| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel Treviño, Alfonso Díaz, Getsemaní González-López, Jorge Guevar. Differential biochemical-inflammatory patterns in the astrocyte-neuron axis of the hippocampus and frontal cortex in Wistar rats with metabolic syndrome induced by high fat or carbohydrate diets. Journal of chemical neuroanatomy. vol 126. 2022-11-14. PMID:36374648. |
at the brain level, it is noteworthy that the hcd group had an increase in lactate and glutamate concentration, reactive astrogliosis, immunoreactive cox2 neurons in the ca1 subfield hippocampus and frontal cortex, and high levels of pge2, tnf-α, il-1β, and il-6, and low bdnf immunoreactivity. |
2022-11-14 |
2023-08-14 |
rat |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Wei Wang, Runshi Gao, Zhiwei Ren, Dongju Yang, Ke Sun, Xiaoling Li, Suying Ya. Global trends in research of glutamate in epilepsy during past two decades: A bibliometric analysis. Frontiers in neuroscience. vol 16. 2022-11-07. PMID:36340784. |
the keywords that appear most frequently are "epilepsy," "glutamate," "temporal lobe epilepsy (tle)," "hippocampus," and "seizures." |
2022-11-07 |
2023-08-14 |
Not clear |
| Fajuan Tang, Lin Chen, Hu Gao, Yupeng Lei, Linli Pan, Dongqiong Xiao, Xihong L. Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels. Neurochemical research. 2022-11-06. PMID:36335177. |
munc18-1 contributes to hippocampal injury in septic rats through regulation of syntanxin1a and synaptophysin and glutamate levels. |
2022-11-06 |
2023-08-14 |
rat |
| Fajuan Tang, Lin Chen, Hu Gao, Yupeng Lei, Linli Pan, Dongqiong Xiao, Xihong L. Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels. Neurochemical research. 2022-11-06. PMID:36335177. |
we found an increase in the content of glutamate in the hippocampus of septic rat, the number of synaptic vesicles in the synaptic active area and the expression of the glutamate receptor nmdar1. |
2022-11-06 |
2023-08-14 |
rat |
| Fajuan Tang, Lin Chen, Hu Gao, Yupeng Lei, Linli Pan, Dongqiong Xiao, Xihong L. Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels. Neurochemical research. 2022-11-06. PMID:36335177. |
we observed a decrease in the content of glutamate in the hippocampus of septic rats, the number of synaptic vesicles in the synaptic activity area and the expression of nmdar1. |
2022-11-06 |
2023-08-14 |
rat |
| Fajuan Tang, Lin Chen, Hu Gao, Yupeng Lei, Linli Pan, Dongqiong Xiao, Xihong L. Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels. Neurochemical research. 2022-11-06. PMID:36335177. |
this study shows that clp induced the increased levels of glutamate in rat hippocampus, and munc18-1 may participate in the process of hippocampal injury in septic rats by affecting the levels of glutamate via regulating syntaxin1a and synaptophysin. |
2022-11-06 |
2023-08-14 |
rat |
| Mohamad Azmeer Effendy, Suleiman Yunusa, Noorul Hamizah Mat, Ahmad Tarmizi Che Has, Christian P Müller, Zurina Hassa. The role of AMPA and NMDA receptors in mitragynine effects on hippocampal synaptic plasticity. Behavioural brain research. 2022-10-23. PMID:36273648. |
here, we determined the role of ampa- and nmda glutamate receptors in mitragynine-induced synaptic plasticity in the hippocampus. |
2022-10-23 |
2023-08-14 |
rat |
| Di Qu, Zichen Ye, Wenli Zhang, Bing Dai, Guo Chen, Li Wang, Xiaolong Shao, An Xiang, Zifan Lu, Juan Sh. Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity. ACS chemical neuroscience. 2022-10-18. PMID:36254458. |
neuroinflammation and disturbance of glutamate metabolism in brain regions, such as the hippocampus, play vital roles in the development of depression. |
2022-10-18 |
2023-08-14 |
mouse |
| Rut Fadó, Anna Molins, Rocío Rojas, Núria Casal. Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235789. |
we observe that memory and learning deficits mediated by high-fat/high-sugar diets, even over short exposure times, are associated with reduced arborization, widened synaptic cleft, narrowed post-synaptic zone, and decreased activity-dependent synaptic plasticity in the hippocampus, and also observe that these alterations correlate with deregulation of the ampa-type glutamate ionotropic receptors (ampars) that are crucial to neuroplasticity. |
2022-10-14 |
2023-08-14 |
human |
| Hunter Franks, Ruishan Wang, Mingqi Li, Bin Wang, Ashton Wildmann, Tyler Ortyl, Shannon O'Brien, Deborah Young, Francesca-Fang Liao, Kazuko Sakat. Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB. Journal of neurochemistry. 2022-10-13. PMID:36227087. |
the results of immunohistochemistry and chromatin immunoprecipitation quantitative pcr (chip-qpcr) showed that administration of kainic acid (a glutamate receptor agonist inducing excitotoxity) to young adult mice induced hsf1 nuclear translocation and its binding to multiple bdnf promoters in the hippocampus. |
