| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seren Gülşen Gürgen, Oya Sayın, Ferihan Çeti N, Hayrunnisa Yeşil Sarsmaz, Gülce Naz Yazıcı, Nurcan Umur, Ayşe Tuç Yüce. The Effect of Monosodium Glutamate on Neuronal Signaling Molecules in the Hippocampus and the Neuroprotective Effects of Omega-3 Fatty Acids. ACS chemical neuroscience. vol 12. issue 16. 2021-09-03. PMID:34328736. |
the effect of monosodium glutamate on neuronal signaling molecules in the hippocampus and the neuroprotective effects of omega-3 fatty acids. |
2021-09-03 |
2023-08-13 |
rat |
| Anna S Berezovskaya, Sergey A Tyganov, Svetlana D Nikolaeva, Alexandra A Naumova, Natalia S Merkulyeva, Boris S Shenkman, Margarita V Glazov. Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats. Cellular and molecular neurobiology. vol 41. issue 7. 2021-09-02. PMID:32683580. |
the results demonstrated a decreased expression of vesicular glutamate transporters 1 and 2 (vglut1/2) in the hippocampus after 3 days of hu, while glutamate decarboxylase 67 (gad67) expression was not affected. |
2021-09-02 |
2023-08-13 |
rat |
| Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Yukiko Ueno, Katsuhiro Kawaai, Shinichi Saito, Tomoko Tashiro, Akihiko Ogur. Transient appearance of Ca Hippocampus. vol 30. issue 7. 2021-09-01. PMID:32320117. |
transient appearance of ca we have previously shown that repetitive induction of long-term potentiation (ltp) by glutamate (100 μm, 3 min, three times at 24-hr intervals) provoked long-lasting synaptic enhancement accompanied by synaptogenesis in rat hippocampal slice cultures, a phenomenon termed rise (repetitive ltp-induced synaptic enhancement). |
2021-09-01 |
2023-08-13 |
rat |
| Olha Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr Maximyuk, Murat Oz, Gregory L Holmes, Oleg Krishtal, Dmytro Isae. Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors. PloS one. vol 16. issue 3. 2021-08-31. PMID:33711021. |
in this work, we studied the ability of the cholinergic system to sustain hippocampal epileptiform activity independently from glutamate and gaba transmission. |
2021-08-31 |
2023-08-13 |
Not clear |
| Matsuhiko Oka, Koki Ito, Minori Koga, Ichiro Kusum. Changes in subunit composition of NMDA receptors in animal models of schizophrenia by repeated administration of methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32473191. |
repeated administration of meth significantly decreased the gene expression levels of glutamate ionotropic receptor nmda type subunit (grin) subtypes grin1 and grin2c in the prefrontal cortex (pfc), grin1 and grin2a in the hippocampus (hpc), and grin1, grin2b, and grin2d in the striatum (st).we observed a significant difference in grin1 expression between the pfc and st. |
2021-08-27 |
2023-08-13 |
mouse |
| Adam Hamed, Miron Bartosz Kurs. Social deprivation substantially changes multi-structural neurotransmitter signature of social interaction: Glutamate concentration in amygdala and VTA as a key factor in social encounter-induced 50-kHz ultrasonic vocalization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 37. 2021-08-26. PMID:32651127. |
social encounter-induced 50-khz usvs were bound up with changes in glutamate in amygdala and vta, glycine in the amygdala, vta, hippocampus, nucleus accumbens and cpu, and dopamine metabolites in vta and cpu. |
2021-08-26 |
2023-08-13 |
rat |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Sonia Jazmín Molina, Gustavo Ezequiel Buján, Laura Ruth Guelma. Noise-induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence. Developmental neurobiology. vol 81. issue 2. 2021-08-25. PMID:33386696. |
short- and long-term measurements were performed to evaluate reactive oxygen species, thioredoxins levels and catalase activity as indicators of hippocampal oxidative status as well as glutamic acid decarboxylase and a subtype of glutamate transporter to evaluate aminoacidergic neurotransmission tone. |
2021-08-25 |
2023-08-13 |
rat |
| Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Darisi Venkata Kishore, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasa. Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:32803629. |
therefore, further mechanism-based studies were performed on the ptz model, and the outcomes have revealed that there was a significant reduction in gaba (p < 0.01 for both regions) and elevation of glutamate (p < 0.01 for both regions) in the cortex and hippocampus regions of ptz-treated animals. |
2021-08-20 |
2023-08-13 |
mouse |
| Heather O'Leary, Lauren Vanderlinden, Lara Southard, Anna Castano, Laura M Saba, Tim A Benk. Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid. Epilepsy research. vol 161. 2021-08-18. PMID:32062370. |
our previous work also demonstrated increased expression of ca1 hippocampal long-term potentiation (ltp) and reduced desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic glutamate receptors (ampa-r) one week following a kainic acid induced seizure (ka-els). |
