| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Niijima, M Yoshid. Activation of mesencephalic dopamine neurons by chemical stimulation of the nucleus tegmenti pedunculopontinus pars compacta. Brain research. vol 451. issue 1-2. 1989-07-31. PMID:3251582. |
these facts indicate: (1) the tpc-derived circling behavior is mediated by the dopamine system, (2) the chemical stimulation of tpc by ka might produce an activation of midbrain dopamine neurons by excitatory tpc efferents to the dopamine neurons and enhance the dopamine turnover in the nucleus accumbens as well as in the striatum, (3) the excitatory tpc efferents may be muscarinic cholinergic in accordance with previous reports. |
1989-07-31 |
2023-08-11 |
rat |
| G R Hanson, K M Merchant, A A Letter, L Bush, J W Gib. Characterization of methamphetamine effects on the striatal-nigral dynorphin system. European journal of pharmacology. vol 155. issue 1-2. 1989-06-06. PMID:2907484. |
selective lesioning of the nigral-striatal dopamine pathway blocked the effects; thus, the meth-induced changes appeared to be mediated by dopamine released from the nigral-striatal dopamine projection. |
1989-06-06 |
2023-08-11 |
Not clear |
| J Maj, M Papp, G Skuza, K Bigajska, M Zazul. The influence of repeated treatment with imipramine, (+)- and (-)-oxaprotiline on behavioural effects of dopamine D-1 and D-2 agonists. Journal of neural transmission. vol 76. issue 1. 1989-06-02. PMID:2565359. |
the results indicate that the enhanced responsiveness of the dopamine system, observed previously after repeated treatment with antidepressants, may be mediated by the dopamine d-2 receptors. |
1989-06-02 |
2023-08-11 |
rat |
| L Hernandez, B G Hoebe. Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens. Physiology & behavior. vol 44. issue 4-5. 1989-05-05. PMID:3237847. |
the results show that perifornical lh stimulation activates the mesolimbic dopamine system and that dopamine release in the accumbens is involved in feeding. |
1989-05-05 |
2023-08-11 |
rat |
| R A Wise, P P Rompr. Brain dopamine and reward. Annual review of psychology. vol 40. 1989-04-24. PMID:2648975. |
it seems clear that the ventral tegmental dopamine system plays a critical role in midline mesencephalic reward, despite the distance from the electrode tip to the dopamine cells where morphine causes its dopamine-dependent facilitory effects or to the dopamine terminals where low-dose neuroleptics presumably cause theirs. |
1989-04-24 |
2023-08-11 |
Not clear |
| A S Undie, E Friedma. Differences in the cataleptogenic actions of SCH23390 and selected classical neuroleptics. Psychopharmacology. vol 96. issue 3. 1989-03-23. PMID:2906152. |
it is inferred that sch23390 differs from the classical neuroleptics in its mechanism of cataleptogenicity, that there is a cholinergic link with the d1 dopamine system, and further, that there may be a difference in the nature or impact of the cholinergic interaction with the d1 and d2 dopamine systems. |
1989-03-23 |
2023-08-11 |
rat |
| D J Sirinathsinghji, R P Heavens, S J Richards, I J Beresford, M D Hal. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--I. Behavioural, neurochemical and histological characterization of the lesion. Neuroscience. vol 27. issue 1. 1989-01-26. PMID:3264391. |
four to 5 days following minipump implantation, all mpp+-treated animals displayed spontaneous ipsilateral postural bias indicating a marked imbalance in striatal dopamine and degeneration of the ipsilateral nigrostriatal dopamine pathway. |
1989-01-26 |
2023-08-11 |
rat |
| I J Beresford, A P Davenport, D J Sirinathsinghji, M D Hall, R G Hill, J Hughe. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--II. Differential localization of dopamine and cholecystokinin receptors. Neuroscience. vol 27. issue 1. 1989-01-26. PMID:3264392. |
the autoradiographical localization of dopamine d1, d2 and cholecystokinin receptors has been investigated in rat brain 6 months following unilateral infusion of 1-methyl-4-phenyl pyridinium ion (mpp+) (10 micrograms/day for 7 days) into the nigrostriatal dopamine pathway. |
1989-01-26 |
2023-08-11 |
rat |
| I J Beresford, A P Davenport, D J Sirinathsinghji, M D Hall, R G Hill, J Hughe. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--II. Differential localization of dopamine and cholecystokinin receptors. Neuroscience. vol 27. issue 1. 1989-01-26. PMID:3264392. |
similar changes in dopamine and cholecystokinin receptor number were found following 6-hydroxydopamine lesion of the nigrostriatal dopamine pathway. |
1989-01-26 |
2023-08-11 |
rat |
| A Y Deutch, M Goldstein, F Baldino, R H Rot. Telencephalic projections of the A8 dopamine cell group. Annals of the New York Academy of Sciences. vol 537. 1989-01-23. PMID:2462395. |
these data therefore suggest that the a8 dopamine cell group is uniquely situated to modulate functional activity within both nigrostriatal and mesocorticolimbic regions, and further suggests that heterogeneities of the midbrain dopamine neurons are embedded within a larger homogeneous mesotelencephalic dopamine system. |
1989-01-23 |
2023-08-11 |
rat |
| P Brundin, R E Strecker, F H Gage, O Lindvall, A Björklun. Intracerebral transplantation of dopamine neurons: understanding the functional role of the mesolimbocortical dopamine system and developing a therapy for Parkinson's disease. Annals of the New York Academy of Sciences. vol 537. 1989-01-23. PMID:3059921. |
