| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Bai, Fang He, Svetlana I Novikova, Ashiwel S Undie, Stella Dracheva, Vahram Haroutunian, Michael S Lido. Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins. Biological psychiatry. vol 56. issue 6. 2004-11-08. PMID:15364041. |
abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins. |
2004-11-08 |
2023-08-12 |
Not clear |
| Jie Bai, Fang He, Svetlana I Novikova, Ashiwel S Undie, Stella Dracheva, Vahram Haroutunian, Michael S Lido. Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins. Biological psychiatry. vol 56. issue 6. 2004-11-08. PMID:15364041. |
dopamine receptor-interacting proteins constitute a part of the dopamine system that is involved in regulation of dopamine receptor-associated intracellular signaling. |
2004-11-08 |
2023-08-12 |
Not clear |
| David A Gorelick, Eliot L Gardner, Zheng-Xiong X. Agents in development for the management of cocaine abuse. Drugs. vol 64. issue 14. 2004-10-25. PMID:15233592. |
development of new medications to treat cocaine dependence has focused on manipulation of this dopamine system, either by direct action on dopamine binding sites (transporter or receptors) or indirectly by affecting other neurotransmitter systems that modulate the dopamine system. |
2004-10-25 |
2023-08-12 |
human |
| Teige P Sheehan, R Andrew Chambers, David S Russel. Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain research. Brain research reviews. vol 46. issue 1. 2004-10-21. PMID:15297155. |
through its connections with the mesocorticolimbic dopamine system, the ls regulates motivation, both by stimulating the activity of midbrain dopamine neurons and regulating the consequences of this activity on the ventral striatum. |
2004-10-21 |
2023-08-12 |
Not clear |
| David B Ry. Parkinson's disease and RLS: the dopaminergic bridge. Sleep medicine. vol 5. issue 3. 2004-09-28. PMID:15165542. |
converging lines of evidence suggest that mesocorticolimbic dopamine circuits are involved in promoting wakefulness, while a less studied diencephalospinal dopamine system might underly the sensorimotor dysfunction of restless legs syndrome. |
2004-09-28 |
2023-08-12 |
Not clear |
| Takemi Watanabe, Kiyoshi Morimoto, Mitsuo Nakamura, Toru Hirao, Takashi Ninomiya, Nobuo Ando, Hiroshi Suwak. Kindling of the ventral tegmental area induces supersensitivity in the central dopamine system. Brain research. vol 1003. issue 1-2. 2004-07-20. PMID:15019580. |
these results indicate that repeated activation of the mesolimbic dopamine system can produce a neuroplastic change, which results in dopamine supersensitivity. |
2004-07-20 |
2023-08-12 |
rat |
| Valtteri Kaasinen, Sargo Aalto, Kjell Någren, Juha O Rinn. Dopaminergic effects of caffeine in the human striatum and thalamus. Neuroreport. vol 15. issue 2. 2004-06-10. PMID:15076753. |
there are indications of specific interactions between striatal adenosine a(2a) and dopamine d(2) receptors, but the in vivo effects of caffeine on human dopamine system have not been investigated. |
2004-06-10 |
2023-08-12 |
human |
| Jeffrey A Lieberma. Dopamine partial agonists: a new class of antipsychotic. CNS drugs. vol 18. issue 4. 2004-05-10. PMID:15015905. |
it should act as a functional antagonist in the mesolimbic dopamine pathway, where excessive dopamine activity is thought to cause positive symptoms, but show functional agonist activity in the mesocortical pathway, where reduced dopamine activity is thought to be associated with negative symptoms and cognitive impairment. |
2004-05-10 |
2023-08-12 |
Not clear |
| A D Roberts, C F Moore, O T DeJesus, T E Barnhart, J A Larson, J Mukherjee, R J Nickles, M J Schueller, S E Shelton, M L Schneide. Prenatal stress, moderate fetal alcohol, and dopamine system function in rhesus monkeys. Neurotoxicology and teratology. vol 26. issue 2. 2004-05-10. PMID:15019951. |
the subjects were assessed for striatal dopamine system function using positron emission tomography (pet), in which the dopamine (da)-rich striatum was evaluated in separate scans for the trapping of [(18)f]-fallypride (fal) and 6-[(18)f]fluoro-m-tyrosine (fmt) to assess dopamine d2 receptor binding potential (bp) and da synthesis via dopa decarboxylase activity, respectively. |
2004-05-10 |
2023-08-12 |
human |
| Jean-Michel Itier, Pablo Ibanez, Maria Angeles Mena, Nacer Abbas, Charles Cohen-Salmon, Georg Andrees Bohme, Michel Laville, Jeremy Pratt, Olga Corti, Laurent Pradier, Gwenaelle Ret, Chantal Joubert, Magali Periquet, Francisco Araujo, Julia Negroni, Maria Jose Casarejos, Santiago Canals, Rosa Solano, Alba Serrano, Eva Gallego, Marina Sanchez, Patrice Denefle, Jesus Benavides, Gunter Tremp, Thomas A Rooney, Alexis Brice, Justo Garcia de Yebene. Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Human molecular genetics. vol 12. issue 18. 2004-04-15. PMID:12915482. |
