| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Pardo, Nicholas E Paul, Lyndsey E Collins-Praino, John D Salamone, Mercè Corre. The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making. Pharmacology, biochemistry, and behavior. vol 198. 2021-04-13. PMID:32910928. |
considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. |
2021-04-13 |
2023-08-13 |
Not clear |
| S Agosta, D Magnago, E Galante, F Ferraro, A Magherini, R Di Giacopo, G Miceli, L Battell. Lateralized cognitive functions in Parkinson's patients: A behavioral approach for the early detection of sustained attention deficits. Brain research. vol 1726. 2021-03-29. PMID:31580872. |
the lateralized motor onset of symptoms indicates asymmetrical dysregulation of the dopamine production in the substantia nigra, in the striatum and, in turns, a dysfunction of the basal ganglia and of the connected cortical areas. |
2021-03-29 |
2023-08-13 |
Not clear |
| Tatyana D Sotnikova, Evgeniya V Efimova, Raul R Gainetdino. Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. International journal of molecular sciences. vol 21. issue 21. 2021-03-11. PMID:33153031. |
dopamine transporter knockout (datk) mice are known to demonstrate profound hyperactivity concurrent with elevated (5-fold) extracellular dopamine in the basal ganglia. |
2021-03-11 |
2023-08-13 |
mouse |
| Tatyana D Sotnikova, Evgeniya V Efimova, Raul R Gainetdino. Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. International journal of molecular sciences. vol 21. issue 21. 2021-03-11. PMID:33153031. |
in the d3k mice, the hyperactivity is also correlated with elevated extracellular dopamine levels (2-fold) in the basal ganglia. |
2021-03-11 |
2023-08-13 |
mouse |
| Luiz Alexandre Viana Magno, Mélcar Collodetti, Helia Tenza-Ferrer, Marco Aurélio Romano-Silv. Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson's Disease. Bio-protocol. vol 9. issue 16. 2021-03-05. PMID:33654842. |
the deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. |
2021-03-05 |
2023-08-13 |
mouse |
| Jennifer L Chain, Kathy Alvarez, Adita Mascaro-Blanco, Sean Reim, Rebecca Bentley, Rebecca Hommer, Paul Grant, James F Leckman, Ivana Kawikova, Kyle Williams, Julie A Stoner, Susan E Swedo, Madeleine W Cunningha. Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections. Frontiers in psychiatry. vol 11. 2021-01-10. PMID:32670106. |
movement, behavioral, and neuropsychiatric disorders in children have been linked to infections and a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. |
2021-01-10 |
2023-08-13 |
Not clear |
| Jessica A Mollick, Hedy Kobe. Computational models of drug use and addiction: A review. Journal of abnormal psychology. vol 129. issue 6. 2021-01-06. PMID:32757599. |
brain-based models have incorporated prefrontal cortex, basal ganglia, and the dopamine system, based on the effects of drugs on dopamine, motivation, and executive control circuits. |
2021-01-06 |
2023-08-13 |
human |
| Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrer. Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy. Cellular and molecular neurobiology. 2021-01-02. PMID:33387119. |
parkinson's disease (pd) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and deficit of dopamine in the basal ganglia. |
2021-01-02 |
2023-08-13 |
Not clear |
| Hong-Yuan Ch. Synaptic and cellular plasticity in Parkinson's disease. Acta pharmacologica Sinica. vol 41. issue 4. 2020-12-21. PMID:32112041. |
in addition, decreased amounts of dopamine (da) level in the basal ganglia induces numerous adaptive changes at the cellular and synaptic levels in the basal ganglia circuits. |
2020-12-21 |
2023-08-13 |
Not clear |
| Ilaria Morella, Harriet Hallum, Riccardo Brambill. Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices. Frontiers in cellular neuroscience. vol 14. 2020-12-12. PMID:33304241. |
