| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy R Dunn, Carlie A Hoffman, Kristen A Stout, Minagi Ozawa, Rohan K Dhamsania, Gary W Mille. Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain. Brain research. vol 1702. 2020-02-07. PMID:29274878. |
sv2c has been increasingly linked to dopamine and basal ganglia function. |
2020-02-07 |
2023-08-13 |
mouse |
| Anu G Nair, Liliana R V Castro, Marianne El Khoury, Victor Gorgievski, Bruno Giros, Eleni T Tzavara, Jeanette Hellgren-Kotaleski, Pierre Vincen. The high efficacy of muscarinic M4 receptor in D1 medium spiny neurons reverses striatal hyperdopaminergia. Neuropharmacology. vol 146. 2020-01-23. PMID:30468798. |
the opposing action of dopamine and acetylcholine has long been known to play an important role in basal ganglia physiology. |
2020-01-23 |
2023-08-13 |
Not clear |
| b' Rosaria De Luca, Desiree Latella, Maria Grazia Maggio, Giuseppe Di Lorenzo, Giuseppa Maresca, Francesca Sciarrone, David Militi, Placido Bramanti, Rocco Salvatore Calabr\\xc3\\xb. Computer assisted cognitive rehabilitation improves visuospatial and executive functions in Parkinson\'s disease: Preliminary results. NeuroRehabilitation. vol 45. issue 2. 2020-01-22. PMID:31498141.' |
parkinson's disease (pd) is a neurodegenerative disease due to dopamine deficiency in the basal ganglia, leading to motor symptoms such as bradykinesia, tremor, stiffness, and postural instability. |
2020-01-22 |
2023-08-13 |
Not clear |
| Masayuki Nakamori, Eunsung Junn, Hideki Mochizuki, M Maral Mouradia. Nucleic Acid-Based Therapeutics for Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 2. 2020-01-09. PMID:30756362. |
accordingly, nucleic acid-based therapeutics for pd include strategies to deliver dopamine biosynthetic enzymes to boost dopamine production or modulate the basal ganglia circuitry in order to improve motor symptoms. |
2020-01-09 |
2023-08-13 |
Not clear |
| Laurent Goetz, Brigitte Piallat, Manik Bhattacharjee, Hervé Mathieu, Olivier David, Stéphan Chabardè. Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP-induced primate model of Parkinson disease. Neurobiology of disease. vol 128. 2020-01-06. PMID:30086388. |
the increased burst activity under dopamine depletion confirms that this specific spike discharge pattern activity also observed in other basal ganglia nuclei and in different pathologies could play a mojor role in the pathophysiology of the disease and could explain several symptoms of pd including the freezing of gait. |
2020-01-06 |
2023-08-13 |
Not clear |
| Dmitrii I Todorov, Robert A Capps, William H Barnett, Elizaveta M Latash, Taegyo Kim, Khaldoun C Hamade, Sergey N Markin, Ilya A Rybak, Yaroslav I Molko. The interplay between cerebellum and basal ganglia in motor adaptation: A modeling study. PloS one. vol 14. issue 4. 2019-12-20. PMID:30978216. |
to do so, this circuit modulates learning rate in the cerebellum and dopamine release in basal ganglia depending on error-based learning efficiency. |
2019-12-20 |
2023-08-13 |
Not clear |
| M. Amalric, C. Baunez, A. Nieoullo. Does the blockade of excitatory amino acid transmission in the basal ganglia simply reverse reaction time deficits induced by dopamine inactivation? Behavioural pharmacology. vol 6. issue 5 And 6. 2019-11-20. PMID:11224358. |
does the blockade of excitatory amino acid transmission in the basal ganglia simply reverse reaction time deficits induced by dopamine inactivation? |
2019-11-20 |
2023-08-12 |
rat |
| M. Amalric, C. Baunez, A. Nieoullo. Does the blockade of excitatory amino acid transmission in the basal ganglia simply reverse reaction time deficits induced by dopamine inactivation? Behavioural pharmacology. vol 6. issue 5 And 6. 2019-11-20. PMID:11224358. |
it has recently been hypothesized that excessive excitatory amino acid (eaa) activity in the corticostriatal pathway and in the subthalamic nucleus could account for the expression of the motor deficits resulting from alteration in dopamine function in the basal ganglia. |
2019-11-20 |
2023-08-12 |
rat |
| Ph. Damie. [On-off fluctuations] Revue neurologique. vol 158. issue 122. 2019-11-20. PMID:12690318. |
a reduction in dopamine storage capacity) are clearly involved, there are also complex postsynaptic anomalies, affecting all the basal ganglia circuitry. |
2019-11-20 |
2023-08-12 |
Not clear |
| Arun Sing. Oscillatory activity in the cortico-basal ganglia-thalamic neural circuits in Parkinson's disease. The European journal of neuroscience. vol 48. issue 8. 2019-11-14. PMID:29381817. |
