| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manfred Laucht, Katja Becker, Josef Frank, Martin H Schmidt, Günter Esser, Jens Treutlein, Markus H Skowronek, Gunter Schuman. Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence. Journal of the American Academy of Child and Adolescent Psychiatry. vol 47. issue 6. 2008-06-11. PMID:18434921. |
to clarify the nature of the association between dopamine genes and smoking by examining whether genetic variability in components of the dopamine pathway could explain refined phenotypes in adolescent smoking progression. |
2008-06-11 |
2023-08-12 |
Not clear |
| A Karwautz, S Campos de Sousa, A Konrad, H-E Zesch, G Wagner, A Zormann, C Wanner, G Breen, M Ray, C Kienbacher, S Natriashvili, D A Collier, C Wöber, C Wöber-Bingö. Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 1. 2008-05-20. PMID:17690944. |
because of the role of dopamine in triggering migraine attacks, genes of the dopamine system are candidates for involvement in migraine. |
2008-05-20 |
2023-08-12 |
Not clear |
| Oleh Hornykiewic. Basic research on dopamine in Parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322366. |
basic research on dopamine in parkinson's disease and the discovery of the nigrostriatal dopamine pathway: the view of an eyewitness. |
2008-05-15 |
2023-08-12 |
Not clear |
| Christoph Fehr, Igor Yakushev, Nina Hohmann, Hans-Georg Buchholz, Christian Landvogt, Hanna Deckers, Alexandra Eberhardt, Marie Kläger, Michael N Smolka, Armin Scheurich, Thomas Dielentheis, Lutz G Schmidt, Frank Rösch, Peter Bartenstein, Gerhard Gründer, Mathias Schreckenberge. Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. The American journal of psychiatry. vol 165. issue 4. 2008-05-14. PMID:18316420. |
prolonged substance consumption impairs the natural function of the mesolimbic dopamine system, as shown by a decrease in the availability of striatal dopamine 2 (d(2)) receptors in patients suffering from cocaine, heroin, amphetamine, and alcohol dependence. |
2008-05-14 |
2023-08-12 |
Not clear |
| R M Khudoerkov, E L Dovedova, D N Voronko. Structural, functional, and biochemical changes in the brain during modeling of dopamine system disturbances in rats. Bulletin of experimental biology and medicine. vol 144. issue 1. 2008-03-11. PMID:18256746. |
thus, dysfunction of the dopamine system resulting in changes in dopamine metabolism not only leads to structural and functional rearrangements reducing functional capacities of the cell systems, but is also associated with compensatory and repair reactions in the brain. |
2008-03-11 |
2023-08-12 |
rat |
| Michael X Cohen, Artus Krohn-Grimberghe, Christian E Elger, Bernd Webe. Dopamine gene predicts the brain's response to dopaminergic drug. The European journal of neuroscience. vol 26. issue 12. 2008-03-06. PMID:18088284. |
this apparent discrepancy can be accounted for by hypothesizing an 'inverted-u' relationship, whereby the effect of dopamine agents depends on baseline dopamine system functioning. |
2008-03-06 |
2023-08-12 |
human |
| Yan Rao, Zhong-Wu Liu, Erzsebet Borok, Rebecca L Rabenstein, Marya Shanabrough, Min Lu, Marina R Picciotto, Tamas L Horvath, Xiao-Bing Ga. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. The Journal of clinical investigation. vol 117. issue 12. 2008-02-12. PMID:18060037. |
blockade of dopamine d1 receptors attenuated prolonged wakefulness and synaptic plasticity in these neurons, suggesting that modafinil functions through activation of the dopamine system. |
2008-02-12 |
2023-08-12 |
mouse |
| Yukiori Goto, Satoru Otani, Anthony A Grac. The Yin and Yang of dopamine release: a new perspective. Neuropharmacology. vol 53. issue 5. 2008-01-14. PMID:17709119. |
in this review, we summarize our recent studies and discuss how modulation of the dopamine system, both in terms of phasic activation and attenuation of tonic dopamine are important for the functions of brain regions receiving this dopamine innervation, and that imbalances in these dopamine release mechanisms may play a significant role in psychiatric disorders such as schizophrenia. |
2008-01-14 |
2023-08-12 |
Not clear |
| Ying-Jay Liou, Ying-Chieh Wang, Jen-Yeu Chen, Ya-Mei Bai, Chao-Cheng Lin, Ding-Lieh Liao, Tzu-Ting Chen, Mao-Liang Chen, Geng-Han Mo, I-Ching La. Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia. Psychiatry research. vol 153. issue 3. 2008-01-08. PMID:17669510. |
chronic administration of typical antipsychotic agents, which predominantly act on dopamine receptors, implicates the dopamine system in susceptibility to td. |
2008-01-08 |
2023-08-12 |
human |
| C H Kim, K A Cheon, M-S Koo, Y H Ryu, J D Lee, J W Chang, H S Le. Dopamine transporter density in the basal ganglia in obsessive-compulsive disorder, measured with [123I]IPT SPECT before and after treatment with serotonin reuptake inhibitors. Neuropsychobiology. vol 55. issue 3-4. 2007-12-03. PMID:17657168. |
5-hydroxytryptophan inhibits dopamine release in healthy persons as well as in patients with ocd, and serotonin tonic inhibition affects dopamine function in basal ganglia, indicating a close relationship between serotonin and the dopamine system. |
2007-12-03 |
2023-08-12 |
Not clear |
| Anees Ahmad Banday, Fatima Rizwan Fazili, Mustafa F Lokhandwal. Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C. American journal of physiology. Renal physiology. vol 293. issue 3. 2007-10-29. PMID:17567939. |
insulin causes renal dopamine d1 receptor desensitization via grk2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase c. the renal dopamine system plays an important role in sodium homeostasis and a defect in dopamine d1 receptor (d1r) function is present in hypertension, diabetes, and aging. |
