| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Watanabe, T Ogura, M Hosoya, N Nishida, Z Ot. Diuretic effect of cilazapril and dopamine system in the spontaneously hypertensive rat. Acta medica Okayama. vol 49. issue 5. 1996-03-20. PMID:8585395. |
to assess the role of the kidney dopamine system on the diuretic state induced by angiotensin-converting enzyme (ace) inhibitors, we examined the changes in urinary excretion and plasma level of dopamine, and kidney dopamine receptors in spontaneously hypertensive rats (shr) treated with cilazapril, an ace inhibitor. |
1996-03-20 |
2023-08-12 |
rat |
| R A Wise, P Leone, R Rivest, K Lee. Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse (New York, N.Y.). vol 21. issue 2. 1996-03-19. PMID:8584975. |
these findings confirm that self-administered doses of intravenous heroin are sufficient to activate the mesolimbic dopamine system and suggest that significant heroin "craving" can emerge when dopamine levels are still moderately elevated, long before the development of dopamine depletion associated with opiate withdrawal. |
1996-03-19 |
2023-08-12 |
rat |
| J S Schneider, A Kean, L DiStefan. GM1 ganglioside rescues substantia nigra pars compacta neurons and increases dopamine synthesis in residual nigrostriatal dopaminergic neurons in MPTP-treated mice. Journal of neuroscience research. vol 42. issue 1. 1996-01-30. PMID:8531220. |
this effect of gm1 on dopamine synthesis was dependent upon the degree of initial damage to the nigrostriatal dopamine system. |
1996-01-30 |
2023-08-12 |
mouse |
| P A Frohna, B S Neal-Beliveau, J N Joyc. Neonatal 6-hydroxydopamine lesions lead to opposing changes in the levels of dopamine receptors and their messenger RNAs. Neuroscience. vol 68. issue 2. 1995-12-12. PMID:7477961. |
previous studies have established that selective damage to the early-developing components of the mesostriatal dopamine system produces profound changes in dopamine d1 receptor-mediated behaviors, while decreasing d1 receptor density. |
1995-12-12 |
2023-08-12 |
rat |
| A J Morton, M N Williams, P C Emson, R L Faul. The morphology of human neuroblastoma cell grafts in the kainic acid-lesioned basal ganglia of the rat. Journal of neurocytology. vol 24. issue 8. 1995-12-07. PMID:7595666. |
since the sh-sy5y cells used in these grafts express the enzyme tyrosine hydroxylase and synthesize dopamine in vitro, these cells were used in the hope that they may potentially be useful for repairing lesions in the dopamine pathway, such as that seen in parkinson's disease. |
1995-12-07 |
2023-08-12 |
human |
| J S Schneider, L Distefan. Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. Neuropharmacology. vol 34. issue 5. 1995-11-22. PMID:7566482. |
gm1 ganglioside treatment had no effect on striatal dopamine levels in mice with more extensive lesions of the dopamine system (i.e. |
1995-11-22 |
2023-08-12 |
mouse |
| Y Shaham, J Stewar. Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology. vol 119. issue 3. 1995-10-18. PMID:7675970. |
in a second experiment it was shown in drug naive animals that these parameters of footshock increased dopamine overflow in the nucleus accumbens, a terminal region of the mesolimbic dopamine system implicated in the reinforcing effects of drugs. |
1995-10-18 |
2023-08-12 |
rat |
| M T Lin, T Y Kao, C C Chio, Y T Ji. Dopamine depletion protects striatal neurons from heatstroke-induced ischemia and cell death in rats. The American journal of physiology. vol 269. issue 2 Pt 2. 1995-09-22. PMID:7653613. |
however, when the striatal dopamine system was destroyed by 6-hydroxydopamine, the heatstroke-induced arterial hypotension, intracranial hypertension, ischemic damage to the striatum, and elevated striatal dopamine release were reduced. |
1995-09-22 |
2023-08-12 |
rat |
| H Watanabe, T Ogura, M Hosoya, J Kageyama, Z Ot. Developmental change of kidney dopamine receptors in spontaneously hypertensive rats. Research communications in molecular pathology and pharmacology. vol 87. issue 3. 1995-08-29. PMID:7620826. |
to elucidate the role of the kidney dopamine system on blood pressure regulation, we investigated the developmental change of kidney dopamine receptors in spontaneously hypertensive rats (shr) and wistar-kyoto (wky) rats. |
1995-08-29 |
2023-08-12 |
rat |
| W P Melega, A E Williams, D A Schmitz, E W DiStefano, A K Ch. Pharmacokinetic and pharmacodynamic analysis of the actions of D-amphetamine and D-methamphetamine on the dopamine terminal. The Journal of pharmacology and experimental therapeutics. vol 274. issue 1. 1995-08-18. PMID:7616454. |