2022-10-13 |
2023-08-14 |
mouse |
| Chongbo Zhong, Wendy Akmentin, Lorna W Role, David A Talmag. Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections. Frontiers in neural circuits. vol 16. 2022-10-10. PMID:36213206. |
by imaging gene chimeric co-cultures from mouse, we examined the role of α7* nachrs mediated cholinergic modulation of glutamate release and synaptic vesicle organization in ventral hippocampal projections. |
2022-10-10 |
2023-08-14 |
mouse |
| Emma Muñoz-Moreno, Rui Vasco Simões, Raúl Tudela, Xavier López-Gil, Guadalupe Sori. Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-10-10. PMID:36216838. |
compared to wt, tgf344-ad rats replicated common findings in ad patients, including decreased n-acetylaspartate in the cortex, hippocampus and thalamus, and decreased glutamate in the thalamus and striatum. |
2022-10-10 |
2023-08-14 |
rat |
| Alfredo Lucas, Ravi Prakash Reddy Nanga, Peter Hadar, Stephanie Chen, Adam Gibson, Kelly Oechsel, Mark A Elliott, Joel M Stein, Sandhitsu Das, Ravinder Reddy, John A Detre, Kathryn A Davi. Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging. Human brain mapping. 2022-09-29. PMID:36173151. |
mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted cest (glucest) imaging. |
2022-09-29 |
2023-08-14 |
Not clear |
| Alfredo Lucas, Ravi Prakash Reddy Nanga, Peter Hadar, Stephanie Chen, Adam Gibson, Kelly Oechsel, Mark A Elliott, Joel M Stein, Sandhitsu Das, Ravinder Reddy, John A Detre, Kathryn A Davi. Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging. Human brain mapping. 2022-09-29. PMID:36173151. |
here we propose the use of glutamate-weighted chemical exchange saturation transfer (glucest) magnetic resonance imaging (mri) at 7 tesla for mapping hippocampal glutamate distribution in epilepsy, allowing to differentiate lesional from non-lesional mesial tle. |
2022-09-29 |
2023-08-14 |
Not clear |
| Alfredo Lucas, Ravi Prakash Reddy Nanga, Peter Hadar, Stephanie Chen, Adam Gibson, Kelly Oechsel, Mark A Elliott, Joel M Stein, Sandhitsu Das, Ravinder Reddy, John A Detre, Kathryn A Davi. Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging. Human brain mapping. 2022-09-29. PMID:36173151. |
overall, our results suggest that hippocampal glutamate mapping through glucest imaging is a valuable addition to the presurgical epilepsy evaluation toolbox. |
2022-09-29 |
2023-08-14 |
Not clear |
| Qi Li, Yuqian Zhao, Chuanchuan Shi, Xuemin Son. IL-33 Alleviates Postoperative Cognitive Impairment by Inhibiting Hippocampal Inflammation and Upregulating Excitatory Synaptic Number in Aged Mice. Brain sciences. vol 12. issue 9. 2022-09-23. PMID:36138980. |
immunofluorescence was used to detect the density of il-33 and glial fibrillary acidic protein (gfap) co-localization, ionized calcium-binding adapter molecule 1, vesicular glutamate transporter 1 (vglut1) and postsynaptic density protein-95 (psd95) co-localization in the hippocampus. |
2022-09-23 |
2023-08-14 |
mouse |
| Maiko A Schneider, Devon Malhotra, Poli M Spritzer, Taylor Hatchard, Luciano Minuzzi, Benicio N Frey, Sasha A Haefner, Andrew Nicholson, Margaret McKinnon, Sabrina K Syan, Taiane de Azevedo Cardoso, Karine Schwarz, Maurício Anés, Alejandro Santos-Díaz, Maria I R Lobat. Estradiol Replacement as a Potential Enhancer of Working Memory and Neuroplasticity in Hypogonadal Trans Women. Neuroendocrinology. 2022-09-21. PMID:36130584. |
the present study examined the effect of estradiol administration in humans on glutamate concentration in brain regions involved in semantic and working memory (i.e., the dorsolateral prefrontal cortex (dlpfc), the posterior hippocampus, and the pregenual anterior cingulate cortex (acc)) and its relationship with memory. |
2022-09-21 |
2023-08-14 |
Not clear |
| Eva Baranovicova, Dagmar Kalenska, Maria Kovalska, Jan Lehotsk. Hippocampal metabolic recovery as a manifestation of the protective effect of ischemic preconditioning in rats. Neurochemistry international. 2022-09-16. PMID:36113578. |
hippocampal tissues were characterized by postischemically decreased glutamate and gaba (4-aminobutyrate) tissue content balanced with increased glutamine level, with most pronounced changes at 3h reperfusion time. |
2022-09-16 |
2023-08-14 |
rat |
| Xingfeng Liu, Site Li, Wenyu Zhang, Zhuo Xie, Jingxin He, Xuanwei Zhang, Shouyang Yu, Song Cao, Tian Yu, Zhi Xia. PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling. iScience. vol 25. issue 9. 2022-09-12. PMID:36093041. |
hippocampal prg-1/n-ethylmaleimide sensitive fusion protein (nsf) interaction was determined to be responsible for the rns-induced impairment via enhanced extracellular glutamate release and ampar glur2 trafficking deficiency in a cell-autonomous manner. |
2022-09-12 |
2023-08-14 |
rat |