| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus. vol 13. issue 11. 2021-12-11. PMID:34877187. |
first, insulin receptors were found in the brain, especially the hippocampus, and insulin transport to the brain is mainly accomplished through the blood-brain barrier. |
2021-12-11 |
2023-08-13 |
human |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus. vol 13. issue 11. 2021-12-11. PMID:34877187. |
thirdly, multiple pathological studies showed that insulin and alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-aβ plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. |
2021-12-11 |
2023-08-13 |
human |
| Yifat Mille. Advancements and future directions in research of the roles of insulin in amyloid diseases. Biophysical chemistry. vol 281. 2021-12-08. PMID:34823073. |
insulin is released from the pancreas, and it is known that insulin downstream signaling molecules are located majorly in the regions of cortex and hippocampus. |
2021-12-08 |
2023-08-13 |
Not clear |
| Hend M Hussien, Doaa A Ghareeb, Hany E A Ahmed, Hani S Hafez, Samar R Sale. Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34235690. |
neuropathological biomarkers including oxidative stress (tbars, no, sod, gpx, gst, and gsh), inflammation (tnf- α, il-6, and il-1β), neurotransmission (ache and mao), and insulin resistance (insulin, insulin receptor, and insulin-degrading enzyme) were altered, which consequently elevated the level of amyloid-β42 and tau protein in the hippocampus tissues inducing neuronal injury. |
2021-12-02 |
2023-08-13 |
rat |
| Noriyasu Kamei, Susumu Suwabe, Kenji Arime, Hidemi Bando, Kaho Murata, Maika Yamaguchi, Natsuki Yokoyama, Erina Tanaka, Ayaka Hashimoto, Takanori Kanazawa, Yukio Ago, Mariko Takeda-Morishit. Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834159. |
we further demonstrated that intranasally delivered insulin with l-penetratin specifically accumulated on the hippocampus neuronal cells. |
2021-11-30 |
2023-08-13 |
Not clear |
| Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowsk. Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834319. |
this study successfully demonstrated region-specific administration at the olfactory mucosa resulting in over 20% of the administered fluorescein dose in the olfactory bulbs, and no peripheral bioactivity of insulin detemir and fc-dependent uptake of two murine igg1 (11c7 and p3x) along the olfactory pathway to cortex and hippocampus. |
2021-11-30 |
2023-08-13 |
mouse |
| Hye Young Ryu, Leah Eunjung Kim, Hyeonjeong Jeong, Bo Kyoung Yeo, Ji-Won Lee, Hyeri Nam, Shinwon Ha, Hyun-Kyu An, Hyunhee Park, Seonghee Jung, Kyung Min Chung, Jiyea Kim, Byung-Hoon Lee, Heesun Cheong, Eun-Kyoung Kim, Seong-Woon Y. GSK3B induces autophagy by phosphorylating ULK1. Experimental & molecular medicine. vol 53. issue 3. 2021-11-18. PMID:33654220. |
we previously identified glycogen synthase kinase 3 beta (gsk3b) as an upstream regulator of insulin withdrawal-induced autophagy in adult hippocampal neural stem cells. |
2021-11-18 |
2023-08-13 |
human |
| Sathiya Sekar, Wendie N Marks, Venkat Gopalakrishnan, Quentin Greba, Terrance P Snutch, John G Howland, Changiz Taghibiglo. Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg. Clinical and experimental pharmacology & physiology. vol 47. issue 9. 2021-11-17. PMID:32304254. |
therefore, we examined the major components of pi3k/akt-mediated insulin signalling in cortical, thalamic, and hippocampal tissues collected from genetic absence epilepsy rats from strasbourg (gaers) and non-epileptic control (nec) rats. |
2021-11-17 |
2023-08-13 |
rat |
| Sathiya Sekar, Wendie N Marks, Venkat Gopalakrishnan, Quentin Greba, Terrance P Snutch, John G Howland, Changiz Taghibiglo. Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg. Clinical and experimental pharmacology & physiology. vol 47. issue 9. 2021-11-17. PMID:32304254. |
an insulin sensitivity assay showed decreased p-akt level in cortical and hippocampal tissues. |
2021-11-17 |
2023-08-13 |
rat |
| Sathiya Sekar, Wendie N Marks, Venkat Gopalakrishnan, Quentin Greba, Terrance P Snutch, John G Howland, Changiz Taghibiglo. Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg. Clinical and experimental pharmacology & physiology. vol 47. issue 9. 2021-11-17. PMID:32304254. |
together, altered hippocampal insulin signalling was more prominent in nf and th compared to cortical and thalamic regions in gaers. |
2021-11-17 |
2023-08-13 |
rat |
| Amanda B Mucellini, Patrícia M Miguel, Roberta Dalle Molle, Danitsa M Rodrigues, Tania D Machado, Roberta S Reis, Rudinéia Toazza, Giovanni A Salum, Andressa Bortoluzzi, Alexandre R Franco, Augusto Buchweitz, Barbara Barth, Marilyn Agranonik, Marouane Nassim, Michael J Meaney, Gisele G Manfro, Patrícia P Silveir. Diminished insulin sensitivity is associated with altered brain activation to food cues and with risk for obesity - Implications for individuals born small for gestational age. Appetite. 2021-11-15. PMID:34767841. |
