| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruce S McEwe. Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. Metabolism: clinical and experimental. vol 55. issue 10 Suppl 2. 2006-11-02. PMID:16979422. |
moreover, brain regions such as the hippocampus are sensitive to glucose and insulin, and both type 1 and type 2 diabetes mellitus are associated with cognitive impairment and (for type 2 diabetes mellitus) increased risk for alzheimer's disease. |
2006-11-02 |
2023-08-12 |
human |
| Luke Benedict, Charles A Nelson, Emily Schunk, Kristin Sullwold, Elizabeth R Seaquis. Effect of insulin on the brain activity obtained during visual and memory tasks in healthy human subjects. Neuroendocrinology. vol 83. issue 1. 2006-07-26. PMID:16707912. |
insulin receptors are found throughout the brain, particularly in the hippocampus, although the impact of insulin on memory is unclear. |
2006-07-26 |
2023-08-12 |
human |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences. vol 99. issue 2. 2006-05-03. PMID:16210778. |
in the hippocampus, insulin promotes learning and memory, independent of the glucoregulatory effect of insulin. |
2006-05-03 |
2023-08-12 |
Not clear |
| Melita Salkovic-Petrisic, Florian Tribl, Manuela Schmidt, Siegfried Hoyer, Peter Riedere. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412093. |
alzheimer-like changes in protein kinase b and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. |
2006-04-06 |
2023-08-12 |
human |
| Lawrence P Reaga. Neuronal insulin signal transduction mechanisms in diabetes phenotypes. Neurobiology of aging. vol 26 Suppl 1. 2006-03-14. PMID:16225964. |
the hippocampus is an important integration center for learning and memory in the mammalian central nervous system (cns) and is particularly sensitive and responsive to changes in insulin and glucose concentrations. |
2006-03-14 |
2023-08-12 |
human |
| Antonio Convi. Links between cognitive impairment in insulin resistance: an explanatory model. Neurobiology of aging. vol 26 Suppl 1. 2006-03-14. PMID:16246463. |
there are two papers in the literature documenting, relative to matched controls, hippocampal volume reductions among both diabetics and insulin resistant individuals. |
2006-03-14 |
2023-08-12 |
Not clear |
| Gordon Winocur, Carol E Greenwood, Gerardo G Piroli, Claudia A Grillo, Leah R Reznikov, Lawrence P Reagan, Bruce S McEwe. Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behavioral neuroscience. vol 119. issue 5. 2006-02-14. PMID:16300445. |
plasma membrane association of the insulin sensitive glucose transporter, glut4, was reduced in the hippocampus of obese rats in the absence of changes in total glut4 and insulin receptor expression. |
2006-02-14 |
2023-08-12 |
human |
| Liang Hui, Dong-Sheng Pei, Quan-Guang Zhang, Qiu-Hua Guan, Guang-Yi Zhan. The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. Brain research. vol 1052. issue 1. 2005-10-27. PMID:16018989. |
the neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of jnk signaling pathway by pi3k/akt activation. |
2005-10-27 |
2023-08-12 |
rat |
| Lars P van der Heide, Amer Kamal, Alain Artola, Willem Hendrik Gispen, Geert M J Ramaker. Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. Journal of neurochemistry. vol 94. issue 4. 2005-09-27. PMID:16092951. |
insulin modulates hippocampal activity-dependent synaptic plasticity in a n-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. |
2005-09-27 |
2023-08-12 |
Not clear |
| Lars P van der Heide, Amer Kamal, Alain Artola, Willem Hendrik Gispen, Geert M J Ramaker. Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. Journal of neurochemistry. vol 94. issue 4. 2005-09-27. PMID:16092951. |
insulin and its receptor are both present in the central nervous system and are implicated in neuronal survival and hippocampal synaptic plasticity. |
2005-09-27 |
2023-08-12 |
Not clear |
| Cheng-Che Lee, Chiung-Chun Huang, Mei-Ying Wu, Kuei-Sen Hs. Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15755733. |