in the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (erk) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine d1 and ionotropic glutamate receptors. |
2020-12-12 |
2023-08-13 |
Not clear |
| Nae Saito, Toshikuni Sasaok. [Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 11. 2020-11-17. PMID:33191292. |
[dopamine and nmda receptors in basal ganglia circuits and their roles regarding motor control and learning]. |
2020-11-17 |
2023-08-13 |
mouse |
| Nae Saito, Toshikuni Sasaok. [Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 11. 2020-11-17. PMID:33191292. |
dopamine (da) plays an important role in the basal ganglia (bg) for motor control, and da deficiency as seen in parkinson's disease, causes movement disorders. |
2020-11-17 |
2023-08-13 |
mouse |
| Takatoshi Hikida, Shuhei Yao, Tom Macpherson, Ayumi Fukakusa, Makiko Morita, Haruhide Kimura, Keisuke Hirai, Tatsuya Ando, Hiroyoshi Toyoshiba, Akira Saw. Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific reports. vol 10. issue 1. 2020-11-10. PMID:32020036. |
within this circuit, two distinct nucleus accumbens (nac) output neuron types, dopamine d1 or d2 receptor-expressing neurons, dynamically control the flow of information through basal ganglia nuclei that eventually project back to the mpfc to complete the loop. |
2020-11-10 |
2023-08-13 |
mouse |
| Fernando E Padovan-Neto, Santanna Patterson, Nivea M F Voelkner, Feras Altwal, Joel A Beverley, Anthony R West, Heinz Steine. Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31468338. |
dopamine and serotonin in the basal ganglia interact in a bidirectional manner. |
2020-11-05 |
2023-08-13 |
Not clear |
| Michinori Koebisu, Takayuki Ishid. [Safinamide Mesilate (Equfina Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 4. 2020-11-02. PMID:32612042. |
dopamine deficiency is thought to disrupt motor control of the basal ganglia and cause characteristic motor symptoms in parkinson's disease such as bradykinesia, akinesia, and tremor. |
2020-11-02 |
2023-08-13 |
rat |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are essential for basal ganglia function. |
2020-11-02 |
2023-08-13 |
Not clear |
| Tuğba Cengiz, Saadet Türkboyları, Onur Serdar Gençler, Ömer Anla. The roles of galectin-3 and galectin-4 in the idiopatic Parkinson disease and its progression. Clinical neurology and neurosurgery. vol 184. 2020-10-23. PMID:31147178. |
idiopathic parkinson's disease is a neurodegenerative disease caused by the loss of cells that secrete dopamine in the basal ganglia. |
2020-10-23 |
2023-08-13 |
Not clear |
| Seo Young Kang, Ji Young Yun, Hye Ok Kim, Byung Seok Moon, Hai-Jeon Yoon, Bom Sahn Ki. The Correlation of Salivary Gland Uptake Between 18F-FP-CIT PET/CT and Salivary Scan. Clinical nuclear medicine. vol 45. issue 8. 2020-10-15. PMID:32520511. |
the uptake of dopamine transporter in the bilateral basal ganglia was well preserved, but reduced uptake in the left parotid gland was incidentally detected. |
2020-10-15 |
2023-08-13 |
Not clear |
| Siegfried Muhlack, Patricia Müsch, Sandra Konietzka, Dirk Woitalla, Horst Przuntek, Thomas Mülle. Impact of Oral Fast Release Amantadine on Movement Performance in Patients with Parkinson's Disease. Pharmaceutics. vol 2. issue 3. 2020-10-01. PMID:27721359. |
therefore, performance of complex motion series improved, whereas carrying-out of simple repetitive movements is more associated to the striatal dopamine dependent basal ganglia function. |
2020-10-01 |
2023-08-13 |
Not clear |
| Pamela Valdés, Bernard L Schneide. Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease? Frontiers in neuroanatomy. vol 10. 2020-10-01. PMID:28066194. |
gene therapies that are the most advanced in the clinic have been designed to more effectively compensate for the lack of dopamine signaling in the basal ganglia and rescue the cardinal motor symptoms of pd. |
2020-10-01 |
2023-08-13 |
Not clear |