2021-08-18 |
2023-08-13 |
rat |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |
| Jesús David Urbano-Gámez, Juan José Casañas, Itziar Benito, María Luz Montesino. Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34034796. |
accordingly, mglur-ltd (metabotropic glutamate receptor-ltd) is enhanced in the hippocampus of ts1cje mice and this is correlated with an increased proportion of a particular category of mushroom spines in hippocampal pyramidal neurons. |
2021-08-12 |
2023-08-13 |
mouse |
| Anderson Camargo, Ana P Dalmagro, Julia M Rosa, Ana Lúcia B Zeni, Manuella P Kaster, Carla I Tasca, Ana Lúcia S Rodrigue. Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling. Neurochemistry international. vol 139. 2021-08-11. PMID:32652267. |
these behavioral alterations were accompanied by impaired hippocampal slices viability, elevated immunocontent of nuclear factor-kappa b (nf-κb) and indoleamine-2,3-dioxygenase 1 (ido-1), and reduced immunocontent of glucocorticoids receptor (gr), glutamate transporter (glt-1), nuclear factor-erythroid 2-related factor 2 (nrf2), and heme oxygenase-1 (ho-1) in the hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Leonid P Savtchenko, Kaiyu Zheng, Dmitri A Rusako. Buffering by Transporters Can Spare Geometric Hindrance in Controlling Glutamate Escape. Frontiers in cellular neuroscience. vol 15. 2021-08-10. PMID:34366791. |
we thus estimate that, in the hippocampal or cerebellar neuropil, the bulk of glutamate released by a synaptic vesicle is rapidly bound by transporters (or high-affinity target receptors) mainly in close proximity of the synaptic cleft, whether or not certain physiological or pathological events change local tissue geometry. |
2021-08-10 |
2023-08-13 |
Not clear |
| Lílian Juliana Lissner, Leticia Rodrigues, Krista Minéia Wartchow, Ederson Borba, Larissa Daniele Bobermin, Fernanda Urruth Fontella, Fernanda Hansen, André Quincozes-Santos, Diogo Onofre Gomes Souza, Carlos-Alberto Gonçalve. Short-Term Alterations in Behavior and Astroglial Function After Intracerebroventricular Infusion of Methylglyoxal in Rats. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33095439. |
in addition, hippocampal glutamate uptake decreased and glutamine synthetase activity and glutathione levels diminished during seventy-two hours after infusion of mg. interestingly, the astrocytic protein, s100b, was increased in the cerebrospinal fluid, accompanied by decreased hippocampal s100b mrna expression, without any change in protein content. |
2021-08-09 |
2023-08-13 |
rat |
| Anna Brachet, Argentina Lario, Alba Fernández-Rodrigo, Frank F Heisler, Yolanda Gutiérrez, Clara Lobo, Matthias Kneussel, José A Esteba. A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. Cell reports. vol 36. issue 5. 2021-08-04. PMID:34348158. |
the synaptic removal of ampa-type glutamate receptors (ampars) is a core mechanism for hippocampal long-term depression (ltd). |
2021-08-04 |
2023-08-13 |
Not clear |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
these results for the first time demonstrated that selective lesions of ms cholinergic and gabaergic neurons differentially affect long-term spatial memory and the memory deficit after ms gabaergic lesion is paralleled with significant changes of hippocampal glutamate, gaba and acetylcholine receptors expression. |
2021-07-28 |
2023-08-13 |
rat |
| Kyoung Hoon Jeong, Kyung-Ok Cho, Mun-Yong Lee, Seong Yun Kim, Won-Joo Ki. Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus. Glia. vol 69. issue 2. 2021-07-28. PMID:32835451. |
therefore, we investigated whether vegfr-3 upregulation within reactive astrocytes is associated with the activation of mammalian target of rapamycin (mtor) signaling, which we confirmed by assaying for the phosphorylated form of s6 protein (ps6), and whether vegfr-3-mediated mtor activation induces astroglial glutamate transporter-1 (glt-1) expression in the hippocampus after pilocarpine-induced se. |
2021-07-28 |
2023-08-13 |
Not clear |
| Gustavo A Chiprés-Tinajero, Miguel A Núñez-Ochoa, Laura Medina-Cej. Increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity. Experimental brain research. vol 239. issue 6. 2021-07-28. PMID:33909110. |
increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity. |
2021-07-28 |
2023-08-13 |
rat |
| Gustavo A Chiprés-Tinajero, Miguel A Núñez-Ochoa, Laura Medina-Cej. Increased immunoreactivity of glutamate receptors, neuronal nuclear protein and glial fibrillary acidic protein in the hippocampus of epileptic rats with fast ripple activity. Experimental brain research. vol 239. issue 6. 2021-07-28. PMID:33909110. |
the animals were sacrificed on day 15, and fluorescence immunohistochemistry was carried out in the hippocampus for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda) and mglu-r5 glutamate receptors as well as neuronal nuclear protein (neun) and glial fibrillary acidic protein (gfap). |
2021-07-28 |
2023-08-13 |
rat |