| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ichrak Drissi, Chloé Deschamps, Rachel Alary, Alexandre Robert, Véronique Dubreuil, Anne Le Mouël, Myriame Mohammed, Délara Sabéran-Djoneidi, Valérie Mezger, Mickael Naassila, Olivier Pierrefich. Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Addiction biology. vol 26. issue 2. 2021-03-25. PMID:32720424. |
ethanol consumption impairs learning and memory through disturbances of nmda-type glutamate receptor-dependent synaptic plasticity (long-term depression [ltd] and long-term potentiation [ltp]) in the hippocampus. |
2021-03-25 |
2023-08-13 |
mouse |
| Stephanie A Korenic, Elizabeth A Klingaman, Emerson M Wickwire, Frank E Gaston, Hongji Chen, S Andrea Wijtenburg, Laura M Rowlan. Sleep quality is related to brain glutamate and symptom severity in schizophrenia. Journal of psychiatric research. vol 120. 2021-03-24. PMID:31610406. |
the pittsburgh sleep quality index (psqi) was used to assess subjective sleep quality and proton magnetic resonance spectroscopy (mrs) was used to quantify glutamate in the bilateral anterior cingulate, left parietal cortex, and left hippocampus. |
2021-03-24 |
2023-08-13 |
Not clear |
| Ángel Alberto Puig-Lagunes, Luisa Rocha, Consuelo Morgado-Valle, Luis BeltrÁn-Parrazal, MarÍa-Leonor LÓpez-Mera. Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid. Anais da Academia Brasileira de Ciencias. vol 93. issue 2. 2021-03-19. PMID:33729379. |
we found that, in vpa rats, glutamate and glutamine concentrations were increased in hippocampus and glycine concentration was increased in cortex. |
2021-03-19 |
2023-08-13 |
rat |
| Ji-Eun Kim, Duk-Shin Lee, Hana Park, Tae-Cheon Kan. Src/CK2/PTEN-Mediated GluN2B and CREB Dephosphorylations Regulate the Responsiveness to AMPA Receptor Antagonists in Chronic Epilepsy Rats. International journal of molecular sciences. vol 21. issue 24. 2021-03-18. PMID:33348808. |
to investigate the roles and interactions of ampar and nmdar in ictogenesis of epileptic hippocampus, we analyzed ampar antagonists (perampanel and gyki 52466)-mediated phosphatase and tensin homolog deleted on chromosome 10 (pten) regulation and glutamate ionotropic receptor nmda type subunit 2b (glun2b) tyrosine (y) 1472 phosphorylation in epilepsy rats. |
2021-03-18 |
2023-08-13 |
rat |
| Xiao-Hui Xian, Jun-Xia Gao, Jie Qi, Shu-Juan Fan, Min Zhang, Wen-Bin L. Activation of p38 MAPK participates in the sulbactam-induced cerebral ischemic tolerance mediated by glial glutamate transporter-1 upregulation in rats. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244020. |
our previous studies have shown that sulbactam can play a neuroprotection role in hippocampal neurons by upregulating the expression and function of glial glutamate transporter-1 (glt-1) during ischemic insult. |
2021-03-15 |
2023-08-13 |
rat |
| Auriane Maïza, Nazha Sidahmed-Adrar, Patrick P Michel, Gilles Carpentier, Damien Habert, Carine Dalle, Walid Redouane, Magda Hamza, T H van Kuppevelt, Mohand Ouidir Ouidja, José Courty, Sandrine Chantepie, Dulce Papy-Garcia, Olivier Stettle. 3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33154448. |
g2 peptide), specifically inhibited neural activity, reduced evoked glutamate release, and impaired synaptic assembly in hippocampal cell cultures. |
2021-03-10 |
2023-08-13 |
mouse |
| Wenjun Wang, Liudi Yang, Tianlong Liu, Jingwen Wang, Aidong Wen, Yi Din. Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2. Aging. vol 12. issue 11. 2021-03-08. PMID:32433038. |
in addition, ea significantly reduced the mortality and ros levels in glutamate (glu)-induced hippocampal neuron injury, and these effects of ea were enhanced in tlr4 sirna-transfected neurons. |
2021-03-08 |
2023-08-13 |
mouse |
| Elisabetta Gerace, Elisa Zianni, Elisa Landucci, Tania Scartabelli, Rolando Berlinguer Palmini, Daniela Iezzi, Flavio Moroni, Monica Di Luca, Guido Mannaioni, Fabrizio Gardoni, Domenico E Pellegrini-Giampietr. Differential mechanisms of tolerance induced by NMDA and 3,5-dihydroxyphenylglycine (DHPG) preconditioning. Journal of neurochemistry. vol 155. issue 6. 2021-03-02. PMID:32343420. |
we investigated the molecular events triggered by nmda and 3,5-dihydroxyphenylglycine (dhpg) preconditioning, that lead to neuroprotection against excitotoxic insults (ampa or oxygen and glucose deprivation) in rat organotypic hippocampal slices, with particular attention on glutamate receptors and on cannabinoid system. |
2021-03-02 |
2023-08-13 |
rat |
| Sheng-Tao Yang, Min Wang, Veronica Galvin, Yang Yang, Amy F T Arnste. Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance. Psychopharmacology. vol 238. issue 1. 2021-02-26. PMID:32939596. |
metabotropic glutamate type 5 receptor (mglur5) antagonists are under development for treating cognitive disorders such as fragile x syndrome and alzheimer's disease, largely based on success in mouse models, where post-synaptic mglur5 stimulation weakens synaptic functions in hippocampus. |
2021-02-26 |
2023-08-13 |
mouse |
| David Kleindienst, Jacqueline Montanaro, Pradeep Bhandari, Matthew J Case, Yugo Fukazawa, Ryuichi Shigemot. Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses. International journal of molecular sciences. vol 21. issue 18. 2021-02-24. PMID:32937911. |
