| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Shuaib, M S Ijaz, T Waqar, C Voll, R Kanthan, H Miyashita, L Li. Insulin elevates hippocampal GABA levels during ischemia. This is independent of its hypoglycemic effect. Neuroscience. vol 67. issue 4. 1995-10-19. PMID:7675207. |
insulin elevates hippocampal gaba levels during ischemia. |
1995-10-19 |
2023-08-12 |
Not clear |
| L Liu, J C Brown, W W Webster, R A Morrisett, D T Monagha. Insulin potentiates N-methyl-D-aspartate receptor activity in Xenopus oocytes and rat hippocampus. Neuroscience letters. vol 192. issue 1. 1995-10-19. PMID:7675309. |
insulin potentiates n-methyl-d-aspartate receptor activity in xenopus oocytes and rat hippocampus. |
1995-10-19 |
2023-08-12 |
rat |
| L Liu, J C Brown, W W Webster, R A Morrisett, D T Monagha. Insulin potentiates N-methyl-D-aspartate receptor activity in Xenopus oocytes and rat hippocampus. Neuroscience letters. vol 192. issue 1. 1995-10-19. PMID:7675309. |
insulin modulation of native nmda receptors is suggested by the observation that insulin potentiated the nmda receptor-mediated synaptic component in hippocampal slices. |
1995-10-19 |
2023-08-12 |
rat |
| A P D'Costa, X Xu, R L Ingram, W E Sonnta. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. vol 65. issue 3. 1995-08-17. PMID:7609879. |
male brown norway rats (5-7 and 27-28 months old) were used to determine (1) whether in vivo protein synthesis in cortex, hippocampus, hypothalamus and cerebellum decreases with age and (2) whether these deficiencies are associated with age-related alterations in response to insulin-like growth factor-1, des (1-3) igf-1 or insulin. |
1995-08-17 |
2023-08-12 |
rat |
| R N Aue. Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia. Neurological research. vol 17. issue 2. 1995-08-11. PMID:7609850. |
the neocortex showed a trend toward a progressively increasing benefit with the addition of u74006f, mk-801, insulin and diazepam, but no clear trends were apparent in hippocampus, striatum, or other brain regions. |
1995-08-11 |
2023-08-12 |
rat |
| Q Wang, Z L. [The presence and distribution of insulin in rat brain and its relation to feeding]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 16. issue 6. 1995-05-25. PMID:7720140. |
using the immunohistochemical method, insulin was proved to exist in cells of hypothalamus, thalamus, cerebral cortex, hippocampus, ependyma of third ventricle and choroid of rat, including some of the neuronal nuclei, and was further confirmed by immunoelectromicroscopy. |
1995-05-25 |
2023-08-12 |
rat |
| N Henneberg, S Hoye. Short-term or long-term intracerebroventricular (i.c.v.) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7970199. |
to investigate whether short-term or long-term administration of insulin to the brain influences brain energy metabolism, we determined tissue concentrations of energy-rich phosphates in cerebral parietotemporal cortex and in hippocampus of 1- (adult) and 2-year-old (aged) male wistar rats treated with intracerebroventricular (i.c.v.) |
1994-12-29 |
2023-08-12 |
rat |
| C Z Zhu, R N Aue. Centrally administered insulin and IGF-1 in transient forebrain ischaemia in fasted rats. Neurological research. vol 16. issue 2. 1994-09-01. PMID:7913995. |
neocortex, striatum, and hippocampus, the three groups showed similar degrees of necrosis (p > 0.05), although there were insignificant trends for a beneficial effect of insulin in reducing selective neuronal necrosis in hippocampus. |
1994-09-01 |
2023-08-12 |
rat |
| D G Baskin, M W Schwartz, A J Sipols, D A D'Alessio, B J Goldstein, M F Whit. Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology. vol 134. issue 4. 1994-04-26. PMID:7511094. |
similarly, irs-1 immunoreactivity in hippocampus and olfactory bulb was concentrated in layers that contain synapses of these neurons and have both high insulin binding and phosphotyrosine levels. |
1994-04-26 |
2023-08-12 |
rat |
| C Z Zhu, R N Aue. Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 14. issue 2. 1994-03-29. PMID:8113320. |
high-dose insulin infusion (23 iu/rat/day; n = 8) produced a robust reduction in cortical (p = 0.0108), striatal (p = 0.003), and hippocampal (p < 0.05) necrosis at all coronal levels. |
1994-03-29 |
2023-08-12 |
rat |
| C Z Zhu, R N Aue. Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 14. issue 2. 1994-03-29. PMID:8113320. |
