| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mickael Decressac, Stéphanie Pain, Pierre-Yves Chabeauti, Laura Frangeul, Nathalie Thiriet, Herbert Herzog, Jackie Vergote, Sylvie Chalon, Mohamed Jaber, Afsaneh Gaillar. Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:21816512. |
in rat and mice models of pd, striatal injection of npy preserved the nigrostriatal dopamine pathway from degeneration as evidenced by quantification of (1) tyrosine hydroxylase (th)-positive cells in the substantia nigra pars compacta, levels of (2) striatal tyrosine hydroxylase and dopamine transporter, (3) dopamine and 3,4-dihydroxyphenylacetic acid (dopac) as well as (4) rotational behavior. |
2012-11-29 |
2023-08-12 |
mouse |
| M R Hutchinson, A L Northcutt, T Hiranita, X Wang, S S Lewis, J Thomas, K van Steeg, T A Kopajtic, L C Loram, C Sfregola, E Galer, N E Miles, S T Bland, J Amat, R R Rozeske, T Maslanik, T R Chapman, K A Strand, M Fleshner, R K Bachtell, A A Somogyi, H Yin, J L Katz, K C Rice, S F Maier, L R Watkin. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895704. |
collectively, these data indicate that the actions of opioids at classical opioid receptors, together with their newly identified tlr4/md2 actions, affect the mesolimbic dopamine system that amplifies opioid-induced elevations in extracellular dopamine levels, therefore possibly explaining altered opioid reward behaviors. |
2012-11-02 |
2023-08-12 |
mouse |
| Ene Reimann, Külli Kingo, Maire Karelson, Paula Reemann, Ulvi Loite, Maris Keermann, Kristi Abram, Eero Vasar, Helgi Silm, Sulev Kõk. Expression profile of genes associated with the dopamine pathway in vitiligo skin biopsies and blood sera. Dermatology (Basel, Switzerland). vol 224. issue 2. 2012-10-03. PMID:22572099. |
in vitiligo patients the level of dopamine is increased and the functioning of several enzymes participating in the dopamine pathway is changed. |
2012-10-03 |
2023-08-12 |
Not clear |
| W A Wolf, D M Kuh. Cocaine and serotonin neurochemistry. Neurochemistry international. vol 18. issue 1. 2012-10-02. PMID:20504672. |
attempts to understand the mechanisms through which the euphoric and rewarding properties of cocaine are mediated have focused on the brain dopamine system, with particular emphasis on the dopamine uptake site. |
2012-10-02 |
2023-08-12 |
human |
| Justin S Rhodes, Stephen C Gammie, Theodore Garlan. Neurobiology of Mice Selected for High Voluntary Wheel-running Activity. Integrative and comparative biology. vol 45. issue 3. 2012-10-02. PMID:21676789. |
in preliminary studies of mice exercised on a treadmill, brain dopamine concentrations did not differ, suggesting that changes in the dopamine system may have occurred downstream of dopamine production (e.g., receptor expression or transduction). |
2012-10-02 |
2023-08-12 |
mouse |
| C Reavill, I P Stolerma. Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in rats. Journal of psychopharmacology (Oxford, England). vol 1. issue 4. 2012-10-02. PMID:22159140. |
in rats with unilateral, 6-hydroxydopamine lesions of the nigrostriatal dopamine pathway, nicotine produced rotation towards the side of the lesion, a characteristic effect of indirectly acting dopamine agonists such as amphetamine. |
2012-10-02 |
2023-08-12 |
rat |
| Beatriz De la Casa-Fages, Francisco Granda. Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Journal of the neurological sciences. vol 312. issue 1-2. 2012-09-07. PMID:21872889. |
dopamine dysregulation syndrome is a complication of the dopaminergic treatment for parkinson's disease, probably related to sensitization of the mesolimbic dopamine system. |
2012-09-07 |
2023-08-12 |
Not clear |
| Beatriz De la Casa-Fages, Francisco Granda. Dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Journal of the neurological sciences. vol 312. issue 1-2. 2012-09-07. PMID:21872889. |
we hypothesized that the combined effect of dopaminergic replacement therapy and deep brain stimulation on the limbic territory of the subthalamic nucleus could have precipitated the dopamine dysregulation syndrome in these patients, by inducing hyperstimulation of the mesolimbic dopamine system. |
2012-09-07 |
2023-08-12 |
Not clear |
| O P Timofeeva, N D Vdovichenko, S V Kuznetso. [Effect of change in activity level of catecholaminergic systems on motor, respiratory, and cardiac activities in rat embryos]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 48. issue 3. 2012-08-27. PMID:22827027. |
the changes in activities of the motor and respiratory systems due to a rise of catecholamine level are not connected with activation of the dopamine system, as they are not reduced by blockade of dopamine receptors. |
2012-08-27 |
2023-08-12 |
rat |
| Daniel F Manvich, Heather L Kimmel, Leonard L Howel. Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 341. issue 2. 2012-08-20. PMID:22328576. |