deep learning-assisted high-throughput analysis of freeze-fracture replica images applied to glutamate receptors and calcium channels at hippocampal synapses. |
2021-02-24 |
2023-08-13 |
Not clear |
| David Kleindienst, Jacqueline Montanaro, Pradeep Bhandari, Matthew J Case, Yugo Fukazawa, Ryuichi Shigemot. Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses. International journal of molecular sciences. vol 21. issue 18. 2021-02-24. PMID:32937911. |
we used darea for comparing glutamate receptor and calcium channel distributions between hippocampal ca3-ca1 spine synapses on apical and basal dendrites, which differ in signaling pathways involved in synaptic plasticity. |
2021-02-24 |
2023-08-13 |
Not clear |
| Neda Valian, Marziyeh Sorayya, Sareh Asadi, Fatemeh Sherafati, Ali Ershad, Sara Savaheli, Abolhassan Ahmadian. Preconditioning by ultra-low dose of tramadol reduces the severity of tramadol-induced seizure: Contribution of glutamate receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-24. PMID:33249277. |
the expression of norbin (as a regulator of metabotropic glutamate receptor 5), calponin3 (as a regulator of excitatory synaptic markers), nr1 (nmda receptor subunit 1) and glur1 (ampa receptor subunit 1) was measured in hippocampus, prefrontal cortex (pfc) and amygdala. |
2021-02-24 |
2023-08-13 |
rat |
| Min-Ho Nam, Woojin Won, Kyung-Seok Han, C Justin Le. Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation. Cellular and molecular life sciences : CMLS. vol 78. issue 2. 2021-02-22. PMID:32671427. |
signaling mechanisms of μ-opioid receptor (mor) in the hippocampus: disinhibition versus astrocytic glutamate regulation. |
2021-02-22 |
2023-08-13 |
Not clear |
| Min-Ho Nam, Woojin Won, Kyung-Seok Han, C Justin Le. Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation. Cellular and molecular life sciences : CMLS. vol 78. issue 2. 2021-02-22. PMID:32671427. |
activation of astrocytic mor has shown to cause glutamate release from hippocampal astrocytes and increase the excitability of presynaptic axon fibers to enhance the release of glutamate at the schaffer collateral-ca1 synapses, thereby, intensifying the synaptic strength and plasticity. |
2021-02-22 |
2023-08-13 |
Not clear |
| Ji-Eun Kim, Hana Park, Ji-Eun Lee, Tae-Hyun Kim, Tae-Cheon Kan. PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats. International journal of molecular sciences. vol 21. issue 16. 2021-02-18. PMID:32781725. |
in the present study, we found that ampar antagonists (perampanel and gyki 52466) decreased glutamate ionotropic receptor ampa type subunit 1 (gria1) surface expression in the epileptic rat hippocampus. |
2021-02-18 |
2023-08-13 |
rat |
| Kirsty Hamilton, Jenni Harve. The Neuronal Actions of Leptin and the Implications for Treating Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 14. issue 1. 2021-02-18. PMID:33440796. |
thus, cellular and behavioural studies support a cognitive enhancing role for leptin as excitatory synaptic transmission, synaptic plasticity and glutamate receptor trafficking at hippocampal schaffer collateral (sc)-ca1 synapses are regulated by leptin, and treatment with leptin enhances performance in hippocampus-dependent memory tasks. |
2021-02-18 |
2023-08-13 |
Not clear |
| Alicia M Purkey, Mark L Dell'Acqu. Phosphorylation-Dependent Regulation of Ca Frontiers in synaptic neuroscience. vol 12. 2021-02-11. PMID:32292336. |
phosphorylation-dependent regulation of ca experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by n-methyl-d-aspartate receptors (nmda) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa)-type ionotropic glutamate receptors (nmdar, ampar). |
2021-02-11 |
2023-08-13 |
Not clear |
| Alessandra Longaretti, Chiara Forastieri, Marina Gabaglio, Tiziana Rubino, Elena Battaglioli, Francesco Ruscon. Termination of acute stress response by the endocannabinoid system is regulated through lysine-specific demethylase 1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL. Journal of neurochemistry. vol 155. issue 1. 2021-02-10. PMID:32141088. |
remarkably, negative transcriptional control of abhd6 and magl is lost in the hippocampus upon chronic psychosocial stress, possibly contributing to trauma-induced drift of synapse physiology toward uncontrolled glutamate transmission. |
2021-02-10 |
2023-08-13 |
mouse |
| Aaron J Salisbury, Christopher A Blackwood, Jean Lud Cade. Prolonged Withdrawal From Escalated Oxycodone Is Associated With Increased Expression of Glutamate Receptors in the Rat Hippocampus. Frontiers in neuroscience. vol 14. 2021-02-06. PMID:33536871. |
prolonged withdrawal from escalated oxycodone is associated with increased expression of glutamate receptors in the rat hippocampus. |
2021-02-06 |
2023-08-13 |
rat |
| Yi-Zhi Ren, Ben-Zheng Zhang, Xiao-Jing Zhao, Zhi-Yuan Zhan. Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria. Journal of neurochemistry. vol 154. issue 5. 2021-02-04. PMID:31951012. |
meanwhile, rvd1 was also shown to increase the expression of brain-derived neurotrophic factor and glutamate aspartate transporter in the hippocampus following tbi, which indicates a possible way by which rvd1 increases the supportive function of astrocytes. |
2021-02-04 |
2023-08-13 |
mouse |