| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reni Ajoy, Yu-Chun Lo, Man-Hau Ho, You-Yin Chen, Yun Wang, Yuan-Hao Chen, Chiu Jing-Yuan, Chun Austin Changou, Yuan-Chin Hsiung, Hui-Min Chen, Tzu-Hao Chang, Cheng-Yang Lee, Yung-Hsiao Chiang, Wen-Chang Chang, Barry Hoffer, Szu-Yi Cho. CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation. Molecular psychiatry. 2021-05-01. PMID:33931731. |
using metabolomics coupled with fdg-pet imaging and seahorse analysis, we found that ccl5 participates in hippocampal fructose and mannose degradation, glycolysis, gluconeogenesis as well as glutamate and purine metabolism. |
2021-05-01 |
2023-08-13 |
mouse |
| Reni Ajoy, Yu-Chun Lo, Man-Hau Ho, You-Yin Chen, Yun Wang, Yuan-Hao Chen, Chiu Jing-Yuan, Chun Austin Changou, Yuan-Chin Hsiung, Hui-Min Chen, Tzu-Hao Chang, Cheng-Yang Lee, Yung-Hsiao Chiang, Wen-Chang Chang, Barry Hoffer, Szu-Yi Cho. CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation. Molecular psychiatry. 2021-05-01. PMID:33931731. |
overexpressing ccl5 in wt mice also enhanced memory-cognition performance as well as hippocampal neuronal activity and connectivity through promotion of de novo purine and glutamate metabolism. |
2021-05-01 |
2023-08-13 |
mouse |
| Ming-Yang Wang, Min Meng, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin L. Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K/Akt/GSK-3β/CREB pathway in rats. Behavioural brain research. vol 379. 2021-04-30. PMID:31669346. |
further data indicated that cig increased the expression of neurotrophic factors (ngf and bdnf) and their receptors (trka and trkb), glutamate receptor subunits (nmdar1 and glur2) in the cerebral cortex and hippocampus of 2vo rats. |
2021-04-30 |
2023-08-13 |
rat |
| Jian Liu, Yuan-Shan Han, Lin Liu, Lin Tang, Hui Yang, Pan Meng, Hong-Qing Zhao, Yu-Hong Wan. Abnormal Glu/mGluR Neural regeneration research. vol 16. issue 4. 2021-04-29. PMID:33063735. |
abnormal glu/mglur our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetes-related depression. |
2021-04-29 |
2023-08-13 |
Not clear |
| Natalia V Gulyaev. Hippocampal hyperglutamatergic signaling matters: Early targeting glutamate neurotransmission as a preventive strategy in Alzheimer's disease: An Editorial Highlight for "Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice" on page 513. Journal of neurochemistry. vol 156. issue 4. 2021-04-28. PMID:33276416. |
hippocampal hyperglutamatergic signaling matters: early targeting glutamate neurotransmission as a preventive strategy in alzheimer's disease: an editorial highlight for "riluzole attenuates glutamatergic tone and cognitive decline in aβpp/ps1 mice" on page 513. |
2021-04-28 |
2023-08-13 |
mouse |
| Natalia V Gulyaev. Hippocampal hyperglutamatergic signaling matters: Early targeting glutamate neurotransmission as a preventive strategy in Alzheimer's disease: An Editorial Highlight for "Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice" on page 513. Journal of neurochemistry. vol 156. issue 4. 2021-04-28. PMID:33276416. |
the mice app/ps1, a model of ad, initially are cognitively normal but have elevated glutamate release in the hippocampus at 2-4 months of age. |
2021-04-28 |
2023-08-13 |
mouse |
| Satoshi Fujii, Yoshihiko Yamazaki, Jun-Ichi Goto, Hiroki Fujiwara, Katsuhiko Mikoshib. Depotentiation depends on IP Learning & memory (Cold Spring Harbor, N.Y.). vol 27. issue 2. 2021-04-26. PMID:31949037. |
