| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Fard. Brain imaging of schizophrenia--the dopamine hypothesis. Schizophrenia research. vol 28. issue 2-3. 1998-05-14. PMID:9468350. |
the two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging studies on the dopamine system. |
1998-05-14 |
2023-08-12 |
Not clear |
| P Willne. The dopamine hypothesis of schizophrenia: current status, future prospects. International clinical psychopharmacology. vol 12. issue 6. 1998-04-14. PMID:9547131. |
it is concluded that schizophrenia does not reflect primary abnormalities of dopamine transmission, but probably does reflect abnormalities in systems that have an intimate interaction with the dopamine system. |
1998-04-14 |
2023-08-12 |
Not clear |
| P Olausson, M Ericson, A Petersson, A Kosowski, B Söderpalm, J A Enge. Nefazodone attenuates the behavioral and neurochemical effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 15. issue 1. 1998-02-02. PMID:9426841. |
these results show that nefazodone modulates the mesolimbic dopamine system in a dopamine activity-dependent manner, and influences the neurochemical and behavioral effects of ethanol in the rat. |
1998-02-02 |
2023-08-12 |
rat |
| V I Pidoplichko, M DeBiasi, J T Williams, J A Dan. Nicotine activates and desensitizes midbrain dopamine neurons. Nature. vol 390. issue 6658. 1997-12-19. PMID:9389479. |
midbrain dopamine neurons normally help to shape behaviour by reinforcing biologically rewarding events, but addictive drugs such as cocaine can inappropriately exert a reinforcing influence by acting upon the mesolimbic dopamine system. |
1997-12-19 |
2023-08-12 |
Not clear |
| S N Haber, J L Fudg. The interface between dopamine neurons and the amygdala: implications for schizophrenia. Schizophrenia bulletin. vol 23. issue 3. 1997-11-25. PMID:9327510. |
in diseases in which dopamine function is compromised, patients exhibit a constellation of symptoms, suggesting that the dopamine system plays an important role in the integration of several functions. |
1997-11-25 |
2023-08-12 |
Not clear |
| S N Haber, J L Fudg. The primate substantia nigra and VTA: integrative circuitry and function. Critical reviews in neurobiology. vol 11. issue 4. 1997-11-14. PMID:9336716. |
in diseases in which dopamine function is compromised, patients exhibit a constellation of symptoms suggesting that the dopamine system plays an important role in the integration of several functions. |
1997-11-14 |
2023-08-12 |
Not clear |
| M Jaber, S Jones, B Giros, M G Caro. The dopamine transporter: a crucial component regulating dopamine transmission. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 5. 1997-11-07. PMID:9380041. |
here we summarize the main findings obtained with these transgenic mice carrying this "genetic defect," leading to a better understanding of the relative contribution of the dopamine transporter regarding locomotor activity, regulation of the expression of peptides under the control of dopaminergic activity, and responses to various drugs targeting the dopamine system. |
1997-11-07 |
2023-08-12 |
mouse |
| F M Bene. The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia. Journal of psychiatric research. vol 31. issue 2. 1997-10-23. PMID:9278189. |
since the cortical dopamine system continues to mature until the start of the early adult period, the normal ingrowth of dopamine fibers during late adolescence and their formation of aberrant connections with abnormal intrinsic corticolimbic circuits could "trigger" the onset of symptoms in those who carry the constitutional vulnerability for schizophrenia. |
1997-10-23 |
2023-08-12 |
Not clear |
| G F Koob, E J Nestle. The neurobiology of drug addiction. The Journal of neuropsychiatry and clinical neurosciences. vol 9. issue 3. 1997-10-16. PMID:9276849. |
the reinforcing effects of indirect sympathomimetics such as cocaine and amphetamine appear to depend on release of dopamine in the terminal fields of the mesocorticolimbic dopamine system. |
1997-10-16 |
2023-08-12 |
Not clear |