2007-10-29 |
2023-08-12 |
Not clear |
| Anita Hsouna, Hakeem O Lawal, Iyare Izevbaye, Tien Hsu, Janis M O'Donnel. Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Developmental biology. vol 308. issue 1. 2007-09-26. PMID:17585895. |
the dopamine pathway mutant phenotypes can be reproduced by pharmacological treatments of dopamine and a pathway inhibitor 3-iodotyrosine (3-it), implicating dopamine as a direct mediator of the regulatory function. |
2007-09-26 |
2023-08-12 |
drosophila_melanogaster |
| Sara Campos de Sousa, Andreas Karwautz, Christian Wöber, Gudrun Wagner, Gerome Breen, Heidi-Elisabeth Zesch, Andrea Konrad, Arno Zormann, Christian Wanner, Christian Kienbacher, David A Collier, Ciçek Wöber-Bingö. A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura. Annals of neurology. vol 61. issue 6. 2007-08-28. PMID:17474108. |
as dopamine plays an important role in the pathophysiology of migraine and antimigraine drugs have an effect on the dopamine system, the objective of this study was to examine the dopamine d4 receptor gene for involvement in the cause of migraine. |
2007-08-28 |
2023-08-12 |
Not clear |
| James M Swanson, Marcel Kinsbourne, Joel Nigg, Bruce Lanphear, Gerry A Stefanatos, Nora Volkow, Eric Taylor, B J Casey, F Xavier Castellanos, Pathik D Wadhw. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology review. vol 17. issue 1. 2007-08-21. PMID:17318414. |
first, we consider evidence of the presence of dopamine deficits based on the recent literature that (1) confirms abnormalities in dopamine-modulated frontal-striatal circuits, reflected by size (smaller-than-average components) and function (hypoactivation); (2) clarifies the agonist effects of stimulant medication on dopaminergic mechanisms at the synaptic and circuit level of analysis; and (3) challenges the most-widely accepted adhd-related neural abnormality in the dopamine system (higher-than-normal dopamine transporter [dat] density). |
2007-08-21 |
2023-08-12 |
Not clear |
| James M Swanson, Marcel Kinsbourne, Joel Nigg, Bruce Lanphear, Gerry A Stefanatos, Nora Volkow, Eric Taylor, B J Casey, F Xavier Castellanos, Pathik D Wadhw. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology review. vol 17. issue 1. 2007-08-21. PMID:17318414. |
third, we review possible environmental etiologies of dopamine deficits based on recent studies of (1) toxic substances that may affect the dopamine system in early development and contribute substantially to the etiology of adhd; (2) fetal adaptations in dopamine systems in response to stress that may alter early development with lasting effects, as proposed by the developmental origins of health and disease hypothesis; and (3) gene-environment interactions that may moderate selective damage or adaptation of dopamine neurons. |
2007-08-21 |
2023-08-12 |
Not clear |
| Tie-Shan Tang, Xi Chen, Jing Liu, Ilya Bezprozvann. Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652581. |
our results suggest that dopamine signaling pathway plays an important role in hd pathogenesis and that antagonists of dopamine pathway such as tetrabenazine or dopamine receptor blockers may have a therapeutic potential for treatment of hd beyond well established "symptomatic" benefit. |
2007-08-20 |
2023-08-12 |
mouse |
| W Michael Caudle, Jason R Richardson, Min Z Wang, Tonya N Taylor, Thomas S Guillot, Alison L McCormack, Rebecca E Colebrooke, Donato A Di Monte, Piers C Emson, Gary W Mille. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652604. |
the vesicular monoamine transporter 2 (vmat2; slc18a2) is responsible for packaging dopamine into vesicles for subsequent release and has been suggested to serve a neuroprotective role in the dopamine system. |
2007-08-20 |
2023-08-12 |
mouse |
| W Michael Caudle, Jason R Richardson, Min Z Wang, Tonya N Taylor, Thomas S Guillot, Alison L McCormack, Rebecca E Colebrooke, Donato A Di Monte, Piers C Emson, Gary W Mille. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652604. |
these data suggest that mishandling of dopamine via reduced vmat2 expression is, in and of itself, sufficient to cause dopamine-mediated toxicity and neurodegeneration in the nigrostriatal dopamine system. |
2007-08-20 |
2023-08-12 |
mouse |
| Sevket Akpinar, Hamdullah Aydin, Yasar Kutukc. In restless legs syndrome, during changes in vigilance, the forced EEG shifts from alpha activity to delta or high alpha may lead to the altered states of dopamine receptor function and the symptoms. Medical hypotheses. vol 69. issue 2. 2007-08-10. PMID:17320307. |
expressions of alpha activity gate dyscontrols may have a gate effect that trigger a second vulnerability-dopamine receptor specific individual sensitivity (drsis) and this leads to a deficiency in dopamine transmissions at diencephalospinal dopamine system (dsds). |
2007-08-10 |
2023-08-12 |
Not clear |
| Yu-Chih Shen, Shaw-Ji Chen, Chaucer C H Lin, Chia-Hsiang Che. Concomitant use of lamotrigine and aripiprazole increases risk of Stevens-Johnson syndrome? International clinical psychopharmacology. vol 22. issue 4. 2007-07-24. PMID:17519650. |
on the basis of the glutamate and dopamine neuron dysregulation hypothesis in schizophrenia, we propose new strategies for the treatment of schizophrenic patients using a glutamate system stabilizer lamotrigine as an adjunctive treatment for the poor responders of a dopamine system stabilizer, aripiprazole. |
2007-07-24 |
2023-08-12 |
Not clear |