intracerebral transplantation of dopamine neurons: understanding the functional role of the mesolimbocortical dopamine system and developing a therapy for parkinson's disease. |
1989-01-23 |
2023-08-11 |
Not clear |
| S A Montgomery, M C Gree. The use of cholecystokinin in schizophrenia: a review. Psychological medicine. vol 18. issue 3. 1988-12-22. PMID:3054990. |
it has been investigated as a candidate treatment for schizophrenia on the assumption that the illness is associated with an imbalance between cck and dopamine in the mesolimbic dopamine system. |
1988-12-22 |
2023-08-11 |
Not clear |
| S Garattini, R Samani. Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists? Psychological medicine. vol 18. issue 2. 1988-09-01. PMID:2899897. |
major changes in monoamine function after repeated treatment with ad include: desensitization and reduced density of noradrenaline receptors coupled to the adenylcyclase system, opposite changes in the sensitivity of alpha 1 (increased) and alpha 2-adrenoreceptors (decreased), down regulation of serotonin2 receptors and complex changes in the behavioural and electrophysiological responsiveness to serotonin agonists, subsensitivity of presynaptic dopamine receptors and enhanced activity of the mesolimbic dopamine system, decreased and increased density of gaba-a and gaba-b receptors respectively and down regulation of [3h]benzodiazepine binding. |
1988-09-01 |
2023-08-11 |
Not clear |
| B G Weick, J R Walter. Effects of D1 and D2 dopamine receptor stimulation on the activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine lesioned rats: D1/D2 coactivation induces potentiated responses. Brain research. vol 405. issue 2. 1987-06-08. PMID:2952219. |
extracellular single unit recording techniques were used to compare the effects of selective and non-selective dopamine agonists on substantia nigra pars reticulata activity in rats with 6-hydroxydopamine induced lesions of the nigrostriatal dopamine pathway. |
1987-06-08 |
2023-08-11 |
rat |
| A Vaccar. High affinity binding of [3H]-tyramine in the central nervous system. British journal of pharmacology. vol 89. issue 1. 1987-03-11. PMID:3801770. |
the binding process of [3h]-pta involved the dopamine system, inasmuch as (a) highest binding capacity was associated with dopamine-rich regions; (b) dopamine and pta equally displaced specifically bound [3h]-pta; (c) there was a severe loss in striatal binding capacity for [3h]-pta and, reportedly, for [3h]-dopamine, following unilateral nigrostriatal lesion; (d) acute in vivo reserpine treatment markedly decreased the density of [3h]-pta and, reportedly, of [3h]-dopamine binding sites. |
1987-03-11 |
2023-08-11 |
rat |
| P Brundin, O Isacson, F H Gage, A Björklun. Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain research. vol 389. issue 1-2. 1986-04-07. PMID:3081240. |
the effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. |
1986-04-07 |
2023-08-11 |
rat |
| S Borg, H Kvande, P Valveriu. Clinical conditions and central dopamine metabolism in alcoholics during acute withdrawal under treatment with different pharmacological agents. Psychopharmacology. vol 88. issue 1. 1986-03-10. PMID:2868481. |
assuming that hva levels reflect the activity of the central nervous dopamine system, the findings indicate a connection between central dopamine metabolism, psychotic symptoms and possibly other symptoms during acute alcohol withdrawal in man. |
1986-03-10 |
2023-08-11 |
Not clear |
| B L Waszczak, J R Walter. Endogenous dopamine can modulate inhibition of substantia nigra pars reticulata neurons elicited by GABA iontophoresis or striatal stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 1. 1986-02-28. PMID:3944613. |
amphetamine caused no decreases in gaba's effectiveness, however, in animals that had previously received treatments that depleted or destroyed nigral dopamine stores, i.e., in rats pretreated with reserpine and alpha-methyl-p-tyrosine, or in rats with 6-hydroxydopamine lesions of the nigrostriatal dopamine pathway. |
1986-02-28 |
2023-08-11 |
rat |
| L Olson, J J Vanderhaeghen, R Freedman, A Henschen, B Hoffer, A Seige. Combined grafts of the ventral tegmental area and nucleus accumbens in oculo. Histochemical and electrophysiological characterization. Experimental brain research. vol 59. issue 2. 1985-10-08. PMID:4029306. |
falck-hillarp fluorescence histochemistry showed dopamine neurons and terminals in single vta grafts, no or almost no catecholamine fibers in single accumbens grafts, and a well-developed vta-accumbens dopamine pathway in combined grafts where cell bodies in the vta part provided the accumbens part with a rich terminal network. |
1985-10-08 |
2023-08-11 |
Not clear |
| P Winn, T W Robbin. Comparative effects of infusions of 6-hydroxydopamine into nucleus accumbens and anterolateral hypothalamus induced by 6-hydroxydopamine on the response to dopamine agonists, body weight, locomotor activity and measures of exploration in the rat. Neuropharmacology. vol 24. issue 1. 1985-05-10. PMID:3920545. |
it seems unlikely that the reductions in exploration previously reported after lesions of the mesolimbicocortical dopamine system at the level of anterolateral hypothalamus induced by 6-ohda are either behaviourally specific or result solely from depletion of dopamine with the nucleus accumbens and frontal cortex. |
1985-05-10 |
2023-08-11 |
rat |