dopamine is an important neurotransmitter that maintains the balance within the basal ganglia between the direct pathway, which promotes movement, and the indirect pathway, which inhibits movement. |
2019-11-14 |
2023-08-13 |
Not clear |
| Véronique Sgambato, Léon Trembla. Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29502255. |
the same pathological mechanism, i.e., an imbalance between serotonin and dopamine terminals may, therefore, favor l-dopa-induced adverse effects according to the basal ganglia territory it inhabits. |
2019-11-04 |
2023-08-13 |
monkey |
| Nedjeljka Ivica, Ulrike Richter, Joel Sjöbom, Ivani Brys, Martin Tamtè, Per Petersso. Changes in neuronal activity of cortico-basal ganglia-thalamic networks induced by acute dopaminergic manipulations in rats. The European journal of neuroscience. vol 47. issue 3. 2019-10-22. PMID:29250896. |
the basal ganglia are thought to be particularly sensitive to changes in dopaminergic tone, and the realization that reduced dopaminergic signaling causes pronounced motor dysfunction is the rationale behind dopamine replacement therapy in parkinson's disease. |
2019-10-22 |
2023-08-13 |
rat |
| Jin-Zhong Huang, Yi Ren, Yuan Xu, Tao Chen, Terry C Xia, Zhuo-Ri Li, Jian-Nong Zhao, Fei Hua, Shi-Ying Sheng, Ying Xi. The delta-opioid receptor and Parkinson's disease. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:30076686. |
although it is known that the major characteristics of pd pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for pd are limited in clinical settings up to date. |
2019-10-14 |
2023-08-13 |
Not clear |
| Mark D Humphries, Jose Angel Obeso, Jakob Kisbye Dreye. Insights into Parkinson's disease from computational models of the basal ganglia. Journal of neurology, neurosurgery, and psychiatry. vol 89. issue 11. 2019-10-03. PMID:29666208. |
for mechanisms, we review models that capture the effects of losing dopamine on basal ganglia function; for dynamics, we discuss models that have transformed our understanding of how beta-band (15-30 hz) oscillations arise in the parkinsonian basal ganglia. |
2019-10-03 |
2023-08-13 |
Not clear |
| Thomas Wichmann, Hagai Bergman, Mahlon R DeLon. Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 3. 2019-09-27. PMID:28601961. |
striatal dopamine release alters the activity of striatal projection neurons which, in turn, influences the (inhibitory) basal ganglia output. |
2019-09-27 |
2023-08-13 |
Not clear |
| Thomas Wichmann, Hagai Bergman, Mahlon R DeLon. Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 3. 2019-09-27. PMID:28601961. |
in parkinsonism, the loss of striatal dopamine results in the emergence of oscillatory burst patterns of firing of basal ganglia output neurons, increased synchrony of the discharge of neighboring basal ganglia neurons, and an overall increase in basal ganglia output. |
2019-09-27 |
2023-08-13 |
Not clear |
| Tiago V Maia, Vasco A Conceiçã. Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account. Biological psychiatry. vol 84. issue 5. 2019-09-27. PMID:29656800. |
we have previously shown, using a computational model of the role of dopamine in basal ganglia, that increased tonic dopamine and increased phasic dopamine likely increase the propensities to express and learn tics, respectively. |
2019-09-27 |
2023-08-13 |
Not clear |
| Elijah A Petter, Samuel J Gershman, Warren H Mec. Integrating Models of Interval Timing and Reinforcement Learning. Trends in cognitive sciences. vol 22. issue 10. 2019-09-23. PMID:30266150. |
we describe how these systems are subserved by a computational division of labor between several brain regions, with a focus on the basal ganglia and the hippocampus, as well as how these regions are influenced by the neuromodulator dopamine. |
2019-09-23 |
2023-08-13 |
Not clear |
| Giada Spigolon, Anna Cavaccini, Massimo Trusel, Raffaella Tonini, Gilberto Fison. cJun N-terminal kinase (JNK) mediates cortico-striatal signaling in a model of Parkinson's disease. Neurobiology of disease. vol 110. 2019-09-06. PMID:29107639. |
this effect is secondary to dopamine depletion, and is restricted to the striatal projection neurons that innervate directly the output structures of the basal ganglia (dspn). |
2019-09-06 |
2023-08-13 |
mouse |
| Jan Aaseth, Petr Dusek, Per M Roo. Prevention of progression in Parkinson's disease. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 31. issue 5. 2019-08-19. PMID:30030679. |
such exposure together with mitochondrial dysfunction evokes a destructive cascade of biochemical events, including oxidative stress and degeneration of the sensitive dopamine (da) production system in the basal ganglia. |
2019-08-19 |
2023-08-13 |
Not clear |