| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian J Sandri, Kathleen Ennis-Czerniak, Priya Kanajam, William H Frey, Eric F Lock, Raghavendra Ra. Intranasal Insulin Treatment Partially Corrects the Altered Gene Expression Profile in the Hippocampus of Developing Rats with Perinatal Iron Deficiency. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-08-21. PMID:37602386. |
intranasal insulin administration improves cognitive deficits in adult humans with alzheimer's disease and type 2 diabetes and could provide benefits in fed-induced hippocampal dysfunction. |
2023-08-21 |
2023-09-07 |
rat |
| Özlem Barutçu, Cem Süer, Nurcan Dursun, Esra Tufan, Ezgi Aslan Gülpınar, Burak Ta. Insulin-induced long-term potentiation in the dentate gyrus of hippocampal formation. Psychoneuroendocrinology. vol 157. 2023-08-10. PMID:37562098. |
mrna expressions of insulin signaling proteins were measured by rt-pcr in the whole hippocampus. |
2023-08-10 |
2023-08-16 |
rat |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
the findings showed that diabetes increased body weight, glucose, and insulin resistance, impaired working, spatial and recognition memory, increased levels of il-6, il-1β, tnf-α, and glutamate levels, and decreased bdnf in the hippocampus of diabetic mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
while higher physical activity was associated with reduced body weight, glucose, and insulin resistance, attenuated memory impairment, il-6, il-1β, tnf-α, and glutamate, and increased bdnf levels in the hippocampus and prefrontal cortex of diabetic mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong M. Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis. European journal of pharmacology. 2023-07-21. PMID:37479016. |
insulin treatment could also inhibit the lps-induced activation of microglia and astrocytes, and the release of tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) in the hippocampus. |
2023-07-21 |
2023-08-14 |
Not clear |
| Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong M. Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis. European journal of pharmacology. 2023-07-21. PMID:37479016. |
furthermore, insulin treatment inhibited lps-induced ferroptosis in the hippocampus by decreasing iron accumulation levels, regulating ferroptosis-related proteins including transferrin, glutathione peroxidase 4 (gpx4), ferritin heavy chin 1 (fth1) and cystine/glutamate antiporter (xct), inhibiting oxidative stress injuries and lipid peroxidation in the hippocampus. |
2023-07-21 |
2023-08-14 |
Not clear |
| Suélen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2023-07-21. PMID:37479008. |
the identification of high density of insulin receptors in the hippocampus also suggests that insulin may present important roles related to memory. |
2023-07-21 |
2023-08-14 |
Not clear |
| Mubeen A Ansari, Aishah Al-Jarallah, Fawzi A Babike. Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment. Cells. vol 12. issue 13. 2023-07-14. PMID:37443762. |
impaired insulin signaling alters mediators of hippocampal synaptic dynamics/plasticity: a possible mechanism of hyperglycemia-induced cognitive impairment. |
2023-07-14 |
2023-08-14 |
Not clear |
| Xiuting Yao, Jingyi Zhao, Yang Yuan, Conghui Wang, Zhehao Yu, Zhihui Huang, Chen Chen, Chenxi Yang, Jiayi Ren, Yu Ma, Yi Rong, Yi Huang, Yue Ming, Lijie Li. Prolonged early exposure to a high-fat diet augments the adverse effects on neurobehavior and hippocampal neuroplasticity: Involvement of microglial insulin signaling. The American journal of pathology. 2023-06-25. PMID:37356575. |
prolonged early exposure to a high-fat diet augments the adverse effects on neurobehavior and hippocampal neuroplasticity: involvement of microglial insulin signaling. |
2023-06-25 |
2023-08-14 |
mouse |
| Xiuting Yao, Jingyi Zhao, Yang Yuan, Conghui Wang, Zhehao Yu, Zhihui Huang, Chen Chen, Chenxi Yang, Jiayi Ren, Yu Ma, Yi Rong, Yi Huang, Yue Ming, Lijie Li. Prolonged early exposure to a high-fat diet augments the adverse effects on neurobehavior and hippocampal neuroplasticity: Involvement of microglial insulin signaling. The American journal of pathology. 2023-06-25. PMID:37356575. |
these findings suggest that aberrant microglia-related histomorphological changes in the hippocampus underlie the exacerbated detrimental neurobehavioral effects of prolonged early hfd exposure and propose that enhanced insulin signaling might drive microglial dysfunction after prolonged early hfd exposure. |
2023-06-25 |
2023-08-14 |
mouse |
