| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward H Nieh, Sung-Yon Kim, Praneeth Namburi, Kay M Ty. Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain research. vol 1511. 2013-12-09. PMID:23142759. |
within the mesolimbic dopamine system, optogenetics has helped separate subsets of dopamine neurons with distinct functions for reward, aversion and salience processing, elucidated gaba neuronal effects on behavior, and characterized connectivity with forebrain and cortical structures. |
2013-12-09 |
2023-08-12 |
Not clear |
| Kristin M Pearson-Fuhrhop, Brian Minton, Daniel Acevedo, Babak Shahbaba, Steven C Crame. Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa. PloS one. vol 8. issue 4. 2013-11-11. PMID:23613810. |
the current study examined the hypothesis that genetic variation in the dopamine system is associated with significant differences in motor learning, brain plasticity, and the effects of the dopamine precursor l-dopa. |
2013-11-11 |
2023-08-12 |
human |
| Mark J Ferris, Erin S Calipari, Jordan T Yorgason, Sara R Jone. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23581570. |
this technique is routinely used for the study of changes that occur in the dopamine system associated with various disease states and pharmacological treatments, and to study mechanisms of local circuitry regulation of dopamine terminal function. |
2013-10-22 |
2023-08-12 |
Not clear |
| I Heitland, J L Kenemans, R S Oosting, J M P Baas, K B E Böcke. Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females. Behavioural brain research. vol 249. 2013-10-21. PMID:23619133. |
in all subjects, genetic polymorphisms within the dopamine system (dopamine transporter [dat1], catecholamine-o-methyltransferase val158met [comt val158met]) and the serotonin system (serotonin transporter [5httlpr]) were assessed. |
2013-10-21 |
2023-08-12 |
human |
| Keke Qi, Chuguang Wei, Yonghui Li, Nan Su. Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference. Frontiers in behavioral neuroscience. vol 7. 2013-10-17. PMID:24133421. |
the nucleus accumbens shell (nacsh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the nacsh can be regulated by orexin transmission. |
2013-10-17 |
2023-08-12 |
Not clear |
| Pei Jiang, Wen-Yuan Zhang, Huan-De Li, Hua-Lin Cai, Ying Xu. Repeated haloperidol administration has no effect on vitamin D signaling but increase retinoid X receptors and Nur77 expression in rat prefrontal cortex. Cellular and molecular neurobiology. vol 33. issue 3. 2013-09-04. PMID:23324997. |
by blocking dopamine d2 receptor, haloperidol induces nur77 expression, suggesting a modulatory role of nur77 in brain dopamine system. |
2013-09-04 |
2023-08-12 |
rat |
| Gerald A Deehan, Sheketha R Hauser, Jessica A Wilden, William A Truitt, Zachary A Rod. Elucidating the biological basis for the reinforcing actions of alcohol in the mesolimbic dopamine system: the role of active metabolites of alcohol. Frontiers in behavioral neuroscience. vol 7. 2013-08-29. PMID:23986666. |
within this neurocircuitry there is convincing evidence that; (1) biologically active metabolites of alcohol can directly or indirectly increase the activity of vta dopamine neurons, (2) alcohol and alcohol metabolites are reinforcing within the mesolimbic dopamine system, (3) inhibiting the alcohol metabolic pathway inhibits the biological consequences of alcohol exposure, (4) alcohol consumption can be reduced by inhibiting/attenuating the alcohol metabolic pathway in the mesolimbic dopamine system, (5) alcohol metabolites can alter neurochemical levels within the mesolimbic dopamine system, and (6) alcohol interacts with alcohol metabolites to enhance the actions of both compounds. |
2013-08-29 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Jun Nakamur. [Nicotine dependence and its molecular pharmacology]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 3. 2013-08-22. PMID:23631238. |
mounting evidence indicates that addictive effects of nicotine occur through interaction with its receptors in the mesolimbic dopamine system, particularly ventral tegmental area neurons, where nicotinic acetylcholine receptors (nachrs) act to promote the release of dopamine. |
2013-08-22 |
2023-08-12 |
Not clear |
| Aaron G Roseberr. Altered feeding and body weight following melanocortin administration to the ventral tegmental area in adult rats. Psychopharmacology. vol 226. issue 1. 2013-07-30. PMID:23010797. |
the mesolimbic dopamine system is another component of the central circuitry controlling feeding, and there is evidence that melanocortins can act on mesolimbic dopamine pathways. |
2013-07-30 |
2023-08-12 |
rat |
| Erin S Calipari, Kimberly N Huggins, Tiffany A Mathews, Sara R Jone. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22819794. |
although the vast majority of research on the dopamine system has been performed in rodents, and it is assumed that this work will inform us about the human condition, there have been very few direct comparisons of presynaptic dopamine terminal function across multiple species. |
2013-06-05 |
2023-08-12 |
mouse |
