| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Stekete. Injection of the protein kinase inhibitor H7 into the A10 dopamine region blocks the acute responses to cocaine: behavioral and in vivo microdialysis studies. Neuropharmacology. vol 32. issue 12. 1994-05-10. PMID:8152520. |
pretreatment with h7 (30.0 nmol/side) also blocked the cocaine-induced rise of extracellular dopamine in a terminal region of the mesolimbic dopamine system, the nucleus accumbens, as measured by in vivo microdialysis. |
1994-05-10 |
2023-08-12 |
Not clear |
| O Lindvall, G Sawle, H Widner, J C Rothwell, A Björklund, D Brooks, P Brundin, R Frackowiak, C D Marsden, P Odi. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Annals of neurology. vol 35. issue 2. 1994-03-21. PMID:8109898. |
these results indicate that grafts of embryonic dopamine neurons can survive, grow, and exert functional effects up to at least 3 years after surgery in the parkinsonian brain, despite an ongoing disease process leading to degeneration of the intrinsic dopamine system. |
1994-03-21 |
2023-08-12 |
human |
| O Blomqvist, J A Engel, H Nissbrandt, B Söderpal. The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine. European journal of pharmacology. vol 249. issue 2. 1994-02-24. PMID:8287902. |
these results provide further evidence that ethanol-induced activation of the mesolimbic dopamine system (increased dopamine synthesis and release) may be mediated via stimulation of central nicotinic acetylcholine receptors. |
1994-02-24 |
2023-08-12 |
rat |
| Z L Rossetti, M Lai, Y Hmaidan, G L Gess. Depletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine. European journal of pharmacology. vol 242. issue 3. 1994-02-14. PMID:8281997. |
the results suggest that a fall in mesolimbic dopamine output may be associated with depressive states and indicate that changes in the functional status of the dopamine system contribute to the mechanism of action of imipramine. |
1994-02-14 |
2023-08-12 |
Not clear |
| B A Blanchard, S Steindorf, S Wang, S D Glic. Sex differences in ethanol-induced dopamine release in nucleus accumbens and in ethanol consumption in rats. Alcoholism, clinical and experimental research. vol 17. issue 5. 1994-02-08. PMID:8279683. |
the pattern of both greater ethanol-induced nucleus accumbens dopamine release and greater ethanol consumption in females supports the hypothesis that ethanol reward is mediated, at least in part, by the mesolimbic dopamine system. |
1994-02-08 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
previous studies using this self-administration model have shown that dopamine receptor antagonists injected systemically or directly into the terminal regions of the mesolimbic dopamine system decrease lever pressing for ethanol, suggesting an important role for dopamine in ethanol reinforcement. |
1993-12-21 |
2023-08-12 |
rat |
| S Rassnick, L Stinus, G F Koo. The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat. Brain research. vol 623. issue 1. 1993-12-21. PMID:8221085. |
results of this study show that 6-hydroxydopamine (6-ohda)-induced lesions of the mesolimbic dopamine system, sufficient to produce a 93% depletion of dopamine in the nucleus accumbens, an 85% depletion in the olfactory tubercle, an 82% depletion in the frontal cortex and a 78% depletion in the amygdala, failed to alter ethanol self-administration as measured by the total lever presses. |
1993-12-21 |
2023-08-12 |
rat |
| T Brannan, J Martínez-Tica, M D Yah. Effect of repeated electroconvulsive shock on striatal L-dopa and dopamine metabolism: an in vivo study. Journal of neural transmission. Parkinson's disease and dementia section. vol 6. issue 1. 1993-12-10. PMID:7692872. |
therefore, we administered repeated ecs (8 ecs at 48 hr intervals) to rats with partial destruction of the nigrostriatal dopamine pathway and used the cerebral microdialysis technique to monitor extracellular concentrations of dopamine and dopamine metabolites (dopac and hva) in the corpus striatum. |
1993-12-10 |
2023-08-12 |
rat |
| R C Pierce, G V Rebe. Intraneostriatal administration of glutamate antagonists increases behavioral activation and decreases neostriatal ascorbate via nondopaminergic mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 10. 1993-11-12. PMID:8105039. |
neostriatal 3,4-dihydroxyphenylacetic acid (dopac), a major dopamine metabolite, also was recorded in order to assess the dependency of any drug effect on the nigrostriatal dopamine system. |
1993-11-12 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, G J Wang, R Hitzemann, J Logan, D J Schlyer, S L Dewey, A P Wol. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse (New York, N.Y.). vol 14. issue 2. 1993-08-18. PMID:8101394. |
to examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach was used to examine dopamine d2 receptor availability and regional brain glucose metabolism in cocaine abusers. |
