| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tom Gilbertson, Douglas Steel. Tonic dopamine, uncertainty and basal ganglia action selection. Neuroscience. vol 466. 2021-06-22. PMID:34015370. |
using a computational model of the basal ganglia, we propose that switches between exploratory and exploitative decisions are mediated by the interaction between tonic dopamine and cortical input to the basal ganglia. |
2021-06-22 |
2023-08-13 |
Not clear |
| Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Ur. Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33037031. |
thus, our data are the first to highlight a unique dopamine receptor-specific topographical pattern in the pfc, which could have profound implications for corticostriatal signaling in the basal ganglia. |
2021-06-18 |
2023-08-13 |
mouse |
| Aristide Merola, Amber Van Laar, Russell Lonser, Krzysztof Bankiewic. Gene therapy for Parkinson's disease: contemporary practice and emerging concepts. Expert review of neurotherapeutics. vol 20. issue 6. 2021-05-17. PMID:32425079. |
several gene therapy clinical trials have been conducted in parkinson's disease (pd) by exploring strategies to either restore dopamine synthesis, enhance the production of trophic factors, enhance lysosomal function, or modify the interaction between different functional nodes of the basal ganglia. |
2021-05-17 |
2023-08-13 |
Not clear |
| Toru Nakamura, Luis Carl Rios, Takeshi Yagi, Toshikuni Sasaoka, Takashi Kitsukaw. Dopamine D1 and muscarinic acetylcholine receptors in dorsal striatum are required for high speed running. Neuroscience research. vol 156. 2021-05-14. PMID:31812651. |
dopamine (da) signaling in the basal ganglia plays important roles in motor control. |
2021-05-14 |
2023-08-13 |
mouse |
| Farhan Augustine, Shreenath Rajendran, Harvey S Singe. Cortical endogenous opioids and their role in facilitating repetitive behaviors in deer mice. Behavioural brain research. vol 379. 2021-04-30. PMID:31676208. |
in this study, we pursue the mechanism of repetitive behaviors by performing stereological analyses and liquid chromatography/ mass spectrometry (lc-ms/ms) measurements of glutamate (glut), gaba, 3,4-dihydroxyphenylacetic acid (dopac), dopamine (da), leu-enkephalin (leu-enk), and dynorphin-a (dyn-a) in frontal cortex (fc), prefrontal cortex (pfc), and basal ganglia. |
2021-04-30 |
2023-08-13 |
mouse |
| Zahra Jafari, Bryan E Kolb, Majid H Mohajeran. Auditory Dysfunction in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 4. 2021-04-27. PMID:32052894. |
improvement in auditory responses following dopaminergic therapies also indicates the presence of similar neurotransmitters (i.e., glutamate and dopamine) in the auditory system and basal ganglia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Marta Pardo, Nicholas E Paul, Lyndsey E Collins-Praino, John D Salamone, Mercè Corre. The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making. Pharmacology, biochemistry, and behavior. vol 198. 2021-04-13. PMID:32910928. |
considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. |
2021-04-13 |
2023-08-13 |
Not clear |
| S Agosta, D Magnago, E Galante, F Ferraro, A Magherini, R Di Giacopo, G Miceli, L Battell. Lateralized cognitive functions in Parkinson's patients: A behavioral approach for the early detection of sustained attention deficits. Brain research. vol 1726. 2021-03-29. PMID:31580872. |
the lateralized motor onset of symptoms indicates asymmetrical dysregulation of the dopamine production in the substantia nigra, in the striatum and, in turns, a dysfunction of the basal ganglia and of the connected cortical areas. |
2021-03-29 |
2023-08-13 |
Not clear |
| Tatyana D Sotnikova, Evgeniya V Efimova, Raul R Gainetdino. Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. International journal of molecular sciences. vol 21. issue 21. 2021-03-11. PMID:33153031. |
dopamine transporter knockout (datk) mice are known to demonstrate profound hyperactivity concurrent with elevated (5-fold) extracellular dopamine in the basal ganglia. |
2021-03-11 |
2023-08-13 |
mouse |