| Adriana M Capucho, Ana Chegão, Fátima O Martins, Bernardete F Melo, Natália Madeira, Joana F Sacramento, Rosalina Fonseca, Hugo Vicente Miranda, Sílvia V Cond. Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changing Insulin Signaling in the Hippocampus and Prefrontal Cortex. Advances in experimental medicine and biology. vol 1427. 2023-06-15. PMID:37322345. |
carotid body resection prevents short-term spatial memory decline in prediabetic rats without changing insulin signaling in the hippocampus and prefrontal cortex. |
2023-06-15 |
2023-08-14 |
rat |
| Adriana M Capucho, Ana Chegão, Fátima O Martins, Bernardete F Melo, Natália Madeira, Joana F Sacramento, Rosalina Fonseca, Hugo Vicente Miranda, Sílvia V Cond. Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changing Insulin Signaling in the Hippocampus and Prefrontal Cortex. Advances in experimental medicine and biology. vol 1427. 2023-06-15. PMID:37322345. |
we evaluated csn resection effects on behavioral parameters and on insulin signaling-related proteins levels, in the prefrontal cortex and the hippocampus. |
2023-06-15 |
2023-08-14 |
rat |
| Julie Brossaud, Clémentine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P Webster, Brian R Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoît Corcuff, Marie-Pierre Moisa. Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency. Diabetologia. 2023-06-10. PMID:37300580. |
we also examined whether diabetes-associated enhancement of hippocampal 11β-hsd1 activity is due to an increase in brain glucose concentrations and/or a decrease in insulin signalling. |
2023-06-10 |
2023-08-14 |
rat |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
since diminished hippocampal insulin signaling leads to memory impairment, insulin resistance and hyperinsulinemia are probably associated with alzheimer's disease (ad). |
2023-06-06 |
2023-08-14 |
rat |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
the effect of intracerebroventricular injection of insulin (ins) and oral cinnamon extract (cinn) on glucose transporter (glut) 1, 3, and 4 gene expressions in the hippocampus and spatial memory in a streptozotocin (stz)-induced ad rat model was investigated in the present study. |
2023-06-06 |
2023-08-14 |
rat |
| Hamed Hajizadeh Tekmeh, Birgul Vanizor Kural, Sevil Kör, Meltem Arıkan Malkoç, Esin Yuluğ, Abdulkadir Kutlu, İsmail Abidin, Asım Ore. How does l-theanine treatment affect the levels of serum and hippocampal BDNF, insulin and adipocytokines in diabetic rats? Biochemical and biophysical research communications. vol 667. 2023-05-21. PMID:37210871. |
how does l-theanine treatment affect the levels of serum and hippocampal bdnf, insulin and adipocytokines in diabetic rats? |
2023-05-21 |
2023-08-14 |
rat |
| Seol-Hwa Jeong, Hyun-Kyu An, Shinwon Ha, Seong-Woon Y. Distinct Signaling Pathways for Autophagy-Driven Cell Death and Survival in Adult Hippocampal Neural Stem Cells. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175992. |
we have previously reported that insulin withdrawal (iw) or corticosterone (cort) induces autophagic cell death (acd) in adult hippocampal neural stem (hcn) cells. |
2023-05-14 |
2023-08-14 |
Not clear |
| Busra Ertas, Ayse Nur Hazar-Yavuz, Fadime Topal, Rumeysa Keles-Kaya, Özge Karakus, Gul Sinemcan Ozcan, Turgut Taskin, Muhammet Emin Ca. Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats. Journal of ethnopharmacology. 2023-04-23. PMID:37088237. |
rosa canina l. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats. |
2023-04-23 |
2023-08-14 |
rat |
| Nazia Siddiqui, Javed Ali, Suhel Parvez, Abul Kalam Najmi, Mohd Akhta. Neuroprotective Role of DPP-4 Inhibitor Linagliptin Against Neurodegeneration, Neuronal Insulin Resistance and Neuroinflammation Induced by Intracerebroventricular Streptozotocin in Rat Model of Alzheimer's Disease. Neurochemical research. 2023-04-20. PMID:37079222. |
the present study is hypothesized to examine linagliptin, a dpp-4i in intracerebroventricular streptozotocin induced neurodegeneration, and neuroinflammation and hippocampal insulin resistance in rat model of ad. |
2023-04-20 |
2023-08-14 |
rat |
| Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Aleksandra Ruzicic, Nebojsa Jasnic, Sinisa Djurasevic, Jelena Djordjevic, Predrag Vujovi. The Expression of Insulin in the Central Nervous System: What Have We Learned So Far? International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047558. |
considering that both insulin mrna and insulin were detected in the central nervous system (cns), it is now known that this hormone is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb. |
2023-04-13 |
2023-08-14 |
Not clear |