differences in feeding behavior in sga individuals were associated with insulin sensitivity and hippocampal alterations, suggesting that cognition and hormonal regulation are important components involved in their food intake modifications throughout life. |
2021-11-15 |
2023-08-13 |
human |
| Sara Chavoshinezhad, Mohammad Ismail Zibaii, Mir Hossein Seyed Nazari, Abdolaziz Ronaghi, Afsaneh Asgari Taei, Ahmad Ghorbani, Sareh Pandamooz, Mohammad Saied Salehi, Neda Valian, Fereshteh Motamedi, Abbas Haghparast, Leila Dargah. Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 111. 2021-11-11. PMID:33964323. |
optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis. |
2021-11-11 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Mohammad Ismail Zibaii, Mir Hossein Seyed Nazari, Abdolaziz Ronaghi, Afsaneh Asgari Taei, Ahmad Ghorbani, Sareh Pandamooz, Mohammad Saied Salehi, Neda Valian, Fereshteh Motamedi, Abbas Haghparast, Leila Dargah. Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 111. 2021-11-11. PMID:33964323. |
our results showed that optogenetic stimulation of the entorhinal cortex promotes hippocampal neurogenesis and synaptic plasticity concomitant with the increased levels of insulin mrna and its signaling markers, neurotrophic factors, and activation of mitochondrial biogenesis. |
2021-11-11 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Mohammad Ismail Zibaii, Mir Hossein Seyed Nazari, Abdolaziz Ronaghi, Afsaneh Asgari Taei, Ahmad Ghorbani, Sareh Pandamooz, Mohammad Saied Salehi, Neda Valian, Fereshteh Motamedi, Abbas Haghparast, Leila Dargah. Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 111. 2021-11-11. PMID:33964323. |
these findings suggest that effects of perforant pathway stimulation on the hippocampus, at least in part, are mediated by insulin increase in the dentate gyrus and subsequently activation of its downstream signaling pathway. |
2021-11-11 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
moreover, berberine downregulated the abnormal phosphorylation of a[formula: see text] and tau protein and improved hippocampal insulin signaling. |
2021-11-04 |
2023-08-13 |
rat |
| Saltuk Bugra Baltaci, Omer Unal, Elif Gulbahce-Mutlu, Haluk Gumus, Suray Pehlivanoglu, Ahmet Yardimci, Rasim Mogulkoc, Abdulkerim Kasim Baltac. The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats. Biological trace element research. 2021-11-02. PMID:34727320. |
the role of zinc status on spatial memory, hippocampal synaptic plasticity, and insulin signaling in icv-stz-induced sporadic alzheimer's-like disease in rats. |
2021-11-02 |
2023-08-13 |
rat |
| Saltuk Bugra Baltaci, Omer Unal, Elif Gulbahce-Mutlu, Haluk Gumus, Suray Pehlivanoglu, Ahmet Yardimci, Rasim Mogulkoc, Abdulkerim Kasim Baltac. The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats. Biological trace element research. 2021-11-02. PMID:34727320. |
here, we investigated the effects of dietary zinc deficiency and supplementation on memory, hippocampal synaptic plasticity, and insulin signaling in intracerebroventricular streptozotocin (icv-stz)-induced sad in rats. |
2021-11-02 |
2023-08-13 |
rat |
| Saltuk Bugra Baltaci, Omer Unal, Elif Gulbahce-Mutlu, Haluk Gumus, Suray Pehlivanoglu, Ahmet Yardimci, Rasim Mogulkoc, Abdulkerim Kasim Baltac. The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats. Biological trace element research. 2021-11-02. PMID:34727320. |
the expression of hippocampal protein and mrna levels of targets related to synaptic plasticity and insulin pathway was assessed by western blot and real-time quantitative pcr. |
2021-11-02 |
2023-08-13 |
rat |
| Saltuk Bugra Baltaci, Omer Unal, Elif Gulbahce-Mutlu, Haluk Gumus, Suray Pehlivanoglu, Ahmet Yardimci, Rasim Mogulkoc, Abdulkerim Kasim Baltac. The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats. Biological trace element research. 2021-11-02. PMID:34727320. |
our data suggest that zinc supplementation improves cognitive deficits and rescues the decline in key molecular targets of synaptic plasticity and insulin signaling in hippocampus caused by icv-stz induced sad in rats. |
2021-11-02 |
2023-08-13 |
rat |
| Taylor McFadden, Madeline Musaus, Jacob L Nelsen, Kiley Martin, Natalie Jones, Palmer Smith, Hannah Kugler, Timothy J Jarom. Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity. Behavioural brain research. vol 393. 2021-10-25. PMID:32603798. |
studies have shown that long-term exposure to high fat and other obesogenic diets results in insulin resistance and altered blood brain barrier permeability, dysregulation of intracellular signaling mechanisms, changes in dna methylation levels and gene expression, and increased oxidative stress and neuroinflammation in the hippocampus, all of which are associated with impaired spatial memory. |
2021-10-25 |
2023-08-13 |
rat |