| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V A Skeberdis, J Lan, X Zheng, R S Zukin, M V Bennet. Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 6. 2001-12-04. PMID:11248117. |
because insulin and insulin receptors are localized to glutamatergic synapses in the hippocampus, insulin-regulated trafficking of nmdars may play a role in synaptic transmission and plasticity, including long-term potentiation. |
2001-12-04 |
2023-08-12 |
xenopus_laevis |
| O Chan, S Chan, K Inouye, M Vranic, S G Matthew. Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment. Endocrinology. vol 142. issue 11. 2001-12-04. PMID:11606455. |
hippocampal mr mrna expression was dramatically increased with diabetes and, moreover, was not normalized by insulin. |
2001-12-04 |
2023-08-12 |
rat |
| C E Greenwood, G Winocu. Glucose treatment reduces memory deficits in young adult rats fed high-fat diets. Neurobiology of learning and memory. vol 75. issue 2. 2001-06-14. PMID:11222059. |
these results demonstrate that glucose administration can overcome those deficits associated with hippocampal function in rats fed high-fat diets and are consistent with the hypothesis that high-fat diets, in part, mediate their effect through the development of insulin resistance and glucose intolerance. |
2001-06-14 |
2023-08-12 |
rat |
| L Gasparini, G K Gouras, R Wang, R S Gross, M F Beal, P Greengard, H X. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306609. |
among these receptors, insulin and insulin-like growth factor-1 receptors are highly expressed in brain, especially in hippocampus and cortex. |
2001-06-07 |
2023-08-12 |
Not clear |
| J W Lin, W Ju, K Foster, S H Lee, G Ahmadian, M Wyszynski, Y T Wang, M Shen. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nature neuroscience. vol 3. issue 12. 2001-04-26. PMID:11100149. |
using immunofluorescence and surface biotinylation, we characterized and quantified basal and regulated ampa receptor endocytosis in cultured hippocampal neurons, in response to synaptic activity, ampa and insulin. |
2001-04-26 |
2023-08-12 |
Not clear |
| P W Marinelli, C Gianoulakis, S Ka. Effects of voluntary ethanol drinking on [125I]insulin-like growth factor-I, [125I]insulin-like growth factor-II and [125I]insulin receptor binding in the mouse hippocampus and cerebellum. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891612. |
[125i]insulin-like growth factor-ii and [125i]insulin receptor-binding sites, on the other hand, did not exhibit any alterations either in the hippocampus or cerebellum following chronic exposure to ethanol. |
2000-09-27 |
2023-08-12 |
mouse |
| P W Marinelli, C Gianoulakis, S Ka. Effects of voluntary ethanol drinking on [125I]insulin-like growth factor-I, [125I]insulin-like growth factor-II and [125I]insulin receptor binding in the mouse hippocampus and cerebellum. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891612. |
these results, in keeping with earlier reports, suggest that hippocampal insulin-like growth factor-i is more sensitive to ethanol treatment than either insulin-like growth factor-ii or insulin, and the observed increase in the [125i]insulin-like growth factor-i receptor levels possibly reflects an activity-dependent response to prevent/slow down neuronal degeneration and/or to regulate subtle functional alterations that follow chronic exposure to ethanol. |
2000-09-27 |
2023-08-12 |
mouse |
| P W Marinelli, C Gianoulakis, S Ka. Effects of voluntary ethanol drinking on [125I]insulin-like growth factor-I, [125I]insulin-like growth factor-II and [125I]insulin receptor binding in the mouse hippocampus and cerebellum. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891612. |
the present study was designed to determine if voluntary ethanol consumption over a 21-day period could alter [125i]insulin-like growth factor-i, [125i]insulin-like growth factor-ii and [125i]insulin receptor-binding sites in the hippocampus and cerebellum-areas known to be severely affected following chronic exposure to ethanol. |
2000-09-27 |
2023-08-12 |
mouse |
| M F McCart. Prenatal high-dose pyridoxine may prevent hypertension and syndrome X in-utero by protecting the fetus from excess glucocorticoid activity. Medical hypotheses. vol 54. issue 5. 2000-07-20. PMID:10859692. |
