| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingjin Li, Jingjing Piao, Xinmiao Piao, Zihui Geng, Ziqian Cheng, Xiaohan Zou, Huiyi Jian. Effect of Kruppel-like factor 4 on PTZ-induced acute seizure mice. Journal of cellular and molecular medicine. vol 28. issue 17. 2024-09-05. PMID:39234952. |
reduced hippocampal protein levels for synaptic proteins, including glutamate receptor 1 (gria1/glua1) and postsynaptic density protein 95 (dlg4/psd95), were also observed after klf4-ko, while increased mrna levels of complement proteins were observed for complement component 1q subcomponent a (c1qa), complement component 1q subcomponent b (c1qb), complement component 1q subcomponent c (c1qc), complement component 3 (c3), complement component 4a (c4a) and complement component 4b (c4b). |
2024-09-05 |
2024-09-08 |
mouse |
| Luciene Covolan, Maria Luiza Motta Pollo, Pedro Bastos Dos Santos, Victor Hugo Cardoso Betta, Felipe Farinha Saad Barbosa, Luciano Arnaldo Mian Covolan, Christiane Gimenes, Clement Haman. Effects and mechanisms of anterior thalamus nucleus deep brain stimulation for epilepsy: a scoping review of preclinical studies. Neuropharmacology. 2024-09-01. PMID:39218248. |
ant dbs was also shown to increase hippocampal levels of lactate, alter the expression of genes involved in calcium signaling, synaptic glutamate, and the nod-like receptor signaling pathway. |
2024-09-01 |
2024-09-04 |
Not clear |
| Jeremiah Pfitzer, Priyanka D Pinky, Savannah Perman, Emma Redmon, Luca Cmelak, Vishnu Suppiramaniam, Vladimir Coric, Irfan A Qureshi, Michael W Gramlich, Miranda N Ree. Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice. Journal of neurochemistry. 2024-08-30. PMID:39214859. |
hippocampal cultures from 3xtg mice were used to determine whether presynaptic vesicular glutamate transporters (vglut) and glutamate are increased at the synaptic level while controlling for postsynaptic activity. |
2024-08-30 |
2024-09-04 |
mouse |
| Jeremiah Pfitzer, Priyanka D Pinky, Savannah Perman, Emma Redmon, Luca Cmelak, Vishnu Suppiramaniam, Vladimir Coric, Irfan A Qureshi, Michael W Gramlich, Miranda N Ree. Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice. Journal of neurochemistry. 2024-08-30. PMID:39214859. |
we observed that 3xtg hippocampal cultures exhibited increased vglut1 associated with an increase in glutamate release, similar to prior observations in cultures from tau mouse models. |
2024-08-30 |
2024-09-04 |
mouse |
| Matteo Spinelli, Francesco Spallotta, Chiara Cencioni, Francesca Natale, Agnese Re, Alice Dellaria, Antonella Farsetti, Salvatore Fusco, Claudio Grass. High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes. Scientific reports. vol 14. issue 1. 2024-08-23. PMID:39179650. |
we also validated the expression of these synaptic and non-synaptic proteins, confirming the downregulation of synaptotagmin 1 (syt1), calcium/calmodulin dependent protein kinase i delta (camk1d), 2b subunit of n-methyl-d-aspartate glutamate receptor (grin2b), the dna-binding protein special at-rich sequence-binding protein 2 (satb2), and rna-binding proteins cytoplasmic polyadenylation element-binding protein 1 (cpeb1) and neuro-oncological ventral antigen 1 (nova1) in the hippocampus of hfd mice. |
2024-08-23 |
2024-08-27 |
mouse |
| Juan Gabriel Riboldi, Julieta Correa, Matías M Renfijes, Ramiro Tintorelli, Haydee Viol. Arc and BDNF mediated effects of hippocampal astrocytic glutamate uptake blockade on spatial memory stages. Communications biology. vol 7. issue 1. 2024-08-22. PMID:39174690. |
