| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Setare Farokhi Larijani, Gholamreza Hassanzadeh, Maryam Zahmatkesh, Forough Radfar, Maryam Farahmandfa. Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptor. Behavioural brain research. 2023-12-17. PMID:38104636. |
intranasal insulin intake and exercise improve memory function in amyloid-β induced alzheimer's-like disease in rats: involvement of hippocampal bdnf-trkb receptor. |
2023-12-17 |
2023-12-21 |
rat |
| Setare Farokhi Larijani, Gholamreza Hassanzadeh, Maryam Zahmatkesh, Forough Radfar, Maryam Farahmandfa. Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptor. Behavioural brain research. 2023-12-17. PMID:38104636. |
the exercise training and intranasal insulin improved working memory deficits, decreased anxiety, and increased bdnf, and trkb levels in the hippocampus of animals received aβ. |
2023-12-17 |
2023-12-21 |
rat |
| Caio Yogi Yonamine, Maria Luiza Estimo Michalani, Rafael Junges Moreira, Ubiratan Fabres Machad. Glucose Transport and Utilization in the Hippocampus: From Neurophysiology to Diabetes-Related Development of Dementia. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003671. |
in addition, insulin resistance-induced abnormalities in the hippocampus of obese/t2d patients, such as inflammatory stress, oxidative stress, and mitochondrial stress, increased generation of advanced glycated end products and bbb dysfunction, as well as their association with dementia/alzheimer's disease, are addressed. |
2023-11-25 |
2023-11-28 |
Not clear |
| Marc James Quesnel, Anne Labonté, Cynthia Picard, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, Sylvia Villeneuve, Judes Poirie. Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains. Brain : a journal of neurology. 2023-11-22. PMID:37992295. |
insulin, insulin-like growth factors (igf) and their receptors are highly expressed in the adult hippocampus. |
2023-11-22 |
2023-11-29 |
human |
| Smilja Todorovic, Valentina Simeunovic, Milica Prvulovic, Tamara Dakic, Tanja Jevdjovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovi. Dietary restriction alters insulin signaling pathway in the brain. BioFactors (Oxford, England). 2023-11-17. PMID:37975613. |
because the effects of dr on insulin signaling in the brain have been poorly studied, we decided to examine the effects of dr that differed in onset and duration: long-term dr (ltdr), medium-term dr (mtdr), and short-term dr (stdr) on the expression of proteins involved in insulin signaling in the hippocampus of 18- and 24-month-old male wistar rats. |
2023-11-17 |
2023-11-20 |
rat |
| Smilja Todorovic, Valentina Simeunovic, Milica Prvulovic, Tamara Dakic, Tanja Jevdjovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovi. Dietary restriction alters insulin signaling pathway in the brain. BioFactors (Oxford, England). 2023-11-17. PMID:37975613. |
significantly changed insulin content in the hippocampus, together with altered insulin signaling were found under the influence of dr, but the outcome was highly dependent on the onset and duration of dr. |
2023-11-17 |
2023-11-20 |
rat |
| Xiying Guo, Min Lei, Guandi Ma, Changhan Ouyang, Xiaosong Yang, Chao Liu, Qingjie Chen, Xiufen Li. Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway. Molecular neurobiology. 2023-11-01. PMID:37910285. |
further research revealed that scha therapy reduced diabetic-induced hippocampus neuron damage and the generation of aβ, as demonstrated by the upregulated phosphorylation levels of insulin signaling pathway connected proteins and by the decreased expression levels of inflammatory-related factors. |
2023-11-01 |
2023-11-08 |
rat |
| Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yada. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders. European journal of pharmacology. 2023-10-31. PMID:37907134. |
insulin degrading enzyme (ide) plays a significant role in the amyloid β metabolism, aggregation, and deposition of misfolded proteins in the brain's hippocampal and cortical neuronal regions. |
2023-10-31 |
2023-11-08 |
mouse |
| Ewan C McNa. Diet-induced diabetes is associated with lower hippocampal glycogen and reduced glycogenolysis following local exogenous insulin. Journal of neurochemistry. 2023-10-27. PMID:37885343. |
diet-induced diabetes is associated with lower hippocampal glycogen and reduced glycogenolysis following local exogenous insulin. |
