| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Alhowai. Mechanisms underlying cognitive impairment induced by prenatal nicotine exposure: a literature review. European review for medical and pharmacological sciences. vol 25. issue 19. 2021-10-19. PMID:34661266. |
the findings of the reviewed studies show that the main mechanisms involved are alteration in the composition of nicotinic acetylcholine receptor subunits, increase in surface expression of the glutamate receptor subunit glur2, a reduction in neurogenesis, alteration of akt and erk1/2 activity, and mitochondrial dysfunction in the hippocampus and cortex. |
2021-10-19 |
2023-08-13 |
human |
| Demet Gurler, David Matthew White, Nina Vanessa Kraguljac, Lawrence Ver Hoef, Clinton Martin, Blake Tennant, Adrienne Carol Laht. Neural Signatures of Memory Encoding in Schizophrenia Are Modulated by Antipsychotic Treatment. Neuropsychobiology. vol 80. issue 1. 2021-10-18. PMID:32316023. |
in this longitudinal study, we combined functional magnetic resonance imaging during a memory encoding task with proton mr spectroscopy to measure hippocampal glutamate + glutamine (glx). |
2021-10-18 |
2023-08-13 |
Not clear |
| Olga Wronikowska, Maria Zykubek, Agnieszka Michalak, Anna Pankowska, Paulina Kozioł, Anna Boguszewska-Czubara, Łukasz Kurach, Artur Łazorczyk, Katarzyna Kochalska, Sylwia Talarek, Tymoteusz Słowik, Radosław Pietura, Joanna Kurzepa, Barbara Budzyńsk. Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study. Molecular neurobiology. vol 58. issue 9. 2021-10-15. PMID:34021482. |
in this study, we comprehensively evaluated glutamatergic involvement in rewarding effects of mephedrone using an interdisciplinary approach including (1) behavioural study on effects of memantine (non-selective nmda antagonist) on expression of mephedrone-induced conditioned place preference (cpp) in rats; (2) evaluation of glutamate concentrations in the hippocampus of rats following 6 days of mephedrone administration, using in vivo magnetic resonance spectroscopy (mrs); and (3) determination of glutamate levels in the hippocampus of rats treated with mephedrone and subjected to mrs, using ion-exchange chromatography. |
2021-10-15 |
2023-08-13 |
rat |
| Olga Wronikowska, Maria Zykubek, Agnieszka Michalak, Anna Pankowska, Paulina Kozioł, Anna Boguszewska-Czubara, Łukasz Kurach, Artur Łazorczyk, Katarzyna Kochalska, Sylwia Talarek, Tymoteusz Słowik, Radosław Pietura, Joanna Kurzepa, Barbara Budzyńsk. Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study. Molecular neurobiology. vol 58. issue 9. 2021-10-15. PMID:34021482. |
mrs study showed that subchronic mephedrone administration increased glutamate level in the hippocampus when measured in vivo 24 h (5 mg/kg, 10 mg/kg and 20 mg/kg) and 2 weeks (5 mg/kg and 20 mg/kg) after last injection. |
2021-10-15 |
2023-08-13 |
rat |
| Olga Wronikowska, Maria Zykubek, Agnieszka Michalak, Anna Pankowska, Paulina Kozioł, Anna Boguszewska-Czubara, Łukasz Kurach, Artur Łazorczyk, Katarzyna Kochalska, Sylwia Talarek, Tymoteusz Słowik, Radosław Pietura, Joanna Kurzepa, Barbara Budzyńsk. Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study. Molecular neurobiology. vol 58. issue 9. 2021-10-15. PMID:34021482. |
ex vivo chromatographic analysis did not show significant changes in hippocampal glutamate concentrations; however, it showed similar results as obtained in the mrs study proving its validity. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
our previous studies indicated that glutamate (glu) and hippocampal neuron apoptosis are key signal and direct factor leading to diabetes-related depression, respectively. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
we found that dd rats exhibit an elevated glutamate levels followed by monoamine neurotransmitter deficiency and depressive-like behaviour, and dd modelling promoted autophagosome formation and caused mitochondrial impairment, eventually leading to hippocampal neuron apoptosis via aberrant glu-glur2-parkin pathway. |
2021-10-15 |
2023-08-13 |
rat |
| Rosa López-Pedrajas, Inmaculada Almansa, María V Sánchez-Villarejo, Borja Muriach, Jorge M Barcia, Francisco J Romero, María Muriac. Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:34625609. |
we also study the involvement of hippocampus in these processes, with special interest on the role of nuclear factor kappa b (nf-κb), n-methyl-d-aspartate glutamate receptor 2b (glun2b), and their relationship with other proteins, such as cyclic amp response element binding protein (creb). |
2021-10-13 |
2023-08-13 |
rat |
| Giselle Fernandes, Pradeep K Mishra, Mohammad Sarfaraz Nawaz, Paul G Donlin-Asp, Mohammed Mostafizur Rahman, Anupam Hazra, Sonal Kedia, Aiman Kayenaat, Dheeraj Songara, David J A Wyllie, Erin M Schuman, Peter C Kind, Sumantra Chattarj. Correction of amygdalar dysfunction in a rat model of fragile X syndrome. Cell reports. vol 37. issue 2. 2021-10-13. PMID:34644573. |