these results suggest that 5-ht(2c)r agonists functionally antagonize the behavioral effects of cocaine in nonhuman primates, possibly via a selective modulation of cocaine-induced dopamine increases within the mesolimbic dopamine system and may therefore represent a novel class of pharmacotherapeutics for the treatment of cocaine abuse. |
2012-08-20 |
2023-08-12 |
human |
| Madiha Khalid, Rabab A Aoun, Tiffany A Mathew. Altered striatal dopamine release following a sub-acute exposure to manganese. Journal of neuroscience methods. vol 202. issue 2. 2012-08-16. PMID:21740928. |
since parkinson's disease symptomatology is primarily attributed to dopamine neurodegeneration in the striatum, dopamine system dysfunction has been implicated in the onset of manganism. |
2012-08-16 |
2023-08-12 |
mouse |
| Stefanie Schulz, Larissa Arning, Marlies Pinnow, Edmund Wascher, Jörg T Epplen, Christian Best. When control fails: influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22067551. |
the results indicate a dissociation of the prefrontal and striatal dopamine system for attentional control and behavioural flexibility in a change detection task: while prefrontal dopamine turnover seems to modulate performance, putatively via difficulties in set shifting leading to behavioural inflexibility in comt met allele carriers, striatal dopamine turnover seems less important in this regard. |
2012-07-27 |
2023-08-12 |
human |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
previous studies on the therapeutic potential of agents affecting the dopamine system in traumatic brain injury (tbi) suggest that dopamine dysregulation may have a major role in behavioral deficit after tbi. |
2012-07-23 |
2023-08-12 |
rat |
| Rajendra D Badgaiyan, David Wac. Evidence of dopaminergic processing of executive inhibition. PloS one. vol 6. issue 12. 2012-07-20. PMID:22162756. |
since the inhibitory system is impaired in patients with dysregulated dopamine system, we examined dopamine neurotransmission in the human brain during processing of a task of executive inhibition. |
2012-07-20 |
2023-08-12 |
human |
| Casey E O'Neill, McKenzie L LeTendre, Ryan K Bachtel. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169945. |
repeated cocaine administration enhances dopamine d(2) receptor sensitivity in the mesolimbic dopamine system, which contributes to drug relapse. |
2012-07-20 |
2023-08-12 |
rat |
| V K Meshavkin, E Yu Batishcheva, N V Kost, O Yu Sokolov, A V Trufanova, G E Samonin. Effects of Pro-Gly-Pro tripeptide on the dopamine system. Bulletin of experimental biology and medicine. vol 151. issue 4. 2012-07-17. PMID:22448358. |
tripeptide pro-gly-pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. |
2012-07-17 |
2023-08-12 |
Not clear |
| K Martinu, C Degroot, C Madjar, A P Strafella, O Monch. Levodopa influences striatal activity but does not affect cortical hyper-activity in Parkinson's disease. The European journal of neuroscience. vol 35. issue 4. 2012-06-12. PMID:22304628. |
our results suggest that dopamine replacement therapy has a non-task-specific effect on motor corticostriatal regions, and support the hypothesis that increases and decreases in cortical activity in pd are related to the mesocortical dopamine pathway imbalance. |
2012-06-12 |
2023-08-12 |
human |
| Debora A Rothmond, Cynthia S Weickert, Maree J Webste. Developmental changes in human dopamine neurotransmission: cortical receptors and terminators. BMC neuroscience. vol 13. 2012-06-08. PMID:22336227. |
dopamine is integral to cognition, learning and memory, and dysfunctions of the frontal cortical dopamine system have been implicated in several developmental neuropsychiatric disorders. |
2012-06-08 |
2023-08-12 |
human |
| Debora A Rothmond, Cynthia S Weickert, Maree J Webste. Developmental changes in human dopamine neurotransmission: cortical receptors and terminators. BMC neuroscience. vol 13. 2012-06-08. PMID:22336227. |
we assessed pre- and postsynaptic components of the dopamine system including tyrosine hydroxylase, the dopamine receptors (d1, d2 short and d2 long isoforms, d4, d5), catechol-o-methyltransferase, and monoamine oxidase (a and b) in the developing human dlpfc (6 weeks -50 years). |
2012-06-08 |
2023-08-12 |
human |
| b' Aneta Laki\\xc4\\x8. Depressive symptoms as a side effect of the sustained release form of methylphenidate in a 7-year-old boy with attention-deficit hyperactivity disorder. Vojnosanitetski pregled. vol 69. issue 2. 2012-05-15. PMID:22500377.' |
in the context of adhd etiology we may say that genetic, clinical and imaging studies point out a disruption of the brain dopamine system, which is corroborated by the clinical effectiveness of stimulant drugs, which increase extracellular dopamine in the brain. |
2012-05-15 |
2023-08-12 |
Not clear |