2023-10-27 |
2023-11-08 |
rat |
| Ewan C McNa. Diet-induced diabetes is associated with lower hippocampal glycogen and reduced glycogenolysis following local exogenous insulin. Journal of neurochemistry. 2023-10-27. PMID:37885343. |
insulin has been shown to be a key regulator of hippocampal cognitive and metabolic processes; in the periphery, insulin facilitates glycogen synthesis and storage, but the impact on brain glycogen is unclear. |
2023-10-27 |
2023-11-08 |
rat |
| Ewan C McNa. Diet-induced diabetes is associated with lower hippocampal glycogen and reduced glycogenolysis following local exogenous insulin. Journal of neurochemistry. 2023-10-27. PMID:37885343. |
here, we show that in rats with high-fat diet-induced diabetes, hippocampal glycogen is reduced and is less responsive to acute intrahippocampal administration of insulin, which significantly reduces glycogen in the hippocampi of control animals: our data suggest that impaired fuel availability from glycogen may be a contributing factor to the cognitive impairment seen in disease states that include central insulin resistance. |
2023-10-27 |
2023-11-08 |
rat |
| Fatih Altintas, Sadettin Caliskan, Melek Tunc-Ata, Emine Kilic-Toprak, Onur Tokgun, Neslihan Esra Avci, Vural Kucukata. Investigation of fructose consumption on hippocampal insulin and glucagon-like peptide-1 receptors, and metabolic effects in rats. Iranian journal of basic medical sciences. vol 26. issue 11. 2023-10-27. PMID:37886000. |
investigation of fructose consumption on hippocampal insulin and glucagon-like peptide-1 receptors, and metabolic effects in rats. |
2023-10-27 |
2023-11-08 |
rat |
| Olumayowa K Idowu, Olushola O Oluyomi, Oluwatomisin O Faniyan, Olufunke O Dosumu, Oluwole B Akinol. The synergistic ameliorative activity of peroxisome proliferator-activated receptor-alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance. Ibrain. vol 8. issue 3. 2023-10-03. PMID:37786742. |
the synergistic ameliorative activity of peroxisome proliferator-activated receptor-alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance. |
2023-10-03 |
2023-10-07 |
rat |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. |
2023-09-27 |
2023-10-07 |
rat |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
in this study, we found that long-term simulated weightlessness induced hippocampal insulin resistance and subsequent neuronal damage and cognitive impairment in rats. |
2023-09-27 |
2023-10-07 |
rat |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
mechanistically, insulin-stimulated hippocampal akt phosphorylation was decreased, while pten, the negative regulator of insulin signaling, was increased in the hippocampus in tail-suspended rats. |
2023-09-27 |
2023-10-07 |
rat |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
these data suggest that long-term simulated weightlessness induces cognitive impairment as well as neuronal apoptosis and neural degeneration, partially through hippocampal insulin resistance via pten up-regulation. |
2023-09-27 |
2023-10-07 |
rat |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
berberine treatment attenuates hippocampal insulin resistance and improves cognitive function. |
2023-09-27 |
2023-10-07 |
rat |
| Melek Tunc-Ata, Zeynep Mine Altunay, Aysel Alphan, Vural Kucukata. Effect of insulin on IR and GLP1-R expressions in HT22 cells. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-15. PMID:37712993. |
this study aims to investigate the effect of insulin administered to immortalized clonal mouse hippocampal cell line (ht22) at different doses and intervals on ir, insulin receptor a (ira), insulin receptor b (irb), and glucagon-like peptide 1 receptor (glp1-r) mrna expression and protein levels. |
2023-09-15 |
2023-10-07 |
mouse |
| Brian J Sandri, Kathleen Ennis-Czerniak, Priya Kanajam, William H Frey, Eric F Lock, Raghavendra Ra. Intranasal Insulin Treatment Partially Corrects the Altered Gene Expression Profile in the Hippocampus of Developing Rats with Perinatal Iron Deficiency. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-08-21. PMID:37602386. |
intranasal insulin treatment partially corrects the altered gene expression profile in the hippocampus of developing rats with perinatal iron deficiency. |
2023-08-21 |
2023-09-07 |
rat |