1993-08-18 |
2023-08-12 |
Not clear |
| A Ueki, L Rosén, B Andbjer, U B Finnman, U Altamimi, A M Janson, M Goldstein, L F Agnati, K Fux. The vigilance-promoting drug modafinil counteracts the reduction of tyrosine hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway. Experimental brain research. vol 93. issue 2. 1993-06-16. PMID:8098283. |
the vigilance-promoting drug modafinil counteracts the reduction of tyrosine hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway. |
1993-06-16 |
2023-08-12 |
rat |
| T S Shippenberg, R Bals-Kubik, A Her. Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8386244. |
examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and d-1 vs. d-2 dopamine receptors. |
1993-05-18 |
2023-08-12 |
rat |
| Z L Rossetti, Y Hmaidan, M Diana, G L Gess. Lack of tolerance to ethanol-induced dopamine release in the rat ventral striatum. European journal of pharmacology. vol 231. issue 2. 1993-04-20. PMID:8453975. |
these results indicate that tolerance does not develop to the ethanol-induced stimulation of dopamine release and support the hypothesis that activation of the mesolimbic dopamine system contributes to the reinforcing properties of ethanol. |
1993-04-20 |
2023-08-12 |
rat |
| J Fornaguera, R K Schwarting, F Boix, J P Husto. Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: a preclinical Parkinson's model. Synapse (New York, N.Y.). vol 13. issue 2. 1993-04-02. PMID:7680495. |
these ipsiversive asymmetries are discussed in relation to asymmetries in self-regulatory mechanisms of the nigro-striatal dopamine system, such as dopamine autoreceptors controlling the release of this transmitter. |
1993-04-02 |
2023-08-12 |
rat |
| C J Schmidt, G M Fadayel, C K Sullivan, V L Taylo. 5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine. European journal of pharmacology. vol 223. issue 1. 1993-02-05. PMID:1362159. |
the results suggest a permissive role for 5-ht2 receptors in the activation of the dopamine system which occurs during states of high serotonergic activity or during conditions of elevated dopamine efflux with high d2 receptor occupancy. |
1993-02-05 |
2023-08-11 |
Not clear |
| K Batsche, M I Granoff, R Y Wan. 5-HT3 receptor antagonists fail to block the suppressant effect of cocaine on the firing rate of A10 dopamine neurons in the rat. Brain research. vol 592. issue 1-2. 1993-01-06. PMID:1450916. |
we have also determined the ability of several 5-ht3 receptor antagonists to alter the electrophysiological response of a10 dopamine neurons in the rat to cocaine, as these compounds have been implicated in modulating the effects of drugs of abuse on the dopamine system. |
1993-01-06 |
2023-08-11 |
rat |
| G S Robertson, G W Hubert, C S Tham, H C Fibige. Lesions of the mesotelencephalic dopamine system enhance the effects of selective dopamine D1 and D2 receptor agonists on striatal acetylcholine release. European journal of pharmacology. vol 219. issue 2. 1992-12-07. PMID:1358643. |
lesions of the mesotelencephalic dopamine system enhance the effects of selective dopamine d1 and d2 receptor agonists on striatal acetylcholine release. |
1992-12-07 |
2023-08-11 |
Not clear |
| M A Päivärinta, R J Marttila, J O Rinne, U K Rinn. Decrease in mesencephalic dopamine autoreceptors in experimental herpes simplex encephalitis. Journal of neural transmission. General section. vol 89. issue 1-2. 1992-12-04. PMID:1418868. |
thus experimental herpes simplex virus infection seems to affect the mesencephalic dopamine autoreceptors, leading to unilateral activation of the mesostriatal dopamine system and rotational behaviour. |
1992-12-04 |
2023-08-11 |
Not clear |
| A A Grac. The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia. Journal of neural transmission. Supplementum. vol 36. 1992-10-22. PMID:1356143. |
furthermore, the clinical profile of the response to antipsychotic drugs appears to correspond to the dopamine system affected: antipsychotic drugs that exert therapeutic actions in schizophrenics inactivate dopamine neuron firing in the limbic-related ventral tegmental area, whereas drugs that precipitate extrapyramidal side effects cause depolarization block of the motor-related substantia nigra dopamine cells. |
1992-10-22 |
2023-08-11 |
rat |
| A A Grac. The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia. Journal of neural transmission. Supplementum. vol 36. 1992-10-22. PMID:1356143. |
thus, attenuating the responsivity of the dopamine system to stimuli may be more relevant to the therapeutic actions of antipsychotic drugs than receptor blockade or decreases in absolute levels of dopamine, which could presumably be circumvented by homeostatic adaptations in this highly plastic system. |
1992-10-22 |
2023-08-11 |
rat |