| V Mileva-Seitz, A S Fleming, M J Meaney, A Mastroianni, J P Sinnwell, M Steiner, L Atkinson, R D Levitan, S G Matthews, J L Kennedy, M B Sokolowsk. Dopamine receptors D1 and D2 are related to observed maternal behavior. Genes, brain, and behavior. vol 11. issue 6. 2013-05-30. PMID:22574669. |
the dopamine pathway and especially the dopamine receptors 1 and 2 (drd1 and drd2) are implicated in the regulation of mothering in rats. |
2013-05-30 |
2023-08-12 |
human |
| Joshua M Bradner, Tiffany A Suragh, W Wyatt Wilson, Carlos R Lazo, Kristen A Stout, Hye Mi Kim, Min Z Wang, Douglas I Walker, Kurt D Pennell, Jason R Richardson, Gary W Miller, W Michael Caudl. Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity. Experimental neurology. vol 241. 2013-04-08. PMID:23287494. |
exposure to the polybrominated diphenyl ether mixture de-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity. |
2013-04-08 |
2023-08-12 |
mouse |
| Joshua M Bradner, Tiffany A Suragh, W Wyatt Wilson, Carlos R Lazo, Kristen A Stout, Hye Mi Kim, Min Z Wang, Douglas I Walker, Kurt D Pennell, Jason R Richardson, Gary W Miller, W Michael Caudl. Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity. Experimental neurology. vol 241. 2013-04-08. PMID:23287494. |
the purpose of this study was to evaluate the neurotoxic effects of the pbde mixture, de-71, on the nigrostriatal dopamine system and address the role of altered dopamine handling in mediating this neurotoxicity. |
2013-04-08 |
2023-08-12 |
mouse |
| Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Shih-Heng Chen, Chun-Hsien Chu, Chen-Lin Wang, I Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru-Band L. Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. Progress in neuro-psychopharmacology & biological psychiatry. vol 40. 2013-03-26. PMID:23044341. |
several studies have hypothesized that genes involved in the dopamine system, including dopamine type-2 receptor (drd2)-related taqia polymorphism and monoamine oxidase-a upstream variable number tandem repeat (uvntr), may be associated with alcoholism. |
2013-03-26 |
2023-08-12 |
Not clear |
| Jason R Cannon, Kindiya D Geghman, Victor Tapias, Thomas Sew, Michelle K Dail, Chenjian Li, J Timothy Greenamyr. Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Experimental neurology. vol 240. 2013-03-25. PMID:23153578. |
at 12 months of age, there was no overt damage to the nigrostriatal dopamine system; however, (i) alterations in striatal neurotransmitter metabolism, (ii) accumulation and aggregation of α-synuclein in nigral dopamine neurons, and (iii) evidence of oxidative stress suggest this model replicates several preclinical features of pd. |
2013-03-25 |
2023-08-12 |
human |
| Dragos Inta, Juan M Lima-Ojeda, Peter Gass, Paolo Fusar-Pol. Postnatal neurogenesis and dopamine alterations in early psychosis. Recent patents on CNS drug discovery. vol 7. issue 3. 2013-03-22. PMID:22963280. |
we discuss also in light of a recently proposed theoretical model the possible relevance of disturbed neurogenesis for the dopamine system, focusing on the dopamine receptors associated with neurogenesis, the d3 receptors, and a d3-expressing structure derived from the subventricular zone, the islands of calleja. |
2013-03-22 |
2023-08-12 |
Not clear |
| Kay M Tye, Julie J Mirzabekov, Melissa R Warden, Emily A Ferenczi, Hsing-Chen Tsai, Joel Finkelstein, Sung-Yon Kim, Avishek Adhikari, Kimberly R Thompson, Aaron S Andalman, Lisa A Gunaydin, Ilana B Witten, Karl Deisserot. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. vol 493. issue 7433. 2013-03-04. PMID:23235822. |
dopamine neurons involved in reward and motivation are among many neural populations that have been hypothesized to be relevant, and certain antidepressant treatments, including medications and brain stimulation therapies, can influence the complex dopamine system. |
2013-03-04 |
2023-08-12 |
Not clear |
| Lea Thaler, Patricia Groleau, Guilaine Badawi, Lindsay Sycz, Nadia Zeramdini, Andrea Too, Mimi Israel, Ridha Joober, Kenneth R Bruce, Howard Steige. Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22683321. |
our findings suggest that genes acting in the dopamine system interact to influence both eating-related and personality psychopathology, with the result that lower levels of dopamine neuro-transmission correspond to increased psychopathology and body mass in women with bulimia-spectrum disorders. |
2013-01-21 |
2023-08-12 |
Not clear |
| Kohji Sat. Disruption of spine homeostasis causes dopaminergic compensatory up-regulation, resulting in schizophrenia. Medical hypotheses. vol 79. issue 3. 2012-12-12. PMID:22683237. |
since spine homeostasis is deeply regulated by dopamine d1 receptors, disturbed spine homeostasis leads to compensatory hyperactivity in the dopamine system to keep normal cognitive functions. |
2012-12-12 |
2023-08-12 |
Not clear |
| Robert H Howlan. Baclofen for the treatment of alcohol dependence. Journal of psychosocial nursing and mental health services. vol 50. issue 10. 2012-12-07. PMID:22998536. |
the mesolimbic dopamine system is a major component of the brain's reward pathways, and gaba neurons are part of this system, decreasing the activity of dopamine neurons through the inhibitory effects of gaba-b receptors. |
2012-12-07 |
2023-08-12 |
human |