| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Holly C Hunsberger, Daniel S Weitzner, Carolyn C Rudy, James E Hickman, Eric M Libell, Rebecca R Speer, Greg A Gerhardt, Miranda N Ree. Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26146790. |
riluzole-treated taup301l mice exhibited improved performance in the water radial arm maze and the morris water maze, associated with a decrease in glutamate release and an increase in glutamate uptake in the dentate gyrus, cornu ammonis 3 (ca3), and cornu ammonis 1 (ca1) regions of the hippocampus. |
2016-01-11 |
2023-08-13 |
mouse |
| Holly C Hunsberger, Daniel S Weitzner, Carolyn C Rudy, James E Hickman, Eric M Libell, Rebecca R Speer, Greg A Gerhardt, Miranda N Ree. Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26146790. |
riluzole also attenuated the taup301l-mediated increase in hippocampal vesicular glutamate transporter 1, which packages glutamate into vesicles and influences glutamate release; and the taup301l-mediated decrease in hippocampal glutamate transporter 1, the major transporter responsible for removing glutamate from the extracellular space. |
2016-01-11 |
2023-08-13 |
mouse |
| L Devi, M Ohn. TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice. Translational psychiatry. vol 5. 2016-01-07. PMID:25942043. |
interestingly, reductions in hippocampal expression of ampa/nmda glutamate receptor subunits as well as impaired signaling pathways downstream to trkb such as creb (camp response element-binding protein) and akt/gsk-3β (glycogen synthase kinase-3β) were observed in trkb(+/-)·5xfad mice but not in 5xfad mice. |
2016-01-07 |
2023-08-13 |
mouse |
| N Dawson, M Kurihara, D M Thomson, C L Winchester, A McVie, J R Hedde, A D Randall, S Shen, P A Seymour, Z A Hughes, J Dunlop, J T Brown, N J Brandon, B J Morris, J A Prat. Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Translational psychiatry. vol 5. 2016-01-07. PMID:25989143. |
glutamate system dysfunction in disc1tr hemi mice was further supported by the attenuated cerebral metabolic response to the nmda receptor (nmdar) antagonist ketamine and decreased hippocampal expression of nmdar subunits 2a and 2b in these animals. |
2016-01-07 |
2023-08-13 |
mouse |
| Meilan Xie, Jie Yan, Chao He, Li Yang, Gang Tan, Chao Li, Zhian Hu, Jiali Wan. Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus. Behavioural brain research. vol 286. 2016-01-04. PMID:25732956. |
short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus. |
2016-01-04 |
2023-08-13 |
rat |
| Ilgam Khalilov, Marat Minlebaev, Marat Mukhtarov, Roustem Khazipo. Dynamic Changes from Depolarizing to Hyperpolarizing GABAergic Actions during Giant Depolarizing Potentials in the Neonatal Rat Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377455. |
during development, gaba exerts depolarizing action on immature neurons and, acting in synergy with glutamate, drives giant depolarizing potentials (gdps) in the hippocampal network. |
2016-01-04 |
2023-08-13 |
rat |
| Jan Lopatář, Nicholas Dale, Bruno G Frenguell. Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations. Neuropharmacology. vol 93. 2016-01-01. PMID:25645390. |
the activation of group i metabotropic glutamate receptors (gi mglurs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. |
2016-01-01 |
2023-08-13 |
human |
| Francisco Q Gonçalves, Johny Pires, Anna Pliassova, Rui Beleza, Cristina Lemos, Joana M Marques, Ricardo J Rodrigues, Paula M Canas, Attila Köfalvi, Rodrigo A Cunha, Daniel Ria. Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus. The European journal of neuroscience. vol 41. issue 7. 2015-12-29. PMID:25704806. |
we performed electrophysiological extracellular recordings in mouse hippocampal slices, and immunological analysis of nerve terminals and glutamate release in hippocampal slices and synaptosomes. |
2015-12-29 |
2023-08-13 |
mouse |
| A Skliris, O Papadaki, P Kafasla, I Karakasiliotis, O Hazapis, M Reczko, S Grammenoudi, J Bauer, D L Kontoyianni. Neuroprotection requires the functions of the RNA-binding protein HuR. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25301069. |
this response was phenocopied in hippocampal cells devoid of ionotropic glutamate receptors in which the loss of hur results in enhanced mitochondrial dysfunction, oxidative damage and programmed necrosis solely after glutamate challenge. |
2015-12-24 |
2023-08-13 |
mouse |
| Catrinel Girbovan, Hélène Plamondo. Resveratrol downregulates type-1 glutamate transporter expression and microglia activation in the hippocampus following cerebral ischemia reperfusion in rats. Brain research. vol 1608. 2015-12-24. PMID:25727173. |