arc and bdnf mediated effects of hippocampal astrocytic glutamate uptake blockade on spatial memory stages. |
2024-08-22 |
2024-08-25 |
rat |
| Cathy Davies, Matthijs G Bossong, Daniel Martins, Robin Wilson, Elizabeth Appiah-Kusi, Grace Blest-Hopley, Paul Allen, Fernando Zelaya, David J Lythgoe, Michael Brammer, Jesus Perez, Philip McGuire, Sagnik Bhattacharyy. Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk. Schizophrenia bulletin open. vol 4. issue 1. 2024-08-15. PMID:39145348. |
hippocampal glutamate, resting perfusion and the effects of cannabidiol in psychosis risk. |
2024-08-15 |
2024-08-17 |
human |
| Shuaiyun Gao, Sheng Huang, Yiwen Xu, Bo Wang, Peng Cheng, Yiming Lu, Eric Gilson, Jing Y. Role of the telomeric factor TRF2 in post-hypoxic brain damages. Redox biology. vol 75. 2024-08-11. PMID:39128227. |
moreover, downregulating the expression of terf2 in hippocampal neural cells of unchallenged mice triggers an excitotoxicity-like phenotype including glutamate overexpression and behavioral alterations while overexpressing terf2 in hippocampal neural cells of mice subjected to a post-hypoxic treatment prevents brain damages. |
2024-08-11 |
2024-08-14 |
mouse |
| Yogesh Srivastava, Maxsam Donta, Lydia L Mireles, Adriana Paulucci-Holthauzen, Leilei Shi, Mark T Bedford, M Neal Waxham, Pierre D McCre. Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39125895. |
our prior work showed that the molecular scaffold pdlim5 and delta-catenin, in conjunction, are two proteins that help regulate the branching and elongation of dendrites in cultured hippocampal neurons and do so through a phosphorylation-dependent mechanism triggered by upstream glutamate signaling. |
2024-08-10 |
2024-08-13 |
human |
| Chi-Feng Hung, Wei-Che Chiu, Jia-Cih Chen, Wu-Chang Chuang, Su-Jane Wan. NRICM101 prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system. International immunopharmacology. vol 140. 2024-08-02. PMID:39094361. |
nricm101 also significantly decreased the neuronal loss and glutamate increase and increased glast, glt-1, gad67, gdh and gs levels in the cortex and hippocampus of ka-treated rats. |
2024-08-02 |
2024-08-06 |
rat |
| Tania Ramos-Moreno, Alexandra Cifra, Nikitidou Ledri Litsa, Esbjörn Melin, Matilda Ahl, Sören H Christiansen, Casper R Gøtzsche, Matilde Cescon, Paolo Bonaldo, Karen van Loo, Valeri Borger, J Anink Jasper, Albert Becker, Erwin A van Vliet, Eleonora Aronica, David P Woldbye, Merab Kokai. Collagen VI: Role in synaptic transmission and seizure-related excitability. Experimental neurology. 2024-08-02. PMID:39094767. |
we further present a novel finding that exposure of mouse hippocampal slices to col-vi augments paired-pulse facilitation in schaffer collateral-ca1 excitatory synapses indicating decreased release probability of glutamate. |
2024-08-02 |
2024-08-06 |
mouse |
| Nishard Abdee. Editorial for "Hippocampal Glutamate Levels and Their Correlation With Subregion Volume in School-Aged Children With MRI-Negative Epilepsy: A Preliminary Study". Journal of magnetic resonance imaging : JMRI. 2024-07-30. PMID:39078258. |
editorial for "hippocampal glutamate levels and their correlation with subregion volume in school-aged children with mri-negative epilepsy: a preliminary study". |
2024-07-30 |
2024-08-02 |
Not clear |
| Vartika Gupta, S Prasa. Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus Are Associated with Recognition Memory Impairment in the Rotenone-Parkinson's Disease Mouse Model: Neuroprotective Role of Bacopa monnieri Extract CDRI 08. Molecular neurobiology. 2024-07-29. PMID:39073529. |
