| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Austin, P W Kaliva. Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata. Brain research. vol 542. issue 1. 1991-08-01. PMID:2054650. |
thus, the motor stimulant response following pharmacological stimulation of the vp/si appears to be mediated by increased dopamine neurotransmission via feedback mechanisms to the mesocorticolimbic dopamine system. |
1991-08-01 |
2023-08-11 |
rat |
| A A Grac. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:1676137. |
phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. |
1991-07-29 |
2023-08-11 |
Not clear |
| B Moghaddam, B S Bunne. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress in neuro-psychopharmacology & biological psychiatry. vol 14 Suppl. 1991-07-23. PMID:2097674. |
haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems. |
1991-07-23 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnet. Increased proenkephalin mRNA levels in the rat neostriatum following lesion of the ipsilateral nigrostriatal dopamine pathway with 1-methyl-4-phenylpyridinium ion (MPP+): reversal by embryonic nigral dopamine grafts. Brain research. Molecular brain research. vol 9. issue 3. 1991-06-19. PMID:1851529. |
increased proenkephalin mrna levels in the rat neostriatum following lesion of the ipsilateral nigrostriatal dopamine pathway with 1-methyl-4-phenylpyridinium ion (mpp+): reversal by embryonic nigral dopamine grafts. |
1991-06-19 |
2023-08-11 |
rat |
| H Nishino, T Hashitani, M Kumazaki, H Sato, F Furuyama, Y Isobe, N Watari, M Kanai, S Shiosak. Long-term survival of grafted cells, dopamine synthesis/release, synaptic connections, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-OHDA lesions in the nigrostriatal dopamine pathway. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1981488. |
long-term survival of grafted cells, dopamine synthesis/release, synaptic connections, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-ohda lesions in the nigrostriatal dopamine pathway. |
1991-04-18 |
2023-08-11 |
rat |
| J S Schneide. Chronic exposure to low doses of MPTP. II. Neurochemical and pathological consequences in cognitively-impaired, motor asymptomatic monkeys. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:2073585. |
since the most profound and consistent deficits were in the nigrostriatal dopamine system, we suggest that most of the behavioral consequences of chronic low-dose mptp exposure stem from the striatal dopamine depletion. |
1991-04-18 |
2023-08-11 |
monkey |
| D J Sirinathsinghji, S B Dunnett, A J Northrop, B J Morri. Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--III. Reversal by embryonic nigral dopamine grafts. Neuroscience. vol 37. issue 3. 1991-01-08. PMID:2247221. |
firstly, they demonstrate that mpp+ infusions into the rat nigrostriatal dopamine pathway can produce a permanent degeneration of nigral dopamine neurons. |
1991-01-08 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Neurotensin-dopamine interactions in the substantia nigra of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2147039. |
prior selective destruction of the nigrostriatal dopamine pathway completely prevented the increase in nigral ntli content induced by treatment with meth, which suggests that the effects of meth on nigral nt systems are mediated by the nigrostriatal dopamine projections. |
1990-12-31 |
2023-08-11 |
rat |
| H Bake. Unilateral, neonatal olfactory deprivation alters tyrosine hydroxylase expression but not aromatic amino acid decarboxylase or GABA immunoreactivity. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:1700334. |
immunoreactivity of tyrosine hydroxylase, the first and rate-limiting enzyme in dopamine biosynthesis, used as a marker of the dopamine system, exhibited a large decrease both 40 and 70 days following olfactory deprivation. |
1990-12-06 |
2023-08-11 |
rat |
| S Izenwasser, L L Werling, B M Co. Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2145054. |
the striatum, while rich in dopamine terminals, is not implicated in drug reinforcement, whereas the mesolimbic dopamine pathway appears to play a primary role. |
1990-11-14 |
2023-08-11 |
rat |
| M W Jann, J H Froemming, R L Boriso. Movement disorders and new azapirone anxiolytic drugs. The Journal of the American Board of Family Practice. vol 3. issue 2. 1990-06-06. PMID:2185606. |
dopamine is a neurotransmitter affecting motor function, and the dopamine system is the focus of abnormality in dyskinetic diseases. |
1990-06-06 |
2023-08-11 |
