| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingying Jiang, Qingying Liu, Yumei Zhao, Chunyang Wang, Ming Su. Activation of CREB-BDNF Pathway in Pyramidal Neurons in the Hippocampus Improves the Neurological Outcome of Mice with Ischemic Stroke. Molecular neurobiology. 2022-12-26. PMID:36571720. |
however, it is unclear whether glutamate in the ventral hippocampal cornus ammonis 1 (vca1) acts a part in neurological deficits, pain perception, anxiety, and depression induced by ischemic stroke. |
2022-12-26 |
2023-08-14 |
mouse |
| Xiao-Hui Tang, Yu-Gang Diao, Zhuo-Yu Ren, Yan-Yu Zang, Guang-Fen Zhang, Xing-Ming Wang, Gui-Fang Duan, Jin-Chun Shen, Kenji Hashimoto, Zhi-Qiang Zhou, Jian-Jun Yan. A role of GABA Neuropharmacology. 2022-12-24. PMID:36565851. |
mice exposed to fss (forced swimming stress) showed depression-like behavior and decreased levels of gaba (γ-aminobutyric acid), but not glutamate, in the hippocampus. |
2022-12-24 |
2023-08-14 |
mouse |
| Xiao-Hui Tang, Yu-Gang Diao, Zhuo-Yu Ren, Yan-Yu Zang, Guang-Fen Zhang, Xing-Ming Wang, Gui-Fang Duan, Jin-Chun Shen, Kenji Hashimoto, Zhi-Qiang Zhou, Jian-Jun Yan. A role of GABA Neuropharmacology. 2022-12-24. PMID:36565851. |
ketamine increased gaba levels and decreased glutamate levels in the hippocampus of mice exposed to fss. |
2022-12-24 |
2023-08-14 |
mouse |
| Ahmed Salim Mahmood, Afaq M Ammoo, Mayssam Hussein Mohammed Ali, Tiba M Hameed, Hany A Al-Hussaniy, Abdulla Amer Abbas Aljumaili, Mohammed Hussein Alaa Al-Fallooji, Ali Hakim Kadhi. Antiepileptic Effect of Neuroaid Pharmaceuticals (Basel, Switzerland). vol 15. issue 12. 2022-12-23. PMID:36558919. |
brain specimens from surviving animals were extracted and examined pathologically for quantification of glutamate receptor (glur) gene expression in the isolated hippocampus employing real-time pcr analysis. |
2022-12-23 |
2023-08-14 |
mouse |
| Ling Zhang, Yu-Zhu Gao, Chun-Jie Zhao, Jiang-Yan Xia, Jian-Jun Yang, Mu-Huo J. Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy. Neuropharmacology. 2022-12-21. PMID:36543316. |
the densities of vesicular γ-aminobutyric acid transporter, vesicular glutamate transporter 1, pnn, and parvalbumin (pv) in the hippocampus were evaluated by immunofluorescence. |
2022-12-21 |
2023-08-14 |
mouse |
| Jongyun Myeong, Vitaly A Klyachk. Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses. Cell reports. vol 41. issue 11. 2022-12-14. PMID:36516768. |
using near-total internal reflection fluorescence (near-tirf) imaging of single vesicle release in cultured hippocampal synapses, we demonstrate a distinctive, release-dependent form of facilitation in which probability of vesicle release is higher following a successful glutamate release event than following a failure. |
2022-12-14 |
2023-08-14 |
Not clear |
| Laura Bellingacci, Martina Tallarico, Andrea Mancini, Alfredo Megaro, Carmen De Caro, Rita Citraro, Giovambattista De Sarro, Alessandro Tozzi, Massimiliano Di Filippo, Miriam Sciaccaluga, Emilio Russo, Antonio Leo, Cinzia Cost. Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis. Neuropharmacology. 2022-12-12. PMID:36502868. |
non-competitive ampa glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis. |
2022-12-12 |
2023-08-14 |
mouse |
| Laura Bellingacci, Martina Tallarico, Andrea Mancini, Alfredo Megaro, Carmen De Caro, Rita Citraro, Giovambattista De Sarro, Alessandro Tozzi, Massimiliano Di Filippo, Miriam Sciaccaluga, Emilio Russo, Antonio Leo, Cinzia Cost. Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral amyloidosis. Neuropharmacology. 2022-12-12. PMID:36502868. |
we aimed to investigate whether the non-competitive block of ampars was able to counteract the alteration of hippocampal epileptic threshold, and of synaptic plasticity linked to aβ oligomers accumulation, being this glutamate receptor a valuable specific therapeutic target. |
2022-12-12 |
2023-08-14 |
mouse |
| Dexiao Zhu, Jian Zhang, Fei Gao, Mei Hu, Jack Hashem, Chu Che. Augmentation of 2-arachidonoylglycerol signaling in astrocytes maintains synaptic functionality by regulation of miRNA-30b. Experimental neurology. 2022-12-08. PMID:36481187. |
here, we provide evidence that pharmacological inactivation of magl suppresses hippocampal expression of mir-30b, a small non-coding microrna, and upregulates expression of its targets, including ephrin type-b receptor 2 (ephb2), sirtuin1 (sirt1), and glutamate ionotropic receptor ampa type subunit 2 (glua2). |
2022-12-08 |
2023-08-14 |
Not clear |
| Zhangbi Wu, Jialin Huang, Xiaojie Bai, Qunan Wang, Fen Wang, Jun Xu, Huiping Tang, Chunying Yin, Yu Wang, Feng Yu, Hong Zhan. Ginsenoside-Rg1 mitigates cardiac arrest-induced cognitive damage by modulating neuroinflammation and hippocampal plasticity. European journal of pharmacology. 2022-12-04. PMID:36463944. |
