| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cummin. Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408789. |
contrary to expectation, comparison of on- and off-sifrol results did not reveal any discernible occupancy in nucleus accumbens, or elsewhere in the extended striatum; present methods should be sensitive to a 10% change in dopamine d2/3 receptor availability in striatum; the significant findings elsewhere in the basal ganglia and in cerebral cortex are consistent with a predominance of d3 receptors in those structures, especially in substantia nigra, and imply that therapeutic effects of pramipexole may be obtained at sites outside the extended striatum. |
2017-11-17 |
2023-08-13 |
Not clear |
| K D Ersche, J Acosta-Cabronero, P S Jones, H Ziauddeen, R P L van Swelm, C M M Laarakkers, R Raha-Chowdhury, G B William. Disrupted iron regulation in the brain and periphery in cocaine addiction. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28221362. |
stimulant drugs acutely increase dopamine neurotransmission in the brain, and chronic use leads to neuroadaptive changes in the mesolimbic dopamine system and morphological changes in basal ganglia structures. |
2017-11-16 |
2023-08-13 |
Not clear |
| George F Koob, Nora D Volko. Neurobiology of addiction: a neurocircuitry analysis. The lancet. Psychiatry. vol 3. issue 8. 2017-11-09. PMID:27475769. |
the rewarding effects of drugs of abuse, development of incentive salience, and development of drug-seeking habits in the binge/intoxication stage involve changes in dopamine and opioid peptides in the basal ganglia. |
2017-11-09 |
2023-08-13 |
Not clear |
| Simone Engelender, Ole Isacso. The Threshold Theory for Parkinson's Disease. Trends in neurosciences. vol 40. issue 1. 2017-11-03. PMID:27894611. |
this is due to the larger functional reserve of the midbrain dopamine and integrated basal ganglia motor systems to control movement. |
2017-11-03 |
2023-08-13 |
Not clear |
| Mikael Lindahl, Jeanette Hellgren Kotalesk. Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model. eNeuro. vol 3. issue 6. 2017-10-24. PMID:28101525. |
untangling basal ganglia network dynamics and function: role of dopamine depletion and inhibition investigated in a spiking network model. |
2017-10-24 |
2023-08-13 |
Not clear |
| Mikael Lindahl, Jeanette Hellgren Kotalesk. Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model. eNeuro. vol 3. issue 6. 2017-10-24. PMID:28101525. |
we present a spiking neural model of basal ganglia including plausible details on synaptic dynamics, connectivity patterns, neuron behavior, and dopamine effects. |
2017-10-24 |
2023-08-13 |
Not clear |
| Mikael Lindahl, Jeanette Hellgren Kotalesk. Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model. eNeuro. vol 3. issue 6. 2017-10-24. PMID:28101525. |
additionally, reversing the dopamine depletion-induced changes to ctx-msn d1, ctx-msn d2, ta-msn, and msn-msn couplings could improve or restore basal ganglia action selection ability. |
2017-10-24 |
2023-08-13 |
Not clear |
| Andrew Sharott, Federica Vinciati, Kouichi C Nakamura, Peter J Magil. A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 41. 2017-10-23. PMID:28847810. |
classical schemes of basal ganglia organization posit that parkinsonian movement difficulties presenting after striatal dopamine depletion stem from the disproportionate firing rates of spiny projection neurons (spns) therein. |
2017-10-23 |
2023-08-13 |
rat |
| Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmic. Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor. CNS neuroscience & therapeutics. vol 23. issue 3. 2017-10-19. PMID:28071873. |
dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. |
2017-10-19 |
2023-08-13 |
Not clear |
| Christopher Pittenge. Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions. Handbook of experimental pharmacology. vol 241. 2017-10-19. PMID:28233179. |
parallel work in these ko mice and in human carriers of the hdc mutation has revealed abnormalities in the basal ganglia system and its modulation by dopamine (da) and has confirmed the etiologic, face, and predictive validity of the model. |
2017-10-19 |
2023-08-13 |
mouse |
| Concepción García, Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Javier Fernández-Rui. Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia. British journal of pharmacology. vol 173. issue 13. 2017-10-12. PMID:26059564. |