the increased risk for hypertension, insulin resistance syndrome, and coronary events associated with small-for-gestational-age birth, has plausibly been attributed to excessive prenatal exposure to glucocorticoids; this may up-regulate glucocorticoid activity throughout life by permanently decreasing expression of hippocampal glucocorticoid receptors crucial for feedback control of cortisol secretion. |
2000-07-20 |
2023-08-12 |
Not clear |
| S Doré, S Kar, J G Chabot, R Quirio. Impact of neonatal kainate treatment on hippocampal insulin-like growth factor receptors. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391481. |
in the developing hippocampus, insulin-like growth factor-i and insulin binding sites are concentrated primarily in the dentate gyrus and the ca2/ca3 subfields, whereas insulin-like growth factor-ii binding is discretely localized to the pyramidal layer and the granular layer of the dentate gyrus. |
1999-10-08 |
2023-08-12 |
rat |
| J M Sullivan, S S Alousi, K R Hikade, N J Bahu, J A Rafols, G S Krause, B C Whit. Insulin induces dephosphorylation of eukaryotic initiation factor 2alpha and restores protein synthesis in vulnerable hippocampal neurons after transient brain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 19. issue 9. 1999-09-21. PMID:10478653. |
insulin induces dephosphorylation of eukaryotic initiation factor 2alpha and restores protein synthesis in vulnerable hippocampal neurons after transient brain ischemia. |
1999-09-21 |
2023-08-12 |
rat |
| J M Christie, R J Wenthold, D T Monagha. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098857. |
rat hippocampal slices were exposed to 1 microm insulin for 20 and 60 min and then solubilized. |
1999-04-13 |
2023-08-12 |
rat |
| J M Christie, R J Wenthold, D T Monagha. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098857. |
this possibility is consistent with our earlier finding that insulin potentiates hippocampal nmda receptor activity after 20 min, but not after 60 min, of insulin exposure. |
1999-04-13 |
2023-08-12 |
rat |
| J M Christie, R J Wenthold, D T Monagha. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098857. |
insulin causes a transient tyrosine phosphorylation of nr2a and nr2b nmda receptor subunits in rat hippocampus. |
1999-04-13 |
2023-08-12 |
rat |
| J M Christie, R J Wenthold, D T Monagha. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098857. |
insulin incubation of hippocampal slices for 20 min elicited an increase in tyrosine phosphorylation to 176 +/- 16% (nr2a) and 203 +/- 15% (nr2b) of control levels. |
1999-04-13 |
2023-08-12 |
rat |
| G J Biessels, A Kamal, I J Urban, B M Spruijt, D W Erkelens, W H Gispe. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain research. vol 800. issue 1. 1998-09-16. PMID:9685609. |
water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. |
1998-09-16 |
2023-08-12 |
rat |
| S Doré, S Kar, W Rowe, R Quirio. Distribution and levels of [125I]IGF-I, [125I]IGF-II and [125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats. Neuroscience. vol 80. issue 4. 1997-10-07. PMID:9284058. |
[125i]igf-ii or [125i]insulin binding levels in any regions or laminae of the hippocampus of young vs aged rats. |
1997-10-07 |
2023-08-12 |
rat |
| B S Singh, P A Rajakumar, E M Eves, M R Rosner, B H Wainer, S U Devaska. Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines. Regulatory peptides. vol 69. issue 1. 1997-07-22. PMID:9163577. |
we conclude that insulin ii is expressed by cultured rat hippocampal clonal cell lines, and not by the peripheral sympathetic pc-12 neuronal cell line. |
1997-07-22 |
2023-08-12 |
rat |
| B S Singh, P A Rajakumar, E M Eves, M R Rosner, B H Wainer, S U Devaska. Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines. Regulatory peptides. vol 69. issue 1. 1997-07-22. PMID:9163577. |
insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines. |
1997-07-22 |
2023-08-12 |
rat |
| F Folli, S Ghidella, L Bonfanti, C R Kahn, A Merigh. The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system. Molecular neurobiology. vol 13. issue 2. 1997-03-14. PMID:8938649. |
in numerous neuronal populations within the olfactory bulb, the cerebral and cerebellar cortex, the hippocampus, some diencephalic and brainstem nuclei, the spinal cord and the retina, specific insulin and igf receptors, as well as crucial components of the intracellular receptor signaling pathway have been demonstrated. |
1997-03-14 |
2023-08-12 |
Not clear |