| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasem. Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143409. |
the results demonstrated that tg impairs spatial cognition and hippocampal insulin signaling. |
2022-09-23 |
2023-08-14 |
rat |
| Stephanie Kullmann, Thomas Goj, Ralf Veit, Louise Fritsche, Lore Wagner, Patrick Schneeweiss, Miriam Hoene, Christoph Hoffmann, Jürgen Machann, Andreas Niess, Hubert Preissl, Andreas L Birkenfeld, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Anja Moller, Cora Weigert, Martin Hen. Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI insight. vol 7. issue 18. 2022-09-22. PMID:36134657. |
brain insulin sensitivity was assessed in 21 participants (14 women, 7 men; age range 21-59 years; bmi range 27.5-45.5 kg/m2) using functional mri, combined with intranasal administration of insulin, before and after the intervention.resultsthe exercise program resulted in enhanced brain insulin action to the level of a person of healthy weight, demonstrated by increased insulin-induced striatal activity and strengthened hippocampal functional connectivity. |
2022-09-22 |
2023-08-14 |
human |
| Jordi Olloquequi, Amanda Cano, Elena Sanchez-López, Marina Carrasco, Ester Verdaguer, Ana Fortuna, Jaume Folch, Mònica Bulló, Carme Auladell, Antoni Camins, Miren Ettchet. Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-20. PMID:36126456. |
conversely, ptp1b inhibition has been shown to prevent microglial activation, thus exerting a potent anti-inflammatory effect and has also shown potential to increase the cognitive process through the stimulation of hippocampal insulin, leptin and bdnf/trkb receptors. |
2022-09-20 |
2023-08-14 |
Not clear |
| Elisa Maffioli, Giulia Murtas, Valentina Rabattoni, Beatrice Badone, Farida Tripodi, Filomena Iannuzzi, Danilo Licastro, Simona Nonnis, Anna Maria Rinaldi, Zoraide Motta, Silvia Sacchi, Nadia Canu, Gabriella Tedeschi, Paola Coccetti, Loredano Pollegion. Insulin and serine metabolism as sex-specific hallmarks of Alzheimer's disease in the human hippocampus. Cell reports. vol 40. issue 10. 2022-09-07. PMID:36070700. |
insulin and serine metabolism as sex-specific hallmarks of alzheimer's disease in the human hippocampus. |
2022-09-07 |
2023-08-14 |
human |
| Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H Frey Ii, Ivan Tkac, Raghavendra B Ra. Intranasal Insulin Attenuates the Long-term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats. Developmental neuroscience. 2022-08-30. PMID:36041414. |
intranasal insulin attenuates the long-term adverse effects of neonatal hyperglycemia on the hippocampus in rats. |
2022-08-30 |
2023-08-14 |
rat |
| João M N Duart. Serine racemase modulation for improving brain insulin resistance: An Editorial Highlight for "Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers". Journal of neurochemistry. 2022-08-23. PMID:35996309. |
report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| João M N Duart. Serine racemase modulation for improving brain insulin resistance: An Editorial Highlight for "Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers". Journal of neurochemistry. 2022-08-23. PMID:35996309. |
the authors explored some of the possible mechanisms mediating the interaction between dampening production of d-serine and the local synthesis of insulin, and they further propose that stimulating insulin production could counteract hippocampal insulin resistance in alzheimer's disease (ad). |
2022-08-23 |
2023-08-14 |
Not clear |
| Luke S Watson, Brynna Wilken-Resman, Alexus Williams, Stephanie DiLucia, Guadalupe Sanchez, Taylor L McLeod, Catrina Sims-Robinso. Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells. Diabetes & vascular disease research. vol 19. issue 4. 2022-08-17. PMID:35975361. |
hippocampal microvessels were isolated from high-fat diet fed mice and assessed for insulin signaling activation, a process known to be involved with receptor internalization. |
2022-08-17 |
2023-08-14 |
mouse |
| Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C Chattipakor. Combined Caloric Restriction and Exercise Provides Greater Metabolic and Neurocognitive Benefits than either as a Monotherapy in Obesity With or Without Estrogen Deprivation. The Journal of nutritional biochemistry. 2022-08-17. PMID:35977664. |
insulin resistance, cognitive decline and hippocampal pathologies were found in both hfs and hfo rats. |
2022-08-17 |
2023-08-14 |
rat |
| Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C Chattipakor. Combined Caloric Restriction and Exercise Provides Greater Metabolic and Neurocognitive Benefits than either as a Monotherapy in Obesity With or Without Estrogen Deprivation. The Journal of nutritional biochemistry. 2022-08-17. PMID:35977664. |
hfo rats had higher levels of insulin resistance and hippocampal ros levels than hfs rats. |
2022-08-17 |
2023-08-14 |
rat |
| Matthew G Engel, Jeremy Smith, Kai Mao, Gabriela Farias Quipildor, Min-Hui Cui, Maria Gulinello, Craig A Branch, Samuel E Gandy, Derek M Huffma. Evidence for preserved insulin responsiveness in the aging rat brain. GeroScience. 2022-07-07. PMID:35798912. |
in contrast, ex vivo stimulation of hippocampus with 10 nm insulin revealed increased akt activation in young (p < 0.05), but not old rats. |
2022-07-07 |
2023-08-14 |
rat |
| Hu Zhang, Ji-Ling Liang, Qiu-Yue Wu, Jin-Xiu Li, Ya Liu, Liang-Wen Wu, Jie-Lun Huang, Xiao-Wen Wu, Ming-Hui Wang, Ning Che. Swimming Suppresses Cognitive Decline of HFD-Induced Obese Mice through Reversing Hippocampal Inflammation, Insulin Resistance, and BDNF Level. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745162. |
swimming suppresses cognitive decline of hfd-induced obese mice through reversing hippocampal inflammation, insulin resistance, and bdnf level. |
2022-06-24 |
2023-08-14 |
mouse |
| Hashan S M Jayarathne, Lucas K Debarba, Jacob J Jaboro, Brett C Ginsburg, Richard A Miller, Marianna Sadagursk. Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice. Aging cell. 2022-06-16. PMID:35707855. |
here, we show that cana treatment significantly improved central insulin sensitivity in the hypothalamus and the hippocampus of 30-month-old male mice. |
2022-06-16 |
2023-08-14 |
mouse |
| Zohreh Zare, Sam Zarbakhsh, Mohsen Tehrani, Moslem Mohammad. Neuroprotective effects of treadmill exercise in hippocampus of ovariectomized and diabetic rats. Neuroscience. 2022-06-14. PMID:35700817. |
to determine detrimental effects of estrogen and insulin deficiencies on hippocampus, we examined apoptosis-induced neuronal damage and cholinergic system in ovariectomized and/or diabetic rat hippocampus. |
2022-06-14 |
2023-08-14 |
rat |
| Enrique Blázquez, Verónica Hurtado-Carneiro, Yannick LeBaut-Ayuso, Esther Velázquez, Luis García-García, Francisca Gómez-Oliver, Juan Miguel Ruiz-Albusac, Jesús Ávila, Miguel Ángel Poz. Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases. Frontiers in endocrinology. vol 13. 2022-05-26. PMID:35615716. |
supporting this relationship is the fact that nasal and hippocampal insulin administration has been found to improve cognitive function. |
2022-05-26 |
2023-08-13 |
Not clear |
| Jiqu Xu, Ben Ni, Congcong Ma, Shuang Rong, Hui Gao, Li Zhang, Xia Xiang, Qingde Huang, Qianchun Deng, Fenghong Huan. Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet. Journal of advanced research. 2022-05-26. PMID:35618634. |
docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet. |
2022-05-26 |
2023-08-13 |
rat |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
in this study, we report that wd-derived impairment in insulin signaling induces tau and aβ brain pathology in wild-type c57bl/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. |
2022-05-14 |
2023-08-13 |
mouse |
| Jin Kwon Jeong, Dong Hee Kim, Byung Ju Lee, Colin N Youn. Angiotensin-II, insulin, and NELL2 involvement in forebrain synaptic circuit modifications during hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554879. |
hippocampal ht22 cells were transfected with a nell2-luciferase dependent vector and insulin was administrated into the medium. |
2022-05-13 |
2023-08-13 |
mouse |
| Caitlin S Mitchell, Elisabeth K Goodman, Caitlin R Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P Beg. The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons. Frontiers in physiology. vol 13. 2022-05-13. PMID:35557971. |
obesogenic diets can produce hippocampal insulin resistance and impairments to hippocampal-dependent cognition. |
2022-05-13 |
2023-08-13 |
mouse |
| Shalaila S Haas, Alison Myoraku, Kathleen Watson, Thalia Robakis, Sophia Frangou, Fahim Abbasi, Natalie Rasgo. Lower functional hippocampal connectivity in healthy adults is jointly associated with higher levels of leptin and insulin resistance. European psychiatry : the journal of the Association of European Psychiatrists. 2022-05-02. PMID:35492025. |
lower functional hippocampal connectivity in healthy adults is jointly associated with higher levels of leptin and insulin resistance. |
2022-05-02 |
2023-08-13 |
Not clear |