| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiang Wu, Bihua Bie, Joseph F Foss, Mohamed Nagui. Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:32008166. |
here, we explored the role of astrocytic glutamate transporter in the synaptic c1q production and microglial phagocytosis of hippocampal glutamatergic synapses in a rat model of ad. |
2021-02-03 |
2023-08-13 |
rat |
| Olga Kopach, Kaiyu Zheng, Dmitri A Rusako. Optical monitoring of glutamate release at multiple synapses in situ detects changes following LTP induction. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32169106. |
here, we took advantage of the recently developed genetically encoded optical sensors of glutamate (iglusnfr) to monitor its release at ca3-ca1 synapses in acute hippocampal slices, before and after the induction of ltp. |
2021-02-03 |
2023-08-13 |
human |
| E V Stelmashook, O P Aleksandrova, P D Rogozin, E E Genrikhs, S V Novikova, T A Gudasheva, I N Sharonova, V G Skrebitsky, N K Isae. GK-2 Reduces Death of Cultured Granule Neurons in Cerebellum Induced by the Toxic Effects of Zinc Ions. Bulletin of experimental biology and medicine. vol 168. issue 4. 2021-02-01. PMID:32146635. |
experiments on cultured rat hippocampal slices demonstrated that gk-2 did not affect reactivity of pyramidal neurons and long-term potentiation in the hippocampal field ca1 and the probability of glutamate release from presynaptic terminals in the synapses of the ca3-ca1 fields. |
2021-02-01 |
2023-08-13 |
rat |
| Ana Paula Dalmagro, Anderson Camargo, Natália B Pedron, Suliana A M Garcia, Ana Lúcia B Zen. Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid. Behavioural pharmacology. vol 31. issue 4. 2021-01-29. PMID:32040015. |
in addition, the treatments protected the hippocampus against the damage induced by the association between corticosterone administration and glutamate excess. |
2021-01-29 |
2023-08-13 |
mouse |
| Shan-Xue Jin, David A Dickson, Jamie Maguire, Larry A Fei. RASGRF1 in CRF cells controls the early adolescent female response to repeated stress. The Journal of endocrinology. vol 245. issue 3. 2021-01-25. PMID:32240981. |
in hippocampus neurons, it mediates the action of nmda and calcium-permeable ampa glutamate receptors on specific forms of synaptic plasticity, learning, and memory in both male and female mice. |
2021-01-25 |
2023-08-13 |
mouse |
| Mozhgan Torabi, Mahnaz Kesmati, Hamid Galehdari, Hossein Najafzadeh Varzi, Nahid Pourrez. MgO and ZnO nanoparticles anti-nociceptive effect modulated by glutamate level and NMDA receptor expression in the hippocampus of stressed and non-stressed rats. Physiology & behavior. vol 214. 2021-01-22. PMID:31676262. |
mgo and zno nanoparticles anti-nociceptive effect modulated by glutamate level and nmda receptor expression in the hippocampus of stressed and non-stressed rats. |
2021-01-22 |
2023-08-13 |
rat |
| Mozhgan Torabi, Mahnaz Kesmati, Hamid Galehdari, Hossein Najafzadeh Varzi, Nahid Pourrez. MgO and ZnO nanoparticles anti-nociceptive effect modulated by glutamate level and NMDA receptor expression in the hippocampus of stressed and non-stressed rats. Physiology & behavior. vol 214. 2021-01-22. PMID:31676262. |
the anti-nociceptive mechanisms of mgo and zno nanoparticles have not been thoroughly investigated; in this study, we evaluated the effects of anti-nociceptive dose of mgo and zno nps on glutamate level and nmda receptor subunits expression (nr1, nr2 and nr2b) in the rat whole hippocampus with and without acute restraint stress. |
2021-01-22 |
2023-08-13 |
rat |
| Mozhgan Torabi, Mahnaz Kesmati, Hamid Galehdari, Hossein Najafzadeh Varzi, Nahid Pourrez. MgO and ZnO nanoparticles anti-nociceptive effect modulated by glutamate level and NMDA receptor expression in the hippocampus of stressed and non-stressed rats. Physiology & behavior. vol 214. 2021-01-22. PMID:31676262. |
magnesium, zinc, glutamate levels and nmda receptor subunits expression were measured in the animal hippocampus. |
2021-01-22 |
2023-08-13 |
rat |
| Mozhgan Torabi, Mahnaz Kesmati, Hamid Galehdari, Hossein Najafzadeh Varzi, Nahid Pourrez. MgO and ZnO nanoparticles anti-nociceptive effect modulated by glutamate level and NMDA receptor expression in the hippocampus of stressed and non-stressed rats. Physiology & behavior. vol 214. 2021-01-22. PMID:31676262. |
mgo and zno nps could affect pain perception by changing glutamate level in the whole hippocampus tissue, while ion level changes followed by injection could probably affect the gene expression in the presence and the absence of stress. |
2021-01-22 |
2023-08-13 |
rat |
| Rodrigo Bainy Leal, Mark William Lopes, Douglas Affonso Formolo, Cristiane Ribeiro de Carvalho, Alexandre Ademar Hoeller, Alexandra Latini, Daniel Santos Sousa, Peter Wolf, Rui Daniel Prediger, Zuner Assis Bortolotto, Marcelo Neves Linhares, Kátia Lin, Roger Wal. Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. Molecular psychiatry. vol 25. issue 3. 2021-01-14. PMID:29880883. |