however, current understanding of the pathogenesis of the disease is based primarily on studies in the hippocampus and neocortex, where fxs defects have been corrected by inhibiting group i metabotropic glutamate receptors (mglurs). |
2021-10-13 |
2023-08-13 |
rat |
| Mary A Zimmerman, Mia Hall, Qi Qi, Suresh L Mehta, Guisheng Chen, P Andy L. Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630650. |
mouse hippocampal neuronal ht22 cells were incubated with glutamate with or without ubisol q10. |
2021-10-12 |
2023-08-13 |
mouse |
| Shiyang Huang, Can Zheng, Guoguang Xie, Zhanming Song, Pingzhang Wang, Yun Bai, Dixin Chen, Yan Zhang, Ping Lv, Weiwei Liang, Shaoping She, Qingqing Li, Zhongtian Liu, Yun Wang, Guo-Gang Xing, Ying Wan. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32317715. |
these behavioral alterations were associated with the decreased expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and n-methyl-d-aspartic acid receptors, as well as significantly reduced glutamate release and neuronal activity in the hippocampus. |
2021-10-11 |
2023-08-13 |
mouse |
| Shi-Feng Chu, Zhao Zhang, Xin Zhou, Wen-Bin He, Bo Yang, Li-Yuan Cui, Hong-Yuan He, Zhen-Zhen Wang, Nai-Hong Che. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Acta pharmacologica Sinica. vol 42. issue 6. 2021-10-07. PMID:33028984. |
furthermore, we showed that glutamatergic transmission was enhanced in l-cort rats, evidenced by enhanced population spike amplitude (psa) recorded from the dentate gyrus of hippocampus in vivo and increased glutamate release from hippocampal synaptosomes caused by high frequency stimulation or cort exposure. |
2021-10-07 |
2023-08-13 |
rat |
| Aisling O'Neill, Luciano Annibale, Grace Blest-Hopley, Robin Wilson, Vincent Giampietro, Sagnik Bhattacharyy. Cannabidiol modulation of hippocampal glutamate in early psychosis. Journal of psychopharmacology (Oxford, England). vol 35. issue 7. 2021-10-07. PMID:33860709. |
cannabidiol modulation of hippocampal glutamate in early psychosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Andrew S Lapato, Sarah M Thompson, Karen Parra, Seema K Tiwari-Woodruf. Astrocyte Glutamate Uptake and Water Homeostasis Are Dysregulated in the Hippocampus of Multiple Sclerosis Patients With Seizures. ASN neuro. vol 12. 2021-10-06. PMID:33297722. |
astrocyte glutamate uptake and water homeostasis are dysregulated in the hippocampus of multiple sclerosis patients with seizures. |
2021-10-06 |
2023-08-13 |
mouse |
| Andrew S Lapato, Sarah M Thompson, Karen Parra, Seema K Tiwari-Woodruf. Astrocyte Glutamate Uptake and Water Homeostasis Are Dysregulated in the Hippocampus of Multiple Sclerosis Patients With Seizures. ASN neuro. vol 12. 2021-10-06. PMID:33297722. |
together, these data suggest that hippocampal astrocytes from ms+s patients display regional differences in expression of molecules associated with glutamate buffering and water homeostasis that could exacerbate neuronal hyperexcitability. |
2021-10-06 |
2023-08-13 |
mouse |
| Thomas P Jensen, Olga Kopach, James P Reynolds, Leonid P Savtchenko, Dmitri A Rusako. Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus. eLife. vol 10. 2021-10-06. PMID:33438578. |
here, we employed classical optical quantal analyses and a genetically encoded optical glutamate sensor in acute hippocampal slices of rats and mice to monitor glutamate release at ca3-ca1 synapses. |
2021-10-06 |
2023-08-13 |
mouse |
| Xiaoxuan Wang, Yu Zhang, Xinkun Wan, Chenjia Guo, Jing Cui, Jing Sun, Liang L. Responsive Expression of MafF to Disease markers. vol 2020. 2021-10-05. PMID:33488846. |
the expression of maff was increased in the hippocampus of ad patients, which was negatively correlated with the expression of the glutamate cysteine ligase catalytic subunit (gclc). |
2021-10-05 |
2023-08-13 |
Not clear |
| Courtney J Wright, Katherine M Rentschler, Nathan T J Wagner, Ashley M Lewis, Sarah Beggiato, Ana Pocivavse. Time of Day-Dependent Alterations in Hippocampal Kynurenic Acid, Glutamate, and GABA in Adult Rats Exposed to Elevated Kynurenic Acid During Neurodevelopment. Frontiers in psychiatry. vol 12. 2021-10-05. PMID:34603109. |
time of day-dependent alterations in hippocampal kynurenic acid, glutamate, and gaba in adult rats exposed to elevated kynurenic acid during neurodevelopment. |
2021-10-05 |
2023-08-13 |
rat |
| Fatma Farhat, Shahira Nofal, Eman M Raafat, Amany Ali Eissa Ahme. Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity. Neuropharmacology. vol 196. 2021-10-01. PMID:34119518. |
akt / gsk3β / nrf2 / ho-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity. |
2021-10-01 |
2023-08-13 |
rat |
| Gabriele Di Cicco, Emanuela Marzano, Luisa Iacovelli, Roberta Celli, Gilles van Luijtelaar, Ferdinando Nicoletti, Richard T Ngomba, Mark J Wal. Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy. Neuropharmacology. vol 196. 2021-10-01. PMID:34197893. |
group i metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of wag/rij rats modelling absence epilepsy. |
2021-10-01 |
2023-08-13 |
rat |