Not clear |
| P Barone, S A Parashos, V Palma, C Marin, G Campanella, T N Chas. Dopamine D1 receptor modulation of pilocarpine-induced convulsions. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2139189. |
however, neither dopamine agonists nor antagonists altered the limbic stereotypes induced by pilocarpine, suggesting a dopamine system involvement primarily in the mechanisms of epilepsy generalization. |
1990-05-21 |
2023-08-11 |
rat |
| K M Merchant, L G Bush, J W Gibb, G R Hanso. Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems of the rat brain. Brain research. vol 500. issue 1-2. 1990-02-20. PMID:2532557. |
quantitatively similar increases were also observed (a) in the striatum following selective degeneration of more than 85% of the nigrostriatal dopamine pathway with 6-hydroxydopamine and (b) in both the striatum and the nucleus accumbens after non-selective depletion of brain dopamine using reserpine plus alpha-methyl-p-tyrosine. |
1990-02-20 |
2023-08-11 |
rat |
| D J Sirinathsinghji, S B Dunnet. Disappearance of the mu-opiate receptor patches in the rat neostriatum following lesioning of the ipsilateral nigrostriatal dopamine pathway with 1-methyl-4-phenylpyridinium ion (MPP+): restoration by embryonic nigral dopamine grafts. Brain research. vol 504. issue 1. 1990-02-06. PMID:2557122. |
disappearance of the mu-opiate receptor patches in the rat neostriatum following lesioning of the ipsilateral nigrostriatal dopamine pathway with 1-methyl-4-phenylpyridinium ion (mpp+): restoration by embryonic nigral dopamine grafts. |
1990-02-06 |
2023-08-11 |
rat |
| T M Engber, Z Susel, J L Juncos, T N Chas. Continuous and intermittent levodopa differentially affect rotation induced by D-1 and D-2 dopamine agonists. European journal of pharmacology. vol 168. issue 3. 1990-01-03. PMID:2573533. |
the effects of continuous and intermittent levodopa treatment on rotational behavior induced by dopamine agonists were examined in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal dopamine pathway. |
1990-01-03 |
2023-08-11 |
rat |
| A Her. Bidirectional effects of opioids in motivational processes and the involvement of D1 dopamine receptors. NIDA research monograph. vol 90. 1989-12-05. PMID:2855853. |
opioid-induced reward as well as aversion seem to be mediated by the mesolimbic dopamine system, reward by increased, aversion by decreased transmission at d1 dopamine receptors. |
1989-12-05 |
2023-08-11 |
Not clear |
| G F Steinfels, S W Tam, L Coo. Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 2. issue 3. 1989-11-13. PMID:2571340. |
these data, in conjunction with anatomic data suggesting sigma receptor localization on dopamine neurons in the substantia nigra (gundlach et al: j neurosci 6:1757-1770, 1986; graybiel et al: soc neurosci abstr 13:28, 1987) demonstrate a relationship of the sigma receptor with the dopamine system and further suggest a model system to study agonist-antagonist interactions of sigma ligands. |
1989-11-13 |
2023-08-11 |
Not clear |
| R K Carder, D Jackson, H J Morris, R D Lund, M J Zigmon. Dopamine released from mesencephalic transplants restores modulation of striatal acetylcholine release after neonatal 6-hydroxydopamine: an in vitro analysis. Experimental neurology. vol 105. issue 3. 1989-10-10. PMID:2569987. |
after chemical lesions which destroy the nigrostriatal dopamine pathway, transplants rich in dopamine neurons innervate the striatum and, with appropriate stimulation, drive host motor behaviors normally mediated by dopamine. |
1989-10-10 |
2023-08-11 |
rat |
| R R Owen, J O Col. Molindone hydrochloride: a review of laboratory and clinical findings. Journal of clinical psychopharmacology. vol 9. issue 4. 1989-09-27. PMID:2671060. |
it also appears to have a greater effect on mesolimbic and mesocortical dopamine neurons than on those in the nigrostriatal dopamine system. |
1989-09-27 |
2023-08-11 |
Not clear |
| R P Dilts, P W Kaliva. Autoradiographic localization of mu-opioid and neurotensin receptors within the mesolimbic dopamine system. Brain research. vol 488. issue 1-2. 1989-08-14. PMID:2545303. |
in vitro autoradiographic techniques were coupled with selective chemical lesions of the a10 dopamine cells and intrinsic perikarya of the a10 region to delineate anatomical localization of the mu-opioid receptors, labeled with 125i-tyr-d-ala-nmephe-gly-oh (125i-dago), and neurotensin receptors, labeled with 125i-[tyr3]neurotensin within the mesolimbic dopamine system. |
1989-08-14 |
2023-08-11 |
Not clear |