| Tatyana D Sotnikova, Evgeniya V Efimova, Raul R Gainetdino. Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. International journal of molecular sciences. vol 21. issue 21. 2021-03-11. PMID:33153031. |
in the d3k mice, the hyperactivity is also correlated with elevated extracellular dopamine levels (2-fold) in the basal ganglia. |
2021-03-11 |
2023-08-13 |
mouse |
| Luiz Alexandre Viana Magno, Mélcar Collodetti, Helia Tenza-Ferrer, Marco Aurélio Romano-Silv. Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson's Disease. Bio-protocol. vol 9. issue 16. 2021-03-05. PMID:33654842. |
the deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. |
2021-03-05 |
2023-08-13 |
mouse |
| Jennifer L Chain, Kathy Alvarez, Adita Mascaro-Blanco, Sean Reim, Rebecca Bentley, Rebecca Hommer, Paul Grant, James F Leckman, Ivana Kawikova, Kyle Williams, Julie A Stoner, Susan E Swedo, Madeleine W Cunningha. Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections. Frontiers in psychiatry. vol 11. 2021-01-10. PMID:32670106. |
movement, behavioral, and neuropsychiatric disorders in children have been linked to infections and a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. |
2021-01-10 |
2023-08-13 |
Not clear |
| Jessica A Mollick, Hedy Kobe. Computational models of drug use and addiction: A review. Journal of abnormal psychology. vol 129. issue 6. 2021-01-06. PMID:32757599. |
brain-based models have incorporated prefrontal cortex, basal ganglia, and the dopamine system, based on the effects of drugs on dopamine, motivation, and executive control circuits. |
2021-01-06 |
2023-08-13 |
human |
| Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrer. Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy. Cellular and molecular neurobiology. 2021-01-02. PMID:33387119. |
parkinson's disease (pd) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and deficit of dopamine in the basal ganglia. |
2021-01-02 |
2023-08-13 |
Not clear |
| Hong-Yuan Ch. Synaptic and cellular plasticity in Parkinson's disease. Acta pharmacologica Sinica. vol 41. issue 4. 2020-12-21. PMID:32112041. |
in addition, decreased amounts of dopamine (da) level in the basal ganglia induces numerous adaptive changes at the cellular and synaptic levels in the basal ganglia circuits. |
2020-12-21 |
2023-08-13 |
Not clear |
| Ilaria Morella, Harriet Hallum, Riccardo Brambill. Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices. Frontiers in cellular neuroscience. vol 14. 2020-12-12. PMID:33304241. |
in the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (erk) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine d1 and ionotropic glutamate receptors. |
2020-12-12 |
2023-08-13 |
Not clear |
| Nae Saito, Toshikuni Sasaok. [Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 11. 2020-11-17. PMID:33191292. |
[dopamine and nmda receptors in basal ganglia circuits and their roles regarding motor control and learning]. |
2020-11-17 |
2023-08-13 |
mouse |
| Nae Saito, Toshikuni Sasaok. [Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 11. 2020-11-17. PMID:33191292. |
dopamine (da) plays an important role in the basal ganglia (bg) for motor control, and da deficiency as seen in parkinson's disease, causes movement disorders. |
2020-11-17 |
2023-08-13 |
mouse |
| Takatoshi Hikida, Shuhei Yao, Tom Macpherson, Ayumi Fukakusa, Makiko Morita, Haruhide Kimura, Keisuke Hirai, Tatsuya Ando, Hiroyoshi Toyoshiba, Akira Saw. Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex. Scientific reports. vol 10. issue 1. 2020-11-10. PMID:32020036. |
within this circuit, two distinct nucleus accumbens (nac) output neuron types, dopamine d1 or d2 receptor-expressing neurons, dynamically control the flow of information through basal ganglia nuclei that eventually project back to the mpfc to complete the loop. |
2020-11-10 |
2023-08-13 |
mouse |
| Fernando E Padovan-Neto, Santanna Patterson, Nivea M F Voelkner, Feras Altwal, Joel A Beverley, Anthony R West, Heinz Steine. Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31468338. |
dopamine and serotonin in the basal ganglia interact in a bidirectional manner. |
2020-11-05 |
2023-08-13 |
Not clear |