| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T den Heijer, S E Vermeer, E J van Dijk, N D Prins, P J Koudstaal, A Hofman, M M B Bretele. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia. vol 46. issue 12. 2004-07-21. PMID:14595538. |
we investigated the association between diabetes mellitus, insulin resistance and the degree of hippocampal and amygdalar atrophy on magnetic resonance imaging (mri) accounting for vascular pathology. |
2004-07-21 |
2023-08-12 |
Not clear |
| Dervla O'Malley, Jenni Harve. Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process. Molecular pharmacology. vol 65. issue 6. 2004-06-21. PMID:15155829. |
indeed, high levels of insulin and insulin receptors are expressed in several brain regions including the hippocampus. |
2004-06-21 |
2023-08-12 |
human |
| Dervla O'Malley, Jenni Harve. Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process. Molecular pharmacology. vol 65. issue 6. 2004-06-21. PMID:15155829. |
we have shown previously that insulin inhibits aberrant synaptic activity in hippocampal neurons via activation of large conductance ca(2+)-activated k+ (bk) channels. |
2004-06-21 |
2023-08-12 |
human |
| Dervla O'Malley, Jenni Harve. Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process. Molecular pharmacology. vol 65. issue 6. 2004-06-21. PMID:15155829. |
in this study, we have examined further the effects of insulin on native hippocampal and recombinant (hslo) bk channels expressed in human embryonic kidney (hek) 293 cells. |
2004-06-21 |
2023-08-12 |
human |
| Dervla O'Malley, Jenni Harve. Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process. Molecular pharmacology. vol 65. issue 6. 2004-06-21. PMID:15155829. |
pipette or bath application of insulin evoked a rapid increase in hippocampal bk channel activity, an action caused by activation of insulin receptors because insulin-like growth factor 1 (igf-1) failed to mimic insulin action. |
2004-06-21 |
2023-08-12 |
human |
| Chiung-Chun Huang, Jia-Lin You, Cheng-Che Lee, Kuei-Sen Hs. Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus. Molecular and cellular neurosciences. vol 24. issue 3. 2004-05-05. PMID:14664829. |
insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus. |
2004-05-05 |
2023-08-12 |
Not clear |
| Chiung-Chun Huang, Cheng-Che Lee, Kuei-Sen Hs. An investigation into signal transduction mechanisms involved in insulin-induced long-term depression in the CA1 region of the hippocampus. Journal of neurochemistry. vol 89. issue 1. 2004-04-26. PMID:15030406. |
recent work has demonstrated that brief application of insulin to hippocampal slices can induce a novel form of long-term depression (insulin-ltd) in the ca1 region of the hippocampus; however, the molecular details of how insulin triggers ltd remain unclear. |
2004-04-26 |
2023-08-12 |
Not clear |
| Y Izumi, K A Yamada, M Matsukawa, C F Zorumsk. Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. Diabetologia. vol 46. issue 7. 2004-04-12. PMID:12827244. |
effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. |
2004-04-12 |
2023-08-12 |
rat |
| Namik Delibas, Ibrahim Kilinc, Zafer Yonden, Recep Sutcu, Fatih Gultekin, Halis Koyl. NMDA receptor subunits 2A and 2B decrease and lipid peroxidation increase in the hippocampus of streptozotocin-diabetic rats: effects of insulin and gliclazide treatments. The International journal of neuroscience. vol 114. issue 3. 2004-03-22. PMID:14754663. |
nmda receptor subunits 2a and 2b decrease and lipid peroxidation increase in the hippocampus of streptozotocin-diabetic rats: effects of insulin and gliclazide treatments. |
2004-03-22 |
2023-08-12 |
rat |
| Namik Delibas, Ibrahim Kilinc, Zafer Yonden, Recep Sutcu, Fatih Gultekin, Halis Koyl. NMDA receptor subunits 2A and 2B decrease and lipid peroxidation increase in the hippocampus of streptozotocin-diabetic rats: effects of insulin and gliclazide treatments. The International journal of neuroscience. vol 114. issue 3. 2004-03-22. PMID:14754663. |
this study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal nmda receptor subunit 2a and 2b (nr2a and nr2b) concentrations. |
2004-03-22 |
2023-08-12 |
rat |
| Hillel Grossma. Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease. CNS spectrums. vol 8. issue 11. 2004-02-23. PMID:14702004. |
insulin dysregulation may contribute to ad pathology through several mechanisms including decreased cortical glucose utilization particularly in the hippocampus and entorhinal cortex; increased oxidative stress through the formation of advanced glycation end-products; increased tau phosphorylation and neurofibrillary tangle formation; increased b-amyloid aggregation through inhibition of insulin-degrading enzyme. |
2004-02-23 |