to establish whether the actions of d-amphetamine (amp) and d-methamphetamine (meamp) on the striatal dopamine system were equipotent, pharmacokinetic profiles of each drug were applied to an analysis of their respective induced dopamine efflux profiles. |
1995-08-18 |
2023-08-12 |
rat |
| F Rodríguez De Fonseca, P Rubio, J L Martín-Calderón, S B Caine, G F Koob, M Navarr. The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference. European journal of pharmacology. vol 274. issue 1-3. 1995-07-05. PMID:7768280. |
it was suggested that the different dose related effects of 7-oh-dpat on the acquisition and expression of morphine place preference might be related to the intrinsic ability of this agonist for interacting with pre- and postsynaptic dopamine d3 receptors located in limbic projecting areas of the mesencephalic dopamine system, although involvement of dopamine d2 receptors cannot be excluded. |
1995-07-05 |
2023-08-12 |
rat |
| G Y Ng, B F O'Dowd, S R Georg. Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains. European journal of pharmacology. vol 269. issue 3. 1995-04-24. PMID:7895774. |
endogenous dopamine d1 and d2 receptor functions differed between strains in the nigrostriatal/mesolimbic dopamine system. |
1995-04-24 |
2023-08-12 |
mouse |
| G Y Ng, B F O'Dowd, S R Georg. Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains. European journal of pharmacology. vol 269. issue 3. 1995-04-24. PMID:7895774. |
strain differences in dopamine d2 receptor function were also observed in the diencephalic dopamine system. |
1995-04-24 |
2023-08-12 |
mouse |
| I Irwin, L E DeLanney, T McNeill, P Chan, L S Forno, G M Murphy, D A Di Monte, M S Sandy, J W Langsto. Aging and the nigrostriatal dopamine system: a non-human primate study. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 3. issue 4. 1995-03-09. PMID:7531106. |
these results suggest that the aging squirrel monkey demonstrates the age-related loss of nigrostriatal dopamine thought to occur in humans and identify this non-human primate as a useful model to further investigate the underlying mechanism(s) and functional consequences of age-related decline of the nigrostriatal dopamine system. |
1995-03-09 |
2023-08-12 |
monkey |
| G Chadi, Y Cao, R F Pettersson, K Fux. Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838386. |
in conclusion, the dopamine cell degeneration may give rise to extracellular signals activating the surrounding astroglia, leading to a sustained increased synthesis of astroglial basic fibroblast growth factor, which may exert neuroprotective action and increase repair on the nigrostriatal dopamine system. |
1995-03-02 |
2023-08-12 |
Not clear |
| A Tomac, E Lindqvist, L F Lin, S O Ogren, D Young, B J Hoffer, L Olso. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. vol 373. issue 6512. 1995-02-17. PMID:7830766. |
gdnf injected over the substantia nigra or in striatum before mptp potently protects the dopamine system, as shown by numbers of mesencephalic dopamine nerve cell bodies, dopamine nerve terminal densities and dopamine levels. |
1995-02-17 |
2023-08-12 |
mouse |
| L D McCullough, J D Salamon. Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens. Psychopharmacology. vol 109. issue 3. 1995-02-14. PMID:1365640. |
these experiments indicate that exposure to anxiogenic drugs increases accumbens dopamine activity, an effect that is consistent with other studies showing that the mesolimbic dopamine system is responsive to stressful stimuli. |
1995-02-14 |
2023-08-11 |
rat |
| T Imamura, K Suzuki, A Yamadori, M Sahara, H Nagasawa, M Itoh, H Ito. [Improved perseveration with amantadine]. No to shinkei = Brain and nerve. vol 46. issue 6. 1994-09-27. PMID:8068438. |
amantadine increases the pre-synaptic synthesis and release of dopamine, and works as a dopamine system activator. |
1994-09-27 |
2023-08-12 |
Not clear |
| T E Robinson, Z Mocsary, D M Camp, I Q Whisha. Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:7514209. |
time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system. |
1994-06-14 |
2023-08-12 |
Not clear |
| J D Stekete. Injection of the protein kinase inhibitor H7 into the A10 dopamine region blocks the acute responses to cocaine: behavioral and in vivo microdialysis studies. Neuropharmacology. vol 32. issue 12. 1994-05-10. PMID:8152520. |
previous studies have suggested that sensitization may result from increased dopamine neuronal activity in the a10 region; the origin of the mesolimbic dopamine system. |
1994-05-10 |
2023-08-12 |
Not clear |