furthermore, ginsenoside-rg1 could ameliorate ca/cpr-induced aberrant expression of the key regulators of hippocampal glutamate signaling pathways, excitatory amino acid transporter 2 (eaat2), excitatory amino acid transporter 1 (eaat1), glutamine synthetase (gs), glun2b, and glutamate. |
2022-12-04 |
2023-08-14 |
rat |
| Nicola Masala, Martin Pofahl, André N Haubrich, Khondker Ushna Sameen Islam, Negar Nikbakht, Maryam Pasdarnavab, Kirsten Bohmbach, Kunihiko Araki, Fateme Kamali, Christian Henneberger, Kurtulus Golcuk, Laura A Ewell, Sandra Blaess, Tony Kelly, Heinz Bec. Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy. Brain : a journal of neurology. 2022-11-30. PMID:36448426. |
two-photon glutamate uncaging experiments revealed a marked increase in the fraction of hippocampal 1st order ca1 pyramidal cell dendrites capable of generating dendritic spikes in the kainate model of chronic epilepsy. |
2022-11-30 |
2023-08-14 |
mouse |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
neonatal isoflurane exposure in rats impairs short-term memory, cell viability, and glutamate uptake in slices of the frontal cerebral cortex, but not the hippocampus, in adulthood. |
2022-11-28 |
2023-08-14 |
rat |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
in pnd8, ex vivo analysis of hippocampal and frontal cortex slices evaluated cell viability and susceptibility to in vitro glutamate challenge. |
2022-11-28 |
2023-08-14 |
rat |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
in adult rats, behavioral parameters related to anxiety-like behavior, short-term memory, and locomotor activity (pnd60-62) and ex vivo analysis of cell viability, membrane permeability, glutamate uptake, and susceptibility to in vitro glutamate challenge in hippocampal and cortical slices from pnd65. |
2022-11-28 |
2023-08-14 |
rat |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
a single isoflurane (3%, 2 h) exposure at pnd7 did not acutely alter cell viability in cortical and hippocampal slices of infant rats (pnd8) per se and did not alter slice susceptibility to in vitro glutamate challenge. |
2022-11-28 |
2023-08-14 |
rat |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
ex vivo analysis of brain slices showed isoflurane neonatal exposure selectively decreased cell viability and glutamate uptake in cortical slices, but it did not alter hippocampal slice viability or glutamate uptake (pnd65). |
2022-11-28 |
2023-08-14 |
rat |
| Laíse Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrinéia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C Pereira, Carla Inês Tasc. Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood. Neurotoxicity research. 2022-11-28. PMID:36441450. |
these findings indicate that a single neonatal isoflurane exposure did not promote acute damage; however, it reduced cortical, but not hippocampal, slice viability and glutamate uptake in the adulthood. |
2022-11-28 |
2023-08-14 |
rat |
| M A Gruden, T V Davydova, A M Ratmirov, R D E Sewel. Cerebral Expression of the Neuregulin-1 Gene NRG1 during Induced Spatial Memory Impairment and Its Reversal in Aging Mice. Bulletin of experimental biology and medicine. 2022-11-27. PMID:36437318. |
we studied the effects of chronic intranasal administration of amyloidogenic fibrils of the proinflammatory protein s100a9 alone or in combination with glutamate antibodies on the expression of the neuregulin-1 gene (nrg1), a regulator of various physiological processes, in particular, regulation of neurogenesis and apoptosis, in the hippocampus, prefrontal cortex, and cerebellum of aging c57bl/6 mice under conditions of long-term memory disturbances. |
2022-11-27 |
2023-08-14 |
mouse |
| Marta De Felice, Chaochao Chen, Mar Rodríguez-Ruiz, Hanna J Szkudlarek, Michael Lam, Selvi Sert, Shawn N Whitehead, Ken K-C Yeung, Walter J Rushlow, Steven R Laviolett. Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-19. PMID:36402837. |
in addition, using matrix-assisted laser desorption/ionization imaging mass spectrometry (maldi-ims), we show for the first time that adolescent thc exposure induces significant and enduring dysregulation of gaba and glutamate levels in dorsal vs. ventral hippocampus. |
2022-11-19 |
2023-08-14 |
Not clear |
| Emily M Pitzer, Chiho Sugimoto, Samantha L Regan, Gary A Gudelsky, Michael T Williams, Charles V Vorhee. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Current research in toxicology. vol 3. 2022-11-17. PMID:36393872. |
potassium stimulated extracellular glutamate release in the hippocampus was not affected using |
2022-11-17 |
2023-08-14 |
rat |