| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saptarnab Naskar, Siddhartha Datta, Sumantra Chattarj. Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala. Neurobiology of stress. vol 18. 2022-03-25. PMID:35330860. |
hence, we tested the impact of riluzole, which potentiates glutamate clearance by astrocytic glutamate transporters, on principal neurons and astrocytes in the basal amygdala (ba) and hippocampal area ca1. |
2022-03-25 |
2023-08-13 |
rat |
| Saptarnab Naskar, Siddhartha Datta, Sumantra Chattarj. Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala. Neurobiology of stress. vol 18. 2022-03-25. PMID:35330860. |
therefore, similar to the impact of repeated stress, pharmacological potentiation of glutamate clearance, with or without stress, also leads to differential effects on dendritic spines in principal neurons of the amygdala and hippocampus. |
2022-03-25 |
2023-08-13 |
rat |
| Dana Lengel, Zoe L Romm, Anna L Bostwick, Jimmy W Huh, Nathaniel W Snyder, George Smith, Ramesh Raghupath. Glucocorticoid Receptor Overexpression in the Dorsal Hippocampus Attenuates Spatial Learning and Synaptic Plasticity Deficits Following Pediatric Traumatic Brain Injury. Journal of neurotrauma. 2022-03-16. PMID:35293260. |
gr overexpression in the dh was also associated with a significant increase in the mrna expression levels of sgk1, and the glutamate receptor subunits glua1 and glua2 within the hippocampus. |
2022-03-16 |
2023-08-13 |
human |
| Dana Lengel, Zoe L Romm, Anna L Bostwick, Jimmy W Huh, Nathaniel W Snyder, George Smith, Ramesh Raghupath. Glucocorticoid Receptor Overexpression in the Dorsal Hippocampus Attenuates Spatial Learning and Synaptic Plasticity Deficits Following Pediatric Traumatic Brain Injury. Journal of neurotrauma. 2022-03-16. PMID:35293260. |
overall, these findings support an important role of dorsal hippocampal gr function in learning and memory deficits following pediatric tbi and suggest that these effects may be related to the regulation of glutamate receptor subunit expression in the dh. |
2022-03-16 |
2023-08-13 |
human |
| Adeyelu Tolulope, Olalekan M Ogundel. Anterior thalamic glutamatergic neurons modulate prefrontal cortical firing and regularity. Neuroscience letters. 2022-03-12. PMID:35278647. |
the diencephalic nucleus is rich in excitatory glutamate neurons that project to both the hippocampus and medial prefrontal cortex (mpfc). |
2022-03-12 |
2023-08-13 |
Not clear |
| J N Bissonnette, A M Francis, S MacNeil, C E Crocker, P G Tibbo, D J Fishe. Glutamate and N-Acetylaspartate Alterations Observed in Early Phase Psychosis: A Systematic Review of Proton Magnetic Resonance Spectroscopy Studies. Psychiatry research. Neuroimaging. vol 321. 2022-02-20. PMID:35183897. |
no studies reported glutamate alterations in the hippocampus or cerebellum. |
2022-02-20 |
2023-08-13 |
Not clear |
| Lucas Taoro-González, Andrea Cabrera-Pastor, María Sancho-Alonso, Vicente Felip. Intracellular and extracelluar cyclic GMP in the brain and the hippocampus. Vitamins and hormones. vol 118. 2022-02-19. PMID:35180929. |
specifically, it has been demonstrated that extracellular cgmp decreases hippocampal il-1β levels restoring membrane expression of glutamate receptors in the hippocampus and cognitive function in hyperammonemic rats. |
2022-02-19 |
2023-08-13 |
rat |
| B Spurny-Dworak, P Handschuh, M Spies, U Kaufmann, R Seiger, M Klöbl, M E Konadu, M B Reed, V Ritter, P Baldinger-Melich, W Bogner, G S Kranz, R Lanzenberge. Effects of sex hormones on brain GABA and glutamate levels in a cis- and transgender cohort. Psychoneuroendocrinology. vol 138. 2022-02-17. PMID:35176535. |
mean gaba+ (combination of gaba and macromolecules) and glx (combination of glutamate and glutamine) ratios to total creatine (gaba+/tcr, glx/tcr) were calculated in five predefined regions-of-interest (hippocampus, insula, pallidum, putamen and thalamus). |
2022-02-17 |
2023-08-13 |
human |
| Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zho. APT1-mediated de-palmitoylation regulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-15. PMID:35165175. |
herein, we employed acyl-biotin exchange, co-immunoprecipitation and biotinylation assays, and behavioral and electrophysiological methods, to explore whether palmitoylation is required for hippocampal synaptic transmission and fear memory formation, and involved in functional modification of synaptic proteins such as psd-95 and glutamate receptors, and detected if de-palmitoylation by specific enzymes has influence on glutamatergic synaptic plasticity. |
2022-02-15 |
2023-08-13 |
rat |
| Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zho. APT1-mediated de-palmitoylation regulates hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-15. PMID:35165175. |
our results showed that global palmitoylation level, palmitoylation of psd-95 and glutamate receptors, post-synapse density-localization of psd-95, surface expression of ampars, and synaptic strength of cultured hippocampal neurons, were all enhanced by ttx pretreatment, and these can be reversed by inhibition of palmitoylation with palmitoyl acyl transferases inhibitors, 2-bromopalmitate and n-(tert-butyl) hydroxylamine hydrochloride. |
2022-02-15 |
2023-08-13 |
rat |
