| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louise Adermark, Bo Söderpalm, John M Burkhard. Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine. Alcohol (Fayetteville, N.Y.). vol 48. issue 5. 2015-02-23. PMID:24961541. |
the mechanisms underlying ethanol-induced activation of the mesolimbic dopamine system are not fully understood, but increased extracellular dopamine in the nucleus accumbens (nac) has been shown to involve nicotinic acetylcholine receptors (nachrs). |
2015-02-23 |
2023-08-13 |
mouse |
| Erin S Calipari, Sara R Jone. Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Neuropharmacology. vol 82. 2015-01-09. PMID:24632529. |
long-access methylphenidate (mph) self-administration has been shown to produce enhanced amphetamine potency at the dopamine transporter and concomitant changes in reinforcing efficacy, suggesting that mph abuse may change the dopamine system in a way that promotes future drug abuse. |
2015-01-09 |
2023-08-12 |
Not clear |
| Ramón Sotomayor-Zárate, Pablo Jara, Patricio Araos, Raúl Vinet, Gabriel Quiroz, Georgina M Renard, Pedro Espinosa, Claudio Hurtado-Guzmán, Pablo R Moya, Patricio Iturriaga-Vásquez, Katia Gysling, Miguel Reyes-Parad. Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction. Basic & clinical pharmacology & toxicology. vol 114. issue 5. 2014-12-18. PMID:24314229. |
in this work, we show that similarly to mta, n,n-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic activation. |
2014-12-18 |
2023-08-12 |
Not clear |
| Catherine Insel, Jenna Reinen, Jochen Weber, Tor D Wager, L Fredrik Jarskog, Daphna Shohamy, Edward E Smit. Antipsychotic dose modulates behavioral and neural responses to feedback during reinforcement learning in schizophrenia. Cognitive, affective & behavioral neuroscience. vol 14. issue 1. 2014-12-16. PMID:24557585. |
schizophrenia is characterized by an abnormal dopamine system, and dopamine blockade is the primary mechanism of antipsychotic treatment. |
2014-12-16 |
2023-08-12 |
human |
| Meiling Yang, Yuanyuan Wei, Feng Jiang, Yanli Wang, Xiaojiao Guo, Jing He, Le Kan. MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. PLoS genetics. vol 10. issue 2. 2014-12-15. PMID:24586212. |
in this study, we report the participation of mir-133 in dopamine production and the behavioral transition by negatively regulating two critical genes, henna and pale, in the dopamine pathway. |
2014-12-15 |
2023-08-12 |
Not clear |
| Eagle Yi-Kung Huang, Tung-Han Tsai, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang, Yuan-Hao Che. Remote effects on the striatal dopamine system after fluid percussion injury. Behavioural brain research. vol 267. 2014-12-11. PMID:24675161. |
to investigate the effects of traumatic brain injury (tbi) on the dopamine system in the brain at different distances from the impaction site, we compared the release, reuptake, metabolism, and release probability of dopamine on the sides of the brain ipsilateral and contralateral to the injury at different time points after varying severities of fluid percussion injuries. |
2014-12-11 |
2023-08-12 |
Not clear |
| Jamie H Rose, Erin S Calipari, Tiffany A Mathews, Sara R Jone. Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PloS one. vol 8. issue 12. 2014-09-29. PMID:24349553. |
because of the role of the dopamine system in reinforcement and reward learning, differences in dopamine signaling between the strains could have implications for addiction-related behaviors that extend beyond ethanol effects in the striatum. |
2014-09-29 |
2023-08-12 |
mouse |
| Mark J Ferris, Rodrigo A España, Jason L Locke, Joanne K Konstantopoulos, Jamie H Rose, Rong Chen, Sara R Jone. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 26. 2014-09-23. PMID:24979798. |
understanding diurnal variation in dopamine tone is critical for understanding and treating the multitude of psychiatric disorders that originate from perturbations of the dopamine system. |
2014-09-23 |
2023-08-13 |
mouse |
| Stefanie L Bronson, Tracy L Bal. Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment. Endocrinology. vol 155. issue 7. 2014-08-25. PMID:24797632. |
fitting with these outcomes and supportive of dopamine pathway involvement, expression of dopamine d1 and d2 receptors was altered by eps in males. |
2014-08-25 |
2023-08-13 |
mouse |
| Anni Richter, Marc Guitart-Masip, Adriana Barman, Catherine Libeau, Gusalija Behnisch, Sophia Czerney, Denny Schanze, Anne Assmann, Marieke Klein, Emrah Düzel, Martin Zenker, Constanze I Seidenbecher, Björn H Schot. Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression. Frontiers in systems neuroscience. vol 8. 2014-08-22. PMID:25147510. |
