| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Sun Choi, Bang-sub Choi, Sang Heon Kim, Sok Cheon Pak, Chul Ho Jang, Young-Won Chin, Young-Mi Kim, Dong-il Kim, Songhee Jeon, Byung-Soo Ko. Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells. Journal of medicinal food. vol 18. issue 10. 2016-07-13. PMID:26295793. |
the dopamine transporter (dat) protein, a component of the dopamine system, undergoes adaptive neurobiological changes from drug abuse. |
2016-07-13 |
2023-08-13 |
rat |
| Katherine Stuhrman, Aaron G Roseberr. Neurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons. Journal of neurophysiology. vol 114. issue 3. 2016-06-17. PMID:26180119. |
there is substantial evidence that the neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate dopamine neuron activity. |
2016-06-17 |
2023-08-13 |
mouse |
| b' Assunta Pelosi, Jean-Antoine Girault, Denis Herv\\xc3\\xa. Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse. PloS one. vol 10. issue 9. 2016-05-25. PMID:26397369.' |
grooming behaviour is known to be affected by alterations of the dopamine system, including dopamine receptor modulation, dopamine alteration in genetically modified animals, and after brain lesion. |
2016-05-25 |
2023-08-13 |
mouse |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mechanisms of ageing and development. vol 149. 2016-05-10. PMID:26065381. |
the nigrostriatal dopamine pathway is one component of this system, with deficits in dopamine signalling contributing to major motor dysfunction, as exemplified in parkinson's disease (pd). |
2016-05-10 |
2023-08-13 |
rat |
| Cody A Siciliano, Mark J Ferris, Sara R Jone. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. The European journal of neuroscience. vol 42. issue 4. 2016-05-06. PMID:26037018. |
cocaine acts on the dopamine system to exert its reinforcing effects and it is thought that cocaine-induced dysregulation of dopamine neurotransmission contributes to the difficulty that cocaine addicts exhibit in selecting environmentally appropriate behaviors. |
2016-05-06 |
2023-08-13 |
rat |
| A Rieckmann, S N Gomperts, K A Johnson, J H Growdon, K R A Van Dij. Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases. NeuroImage. Clinical. vol 8. 2016-04-04. PMID:26137443. |
this study examines whether individual differences in midbrain-striatal connectivity are proportional to the integrity of the dopamine system in patients with nigrostriatal dopamine loss (parkinson's disease and dementia with lewy bodies). |
2016-04-04 |
2023-08-13 |
Not clear |
| R Salgado, S López-Doval, N Pereiro, A Lafuent. Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions. Toxicology letters. vol 240. issue 1. 2016-03-28. PMID:26529483. |
the obtained results suggest that: (1) pfos can alter the dopamine system by modifying its neuronal activity and/or its d1 and d2 receptors in the studied brain regions; (2) the dopamine concentration and metabolism seem to be more sensitive against pfos toxicity in the hippocampus than in the other analyzed brain areas; (3) the inhibited gene and protein expression of the d1 receptors induced by pfos in the amygdala could be related to several changes in the hpa axis activity, and lastly; (4) the observed alterations on the dopamine system induced by pfos could be a possible neurotoxicity mechanism of pfos, leading to many neurological diseases. |
2016-03-28 |
2023-08-13 |
rat |
| Kelly M Lohr, Kristen A Stout, Amy R Dunn, Minzheng Wang, Ali Salahpour, Thomas S Guillot, Gary W Mille. Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25746685. |
based on the altered compartmentalization of intracellular dopamine in the vmat2-hi mice, we assessed whether enhanced vesicular function was capable of reducing meth-induced damage to the striatal dopamine system. |
2016-03-07 |
2023-08-13 |
mouse |
| Marcus Lira Brandão, Amanda Ribeiro de Oliveira, Sangu Muthuraju, Ana Caroline Colombo, Viviane Mitsuko Saito, Teddy Talbo. Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear. FEBS letters. vol 589. issue 22. 2016-02-15. PMID:25783771. |
dopamine d2 receptor inhibition in the terminal fields of the mesolimbic dopamine system generally causes anxiolytic-like effects, whereas the activity of midbrain substrates of unconditioned fear are enhanced by d2 receptor antagonists, suggesting that d2 receptor-mediated mechanisms play opposing roles in fear/anxiety processes, depending on the brain region under study. |
2016-02-15 |
2023-08-13 |
rat |
| Emma Arvidsson, Thomas Viereckel, Sanja Mikulovic, Åsa Wallén-Mackenzi. Age- and sex-dependence of dopamine release and capacity for recovery identified in the dorsal striatum of C57/Bl6J mice. PloS one. vol 9. issue 6. 2015-12-14. PMID:24925086. |
several components of the dopamine system have been shown to vary with age and sex, however knowledge of the contribution of these factors for dopamine release kinetics in the c57/bl6j mouse strain is lacking. |