depotentiation depends on ip in ca1 neurons of guinea pig hippocampal slices, long-term potentiation (ltp) was induced in field excitatory postsynaptic potentials (epsps) or population spikes (pss) by the delivery of high-frequency stimulation (hfs, 100 pulses at 100 hz) to ca1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (lfs, 1000 pulses at 2 hz) at 30 min after hfs (depotentiation), and this effect was inhibited when test synaptic stimulation was halted for a 19-min period after hfs or for a 20-min period after lfs or applied over the same time period in the presence of an antagonist of n-methyl-d-aspartate receptors (nmdars), group i metabotropic glutamate receptors (mglurs), or inositol 1, 4, 5-trisphosphate receptors (ip |
2021-04-26 |
2023-08-13 |
Not clear |
| José Luis Castañeda-Cabral, José Guadalupe López-Ortega, Blanca Fabiola Fajardo-Fregoso, Carlos Beas-Zárate, Mónica E Ureña-Guerrer. Glutamate induced neonatal excitotoxicity modifies the expression level of EAAT1 (GLAST) and EAAT2 (GLT-1) proteins in various brain regions of the adult rat. Neuroscience letters. vol 735. 2021-04-23. PMID:32645399. |
in this study, the expression levels of eaat1 (glast) and eaat2 (glt-1) proteins were assessed in the cerebral motor cortex (cmc), striatum, hippocampus and entorhinal cortex (ec) of male adult rats following the neonatal excitotoxic process triggered by monosodium glutamate (msg)-treatment (4 g/kg of body weight at postnatal days 1,3,5 and 7, subcutaneously). |
2021-04-23 |
2023-08-13 |
rat |
| José Luis Castañeda-Cabral, José Guadalupe López-Ortega, Blanca Fabiola Fajardo-Fregoso, Carlos Beas-Zárate, Mónica E Ureña-Guerrer. Glutamate induced neonatal excitotoxicity modifies the expression level of EAAT1 (GLAST) and EAAT2 (GLT-1) proteins in various brain regions of the adult rat. Neuroscience letters. vol 735. 2021-04-23. PMID:32645399. |
our results show that a neonatal excitotoxic processes can induce lasting changes in the expression levels of eaat1 and eaat2 proteins and suggest that although astrogliosis occurs, glutamate uptake could be deficient, particularly in the cmc and hippocampus. |
2021-04-23 |
2023-08-13 |
rat |
| Bingrui Xiong, Wen Zhang, Longqing Zhang, Xian Huang, Wenchang Zhou, Qian Zou, Anne Manyande, Jie Wang, Yuke Tian, Xuebi Tia. Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction in rats with neuropathic pain. Pain. vol 161. issue 8. 2021-04-21. PMID:32701842. |
we showed a dramatic decrease in hippocampal glutamate concentration using nuclear magnetic resonance and reduced glutamatergic synaptic transmission using whole-cell recordings. |
2021-04-21 |
2023-08-13 |
rat |
| Swati Sahoo, Prashant S Kharkar, Niteshkumar U Sahu, Brijesh . Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy research : PTR. vol 35. issue 3. 2021-04-19. PMID:33034100. |
neurotransmitters such as monoamines (serotonin, norepinephrine, and dopamine), γ-aminobutyric acid (gaba), and glutamate were estimated in different regions of the brain (cortex, hippocampus, and cerebellum and brain stem). |
2021-04-19 |
2023-08-13 |
mouse |
| Nobuhiro Moro, Sima S Ghavim, Richard L Sutto. Massive efflux of adenosine triphosphate into the extracellular space immediately after experimental traumatic brain injury. Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-16. PMID:33850547. |
concentrations of atp, glutamate, glucose and lactate were measured in cerebral microdialysis samples obtained from the ipsilateral cortex and underlying hippocampus of rats with mild unilateral controlled cortical impact (cci) or sham injury. |
2021-04-16 |
2023-08-13 |
rat |
| Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Ha. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Molecular cell. vol 81. issue 7. 2021-04-14. PMID:33662272. |