in all mammals, including humans, the monoamine neurotransmitter dopamine is particularly important in the neural manifestation of appetitively motivated behavior, and the human dopamine system is subject to considerable genetic variability. |
2014-08-22 |
2023-08-13 |
human |
| Oliver D Howes, Robin M Murra. Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet (London, England). vol 383. issue 9929. 2014-08-20. PMID:24315522. |
in this review we show that developmental alterations secondary to variant genes, early hazards to the brain, and childhood adversity sensitise the dopamine system, and result in excessive presynaptic dopamine synthesis and release. |
2014-08-20 |
2023-08-12 |
Not clear |
| Jianjun Sun, Evguenia Kouranova, Xiaoxia Cui, Robert H Mach, Jinbin X. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24157858. |
these distinctive changes in the expression of dopamine presynaptic markers and receptors in the striatum may reflect different compensatory regulation of dopamine system in dj-1 versus pink1 knockout rat models of familial pd. |
2014-08-18 |
2023-08-12 |
rat |
| Kathryn E Merritt, Ryan K Bachtel. Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. PloS one. vol 8. issue 11. 2014-08-08. PMID:24223783. |
the activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. |
2014-08-08 |
2023-08-12 |
rat |
| Toni-Kim Clarke, Amy R D Weiss, Thomas N Ferarro, Kyle M Kampman, Charles A Dackis, Helen M Pettinati, Charles P O'brien, David W Oslin, Falk W Lohoff, Wade H Berrettin. The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. Annals of human genetics. vol 78. issue 1. 2014-08-01. PMID:24359476. |
genes of the dopamine system are likely candidates to harbour risk variants, as dopamine neurotransmission is involved in mediating the rewarding effects of drugs of abuse. |
2014-08-01 |
2023-08-12 |
Not clear |
| George F Koob, Cara L Buck, Ami Cohen, Scott Edwards, Paula E Park, Joel E Schlosburg, Brooke Schmeichel, Leandro F Vendruscolo, Carrie L Wade, Timothy W Whitfield, Olivier Georg. Addiction as a stress surfeit disorder. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23747571. |
excessive activation of the nucleus accumbens via the release of mesocorticolimbic dopamine or activation of opioid receptors has long been hypothesized to subsequently activate the dynorphin-κ opioid system, which in turn can decrease dopaminergic activity in the mesocorticolimbic dopamine system. |
2014-07-29 |
2023-08-12 |
Not clear |
| Li Chen, Daniel J Lodg. The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons. Journal of neurophysiology. vol 110. issue 10. 2014-06-28. PMID:24004527. |
taken together, we provide further evidence that the mesopontine tegmentum regulates discrete dopamine neuron activity states that are relevant for the understanding of dopamine system function in both normal and disease states. |
2014-06-28 |
2023-08-12 |
Not clear |
| Sarah H Lockie, Zane B Andrew. The hormonal signature of energy deficit: Increasing the value of food reward. Molecular metabolism. vol 2. issue 4. 2014-06-24. PMID:24327949. |
these processes are mediated by a number of alterations in the mesolimbic dopamine system which serves to increase dopamine availability in the forebrain during energy deficit. |
2014-06-24 |
2023-08-12 |
Not clear |
| Shawn P Alter, Gina M Lenzi, Alison I Bernstein, Gary W Mille. Vesicular integrity in Parkinson's disease. Current neurology and neuroscience reports. vol 13. issue 7. 2014-04-21. PMID:23690026. |
from direct inhibition of dopamine transport into vesicles by pharmacological or toxicological agents to alterations in vesicle trafficking by pd-related gene products, variations in the proper compartmentalization of dopamine can wreak havoc on a functional dopamine pathway. |
2014-04-21 |
2023-08-12 |
Not clear |
| Thomas W Weickert, Venkata S Mattay, Saumitra Das, Llewellyn B Bigelow, Jose A Apud, Michael F Egan, Daniel R Weinberger, Terry E Goldber. Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease. Schizophrenia research. vol 149. issue 1-3. 2014-03-11. PMID:23830543. |
the role of dopaminergic treatment (dopamimetic versus dopamine antagonistic) effects on probabilistic association learning in these diseases that directly impact the dopamine system is not fully understood. |
2014-03-11 |
2023-08-12 |
Not clear |
| William M Doyon, Alyse M Thomas, Alexey Ostroumov, Yu Dong, John A Dan. Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23876345. |
both nicotine and alcohol activate the mesocorticolimbic dopamine system, producing downstream dopamine signals that promote the drug reinforcement process. |
2013-12-17 |
2023-08-12 |
Not clear |