| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ankita B Jaykumar, Derk Binns, Clinton A Taylor, Anthony Anselmo, Shari G Birnbaum, Kimberly M Huber, Melanie H Cob. WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38915673. |
certain areas of the brain involved in episodic memory and behavior, such as the hippocampus, express high levels of insulin receptors and glucose transporter-4 (glut4) and are responsive to insulin. |
2024-06-25 |
2024-06-27 |
mouse |
| Ankita B Jaykumar, Derk Binns, Clinton A Taylor, Anthony Anselmo, Shari G Birnbaum, Kimberly M Huber, Melanie H Cob. WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38915673. |
inhibition of wnk enhances insulin signaling output and insulin-dependent glut4 trafficking to the plasma membrane in mice primary neuronal cultures and hippocampal slices. |
2024-06-25 |
2024-06-27 |
mouse |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Bartosz Kula, Botond Antal, Corey Weistuch, Florian Gackière, Alexander Barre, Victor Velado, Jeffrey M Hubbard, Maria Kukley, Lilianne R Mujica-Parodi, Nathan A Smit. D-ꞵ-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance. PNAS nexus. vol 3. issue 5. 2024-06-01. PMID:38818236. |
d-ꞵ-hydroxybutyrate stabilizes hippocampal ca3-ca1 circuit during acute insulin resistance. |
2024-06-01 |
2024-06-02 |
mouse |
| William H Gendron, Emre Fertan, Kyle M Roddick, Aimée A Wong, Maria Maliougina, Yassine El Hiani, Younes Anini, Richard E Brow. Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice. Physiology & behavior. vol 281. 2024-05-25. PMID:38750806. |
p-akt signaling in the hippocampus was increased by insulin in a dose-dependent manner. |
2024-05-25 |
2024-05-27 |
mouse |
| Han-Ming Wu, Yang Vivian Yang, Na-Jun Huang, Li-Ping Fan, Ying-Ying Dai, Ke-Ting Hu, Tian-Yu Tang, Lin Liu, Yue Xu, Dong-Tai Liu, Ze-Xin Cai, Xiao-Yu Niu, Xin-Yi Ren, Zheng-Hao Yao, Hao-Yu Qin, Jian-Zhen Chen, Xi Huang, Cixiong Zhang, Xiang You, Chen Wang, Ying He, Wei Hong, Yu-Xia Sun, Yi-Hong Zhan, Shu-Yong Li. Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance. Frontiers in neuroscience. vol 18. 2024-05-08. PMID:38716255. |
instead, probucol could regulate the levels of nitric oxide and superoxide-generating proteins, and it could specifically alleviate hfd-induced hippocampal insulin resistance. |
2024-05-08 |
2024-05-27 |
mouse |
| Punya Sachdeva, Kannan Badri Narayanan, Jitendra Kumar Sinha, Saurabh Gupta, Shampa Ghosh, Krishna Kumar Singh, Rakesh Bhaskar, Abdulmajeed G Almutary, James H Zothantluanga, Kranthi Kumar Kotta, Vinod Kumar Nelson, Ana Cláudia Paiva-Santos, Mosleh Mohammad Abomughaid, Mehnaz Kamal, Danish Iqbal, Mohammed Hamoud ALHarbi, Awadh Aedh ALMutairi, Saikat Dewanjee, Mohana Vamsi Nuli, Shanmugam Vippamakula, Saurabh Kumar Jha, Shreesh Ojha, Niraj Kumar Jh. Recent Advances in Drug Delivery Systems Targeting Insulin Signalling for the Treatment of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-12. PMID:38607755. |
insulin and the downstream insulin signaling molecules are found mainly in the hippocampus and cortex. |
2024-04-12 |
2024-04-15 |
Not clear |
| Mubeen A Ansari, Aishah Al-Jarallah, Muddanna S Rao, Ahmed Babiker, Khaled Bensalama. Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease. Brain research. 2024-03-29. PMID:38552936. |
upregulation of nadph-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: development of sporadic alzheimer's disease. |
2024-03-29 |
2024-04-01 |
rat |
| Hadi Moatamed Jahromi, Ali Rafati, Saied Karbalay-Doust, Somaye Keshavarz, Maryam Nase. The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury. Brain structure & function. 2024-03-18. PMID:38498064. |
the present study aimed to investigate the combination effects of hypothermia (ht) and intranasal insulin (ins) on structural changes of the hippocampus and cognitive impairments in the traumatic brain injury (tbi) rat model. |
2024-03-18 |
2024-03-20 |
rat |
| Daymara Mercerón-Martínez, Laura Alacán Ricardo, Arturo Bejerano Pina, Norma Orama Rojo, Ariel Expósito Seco, Yamilé Vega Hurtado, Bárbara Estupiñán Días, Isabel Fernández, Laura García Pupo, Marquiza Sablón Carrazana, Chryslaine Rodríguez-Tanty, Roberto Menéndez Soto Del Valle, William Almaguer-Melia. Amylovis-201 enhances physiological memory formation and rescues memory and hippocampal cell loss in a streptozotocin-induced Alzheimer's disease animal model. Brain research. 2024-03-03. PMID:38432261. |
furthermore, daily administration of amylovis-201 to animals with bilateral intracerebroventricular injection of stz produces a reduction in the loss of the hippocampus dentate gyrus cells and an improvement in spatial memory, probably because amylovis-201 can interact with some of the protein kinases of the insulin signaling cascade, also involved in neural plasticity, and thereby halt or reverse some of the effects of stz. |
2024-03-03 |
2024-03-06 |
Not clear |
| Amanda Brondani Mucellini, Daniela Pereira Laureano, Márcio Bonesso Alves, Roberta Dalle Molle, Mariana Balbinot Borges, Ana Paula da Ascenção Salvador, Irina Pokhvisneva, Gisele Gus Manfro, Patrícia Pelufo Silveir. The impact of poor fetal growth and chronic hyperpalatable diet exposure in adulthood on hippocampal function and feeding patterns in male rats. Developmental psychobiology. vol 66. issue 2. 2024-02-19. PMID:38372503. |
we investigated whether poor fetal growth and exposure to chronic hyperpalatable food in adulthood could influence the recognition of environmental and food cues, eating behavior patterns, and hippocampal insulin signaling. |
2024-02-19 |
2024-02-21 |
rat |
| Amanda Brondani Mucellini, Daniela Pereira Laureano, Márcio Bonesso Alves, Roberta Dalle Molle, Mariana Balbinot Borges, Ana Paula da Ascenção Salvador, Irina Pokhvisneva, Gisele Gus Manfro, Patrícia Pelufo Silveir. The impact of poor fetal growth and chronic hyperpalatable diet exposure in adulthood on hippocampal function and feeding patterns in male rats. Developmental psychobiology. vol 66. issue 2. 2024-02-19. PMID:38372503. |
poor fetal growth and chronic hfs diet in adulthood altered hippocampal insulin signaling and eating patterns, diminishing the flexibility associated with eating behavior in response to extrinsic changes in food availability in the environment. |
2024-02-19 |
2024-02-21 |
rat |
| Filipe Valvassori do Nascimento, Betânia Souza de Freitas, Maiara Priscila Dos Passos, Luiza Kleverston, Cristophod de Souza Dos Santos, Luiza Wilges Kist, Maurício Reis Bogo, Elke Bromberg, Nadja Schröde. A high fat diet potentiates neonatal iron overload-induced memory impairments in rats. European journal of nutrition. 2024-02-15. PMID:38358514. |
iron overload and exposure to a hypercaloric/hyperlipidic diet, on cognition, insulin resistance, and hippocampal glut1, glut3, insr mrna expression, and akt phosporylation. |
2024-02-15 |
2024-02-17 |
rat |
| Mubeen A Ansari, Muddanna Sakkattu Rao, Aishah Al-Jaralla. Insights into early pathogenesis of sporadic Alzheimer's disease: role of oxidative stress and loss of synaptic proteins. Frontiers in neuroscience. vol 17. 2024-01-23. PMID:38260013. |
this study evaluated early hippocampal oxidative stress, pre- and post-synaptic proteins in intraperitoneal (ip) and intracerebroventricular (icv) streptozotocin (stz) models of impaired insulin signaling. |
2024-01-23 |
2024-01-25 |
rat |
| Bartosz Kula, Botond Antal, Corey Weistuch, Florian Gackiere, Alexander Barre, Victor Velado, Jeffrey M Hubbard, Maria Kukley, Lilianne R Mujica-Parodi, Nathan A Smit. D-ꞵ-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance. bioRxiv : the preprint server for biology. 2024-01-15. PMID:37662316. |
d-ꞵ-hydroxybutyrate stabilizes hippocampal ca3-ca1 circuit during acute insulin resistance. |
2024-01-15 |
2024-01-17 |
mouse |
| Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. |
the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. |
2024-01-11 |
2024-01-13 |
rat |
| Benedetta Bigio, Shofiul Azam, Aleksander A Mathé, Carla Nasc. The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications. Discover mental health. vol 4. issue 1. 2024-01-03. PMID:38169018. |
in addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of lac protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as nfkb in hippocampal and cortical neurons. |
2024-01-03 |
2024-01-06 |
Not clear |
| Mahdi Khorsand Ghaffari, Ali Rafati, Narges Karbalaei, Masoud Haghani, Marzieh Nemati, Niloofar Sefati, Mohammad Reza Namava. The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-STZ in a rat model. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-29. PMID:38157024. |
the effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-stz in a rat model. |
2023-12-29 |
2024-01-05 |
rat |
| Mahdi Khorsand Ghaffari, Ali Rafati, Narges Karbalaei, Masoud Haghani, Marzieh Nemati, Niloofar Sefati, Mohammad Reza Namava. The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-STZ in a rat model. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-29. PMID:38157024. |
so, in the present study, we examined the effects of intranasal co-treatment of insulin and a pool of growth factor-rich serum (gfrs) which separated from activated platelets on memory, and behavioral defects induced by intracerebroventricular streptozotocin (icv-stz) rat model also investigated changes in the hippocampal oxidative-nitrosative state and histology. |
2023-12-29 |
2024-01-05 |
rat |
| Mahdi Khorsand Ghaffari, Ali Rafati, Narges Karbalaei, Masoud Haghani, Marzieh Nemati, Niloofar Sefati, Mohammad Reza Namava. The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-STZ in a rat model. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-29. PMID:38157024. |
memory and behavioral improvements in the co-treatment of insulin and gfrs could be attributed to their effects on neuronal/oligodendroglia survival and reduction of neuroinflammation in the hippocampus. |
2023-12-29 |
2024-01-05 |
rat |