| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nai-You Zhang, Ting-Hsuan Wang, Ching-Hsuan Chou, Kuo-Chen Wu, Chia-Ron Yang, Fan-Lu Kung, Chun-Jung Li. Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathways. European journal of pharmacology. 2022-09-11. PMID:36088983. |
in addition, the decreased excitatory amino acid transporter 2 level, the increased extracellular glutamate, and the upregulated hippocampal nmda receptor 2b of cia rats were all normalized by ibuprofen treatment. |
2022-09-11 |
2023-08-14 |
rat |
| Alexander Beletskiy, Ekaterina Positselskaya, Aliya Kh Vinarskaya, Yulia S Spivak, Yulia V Dobryakova, Iliya Tyulenev, Vladimir A Markevich, Alexey P Bolshako. Detailed Analysis of Dorsal-Ventral Gradients of Gene Expression in the Hippocampus of Adult Rats. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077346. |
our data suggest that the dorsal and ventral parts of the hippocampus differ in the expression of genes related to signaling pathways mediated by classical neurotransmitters (glutamate, gaba, monoamines, etc.) |
2022-09-09 |
2023-08-14 |
rat |
| Yirong Xu, Guangheng Zhang, Yingying Zhao, Fan Bu, Yeping Zhan. Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum Neurotoxicity. Neurotoxicity research. 2022-09-06. PMID:36066748. |
mechanistically, aluminum reduced the levels of the synaptic prps (camp-response element binding protein (creb), glutamate receptor 1 (glur1), glutamate receptor 2 (glur2), and postsynaptic density protein 95 (psd-95), and it increased p-tau deposition in the hippocampus of sd rats. |
2022-09-06 |
2023-08-14 |
rat |
| Maryvonne Ardourel, Arnaud Pâris, Chloé Felgerolle, Fabien Lesne, Isabelle Ranchon-Cole, Sylvain Briault, Olivier Perch. FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment. Experimental eye research. 2022-09-06. PMID:36067823. |
indeed, glutamate homeostasis deficit has been observed in absence of fmrp in-vivo in cortex and hippocampus structures as well as in vitro on astroglial cell culture. |
2022-09-06 |
2023-08-14 |
human |
| Michael A Conoscenti, Nancy J Smith, Michael S Fanselo. Dissociable consequences of moderate and high volume stress are mediated by the differential energetic demands of stress. PloS one. vol 17. issue 9. 2022-09-01. PMID:36048782. |
finally, we provide evidence that stressors of different volumes produce dissociable changes in glutamate receptor proteins in the basolateral amygdala (bla) and dorsal hippocampus (dh). |
2022-09-01 |
2023-08-14 |
human |
| Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H Frey Ii, Ivan Tkac, Raghavendra B Ra. Intranasal Insulin Attenuates the Long-term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats. Developmental neuroscience. 2022-08-30. PMID:36041414. |
the acute effects on hippocampal neurochemical profile and transcript mrna expression of insulin receptor (insr), glucose transporters (glut1, glut 4 and glut8) and poly(adp-ribose)polymerase-1(parp1, a marker of oxidative stress) were determined on p7 using in vivo 1h mr spectroscopy (mrs) and qpcr. |
2022-08-30 |
2023-08-14 |
rat |
| T A Gudasheva, N M Sazonova, A V Tarasiuk, I O Logvinov, T A Antipova, D M Nikiforov, P Yu Povarnina, S B Seredeni. The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties. Doklady. Biochemistry and biophysics. vol 505. issue 1. 2022-08-29. PMID:36038682. |
gts-301 showed neuroprotective activity in experiments on ht-22 mouse hippocampal cells under conditions of oxidative stress and glutamate toxicity at concentrations of 10 |
2022-08-29 |
2023-08-14 |
mouse |
| Alba García-Baos, Ines Gallego-Landin, Irene Ferreres-Álvarez, Xavier Puig-Reyne, Adriana Castro-Zavala, Olga Valverde, Ana Martín-Sánche. Effects of fast-acting antidepressant drugs on a postpartum depression mice model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2022-08-27. PMID:36029538. |
such symptoms are accompanied by lower allopregnanolone serum levels, reduction of vesicular transporters of gaba (vgat) and glutamate (vglut1) in the infralimbic cortex (il), as well as decreased hippocampal cellular proliferation. |
2022-08-27 |
2023-08-14 |
mouse |
| Anna Maria Tartaglione, Melania Maria Serafini, Francesca Ferraris, Andrea Raggi, Annalisa Mirabello, Rita Di Benedetto, Laura Ricceri, Miriam Midali, Francesco Cubadda, Luisa Minghetti, Barbara Viviani, Gemma Calamandre. Short- and Long-Term Effects of Suboptimal Selenium Intake and Developmental Lead Exposure on Behavior and Hippocampal Glutamate Receptors in a Rat Model. Nutrients. vol 14. issue 16. 2022-08-26. PMID:36014775. |
short- and long-term effects of suboptimal selenium intake and developmental lead exposure on behavior and hippocampal glutamate receptors in a rat model. |