amygdala levels of the glua1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. |
2021-01-14 |
2023-08-13 |
human |
| Suwarna Chakraborty, Sunil Jamuna Tripathi, T R Raju, B S Shankaranarayana Ra. Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment. Psychopharmacology. vol 237. issue 10. 2021-01-12. PMID:32572589. |
recent studies have demonstrated that n-acetyl cysteine (nac), a pleiotropic drug, exerts antidepressant-like effect by modulation of hippocampal functions, periterminal release of glutamate, and/or redox systems. |
2021-01-12 |
2023-08-13 |
Not clear |
| Georg Pretsch, Nasim Sanadgol, Roman Smidak, Jana Lubec, Volker Korz, Harald Höger, Katja Zappe, Margit Cichna-Markl, Gert Lube. Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. Amino acids. vol 52. issue 4. 2021-01-11. PMID:32236698. |
the aim of the current study was to investigate whether doublecortin (dcx), insulin-like growth factor receptor 1 (igf-1r) and metabotropic glutamate receptor 5 (mglur5) levels are indeed modified in the aging rat hippocampal individual subareas (rather than total hippocampal tissue as in previous reports) at the protein and mrna level and whether the methylation status contributes to these changes. |
2021-01-11 |
2023-08-13 |
rat |
| Ana Teresa Barros-Viegas, Vítor Carmona, Elisabete Ferreiro, Joana Guedes, Ana Maria Cardoso, Pedro Cunha, Luís Pereira de Almeida, Catarina Resende de Oliveira, João Pedro de Magalhães, João Peça, Ana Luísa Cardos. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:32069773. |
furthermore, the increase of mir-31 levels was enough to reduce the accumulation of glutamate vesicles in the hippocampus to levels found in non-transgenic age-matched animals. |
2021-01-10 |
2023-08-13 |
mouse |
| Frank A Provenzano, Jia Guo, Melanie M Wall, Xinyang Feng, Hannah C Sigmon, Gary Brucato, Michael B First, Douglas L Rothman, Ragy R Girgis, Jeffrey A Lieberman, Scott A Smal. Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia. Biological psychiatry. vol 87. issue 3. 2021-01-06. PMID:31771861. |
we hypothesized that glutamate hyperactivity, reflected by increased metabolic activity derived from functional magnetic resonance imaging in the ca1 hippocampal subregion and from proton magnetic resonance spectroscopy-derived hippocampal levels of glutamate/glutamine, represents early hippocampal dysfunction in chr subjects and is predictive of conversion to syndromal psychosis. |
2021-01-06 |
2023-08-13 |
human |
| Inwoo Hwang, Jee-Yin Ah. Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1 International journal of molecular sciences. vol 21. issue 7. 2021-01-06. PMID:32283721. |
in the hippocampus of postmortem schizophrenia (sz) patients, the most notable finding is the deregulation of gad67 along with differential regulation of epigenetic factors associated with glutamate decarboxylase 67 (gad67) expression. |
2021-01-06 |
2023-08-13 |
Not clear |
| Manana G Dashniani, Mariam R Chighladze, Revaz O Solomonia, Maia A Burjanadze, Manana Kandashvili, Nino C Chkhikvishvili, Gela V Beselia, Lali B Kruashvil. Memantine treatment prevents okadaic acid induced neurotoxicity at the systemic and molecular levels. Neuroreport. vol 31. issue 4. 2021-01-04. PMID:31834143. |
the present study was designed to investigate the effects of okadaic acid intracerebroventricular (icv) injection on memory function and expression level of α7 subunit of nicotinic acetylcholine receptor (nachr) and nr2b subunit of nmda glutamate receptors in the hippocampus, as well as effect of the antidementic drug memantine on okadaic acid induced changes at systemic and molecular levels in rats. |
2021-01-04 |
2023-08-13 |
rat |
| Xing Li, Fan Jiang, Kai Yao, Lujia Yang, Xingyue Gao, Hongxia Chen, Xiaoli Wei, Ning Wu, Ru Zhou, Weixiu Yuan, Shuzhuo Zhan. Neuropeptide S attenuates methamphetamine-induced stereotyped behavior in rats. Biochemical and biophysical research communications. vol 527. issue 1. 2021-01-04. PMID:32446398. |
when meth (10 mg/kg) was administered to rats, the level of nps in the cerebrospinal fluid was not affected, but pretreatment with nps reversed meth-induced glutamate release in the hippocampus and striatum. |
2021-01-04 |
2023-08-13 |
rat |
| Filip S Polli, Theis H Ipsen, Maitane Caballero-Puntiverio, Tina Becher Østerbøg, Susana Aznar, Jesper T Andreasen, Kristi A Kohlmeie. Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31916029. |
cellular and molecular changes in hippocampal glutamate signaling and alterations in learning, attention, and impulsivity following prenatal nicotine exposure. |
2020-12-29 |
2023-08-13 |
mouse |
| Filip S Polli, Theis H Ipsen, Maitane Caballero-Puntiverio, Tina Becher Østerbøg, Susana Aznar, Jesper T Andreasen, Kristi A Kohlmeie. Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31916029. |
pne induced increases in the expression levels of mrna coding for different glutamate receptors and subunits within the hippocampus. |
2020-12-29 |
2023-08-13 |
mouse |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |