| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Chun Huang, Yu-Chin Wu, Lee-Yung Shih, Woei-Chung Lo, Chon-Haw Tsai, Woei-Cherng Shy. Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea. Journal of neurology. vol 258. issue 11. 2012-02-29. PMID:21559940. |
we report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)f]fluoro-2-deoxy-d-glucose positron emission tomography (fdg pet) and (99m)tc-labeled tropane dopamine transporter ((99m)tc-trodat-1) single photon emission computed tomography (spect). |
2012-02-29 |
2023-08-12 |
Not clear |
| B A Morrow, R H Roth, D E Redmond, J D Elswort. Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease. Neuroscience. vol 189. 2012-02-24. PMID:21640165. |
implications of these primate studies are: (1) the susceptibility of dopamine neurons at mid-gestation to methamphetamine warns against the risk of exposing pregnant women to the drug or oxidative stressors, and supports the hypothesis of parkinson's disease being associated with oxidative stress during development, (2) elucidation of the mechanism of resistance of dopamine neurons in the young animals to methamphetamine-induced oxidative stress may provide targets for slowing or preventing age- or disease-related loss of adult nigrostriatal dopamine (da) neurons, and (3) the increased striatal production of gdnf in young animals, but not in adults, in response to methamphetamine, suggests the possibility of an age-related change in the neurotrophic capacity of the striatal dopamine system. |
2012-02-24 |
2023-08-12 |
monkey |
| Kelly E Bosse, Francis K Maina, Johnna A Birbeck, Marion M France, Joseph J P Roberts, Michelle L Colombo, Tiffany A Mathew. Aberrant striatal dopamine transmitter dynamics in brain-derived neurotrophic factor-deficient mice. Journal of neurochemistry. vol 120. issue 3. 2012-02-24. PMID:21988371. |
together, this study indicates that endogenous bdnf influences dopamine system homeostasis by regulating the release and uptake dynamics of pre-synaptic dopamine transmission. |
2012-02-24 |
2023-08-12 |
mouse |
| Daniel J Lodg. The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21307842. |
taken together, these data demonstrate that the mpfc and ofc differentially regulate dopamine neuron activity, and that the pattern of cortical activation is critical for determining dopamine system output. |
2012-02-09 |
2023-08-12 |
Not clear |
| Manuel Mameli, Christian Lüsche. Synaptic plasticity and addiction: learning mechanisms gone awry. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21277315. |
in the present review we will discuss how different classes of addictive drugs cause an increase of dopamine release and describe their effects on synapses within the mesolimbic dopamine system. |
2012-01-27 |
2023-08-12 |
Not clear |
| Jennifer Carrillo, Rueben A Gonzale. A single exposure to voluntary ethanol self-administration produces adaptations in ethanol consumption and accumbal dopamine signaling. Alcohol (Fayetteville, N.Y.). vol 45. issue 6. 2011-12-05. PMID:21827930. |
furthermore, we speculate that the dopamine response during ethanol consumption likely reflects the reward-prediction role of the mesolimbic dopamine system. |
2011-12-05 |
2023-08-12 |
rat |
| Han Kong, Ming X. Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886552. |
we have been investigating the notion that the dopamine d1 receptor and the immediate early gene product c-fos expressed in d1 receptor-bearing neurons mediate the development of persistent neuroadaptation in the brain dopamine system by regulating cell signaling and gene expression. |
2011-11-10 |
2023-08-12 |
mouse |
| Zsofia Nemoda, Karlen Lyons-Ruth, Anna Szekely, Eszter Bertha, Gabor Faludi, Maria Sasvari-Szekel. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behavioral and brain functions : BBF. vol 6. 2011-11-03. PMID:20205808. |
however, the efficacy of dopamine d2 receptor (drd2) blocking antipsychotic drugs in bpd treatment also suggests involvement of the dopamine system in the neurobiology of bpd. |
2011-11-03 |
2023-08-12 |
Not clear |
| Keisuke Matsubara, Hiroshi Watabe, Yoshitaka Kumakura, Takuya Hayashi, Christopher J Endres, Kotaro Minato, Hidehiro Iid. Sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [¹⁸F]FDOPA PET by a model with detailed dopamine pathway. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21190220. |
sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [¹⁸f]fdopa pet by a model with detailed dopamine pathway. |
2011-10-18 |
2023-08-12 |
Not clear |
| T A Kato, A Monji, Y Mizoguchi, S Hashioka, H Horikawa, Y Seki, M Kasai, H Utsumi, S Kanb. Anti-Inflammatory properties of antipsychotics via microglia modulations: are antipsychotics a 'fire extinguisher' in the brain of schizophrenia? Mini reviews in medicinal chemistry. vol 11. issue 7. 2011-10-06. PMID:21699487. |
these drugs proved to be antagonists of dopamine d2 receptor (d2r), thus dopamine system dysfunction came to be hypothesized in the pathophysiology of schizophrenia, and d2r antagonism against dopamine neurons has been considered as the primary therapeutic target for schizophrenia. |
2011-10-06 |
2023-08-12 |
Not clear |
| Meredith N Braskie, Susan M Landau, Claire E Wilcox, Stephanie D Taylor, James P O'Neil, Suzanne L Baker, Cindee M Madison, William J Jagus. Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Human brain mapping. vol 32. issue 6. 2011-09-12. PMID:20578173. |
our results suggest that dopamine synthesis helps modulate default network activity in younger adults and that alterations to the dopamine system may contribute to age-related changes in working memory function. |
2011-09-12 |
2023-08-12 |
human |
| Victoria B Gradin, Poornima Kumar, Gordon Waiter, Trevor Ahearn, Catriona Stickle, Marteen Milders, Ian Reid, Jeremy Hall, J Douglas Steel. Expected value and prediction error abnormalities in depression and schizophrenia. Brain : a journal of neurology. vol 134. issue Pt 6. 2011-07-29. PMID:21482548. |
the dopamine system has been linked to anhedonia in depression and both the positive and negative symptoms of schizophrenia, but it remains unclear how dopamine dysfunction could mechanistically relate to observed symptoms. |
2011-07-29 |
2023-08-12 |
Not clear |
| Po See Chen, Tzung Lieh Yeh, I Hui Lee, Cheng Bill Lin, Hsin Chun Tsai, Kao Chin Chen, Nan-Tsing Chiu, Wei Jen Yao, Yen Kuang Yang, Yuan-Hwa Cho. Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study. NeuroImage. vol 56. issue 3. 2011-07-25. PMID:21371559. |
these results indicated that genetic variation in the common downstream signaling molecule of the dopamine autoreceptor could affect the functional status of the striatal dopamine system. |
2011-07-25 |
2023-08-12 |
human |
| Donita L Robinson, Dawnya L Zitzman, Sarah K William. Mesolimbic dopamine transients in motivated behaviors: focus on maternal behavior. Frontiers in psychiatry. vol 2. 2011-07-14. PMID:21629844. |
phasic activity of the mesolimbic dopamine pathway - burst-firing of dopamine neurons and the resulting dopamine release events at striatal targets - have been associated with a variety of motivational events, such as novelty, salient stimuli, social interaction, and reward prediction. |
2011-07-14 |
2023-08-12 |
Not clear |
| Brendon W Kent, Zachary A Weinstein, Vincent Passarelli, Yue Chen, Larry J Sieve. Deficient visual sensitivity in schizotypal personality disorder. Schizophrenia research. vol 127. issue 1-3. 2011-07-01. PMID:20541911. |
these results, based upon a paradigm reflecting dopamine activity in the early visual system, highlight the differences as well as similarities between spd and schizophrenia with regard to the dopamine system in schizophrenia spectrum (siever and davis, 2004). |
2011-07-01 |
2023-08-12 |
human |
| Michelle M Martel, Molly Nikolas, Katherine Jernigan, Karen Friderici, Irwin Waldman, Joel T Nig. The dopamine receptor D4 gene (DRD4) moderates family environmental effects on ADHD. Journal of abnormal child psychology. vol 39. issue 1. 2011-06-01. PMID:20644990. |
attention-deficit/hyperactivity disorder (adhd) is a prime candidate for exploration of gene-by-environment interaction (i.e., g x e), particularly in relation to dopamine system genes, due to strong evidence that dopamine systems are dysregulated in the disorder. |
2011-06-01 |
2023-08-12 |
human |
| D L Robinson, D L Zitzman, K J Smith, L P Spea. Fast dopamine release events in the nucleus accumbens of early adolescent rats. Neuroscience. vol 176. 2011-06-01. PMID:21182904. |
as the mesolimbic dopamine system undergoes dynamic changes during adolescence in the rat, it is possible that dopamine transients encode reward and stimulus presentations differently in adolescents. |
2011-06-01 |
2023-08-12 |
rat |
| M M Blanchard, S R Chamberlain, J Roiser, T W Robbins, U Mülle. Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers. Psychological medicine. vol 41. issue 3. 2011-05-24. PMID:21272388. |
the dopamine transporter and catechol-o-methyltransferase (comt) are proteins involved in dopamine clearance and the dopamine system is implicated in the modulation of working memory (wm) processes and neurochemical models of psychiatric diseases. |
2011-05-24 |
2023-08-12 |
human |
| Betsy Lozof. Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction. The Journal of nutrition. vol 141. issue 4. 2011-05-24. PMID:21346104. |
to honor the late john beard's many contributions regarding iron and dopamine biology, this review focuses on recent human studies that test specific hypotheses about effects of early iron deficiency on dopamine system functioning. |
2011-05-24 |
2023-08-12 |
human |
| Diana Dow-Edward. Translational issues for prenatal cocaine studies and the role of environment. Neurotoxicology and teratology. vol 33. issue 1. 2011-05-06. PMID:20600842. |
the review concludes that there is ample evidence for the biological effects of cocaine on cortical and mesolimbic dopamine system development and that manipulation of the rearing environment can dramatically alter the manifestation of these effects including function of the mesolimbic dopamine reward system. |
2011-05-06 |
2023-08-12 |
human |