| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy R Dunn, Kristen A Stout, Minagi Ozawa, Kelly M Lohr, Carlie A Hoffman, Alison I Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W Michael Caudle, Gary W Mille. Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 11. 2018-04-23. PMID:28246328. |
here we identify sv2c as a mediator of dopamine homeostasis and report that disrupted expression of sv2c within the basal ganglia is a pathological feature of pd. |
2018-04-23 |
2023-08-13 |
mouse |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Variation on the dopamine D2 receptor gene (DRD2) is associated with basal ganglia-to-frontal structural connectivity. NeuroImage. vol 155. 2018-04-20. PMID:28392487. |
carriers of the cc genotype who are characterized by elevated striatal dopamine turnaround showed higher integrity in terms of fractional anisotropy on fiber tracts between the basal ganglia and frontal regions compared to carriers of the ct and tt variant. |
2018-04-20 |
2023-08-13 |
human |
| Janet Charoensook, Gerald A Maguir. A case series on the effectiveness of lurasidone in patients with stuttering. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 29. issue 3. 2018-04-17. PMID:28738099. |
the dopamine hypothesis of stuttering explains that abnormally increased cerebral dopamine affects the balanced levels that maintain the basal ganglia circuits, which helps with timing cues in initiating speech. |
2018-04-17 |
2023-08-13 |
Not clear |
| Harith Akram, Chengyuan Wu, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Tarek Yousry, Marjan Jahanshahi, Marwan Hariz, Timothy Behrens, John Ashburner, Ludvic Zrinz. l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 6. 2018-03-30. PMID:28597560. |
neuronal loss and dopamine depletion alter motor signal processing between cortical motor areas, basal ganglia, and the thalamus, resulting in the motor manifestations of parkinson's disease. |
2018-03-30 |
2023-08-13 |
Not clear |
| Patrik Fazio, Martin Schain, Ladislav Mrzljak, Nahid Amini, Sangram Nag, Nabil Al-Tawil, Cheryl J Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Cristina Sampaio, Christer Halldin, Andrea Varron. Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D NeuroImage. vol 152. 2018-03-09. PMID:28254508. |
pde10a is expressed on striatal neurones in basal ganglia where other known molecular targets are enriched such as dopamine d |
2018-03-09 |
2023-08-13 |
Not clear |
| R Abboud, C Noronha, V A Diwadka. Motor system dysfunction in the schizophrenia diathesis: Neural systems to neurotransmitters. European psychiatry : the journal of the Association of European Psychiatrists. vol 44. 2018-03-07. PMID:28641214. |
at the molecular scale, both dopamine and γ-aminobutyric acid (gaba) abnormalities have been associated with working memory dysfunction, but particularly relating to the basal ganglia and the prefrontal cortex respectively. |
2018-03-07 |
2023-08-13 |
human |
| M J Sanchez-Catalan, J Kaufling, F Georges, P Veinante, M Barro. The antero-posterior heterogeneity of the ventral tegmental area. Neuroscience. vol 282. 2018-01-26. PMID:25241061. |
it controls vta and substantia nigra dopamine cells, thus exerting a major influence on basal ganglia functions. |
2018-01-26 |
2023-08-13 |
Not clear |
| Arun Singh, Klaus Mewes, Robert E Gross, Mahlon R DeLong, José A Obeso, Stella M Pap. Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 34. 2018-01-26. PMID:27503874. |
circuitry models of parkinson's disease (pd) are based on striatal dopamine loss and aberrant striatal inputs into the basal ganglia network. |
2018-01-26 |
2023-08-13 |
human |
| Katsuya Yamada, Susumu Takahashi, Fuyuki Karube, Fumino Fujiyama, Kazuto Kobayashi, Akinori Nishi, Toshihiko Momiyam. Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. The journal of physiological sciences : JPS. vol 66. issue 6. 2018-01-25. PMID:26979514. |
based on their expertise in their respective fields, as denoted in the text, the authors discuss five distinct research topics, as follows: (1) area-specific dopamine receptor expression of astrocytes in basal ganglia, (2) the role of physiologically released dopamine in the striatum, (3) control of behavioral flexibility by striatal cholinergic interneurons, (4) regulation of phosphorylation states of darpp-32 by protein phosphatases and (5) physiological perspective on deep brain stimulation with optogenetics and closed-loop control for ameliorating parkinsonism. |
2018-01-25 |
2023-08-13 |
Not clear |
| Wolfram Schult. Reward functions of the basal ganglia. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 7. 2018-01-23. PMID:26838982. |