| Zhitao Hou, Xinyu Yang, Yang Li, Jing Chen, Hongcai Shan. Electroacupuncture Enhances Neuroplasticity by Regulating the Orexin A-Mediated cAMP/PKA/CREB Signaling Pathway in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. Oxidative medicine and cellular longevity. vol 2022. 2022-02-14. PMID:35154573. |
the results showed that 10 hz electroacupuncture (ea) effectively alleviated learning and memory impairment in 7-month-old samp8 mice, reduced oxa levels in the csf, increased the level of the neurotransmitter glutamate, alleviated pathological damage to hippocampal tissue, improved the synaptic structure, enhanced synaptic transmission, and regulated the expression of camp/pka/creb signaling pathway-related proteins. |
2022-02-14 |
2023-08-13 |
mouse |
| Chiang-Wen Lee, Lee-Fen Hsu, I-Lin Wu, Yung-Li Wang, Wei-Chen Chen, Yan-Jun Liu, Lu-Tang Yang, Chong-Lun Tan, Yueh-Hsia Luo, Chia-Ching Wang, Hui-Wen Chiu, Thomas Chung-Kuang Yang, Yen-Yue Lin, Hsin-An Chang, Yao-Chang Chiang, Ching-Hsiang Chen, Ming-Hsueh Lee, Kuo-Ti Peng, Cathy Chia-Yu Huan. Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice. Journal of hazardous materials. vol 430. 2022-02-12. PMID:35150991. |
concurrently, the hippocampus had decreased levels of immediate-early genes, aberrantly enhanced synaptic glutamate ampa receptors, and elevated neuroinflammation, all of which are critical for synaptic plasticity and memory. |
2022-02-12 |
2023-08-13 |
mouse |
| Ines Luttenbacher, Angela Phillips, Reza Kazemi, Abed L Hadipour, Isha Sanghvi, Julian Martinez, Maheen M Adamso. Transdiagnostic role of glutamate and white matter damage in neuropsychiatric disorders: A Systematic Review. Journal of psychiatric research. vol 147. 2022-02-12. PMID:35151030. |
the findings point to decreased levels of glutamate in the anterior cingulate cortex in both sz and bd, whereas glx is elevated in the hippocampus in sz and mdd. |
2022-02-12 |
2023-08-13 |
Not clear |
| Yosra A Hussien, Dina F Mansour, Somaia A Nada, Sahar S Abd El-Rahman, Rania M Abdelsalam, Amina S Attia, Dalia M El-Tanboul. Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: Modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects. Life sciences. 2022-02-08. PMID:35134437. |
lng modulated taa-induced disturbances in hippocampal amino acids; glutamate, and gaba with a significant increase in hippocampal bdnf. |
2022-02-08 |
2023-08-13 |
rat |
| Anca R Rǎdulescu, Gabrielle C Todd, Cassandra L Williams, Benjamin A Bennink, Alex A Lemus, Haley E Chesbro, Justin R Bourgeois, Ashley M Kopec, Damian G Zuloaga, Annalisa Scimem. Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. PLoS computational biology. vol 18. issue 2. 2022-02-04. PMID:35120128. |
estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. |
2022-02-04 |
2023-08-13 |
mouse |
| Anca R Rǎdulescu, Gabrielle C Todd, Cassandra L Williams, Benjamin A Bennink, Alex A Lemus, Haley E Chesbro, Justin R Bourgeois, Ashley M Kopec, Damian G Zuloaga, Annalisa Scimem. Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. PLoS computational biology. vol 18. issue 2. 2022-02-04. PMID:35120128. |
glutamate transporters are abundantly expressed in astrocytes, and previous estimates have been obtained about their surface expression in astrocytes of the rat hippocampus and cerebellum. |
2022-02-04 |
2023-08-13 |
mouse |
| Anca R Rǎdulescu, Gabrielle C Todd, Cassandra L Williams, Benjamin A Bennink, Alex A Lemus, Haley E Chesbro, Justin R Bourgeois, Ashley M Kopec, Damian G Zuloaga, Annalisa Scimem. Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes. PLoS computational biology. vol 18. issue 2. 2022-02-04. PMID:35120128. |
together, these findings provide information on how heterogeneity in the spatial distribution of glutamate transporters in the plasma membrane of hippocampal astrocytes my alter glutamate receptor activation out of the synaptic cleft. |
2022-02-04 |
2023-08-13 |
mouse |
| Jennifer M Erichsen, Jennifer L Woodruff, Claudia A Grillo, Lawrence P Reagan, James R Fade. Molecular effects of intranasal insulin in the rodent brain: Examination of insulin receptor signaling and the glutamatergic system. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109179. |
to investigate the mechanistic basis for the pro-cognitive effects of ini, insulin receptor (ir) signaling and the expression of glutamate receptors and transporters, due to the role of the glutamatergic system in hippocampal synaptic transmission, was examined. |
2022-02-03 |
2023-08-13 |
Not clear |
| Anas Anas Sohail, Fernando Ortiz, Teresa Varghese, Stephanie P Fabara, Arshdeep S Batth, Darshan P Sandesara, Ahtesham Sabir, Mahika Khurana, Shae Datta, Urvish K Pate. The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review. Cureus. vol 13. issue 12. 2022-02-03. PMID:35111479. |
the mechanism of action is that it behaves like a glutamate reuptake inhibitor while also acting in the hippocampus as a competitive low-affinity glutamate receptor antagonist. |
2022-02-03 |
2023-08-13 |
Not clear |
| Céline D Dürst, Thomas G Oertne. Imaging Synaptic Glutamate Release with Two-Photon Microscopy in Organotypic Slice Cultures. Methods in molecular biology (Clifton, N.J.). vol 2417. 2022-01-31. PMID:35099802. |
sparse labeling is achieved via transfection of pyramidal cells in organotypic hippocampal cultures, and imaging of evoked glutamate transients with two-photon laser scanning microscopy. |
2022-01-31 |
2023-08-13 |
Not clear |