here, we have investigated the possible alterations in the expression of glutamate receptor and its trafficking/scaffolding/regulatory proteins underlying the memory formation and neuroprotective effects of a specialized bacopa monnieri extract, cdri-08 (bme) in the hippocampus of the rotenone-induced pd mouse model. |
2024-07-29 |
2024-08-02 |
mouse |
| Liesl Maria Fernandes E Mendonça, Arun Bhimrao Joshi, Anant Bhandarkar, Shamshad Shaikh, Samantha Fernandes, Himanshu Joshi, Shrinivas Josh. Potential anxiolytic therapeutics from Hybanthus enneaspermus (L.) F. Muell. - mitigate anxiety by plausibly modulating the GABA Neurochemistry international. 2024-07-13. PMID:39002759. |
monoamines (serotonin, noradrenaline, dopamine), gamma-aminobutyric acid (gaba), and glutamate were quantified in the different regions of rats' brain (cortex, hippocampus, pons, medulla oblongata, cerebellum). |
2024-07-13 |
2024-07-16 |
rat |
| Xian-Xi Ye, Qiao-Ying Jiang, Meng-Jun Wu, Qing-Huai Ye, Hong Zhen. Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation. Acta pharmacologica Sinica. 2024-07-11. PMID:38992120. |
fmt also reshaped the metabolic phenotypes in the hippocampus of t1d mice especially for alanine, aspartate and glutamate metabolism. |
2024-07-11 |
2024-07-14 |
mouse |
| Benedikt Zott, Lea Nästle, Christine Grienberger, Felix Unger, Manuel M Knauer, Christian Wolf, Aylin Keskin-Dargin, Anna Feuerbach, Marc Aurel Busche, Arne Skerra, Arthur Konnert. β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer's Disease. Nature communications. vol 15. issue 1. 2024-07-10. PMID:38987287. |
using in vivo two-photon calcium imaging and sf-iglusnfr-based glutamate imaging in hippocampal slices, we demonstrate that an aβ binding anticalin protein (aβ-anticalin) can suppress early neuronal hyperactivity and synaptic glutamate accumulation in the app23xps45 mouse model of β-amyloidosis. |
2024-07-10 |
2024-07-13 |
mouse |
| Donghao Xu, Qingfa Ren, Quanyuan Liu, Miaomiao Liu, He Gong, Yuwei Liu, Zhijie Yin, Zhen Zeng, Shuyuan Xia, Yanyan Zhang, Jie Li, Quansheng Gao, Jing Wang, Xianglin L. Hippocampal Glutamate Levels and Their Correlation With Subregion Volume in School-Aged Children With MRI-Negative Epilepsy: A Preliminary Study. Journal of magnetic resonance imaging : JMRI. 2024-07-06. PMID:38970314. |
hippocampal glutamate levels and their correlation with subregion volume in school-aged children with mri-negative epilepsy: a preliminary study. |
2024-07-06 |
2024-07-12 |
Not clear |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
we observed that physostigmine induces acute stress in tandem with long term depression of glutamate release in the hippocampus of mice. |
2024-07-02 |
2024-07-06 |
mouse |
| Tristram Buck, Erbo Dong, Michael McCarthy, Alessandro Guidotti, Monsheel Sodh. Prenatal stress alters transcription of NMDA-type glutamate receptors in the hippocampus. Neuroscience letters. 2024-06-25. PMID:38917870. |
prenatal stress alters transcription of nmda-type glutamate receptors in the hippocampus. |
2024-06-25 |
2024-06-29 |
mouse |
| Fatemeh Rahmati-Dehkordi, Hadi Khanifar, Nazanin Najari, Zeinab Tamtaji, Abdolkarim Talebi Taheri, Michael Aschner, Mehdi Shafiee Ardestani, Hamed Mirzaei, Ehsan Dadgostar, Fatemeh Nabavizadeh, Omid Reza Tamtaj. Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders. Neurochemical research. 2024-06-25. PMID:38918332. |
in the hippocampus, fingolimod decreases glutamate levels and increases gaba levels, suggesting a potential role in modulating synaptic transmission and neuronal excitability. |
2024-06-25 |
2024-06-29 |
Not clear |