this review describes the reward functions of three brain structures that are major components of the basal ganglia or are closely associated with the basal ganglia, namely midbrain dopamine neurons, pedunculopontine nucleus, and striatum (caudate nucleus, putamen, nucleus accumbens). |
2018-01-23 |
2023-08-13 |
Not clear |
| Marta Celorrio, Diana Fernández-Suárez, Estefanía Rojo-Bustamante, Víctor Echeverry-Alzate, María J Ramírez, Cecilia J Hillard, José A López-Moreno, Rafael Maldonado, Julen Oyarzábal, Rafael Franco, María S Aymeric. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27318096. |
elements of the endocannabinoid system are strongly expressed in the basal ganglia where they suffer profound rearrangements after dopamine depletion. |
2018-01-11 |
2023-08-13 |
mouse |
| Jacob J Crouse, Joseph R Phillips, Marjan Jahanshahi, Ahmed A Moustaf. Postural instability and falls in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 5. 2018-01-02. PMID:26966928. |
the delayed effect of dopaminergic medication combined with the success of extrastriatal deep brain stimulation suggests that pi involves neurotransmitter systems other than dopamine and brain regions extending beyond the basal ganglia, further challenging the traditional view of pd as a predominantly single-system neurodegenerative disease. |
2018-01-02 |
2023-08-13 |
Not clear |
| W Michael Caudl. Occupational Metal Exposure and Parkinsonism. Advances in neurobiology. vol 18. 2017-12-28. PMID:28889266. |
of these, metals have received significant attention given their propensity to accumulate in the basal ganglia and participate in neurotoxic cascades, through the generation of reactive oxygen species as well as their pathogenic interaction with intracellular targets in the dopamine neuron. |
2017-12-28 |
2023-08-13 |
Not clear |
| Sten Grillner, Brita Robertso. The Basal Ganglia Over 500 Million Years. Current biology : CB. vol 26. issue 20. 2017-12-26. PMID:27780050. |
the 'indirect pathway' with dopamine d2 receptor-expressing spns and intrinsic basal ganglia nuclei is also conserved. |
2017-12-26 |
2023-08-13 |
Not clear |
| Karla De Michelis Mograbi, Ana Carolini Ferreira de Castro, Jainny Aniely Rocha de Oliveira, Patrick Jean Barbosa Sales, Luciene Covolan, Eliane Aparecida Del Bel, Albert Schiaveto de Souz. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiological reports. vol 5. issue 6. 2017-12-07. PMID:28351968. |
there is an interaction between dopamine and gaba in the basal ganglia and the blocking gabaa receptors may have therapeutic potential in the treatment of pd. |
2017-12-07 |
2023-08-13 |
mouse |
| Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cummin. Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408789. |
contrary to expectation, comparison of on- and off-sifrol results did not reveal any discernible occupancy in nucleus accumbens, or elsewhere in the extended striatum; present methods should be sensitive to a 10% change in dopamine d2/3 receptor availability in striatum; the significant findings elsewhere in the basal ganglia and in cerebral cortex are consistent with a predominance of d3 receptors in those structures, especially in substantia nigra, and imply that therapeutic effects of pramipexole may be obtained at sites outside the extended striatum. |
2017-11-17 |
2023-08-13 |
Not clear |
| K D Ersche, J Acosta-Cabronero, P S Jones, H Ziauddeen, R P L van Swelm, C M M Laarakkers, R Raha-Chowdhury, G B William. Disrupted iron regulation in the brain and periphery in cocaine addiction. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28221362. |
stimulant drugs acutely increase dopamine neurotransmission in the brain, and chronic use leads to neuroadaptive changes in the mesolimbic dopamine system and morphological changes in basal ganglia structures. |
2017-11-16 |
2023-08-13 |
Not clear |
| George F Koob, Nora D Volko. Neurobiology of addiction: a neurocircuitry analysis. The lancet. Psychiatry. vol 3. issue 8. 2017-11-09. PMID:27475769. |
the rewarding effects of drugs of abuse, development of incentive salience, and development of drug-seeking habits in the binge/intoxication stage involve changes in dopamine and opioid peptides in the basal ganglia. |
2017-11-09 |
2023-08-13 |
Not clear |
| Simone Engelender, Ole Isacso. The Threshold Theory for Parkinson's Disease. Trends in neurosciences. vol 40. issue 1. 2017-11-03. PMID:27894611. |
this is due to the larger functional reserve of the midbrain dopamine and integrated basal ganglia motor systems to control movement. |
2017-11-03 |
2023-08-13 |
Not clear |
| Mikael Lindahl, Jeanette Hellgren Kotalesk. Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model. eNeuro. vol 3. issue 6. 2017-10-24. PMID:28101525. |
untangling basal ganglia network dynamics and function: role of dopamine depletion and inhibition investigated in a spiking network model. |
2017-10-24 |
2023-08-13 |
Not clear |