2022-08-26 |
2023-08-14 |
rat |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| Xiaoling Li, Mengjiao Sun, Wei Liu, Ning Liu, Boyao Yuan, Xiaolu S. Primary large B-cell lymphoma of the central nervous system with positive NMDAR antibody: a case report. BMC neurology. vol 22. issue 1. 2022-08-12. PMID:35962342. |
n-methyl-d-aspartate receptor (nmdar) is an ionotropic glutamate (glu) receptor that is widely expressed in the central nervous system (cns), mainly in the hippocampus. |
2022-08-12 |
2023-08-14 |
Not clear |
| Maria Zimmermann, Luciano Minuzzi, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A Hall, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Eliane Kobayash. Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An Frontiers in neurology. vol 13. 2022-08-08. PMID:35937057. |
reduced metabotropic glutamate receptor type 5 availability in the epileptogenic hippocampus: an abnormalities in the expression of metabotropic glutamate receptor type 5 (mglur5) have been observed in the hippocampus of patients with drug-resistant mesial temporal lobe epilepsy (mtle). |
2022-08-08 |
2023-08-14 |
Not clear |
| Josephine M Brown-Leung, Jason R Canno. Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes. Chemical research in toxicology. 2022-08-03. PMID:35921496. |
evaluated research has shown there are highly reproduced increased glutamate levels in the hippocampus and catecholamine levels in the hypothalamus and decreased dopamine in the whole brain after pfas exposure. |
2022-08-03 |
2023-08-14 |
rat |
| Mengxi Lu, Xia He, Zhexiao Jiao, Zewen Hu, Zijing Guo, Shiyun Dai, Hui Wang, Dan X. The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure. Environmental toxicology. 2022-08-02. PMID:35917217. |
the upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure. |
2022-08-02 |
2023-08-14 |
rat |
| Mengxi Lu, Xia He, Zhexiao Jiao, Zewen Hu, Zijing Guo, Shiyun Dai, Hui Wang, Dan X. The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure. Environmental toxicology. 2022-08-02. PMID:35917217. |
compared with the control group, hippocampal neurons of male fetal rats by pce displayed increased apoptosis and reduced synaptic plasticity, whereas glutamate decarboxylase 67 (gad67) expression was increased. |
2022-08-02 |
2023-08-14 |
rat |
| Mengxi Lu, Xia He, Zhexiao Jiao, Zewen Hu, Zijing Guo, Shiyun Dai, Hui Wang, Dan X. The upregulation of glutamate decarboxylase 67 against hippocampal excitability damage in male fetal rats by prenatal caffeine exposure. Environmental toxicology. 2022-08-02. PMID:35917217. |
these results indicated that pce inhibits the bdnf pathway and mediates the hippocampus's glutamate (glu) excitotoxicity. |
2022-08-02 |
2023-08-14 |
rat |
| Anup Gopalakrishna Pillai, Suhita Nadkarn. Amyloid pathology disrupts gliotransmitter release in astrocytes. PLoS computational biology. vol 18. issue 8. 2022-08-01. PMID:35913987. |
we developed a biophysical model that describes calcium signaling and the ensuing gliotransmitter release from a single astrocytic process when stimulated by glutamate release from hippocampal neurons. |
2022-08-01 |
2023-08-14 |
Not clear |
| Laura Musazzi, Paolo Tornese, Nathalie Sala, Francis S Lee, Maurizio Popoli, Alessandro Ierac. Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNF Journal of cellular physiology. 2022-07-31. PMID:35908196. |
acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of bdnf stressful life events are considered major risk factors for the development of several psychiatric disorders, though people differentially cope with stress. |
2022-07-31 |
2023-08-14 |
human |
| V N Zorina, A Ya Bespalov, K A Krasnov, A S Melekhova, V L Reinu. [Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 7. 2022-07-29. PMID:35904287. |
the antiepileptic, mood stabilizing and neuroprotective properties of valproate due to pre- and postsynaptic modulation of gaba-ergic transmission, regulation of glutamate activity, serotonin and dopamine levels in the hippocampus, modulation of sodium, calcium and potassium channels, epigenetic effects on the body are described. |
2022-07-29 |
2023-08-14 |
Not clear |
| Jeremy J Watts, Elisa Guma, Sofia Chavez, Rachel F Tyndale, Ruth A Ross, Sylvain Houle, Alan A Wilson, Mallar Chakravarty, Pablo M Rusjan, Romina Mizrah. In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-07-29. PMID:35906490. |
in vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with pet, dysregulation of hippocampus glutamatergic neurotransmission and reductions in hippocampal volume have been associated with psychiatric disorders. |
2022-07-29 |
2023-08-14 |
Not clear |