quantitative neuropathology after 1-week survival showed that low-dose insulin (7 iu/rat/day; n = 10) reduced selective necrosis in the striatum (p = 0.015) and one level of the hippocampus (p = 0.023) as compared with animals infused with phosphate-buffered saline (200 microliters/rat/day; n = 8). |
1994-03-29 |
2023-08-12 |
rat |
| T Bartfai, T Hökfelt, U Lange. Galanin--a neuroendocrine peptide. Critical reviews in neurobiology. vol 7. issue 3-4. 1993-12-10. PMID:7693357. |
it inhibits glucose-induced insulin release, hippocampal acetylcholine release, hippocampal glutamate but not gaba release, and it lowers spinal excitability and firing of locus coeruleus neurons. |
1993-12-10 |
2023-08-12 |
Not clear |
| S Hoyer, L Prem, S Sorbi, L Amaducc. Stimulation of glycolytic key enzymes in cerebral cortex by insulin. Neuroreport. vol 4. issue 7. 1993-10-08. PMID:8369496. |
the data clearly demonstrated an increase in these enzyme activities in cerebral cortex by approximately 20% after 80 mu insulin, whereas the increase in the hippocampus was just short of statistical significance. |
1993-10-08 |
2023-08-12 |
rat |
| S Kar, A Baccichet, R Quirion, J Poirie. Entorhinal cortex lesion induces differential responses in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in the rat hippocampal formation. Neuroscience. vol 55. issue 1. 1993-09-15. PMID:8350993. |
a lesion-induced bilateral increase (p < 0.05) in [125i]insulin binding sites was evident in all layers of the hippocampus between two to eight days and at 30 days post lesion. |
1993-09-15 |
2023-08-12 |
rat |
| T Bartfai, G Fisone, U Lange. Galanin and galanin antagonists: molecular and biochemical perspectives. Trends in pharmacological sciences. vol 13. issue 8. 1992-11-20. PMID:1384214. |
the neuropeptide galanin potently inhibits insulin release, hippocampal acetylcholine release and firing of locus coeruleus cells, and stimulates feeding and release of growth hormone. |
1992-11-20 |
2023-08-11 |
Not clear |
| A Iguchi, K Uemura, H Miura, T Ishiguro, K Nonogaki, T Tamagawa, K Goshima, N Sakamot. Mechanism of intrahippocampal neostigmine-induced hyperglycemia in fed rats. Neuroendocrinology. vol 55. issue 1. 1992-07-20. PMID:1608508. |
to evaluate the relative contribution of these glucoregulatory hormones and the nervous system to the net hyperglycemic response, we unilaterally injected neostigmine (5 x 10(-8) mol) into the dorsal hippocampus in the following groups of rats: intact rats with bilateral adrenalectomy to eliminate the action of epinephrine, and rats receiving a constant infusion of somatostatin and insulin to prevent the glucagon response and to maintain the basal insulin level. |
1992-07-20 |
2023-08-11 |
rat |
| P Thakran, M P Leuschen, M Ebad. Metallothionein induction in rat hippocampal neurons in primary culture. In vivo (Athens, Greece). vol 3. issue 3. 1992-03-09. PMID:2519854. |
we developed a model system for culturing hippocampal neurons on poly-l-lysine in iscove's modification of dulbecco's mem (imdm) supplemented with k+, d-glucose, glutamine, insulin, p-amino benzoic acid, transferrin, bsa, beta-estradiol, gentamycin, and fungizone. |
1992-03-09 |
2023-08-11 |
rat |
| D P Figlewicz, P Szo. Insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha 1-adrenergic activity in the rat hippocampus. Brain research. vol 550. issue 1. 1991-10-17. PMID:1653632. |
concentrations of 1, 10 and 100 nm insulin significantly stimulated the accumulation of [3h]inositol phosphate ([3h]ip1) and [3h]ip2 in hippocampal slices labelled with [3h]myoinositol. |
1991-10-17 |
2023-08-11 |
rat |
| D P Figlewicz, P Szo. Insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha 1-adrenergic activity in the rat hippocampus. Brain research. vol 550. issue 1. 1991-10-17. PMID:1653632. |
addition of tetrodotoxin resulted in a suppression of insulin stimulation of [3h]ip1 release, suggesting that insulin effects may be indirect and mediated via release of an endogenous neuronal transmitter within the hippocampus. |
1991-10-17 |
2023-08-11 |
rat |
| D P Figlewicz, P Szo. Insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha 1-adrenergic activity in the rat hippocampus. Brain research. vol 550. issue 1. 1991-10-17. PMID:1653632. |
insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha 1-adrenergic activity in the rat hippocampus. |
1991-10-17 |
2023-08-11 |
rat |