal insulin resistance. |
2022-12-02 |
2023-08-14 |
mouse |
| Masoomeh Mohammadi, Ali Haeri Rohani, Parichehr Yaghmaei, Hedayat Sahrae. Prenatal Stress-induced Spatial Memory Deficit in a Sex-specific Manner in Mice: A Possible Involvement of Hippocampal Insulin Resistance. Basic and clinical neuroscience. vol 13. issue 3. 2022-12-02. PMID:36457886. |
in the present study, the effects of prenatal stress on spatial learning and memory deficit and its relationship with hippocampal insulin resistance were examined in male and female offspring. |
2022-12-02 |
2023-08-14 |
mouse |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. The Role of Insulin Signaling in Hippocampal-Related Diseases: A Focus on Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430894. |
studies have shown that type 2 diabetes mellitus, characterized by insulin resistance, is closely related to ad, which has drawn extensive attention to the relationship between hippocampal insulin signaling and ad. |
2022-11-26 |
2023-08-14 |
human |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. The Role of Insulin Signaling in Hippocampal-Related Diseases: A Focus on Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430894. |
we also highlight the molecular link between hippocampal insulin resistance and ad and provide a theoretical basis for finding new therapeutic targets for ad in clinical practice. |
2022-11-26 |
2023-08-14 |
human |
| Maria Luisa Abascal, Javier Sanjuan, Paula Moyano, Emma Sola, Andrea Flores, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, Javier Del Pin. Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ Chemical research in toxicology. 2022-11-17. PMID:36394833. |
insulin signaling disruption and inf-γ upregulation induce aβ acute and long-term paraquat (pq) exposure produces hippocampal neurodegeneration and cognition decline. |
2022-11-17 |
2023-08-14 |
Not clear |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
in vivo, mr inhibited the damage and apoptosis of hippocampal neurons caused by a high-fat diet, reduced hippocampal oxidative stress, improved hippocampal glucose metabolism, relieved insulin resistance, and enhanced cognitive ability. |
2022-11-11 |
2023-08-14 |
mouse |
| Mubeen A Ansari, Muddanna S Rao, Aishah Al-Jarallah, Fawzi M Babike. Early Time Course of Oxidative Stress in Hippocampal Synaptosomes and Cognitive Loss Following Impaired Insulin Signaling in Rats: Development of Sporadic Alzheimer's Disease. Brain research. 2022-11-03. PMID:36328067. |
early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: development of sporadic alzheimer's disease. |
2022-11-03 |
2023-08-14 |
rat |
| Mubeen A Ansari, Muddanna S Rao, Aishah Al-Jarallah, Fawzi M Babike. Early Time Course of Oxidative Stress in Hippocampal Synaptosomes and Cognitive Loss Following Impaired Insulin Signaling in Rats: Development of Sporadic Alzheimer's Disease. Brain research. 2022-11-03. PMID:36328067. |
we investigated the oxidative stress parameters in the synaptosomes prepared from the hippocampus tissue in order to identify their potential role in sad development in intraperitoneal (ip) and intracerebroventricular (icv) streptozotocin (stz) injections models of insulin signaling impairment. |
2022-11-03 |
2023-08-14 |
rat |
| Saeid Bagheri-Mohammadi, Sahar Askari, Behrang Alani, Maryam Moosavi, Rasoul Ghasem. Cinnamaldehyde Regulates Insulin and Caspase-3 Signaling Pathways in the Sporadic Alzheimer's Disease Model: Involvement of Hippocampal Function via IRS-1, Akt, and GSK-3β Phosphorylation. Journal of molecular neuroscience : MN. 2022-10-09. PMID:36210429. |
cinnamaldehyde regulates insulin and caspase-3 signaling pathways in the sporadic alzheimer's disease model: involvement of hippocampal function via irs-1, akt, and gsk-3β phosphorylation. |
2022-10-09 |
2023-08-14 |
rat |
| Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasem. Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143409. |
however, few studies have probed the relationship between memory, central er stress, inflammation, hippocampal mitogen-activated protein kinase (mapk) activity and insulin resistance. |
2022-09-23 |
2023-08-14 |
rat |