resveratrol downregulates type-1 glutamate transporter expression and microglia activation in the hippocampus following cerebral ischemia reperfusion in rats. |
2015-12-24 |
2023-08-13 |
rat |
| Catrinel Girbovan, Hélène Plamondo. Resveratrol downregulates type-1 glutamate transporter expression and microglia activation in the hippocampus following cerebral ischemia reperfusion in rats. Brain research. vol 1608. 2015-12-24. PMID:25727173. |
following cerebral ischemia, reduced astroglial type-1 glutamate transporter (glt-1) expression in the ca1 pyramidal layers of the hippocampus contribute to neurotoxic glutamate levels. |
2015-12-24 |
2023-08-13 |
rat |
| Elham Goudarzi, Mahmoud Elahdadi Salmani, Taghi Lashkarbolouki, Iran Goudarz. Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. Pharmacology, biochemistry, and behavior. vol 130. 2015-12-23. PMID:25600753. |
therefore, in this study, the effect of hippocampal orexin 1 and 2 receptors on seizure and glutamate and gaba (gamma-aminobutyric acid) contents was explored. |
2015-12-23 |
2023-08-13 |
rat |
| María Fernanda Podestá, Patricia Yam, Martín Gabriel Codagnone, Nonthué Alejandra Uccelli, David Colman, Analía Reiné. Distinctive PSA-NCAM and NCAM hallmarks in glutamate-induced dendritic atrophy and synaptic disassembly. PloS one. vol 9. issue 10. 2015-12-17. PMID:25279838. |
cultured hippocampal neurons exposed to glutamate (5 µm) showed a reduced map-2 (+) area in the absence of neuronal death 24 h after the insult. |
2015-12-17 |
2023-08-13 |
Not clear |
| G Zhu, Y Wang, J Li, J Wan. Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice. Neuroscience. vol 292. 2015-12-16. PMID:25724866. |
in addition, ginsenoside rg1 administration up-regulated the expression of hippocampal p-akt, brain-derived neurotrophic factor (bdnf), probdnf and glutamate receptor 1 (glur1), but not p-erk. |
2015-12-16 |
2023-08-13 |
mouse |
| I L Llorente, E Landucci, D E Pellegrini-Giampietro, A Fernández-Lópe. Glutamate receptor and transporter modifications in rat organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation: the contribution of cyclooxygenase-2. Neuroscience. vol 292. 2015-12-16. PMID:25732138. |
glutamate receptor and transporter modifications in rat organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation: the contribution of cyclooxygenase-2. |
2015-12-16 |
2023-08-13 |
rat |
| A Franceschelli, J Sens, S Herchick, C Thelen, P M Pitychouti. Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress. Neuroscience. vol 290. 2015-12-15. PMID:25595985. |
moreover, tissue levels of the excitatory amino acids glutamate and aspartate, as well as serotonergic activity, were affected in a sex-dependent manner in the prefrontal cortex and the hippocampus, at the same time-points. |
2015-12-15 |
2023-08-13 |
mouse |
| E J Connors, A N Shaik, M M Migliore, A C Kentne. Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system. Brain, behavior, and immunity. vol 42. 2015-12-14. PMID:25011058. |
ee protected against both the social and hypothalamic pituitary adrenal axis consequences of mia in juvenile male rats, but surprisingly not against the spatial discrimination deficits or accompanying decrease in glutamate levels within the hippocampus (as measured via lcms-ms). |
2015-12-14 |
2023-08-13 |
rat |
| Mingchao Liu, Juan Li, Peng Dai, Fang Zhao, Gang Zheng, Jinfei Jing, Jiye Wang, Wenjing Luo, Jingyuan Che. Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction. Stress (Amsterdam, Netherlands). vol 18. issue 1. 2015-12-14. PMID:25472821. |
cus also induced hippocampal microglial activation and attenuated phosphorylation of glutamate receptor 1 (glur1 or glua1). |
2015-12-14 |
2023-08-13 |
rat |
| Ji Seon Yang, Shazia Perveen, Tae Joung Ha, Seong Yun Kim, Shin Hee Yoo. Cyanidin-3-glucoside inhibits glutamate-induced Zn2+ signaling and neuronal cell death in cultured rat hippocampal neurons by inhibiting Ca2+-induced mitochondrial depolarization and formation of reactive oxygen species. Brain research. vol 1606. 2015-12-14. PMID:25721794. |
treatment with glutamate (100 µm) for 7 min induces reproducible [zn(2+)]i increase at 35 min interval in cultured rat hippocampal neurons. |
2015-12-14 |
2023-08-13 |
rat |
| A D Stan, S Ghose, C Zhao, K Hulsey, P Mihalakos, M Yanagi, S U Morris, J J Bartko, C Choi, C A Tamming. Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia. Molecular psychiatry. vol 20. issue 4. 2015-12-09. PMID:24912493. |
the results show significantly lower glutamate concentrations in hippocampus in schizophrenia, an in vivo finding mirrored by lower glun1 protein levels selectively in the dentate gyrus (dg) in vitro. |
2015-12-09 |
2023-08-13 |
mouse |