although there was no evidence for a reduction of nigrostriatal dopamine neurons in the parkin mutant mice, the level of dopamine transporter protein was reduced in these animals, suggesting a decreased density of dopamine terminals, or adaptative changes in the nigrostriatal dopamine system. |
2004-04-15 |
2023-08-12 |
mouse |
| Anna M S Kindlundh, Sadia Rahman, Jonas Lindblom, Fred Nyber. Increased dopamine transporter density in the male rat brain following chronic nandrolone decanoate administration. Neuroscience letters. vol 356. issue 2. 2004-03-10. PMID:14746881. |
in conclusion, this study confirms that chronic nandrolone administration increases dopamine transporter density in the cpu and therefore supports the theory that aas affects the dopamine system in the male rat brain. |
2004-03-10 |
2023-08-12 |
rat |
| Kenneth Marek, Danna Jennings, John Seiby. Imaging the dopamine system to assess disease-modifying drugs: studies comparing dopamine agonists and levodopa. Neurology. vol 61. issue 6 Suppl 3. 2004-02-05. PMID:14504379. |
imaging the dopamine system to assess disease-modifying drugs: studies comparing dopamine agonists and levodopa. |
2004-02-05 |
2023-08-12 |
Not clear |
| Davide Viggiano, Daniela Vallone, Lucia A Ruocco, Adolfo G Sadil. Behavioural, pharmacological, morpho-functional molecular studies reveal a hyperfunctioning mesocortical dopamine system in an animal model of attention deficit and hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624812. |
therefore, a multiple approach based on morphological studies of dopamine, norepinephrine, glutamate, acetylcholine and gaba systems, synaptic (calcium/calmodulin kinase ii) and extrasynaptic (chondroitin sulphates) environments, and molecular biology and pharmacological studies on the dopamine system has been carried out. |
2004-01-15 |
2023-08-12 |
rat |
| Junghyun Hahn, Tonia E Tse, Edwin S Levita. Long-term K+ channel-mediated dampening of dopamine neuron excitability by the antipsychotic drug haloperidol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 34. 2003-12-16. PMID:14645479. |
the resultant long-term dampening of dopamine neuron excitability may serve to tone down the dopamine system. |
2003-12-16 |
2023-08-12 |
Not clear |
| Stan B Floresco, Anthony R West, Brian Ash, Holly Moore, Anthony A Grac. Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nature neuroscience. vol 6. issue 9. 2003-10-28. PMID:12897785. |
these results provide insight into multiple regulatory systems that modulate dopamine system function: burst firing induces massive synaptic dopamine release, which is rapidly removed by reuptake before escaping the synaptic cleft, whereas increased population activity modulates tonic extrasynaptic dopamine levels that are less influenced by reuptake. |
2003-10-28 |
2023-08-12 |
rat |
| J M Goldstei. Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs of today (Barcelona, Spain : 1998). vol 35. issue 3. 2003-10-24. PMID:12973385. |
quetiapine also has minimal activity on dopamine receptors in the tuberoinfundibular dopamine system, thereby avoiding the problem of hyperprolactinemia, common with the standard antipsychotics and some atypical antipsychotics. |
2003-10-24 |
2023-08-12 |
Not clear |
| Clare Bergson, Robert Levenson, Patricia S Goldman-Rakic, Michael S Lido. Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling. Trends in pharmacological sciences. vol 24. issue 9. 2003-10-21. PMID:12967774. |
abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. |
2003-10-21 |
2023-08-12 |
Not clear |
| Robert Y Moor. Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease. Parkinsonism & related disorders. vol 9 Suppl 2. 2003-10-20. PMID:12915070. |
positron emission tomography with specific ligands for the dopamine system is a powerful tool for analysis of both degenerative and compensatory processes in the pathophysiology of parkinson disease in vivo and can be used to confirm the diagnosis of dopamine deficient parkinson disease. |
2003-10-20 |
2023-08-12 |
Not clear |
| Julie L Fudge, Ana B Emilian. The extended amygdala and the dopamine system: another piece of the dopamine puzzle. The Journal of neuropsychiatry and clinical neurosciences. vol 15. issue 3. 2003-09-24. PMID:12928506. |
the extended amygdala and the dopamine system: another piece of the dopamine puzzle. |
2003-09-24 |
2023-08-12 |
Not clear |
| M Narita, K Aoki, M Takagi, Y Yajima, T Suzuk. Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809697. |
bdnf has been shown to influence the release of dopamine in the mesolimbic dopamine system. |
2003-09-12 |
2023-08-12 |
rat |