here we present evidence that brief incubations of rat hippocampal slices with insulin resulted in an increased protein expression of dendritic scaffolding protein postsynaptic density-95 (psd-95) in area ca1. |
2005-09-02 |
2023-08-12 |
rat |
| Cheng-Che Lee, Chiung-Chun Huang, Mei-Ying Wu, Kuei-Sen Hs. Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15755733. |
taken together, these findings suggest that activation of the pi3k-akt-mtor signaling pathway is essential for the insulin-induced up-regulation of local psd-95 protein synthesis in neuronal dendrites and indicate a new molecular mechanism that may contribute to the modulation of synaptic function by insulin in hippocampal area ca1. |
2005-09-02 |
2023-08-12 |
rat |
| Owen Chan, Karen Inouye, Eitan M Akirav, Edward Park, Michael C Riddell, Stephen G Matthews, Mladen Vrani. Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 289. issue 1. 2005-07-13. PMID:15774766. |
increases in hypothalamic corticotrophin-releasing hormone (crh) and inhibitory hippocampal mineralocorticoid receptor (mr) mrna with stz diabetes were not restored with either insulin or phloridzin treatments. |
2005-07-13 |
2023-08-12 |
rat |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
we show that treatment of primary hippocampal neurons with insulin increased ide protein levels by approximately 25%. |
2005-07-07 |
2023-08-12 |
mouse |
| Gholamreza Ahmadian, William Ju, Lidong Liu, Michael Wyszynski, Sang Hyoung Lee, Anthone W Dunah, Changiz Taghibiglou, Yushan Wang, Jie Lu, Tak Pan Wong, Morgan Sheng, Yu Tian Wan. Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. The EMBO journal. vol 23. issue 5. 2005-06-20. PMID:14976558. |
moreover, in hippocampal slices, both insulin treatment and low-frequency stimulation (lfs) specifically stimulated tyrosine phosphorylation of the glur2 subunits of native ampa receptors, and the enhanced phosphorylation appears necessary for both insulin- and lfs-induced long-term depression of ampa receptor-mediated excitatory postsynaptic currents. |
2005-06-20 |
2023-08-12 |
human |
| K Paulus, C Schulz, H Lehner. Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats. Neuropsychobiology. vol 51. issue 2. 2005-04-29. PMID:15741751. |
central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in wistar rats. |
2005-04-29 |
2023-08-12 |
rat |
| K Paulus, C Schulz, H Lehner. Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats. Neuropsychobiology. vol 51. issue 2. 2005-04-29. PMID:15741751. |
we explored whether the intrahippocampal administration of insulin or leptin improved spatial memory formation in rats following a radial maze task and whether the insulin and leptin receptor expression in different areas of the hippocampus was affected. |
2005-04-29 |
2023-08-12 |
rat |
| K Paulus, C Schulz, H Lehner. Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats. Neuropsychobiology. vol 51. issue 2. 2005-04-29. PMID:15741751. |
the application of insulin increased the expression of the long form of the leptin receptor in the ammon's horn and dentate gyrus region of the hippocampus in the learning group only. |
2005-04-29 |
2023-08-12 |
rat |
| Christian Benedict, Manfred Hallschmid, Astrid Hatke, Bernd Schultes, Horst L Fehm, Jan Born, Werner Ker. Intranasal insulin improves memory in humans. Psychoneuroendocrinology. vol 29. issue 10. 2004-12-14. PMID:15288712. |
based on previous results indicating a prevalence of insulin receptors in limbic and hippocampal regions as well as improvements in memory with systemic insulin administration, we expected that intranasal administration of insulin improves primarily hippocampus dependent declaration memory function. |
2004-12-14 |
2023-08-12 |
human |
| R Ramakrishnan, R Sheeladevi, N Suthanthiraraja. PKC-alpha mediated alterations of indoleamine contents in diabetic rat brain. Brain research bulletin. vol 64. issue 2. 2004-11-29. PMID:15342107. |
striatum (st), hippocampus (hc), hypothalamus (ht), midbrain (mb), pons medulla (pm), cerebellum (cb) and cerebral cortex (ccx) of control, untreated diabetic and insulin treated diabetic rats after 30 days. |
2004-11-29 |
2023-08-12 |
rat |