| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Ding, Cunqing Chang, Lan Xie, Zhimin Chen, Hua A. Intense exercise can cause excessive apoptosis and synapse plasticity damage in rat hippocampus through Ca²⁺ overload and endoplasmic reticulum stress-induced apoptosis pathway. Chinese medical journal. vol 127. issue 18. 2016-05-23. PMID:25266525. |
the initial reason for hippocampus injury is the excitotoxicity of glutamate and calcium overload. |
2016-05-23 |
2023-08-13 |
rat |
| Murat Kara, Onder Yumrutas, Caner F Demir, Hasan Huseyin Ozdemir, Ibrahim Bozgeyik, Salih Coskun, Ersen Eraslan, Ramazan Ba. Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model. International journal of experimental pathology. vol 96. issue 5. 2016-05-23. PMID:26568164. |
their learning activities were evaluated, and the expression levels of the inotropic glutamate receptor grin1, synoptophysin, growth-associated protein 43 and the muscarinic receptor m1 in hippocampus were determined by real-time pcr method. |
2016-05-23 |
2023-08-13 |
rat |
| Chia Ying Chang, Tzu Yu Lin, Cheng Wei Lu, Chia Chuan Wang, Ying Chou Wang, Shang Shing Peter Chou, Su Jane Wan. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European journal of pharmacology. vol 762. 2016-05-20. PMID:26007643. |
apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. |
2016-05-20 |
2023-08-13 |
rat |
| Chia Ying Chang, Tzu Yu Lin, Cheng Wei Lu, Chia Chuan Wang, Ying Chou Wang, Shang Shing Peter Chou, Su Jane Wan. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European journal of pharmacology. vol 762. 2016-05-20. PMID:26007643. |
the purpose of this study was to examine the effect and mechanism of apigenin, a natural flavonoid, on glutamate release in the rat hippocampus. |
2016-05-20 |
2023-08-13 |
rat |
| Chia Ying Chang, Tzu Yu Lin, Cheng Wei Lu, Chia Chuan Wang, Ying Chou Wang, Shang Shing Peter Chou, Su Jane Wan. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European journal of pharmacology. vol 762. 2016-05-20. PMID:26007643. |
in rat hippocampal nerve terminals (synaptosomes), apigenin inhibited glutamate release and the elevation of the cytosolic free ca(2+) concentration evoked by 4-aminopyridine, whereas it had no effect on 4-aminopyridine-mediated depolarization and na(+) influx. |
2016-05-20 |
2023-08-13 |
rat |
| Chia Ying Chang, Tzu Yu Lin, Cheng Wei Lu, Chia Chuan Wang, Ying Chou Wang, Shang Shing Peter Chou, Su Jane Wan. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European journal of pharmacology. vol 762. 2016-05-20. PMID:26007643. |
on the basis of these results, we suggested that apigenin exerts its presynaptic inhibition probably by reducing ca(2+) entry mediated by the cav2.2 (n-type) and cav2.1 (p/q-type) channels, thereby inhibiting glutamate release from the rat hippocampal nerve terminals. |
2016-05-20 |
2023-08-13 |
rat |
| Stuart A Collins, Gary A Gudelsky, Bryan K Yamamot. MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors. European journal of pharmacology. vol 761. 2016-05-17. PMID:25936514. |
recently, it was shown that mdma increases extracellular glutamate concentrations in the dorsal hippocampus, which is dependent on serotonin release and 5ht2a/2c receptor activation. |
2016-05-17 |
2023-08-13 |
rat |
| André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A Valente, David Blum, Ana Maria Sebastião, Maria José Diógene. Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24860020. |
in the present study, we found that (1) aβ selectively increases mrna levels for the truncated trkb isoforms without affecting trkb-fl mrna levels, (2) aβ induces a calpain-mediated cleavage on trkb-fl receptors, downstream of shc-binding site, originating a new truncated trkb receptor (trkb-t') and an intracellular fragment (trkb-icd), which is also detected in postmortem human brain samples, (3) aβ impairs bdnf function in a calpain-dependent way, as assessed by the inability of bdnf to modulate neurotransmitter (gaba and glutamate) release from hippocampal nerve terminals, and long-term potentiation in hippocampal slices. |
2016-05-10 |
2023-08-13 |
human |
| B Guardiola-Lemaitre, C De Bodinat, P Delagrange, M J Millan, C Munoz, E Mocaë. Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties. British journal of pharmacology. vol 171. issue 15. 2016-05-09. PMID:24724693. |
the recent demonstration of the existence of heteromeric complexes of mt1 and mt2 with 5-ht2c receptors at the cellular level may explain how these two properties of agomelatine translate into a synergistic action that, for example, leads to increases in hippocampal proliferation, maturation and survival through modulation of multiple cellular pathways (increase in trophic factors, synaptic remodelling, glutamate signalling) and key targets (early genes, kinases). |
2016-05-09 |
2023-08-13 |
Not clear |
| Michelle L Previtera, Bonnie L Firestei. Glutamate affects dendritic morphology of neurons grown on compliant substrates. Biotechnology progress. vol 31. issue 4. 2016-05-09. PMID:25827105. |