endocannabinoids and their receptors play a modulatory role in the control of dopamine transmission in the basal ganglia. |
2017-10-12 |
2023-08-13 |
Not clear |
| E P Bello, R Casas-Cordero, G L Galiñanes, E Casey, M A Belluscio, V Rodríguez, D Noaín, M G Murer, M Rubinstei. Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism. Molecular psychiatry. vol 22. issue 4. 2017-10-10. PMID:27431292. |
motor execution and planning are tightly regulated by dopamine d1 and d2 receptors present in basal ganglia circuits. |
2017-10-10 |
2023-08-13 |
mouse |
| S Lohani, A J Poplawsky, S-G Kim, B Moghadda. Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI. Molecular psychiatry. vol 22. issue 4. 2017-10-10. PMID:27457809. |
they further suggest that mesolimbic and non-limbic basal ganglia dopamine circuits are functionally connected and thus provide a potential novel framework for understanding dopamine-dependent functions and interpreting data obtained from human fmri studies. |
2017-10-10 |
2023-08-13 |
human |
| Mazhar Özkan, Nicholas W Johnson, Umit S Sehirli, Gavin L Woodhall, Ian M Stanfor. Dopamine acting at D1-like, D2-like and α1-adrenergic receptors differentially modulates theta and gamma oscillatory activity in primary motor cortex. PloS one. vol 12. issue 7. 2017-09-25. PMID:28732063. |
the loss of dopamine (da) in parkinson's is accompanied by the emergence of exaggerated theta and beta frequency neuronal oscillatory activity in the primary motor cortex (m1) and basal ganglia. |
2017-09-25 |
2023-08-13 |
rat |
| Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, Wenhua Zhen. The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget. vol 8. issue 32. 2017-09-25. PMID:28881851. |
dopamine and cyclic amp-regulated phosphoprotein of relative molecular mass 32,000 (darpp-32) is a cytosolic protein highly enriched in the medium spiny neurons of the neostriatum, considered as the most important integrator between the cortical input and the basal ganglia, and associated with motor control. |
2017-09-25 |
2023-08-13 |
Not clear |
| Tonghui Xu, Shaofang Wang, Rupa R Lalchandani, Jun B Din. Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex. Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 4. 2017-08-25. PMID:28343366. |
the basal ganglia have been well studied in the context of pd, and circuit changes in response to dopamine loss have been linked to the motor dysfunctions in pd. |
2017-08-25 |
2023-08-13 |
mouse |
| Hyun Joo Lee, Andrew J Weitz, David Bernal-Casas, Ben A Duffy, ManKin Choy, Alexxai V Kravitz, Anatol C Kreitzer, Jin Hyung Le. Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses. Neuron. vol 91. issue 2. 2017-08-22. PMID:27373834. |
a central theory of basal ganglia function is that striatal neurons expressing the d1 and d2 dopamine receptors exert opposing brain-wide influences. |
2017-08-22 |
2023-08-13 |
Not clear |
| Hagar Lavian, Mara Almog, Ravit Madar, Yocheved Loewenstern, Izhar Bar-Gad, Eitan Okun, Alon Korngree. Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 30. 2017-08-22. PMID:28652413. |
dopamine is known to differentially modulate the impact of cortical input to the striatum between the direct and indirect pathways of the basal ganglia (bg). |
2017-08-22 |
2023-08-13 |
rat |
| Antonio Suppa, Matteo Bologna, Antonella Conte, Alfredo Berardelli, Giovanni Fabbrin. The effect of L-dopa in Parkinson's disease as revealed by neurophysiological studies of motor and sensory functions. Expert review of neurotherapeutics. vol 17. issue 2. 2017-07-24. PMID:27477028. |
areas covered: we analyzed papers in english using pubmed with the following keywords: l-dopa, dopamine, bradykinesia, basal ganglia, kinematic analysis, tms, motor cortex plasticity, motor cortex excitability, somatosensory discrimination threshold, pain expert commentary: l-dopa improves the amplitude and speed of upper limb voluntary movements, but it does not restore abnormalities in the sequence effect or voluntary facial movements. |
2017-07-24 |
2023-08-13 |
Not clear |
| Donghwi Par. Pramipexole-induced limb dystonia and its associated complex regional pain syndrome in idiopathic Parkinson's disease: A case report. Medicine. vol 96. issue 28. 2017-07-24. PMID:28700507. |
this case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (d1r) boosted by pramipexole binding on dopamine 3-like receptor (d3r) in a situation where d3r was overexpressed by the chronic treatment of l-dopa. |
2017-07-24 |
2023-08-13 |
Not clear |