2015-12-14 |
2023-08-13 |
mouse |
| Deanna M Barch, Michael T Treadway, Nathan Schoe. Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment. Journal of abnormal psychology. vol 123. issue 2. 2015-09-03. PMID:24886012. |
in animal models, dopamine abnormalities decrease willingness to work for rewards, implicating dopamine (da) function as a candidate substrate for negative symptoms given that schizophrenia involves dysregulation of the dopamine system. |
2015-09-03 |
2023-08-13 |
Not clear |
| Darakhshan J Halee. 5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson's disease and schizophrenia. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25503261. |
the striatum, the terminal region of the nigrostriatal dopamine pathway, is the main input nucleus of the basal ganglia, and dopamine neurotransmission through the nigrostriatal pathway plays a crucial role in the modulation of basal ganglia output and mediated behaviors. |
2015-09-03 |
2023-08-13 |
Not clear |
| Timo Berse, Kathrin Rolfes, Jonathan Barenberg, Stephan Dutke, Gregor Kuhlenbäumer, Klaus Völker, Bernward Winter, Michael Wittig, Stefan Knech. Acute physical exercise improves shifting in adolescents at school: evidence for a dopaminergic contribution. Frontiers in behavioral neuroscience. vol 9. 2015-08-18. PMID:26283937. |
exercise-induced performance gains in switch costs were predicted by a single nucleotide polymorphism (snp) targeting the dopamine transporter (dat1/slca6a3) gene suggesting that the brain dopamine system contributed to the effect. |
2015-08-18 |
2023-08-13 |
human |
| Judith V Schweimer, Gaelle S L Coullon, Jill F Betts, Philip W J Burnet, Sandra J Engle, Nicholas J Brandon, Paul J Harrison, Trevor Shar. Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. The European journal of neuroscience. vol 40. issue 7. 2015-06-29. PMID:25040393. |
in schizophrenia, the critical neurochemical abnormality affects dopamine, but to date there is little evidence that dao impacts on the dopamine system. |
2015-06-29 |
2023-08-13 |
mouse |
| L J van der Knaap, J M Schaefer, I H A Franken, F C Verhulst, F V A van Oort, H Ries. Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:24902721. |
the dopamine system plays a role in substance use, and catechol-o-methyltransferase (comt) is an important enzyme that degrades dopamine. |
2015-05-22 |
2023-08-13 |
Not clear |
| Alexandra Stolyarova, Alicia Izquierd. Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood. Frontiers in behavioral neuroscience. vol 9. 2015-05-22. PMID:25999830. |
additionally, we examined developmental differences in dopamine d1-like receptor (d1r), dopamine d2-like receptor (d2r), and polysialylated neural cell adhesion molecule (psa-ncam) expression in animals that were trained on an effortful reward valuation task, given that these proteins play an important role in the functional development of the amygdala-prefrontocortical (pfc) circuit and mesocorticolimbic dopamine system. |
2015-05-22 |
2023-08-13 |
Not clear |
| Guido K W Fran. Could dopamine agonists aid in drug development for anorexia nervosa? Frontiers in nutrition. vol 1. 2015-05-19. PMID:25988121. |
treatment with dopamine antagonists has shown little benefit, and it is possible that antagonists over time increase an already hypersensitive dopamine pathway activity in anorexia nervosa. |
2015-05-19 |
2023-08-13 |
Not clear |
| Rhona B C Clarke, Louise Adermark, PeiPei Chau, Bo Söderpalm, Mia Ericso. Increase in nucleus accumbens dopamine levels following local ethanol administration is not mediated by acetaldehyde. Alcohol and alcoholism (Oxford, Oxfordshire). vol 49. issue 5. 2015-05-12. PMID:25063803. |
ethanol (etoh) activates the mesolimbic dopamine system and increases dopamine levels in the nucleus accumbens (nac), which is believed to underlie the rewarding effects of alcohol. |
2015-05-12 |
2023-08-13 |
Not clear |
| Jörgen A Engel, Elisabet Jerlha. Alcohol: mechanisms along the mesolimbic dopamine system. Progress in brain research. vol 211. 2015-04-06. PMID:24968782. |
an important part of these systems is the mesolimbic dopamine system, consisting of a dopamine projection from the ventral tegmental area to nucleus accumbens. |
2015-04-06 |
2023-08-13 |
Not clear |
| Li Chen, Stephanie M Perez, Daniel J Lodg. An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia. Developmental neurobiology. vol 74. issue 9. 2015-02-27. PMID:24554310. |
furthermore, we now report that while the afferent regulation of ventral tegmental area dopamine neurons (from the hippocampus and pedunculopontine tegmental area) appears intact in preadolescent rats, the behavioral response to alterations in dopamine system function appears to be attenuated in preadolescent rats. |
2015-02-27 |
2023-08-12 |
rat |