in the current study, we examine whether exposure to glutamate itself alters stiffness-mediated changes to dendrites in hippocampal neurons. |
2016-05-09 |
2023-08-13 |
Not clear |
| Sayuri Ishiwata, Asami Umino, Darrick T Balu, Joseph T Coyle, Toru Nishikaw. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 8. 2016-05-05. PMID:25782690. |
in the hippocampus of mice lacking the gene for serine racemase (sr), a d-serine synthesizing enzyme, in the camkiiα-expressing neurons, we observed a significant decrease in the extracellular concentration of d-serine, a coagonist for the n-methyl-d-aspartate type glutamate receptor (nmdar), and nmdar hypofunction as revealed by diminished extracellular taurine concentrations after an intra-hippocampal nmda infusion when compared to the wild type controls. |
2016-05-05 |
2023-08-13 |
mouse |
| Chiara Chiapponi, Federica Piras, Fabrizio Piras, Carlo Caltagirone, Gianfranco Spallett. GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies. Frontiers in psychiatry. vol 7. 2016-05-05. PMID:27148090. |
conversely, multimodal results showed reduced level of glutamate, but not of gaba, in patients mirrored by in vitro biochemical findings revealing hippocampal reduction in glutamate signaling in sz, and no deficits in gaba synthesis. |
2016-05-05 |
2023-08-13 |
mouse |
| Elizabeth Hanson, Moritz Armbruster, David Cantu, Lauren Andresen, Amaro Taylor, Niels Christian Danbolt, Chris G Dull. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia. vol 63. issue 10. 2016-05-03. PMID:25914127. |
astrocytic glutamate uptake has been shown to undergo post-natal maturation in the hippocampus, but has been largely unexplored in other brain regions. |
2016-05-03 |
2023-08-13 |
Not clear |
| Elizabeth Hanson, Moritz Armbruster, David Cantu, Lauren Andresen, Amaro Taylor, Niels Christian Danbolt, Chris G Dull. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia. vol 63. issue 10. 2016-05-03. PMID:25914127. |
using astrocytic and neuronal electrophysiology, immunofluorescence, and western blot analysis we show that: (1) glutamate uptake in the neonatal neocortex is slow relative to neonatal hippocampus; (2) astrocytes in the neonatal neocortex undergo a significant maturation of intrinsic membrane properties; (3) slow glutamate uptake is accompanied by lower expression of both glt-1 and glast; (4) glutamate uptake is less dependent on glt-1 in neonatal neocortex than in neonatal hippocampus; and (5) the slow glutamate uptake we report in the neonatal neocortex corresponds to minimal astrocytic control of neuronal nmda receptor activation. |
2016-05-03 |
2023-08-13 |
Not clear |
| Elizabeth Hanson, Moritz Armbruster, David Cantu, Lauren Andresen, Amaro Taylor, Niels Christian Danbolt, Chris G Dull. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia. vol 63. issue 10. 2016-05-03. PMID:25914127. |
taken together, our results clearly show fundamental differences between astrocytic maturation in the developing neocortex and hippocampus, and corresponding changes in how astrocytes control glutamate signaling. |
2016-05-03 |
2023-08-13 |
Not clear |
| Gang Liu, Chao Liu, Xue-Ning Zhan. Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular medicine reports. vol 12. issue 3. 2016-05-03. PMID:25998151. |
the content of glutamate in the hippocampus was detected using high‑performance liquid chromatography. |
2016-05-03 |
2023-08-13 |
rat |
| Gang Liu, Chao Liu, Xue-Ning Zhan. Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular medicine reports. vol 12. issue 3. 2016-05-03. PMID:25998151. |
the glutamate content was significantly upregulated by ect, reduced by 2,6‑diisopropylphenol, and was unaffected by the nmda receptor antagonist in the hippocampus of the depressed rats. |
2016-05-03 |
2023-08-13 |
rat |
| Jian Guan, Alastair MacGibbon, Bertram Fong, Rong Zhang, Karen Liu, Angela Rowan, Paul McJarro. Long-Term Supplementation with Beta Serum Concentrate (BSC), a Complex of Milk Lipids, during Post-Natal Brain Development Improves Memory in Rats. Nutrients. vol 7. issue 6. 2016-05-03. PMID:26056919. |
supplemented rats showed an increase in striatal dopamine terminals and hippocampal glutamate receptors. |
2016-05-03 |
2023-08-13 |
rat |
| Natalie Matosin, Francesca Fernandez-Enright, Jeremy S Lum, Jessica L Andrews, Martin Engel, Xu-Feng Huang, Kelly A Newel. Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia. Schizophrenia research. vol 166. issue 1-3. 2016-05-02. PMID:26048293. |
metabotropic glutamate receptor 5, and its trafficking molecules norbin and tamalin, are increased in the ca1 hippocampal region of subjects with schizophrenia. |
2016-05-02 |
2023-08-13 |
human |
| Suzan G Rosa, Caroline B Quines, Juliana T da Rocha, Cristiani F Bortolatto, Thiago Duarte, Cristina W Nogueir. Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats. European journal of pharmacology. vol 758. 2016-04-26. PMID:25841878. |
ex vivo assays were performed in samples of hippocampus to determine na(+), k(+)-atpase and ca(2+)-atpase activities, cytokine levels and [(3)h]glutamate uptake. |
2016-04-26 |
2023-08-13 |
rat |