moreover, we show that pqbp1 regulates hippocampal metabotropic glutamate receptor-dependent long-term depression (mglur-ltd) and mglur-ltd-associated behaviors by suppressing eef2k-mediated phosphorylation. |
2021-04-14 |
2023-08-13 |
Not clear |
| Jessica C Pressey, Melanie A Woodi. Kainate receptor regulation of synaptic inhibition in the hippocampus. The Journal of physiology. vol 599. issue 2. 2021-04-12. PMID:32162694. |
in the ca1 region of the hippocampus, presynaptic kar activation bidirectionally regulates γ-aminobutyric acid (gaba) release in a manner that depends on the glutamate concentration; lower levels of glutamate facilitate gaba release via an ionotropic pathway, while higher levels of glutamate depress gaba release via a metabotropic pathway. |
2021-04-12 |
2023-08-13 |
Not clear |
| Kiharu Igarashi, Daisuke Kurat. Effect of High-Oleic Peanut Intake on Aging and Its Hippocampal Markers in Senescence-Accelerated Mice (SAMP8). Nutrients. vol 12. issue 11. 2021-04-12. PMID:33187266. |
hippocampus solute carrier family 1 (glial high-affinity glutamate transporter), calcium/calmodulin-dependent protein kinase type ii, and sodium- and chloride-dependent gaba transporter, which all are considered to be closely related to glutamic acid concentration were decreased by feeding of the samples, and the gaba/glutamic acid ratio in the hippocampus was increased by feeding with the samples. |
2021-04-12 |
2023-08-13 |
mouse |
| Koyam Morales-Weil, Macarena Moreno, Juan Ahumada, Jorge Arriagada, Pablo Fuentealba, Christian Bonansco, Marco Fuenzalid. Priming of GABAergic Long-term Potentiation by Muscarinic Receptors. Neuroscience. vol 428. 2021-04-07. PMID:31917346. |
here, using electrophysiological and pharmacological approaches in acute rat hippocampal slices, we show that activation of cholinergic receptors followed by either high-frequency stimulation of schaeffer collaterals or exogenous activation of metabotropic glutamate receptor (mglur) induces a robust long-term potentiation at gabaergic synapses (iltp). |
2021-04-07 |
2023-08-13 |
rat |
| Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikuma. Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2. eLife. vol 9. 2021-04-07. PMID:32310084. |
group iii metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area ca2. |
2021-04-07 |
2023-08-13 |
rat |
| Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikuma. Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2. eLife. vol 9. 2021-04-07. PMID:32310084. |
among group iii metabotropic glutamate receptors, mglur7 and mglur4 show high relative expression in the rat hippocampal area ca2. |
2021-04-07 |
2023-08-13 |
rat |
| Shaolin Mei, Hongyu Ruan, Qi Ma, Wei-Dong Ya. The ubiquitin-editing enzyme A20 regulates synapse remodeling and efficacy. Brain research. vol 1727. 2021-04-05. PMID:31783001. |
in cultured hippocampal neurons, overexpression of a20 reduced dendritic complexity and spine size and density, whereas a20 knockdown increased spine size and density, as well as clustering of the postsynaptic scaffold psd-95 and glutamate receptor subunit glua1. |
2021-04-05 |
2023-08-13 |
mouse |
| Shu Peng, Jin Yang, Yufeng Wang, Yang Fan, Feng Tang, Changyue Hou, Juming Yu, Xiaoming Wang, Guohui Jian. Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy. Brain research. vol 1726. 2021-03-29. PMID:31557476. |
in this study we show that low-dose intranasal insulin inhibited kainic acid (ka)- or pentylenetetrazole (ptz)-induced acute seizures and reduced epileptic discharge activities in mice, potentially by alleviating the increase in seizure-induced glutamate in the hippocampus. |
2021-03-29 |
2023-08-13 |
mouse |