2023-08-12 |
Not clear |
| Mayuko Kino, Takako Yamato, Masahiro Aomin. Simultaneous measurement of nitric oxide, blood glucose, and monoamines in the hippocampus of diabetic rat: an in vivo microdialysis study. Neurochemistry international. vol 44. issue 2. 2003-11-12. PMID:12971908. |
the results in the present study showed that: (1) the plasma levels of nox in both diabetic rats were low compared to those in control rats, (2) the hippocampal nox levels in both diabetic rats were almost the same as those in control rats, while the levels of 5-ht and da were low in the diabetics, and (3) a sudden decrease in the plasma glucose level due to insulin administration reduced the nox level as well as enhanced the 5-ht level in the diabetic hippocampus, a finding consistent with the results of 7 days administration of insulin. |
2003-11-12 |
2023-08-12 |
rat |
| Dervla O'Malley, Lynne J Shanley, Jenni Harve. Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726817. |
in functional studies, insulin inhibited spontaneous ca(2+) oscillations evoked in cultured hippocampal neurones following mg(2+) removal. |
2003-08-04 |
2023-08-12 |
rat |
| Dervla O'Malley, Lynne J Shanley, Jenni Harve. Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726817. |
insulin inhibits rat hippocampal neurones via activation of atp-sensitive k+ and large conductance ca2+-activated k+ channels. |
2003-08-04 |
2023-08-12 |
rat |
| Dervla O'Malley, Lynne J Shanley, Jenni Harve. Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726817. |
in this study, we have used a combination of immunocytochemical and ca(2+) imaging techniques to determine the functional localisation of insulin receptors as well as the potential role for insulin in modulating hippocampal synaptic activity. |
2003-08-04 |
2023-08-12 |
rat |
| B Valastro, J Cossette, N Lavoie, S Gagnon, F Trudeau, G Massicott. Up-regulation of glutamate receptors is associated with LTP defects in the early stages of diabetes mellitus. Diabetologia. vol 45. issue 5. 2003-01-03. PMID:12107744. |
recent studies involving electrophysiology and immunolabelling indicate that short-term insulin treatment of hippocampal neurons in culture induces changes in glutamate receptor function, suggesting that this receptor system can be altered on a relatively rapid time scale during diabetic conditions. |
2003-01-03 |
2023-08-12 |
mouse |
| Gerardo G Piroli, Claudia A Grillo, Elena K Hoskin, Vladimir Znamensky, Ellen B Katz, Teresa A Milner, Bruce S McEwen, Maureen J Charron, Lawrence P Reaga. Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus. The Journal of comparative neurology. vol 452. issue 2. 2002-10-30. PMID:12271485. |
these results demonstrate that glut8 undergoes rapid translocation to the rough er in the rat hippocampus following peripheral glucose administration, trafficking that is impaired in stz diabetes, suggesting that insulin serves as a stimulus for glut8 translocation in hippocampal neurons. |
2002-10-30 |
2023-08-12 |
rat |
| F Gardoni, A Kamal, C Bellone, G J Biessels, G M J Ramakers, F Cattabeni, W H Gispent, M Di Luc. Effects of streptozotocin-diabetes on the hippocampal NMDA receptor complex in rats. Journal of neurochemistry. vol 80. issue 3. 2002-04-04. PMID:11908465. |
this study examined the time course of the effects of stz-diabetes and insulin treatment on the hippocampal post-synaptic glutamate n-methyl-d-aspartate (nmda) receptor complex and other key proteins regulating hippocampal synaptic transmission in the post-synaptic density (psd) fraction. |
2002-04-04 |
2023-08-12 |
rat |
| T Löffler, S K Lee, M Nöldner, S S Chatterjee, S Hoyer, R Schlieb. Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810408. |
to reveal whether an extract of ginkgo biloba (egb761) may affect streptozotocin (stz)-induced impairments in brain glucose metabolism, autoradiographies of [3h]cytochalasin-b binding to the total population of glucose transporters, [125i]insulin binding to insulin receptors, [3h]glyburide binding to sulfonylurea receptors, and radioactive in situ hybridization for glut3 mrna were carried out in hippocampal brain sections of adult rats that have additionally been divided into good performers (gp) and poor performers (pp) by behavioural tests before the experiments. |
2002-03-07 |
2023-08-12 |
rat |
| I Kisfalvi, G Rácz, A Bálint, M Máté, A Oláh, T Zelles, E S Vizi, G Varg. Effects of putative galanin antagonists M35 and C7 on rat exocrine pancreas. Journal of physiology, Paris. vol 95. issue 1-6. 2002-02-19. PMID:11595464. |
these antagonists have blocked the actions of galanin on flexor reflex, glucose-induced insulin secretion, and acetyicholine release from hippocampus. |
2002-02-19 |
2023-08-12 |
rat |