| G F Koob, E J Nestle. The neurobiology of drug addiction. The Journal of neuropsychiatry and clinical neurosciences. vol 9. issue 3. 1997-10-16. PMID:9276849. |
the acute reinforcing effects of opiates involve not only an activation of dopamine, but also dopamine-independent elements in the terminal regions of the mesocorticolimbic dopamine system. |
1997-10-16 |
2023-08-12 |
Not clear |
| T A Jenkins, S Y Chai, F A Mendelsoh. Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 19. issue 5-6. 1997-09-29. PMID:9247745. |
thus, despite reports of increased activity of the brain angiotensin ii and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system. |
1997-09-29 |
2023-08-12 |
rat |
| R Karler, J B Bedingfield, D K Thai, L D Calde. The role of the frontal cortex in the mouse in behavioral sensitization to amphetamine. Brain research. vol 757. issue 2. 1997-08-25. PMID:9200751. |
the dopamine antagonists sulpiride and spiperone were both ineffective against the acute response to amphetamine; nevertheless, both blocked the induction of sensitization, suggesting that the mesocortical dopamine pathway is not involved in the acute response but is necessary for the induction of sensitization. |
1997-08-25 |
2023-08-12 |
mouse |
| M E Reith, C Xu, N H Che. Pharmacology and regulation of the neuronal dopamine transporter. European journal of pharmacology. vol 324. issue 1. 1997-07-24. PMID:9137907. |
the dopamine transporter is involved in the uptake of toxins generating parkinson's disease; it is also an important target for psychostimulant drugs, ligands for in vivo imaging and medications used for neurologic diseases involving changes in the dopamine system. |
1997-07-24 |
2023-08-12 |
Not clear |
| C D Blaha, C R Yang, S B Floresco, A M Barr, A G Phillip. Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens. The European journal of neuroscience. vol 9. issue 5. 1997-07-21. PMID:9182943. |
6-hydroxydopamine lesions of the mesoaccumbens dopamine pathway or transection of the fimbria-fornix blocked all of the evoked changes in the dopamine signal. |
1997-07-21 |
2023-08-12 |
rat |
| J W Tidey, K A Micze. Acquisition of cocaine self-administration after social stress: role of accumbens dopamine. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151353. |
exposure to either aversive or rewarding environmental stimuli increases extracellular dopamine (da) concentrations in terminal areas of the mesocorticolimbic dopamine system. |
1997-07-07 |
2023-08-12 |
rat |
| V David, T P Durkin, P Cazal. Self-administration of the GABAA antagonist bicuculline into the ventral tegmental area in mice: dependence on D2 dopaminergic mechanisms. Psychopharmacology. vol 130. issue 2. 1997-06-26. PMID:9106904. |
these data demonstrate the dopamine d2 dependence of this bicuculline self-administration behavior, and confirm that gabaergic interneurons and/or inputs normally transynaptically inhibit neuronal activity in the mesocorticolimbic dopamine system. |
1997-06-26 |
2023-08-12 |
mouse |
| C S Lee, H Sauer, A Bjorklun. Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by instrastriatal 6-hydroxydopamine in the rat. Neuroscience. vol 72. issue 3. 1997-05-22. PMID:9157311. |
rats with intrastriatal 6-hydroxydopamine lesions thus provide a model of progressive dopamine neuron degeneration useful not only for the exploration of neuroprotective therapeutic intervention but also for the study of mechanisms of functional and structural recovery after subtotal damage of the nigrostriatal dopamine system. |
1997-05-22 |
2023-08-12 |
rat |
| J S Schneide. Preservation of autoreceptor-mediated increases in dopamine synthesis in aged mice with experimentally-induced parkinsonism. Neuroscience letters. vol 222. issue 2. 1997-05-12. PMID:9111748. |
this study examined autoreceptor (i.e haloperidol)-mediated regulation of dopamine synthesis in normal aged mice and aged mice with a partial lesion of the nigrostriatal dopamine system induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1997-05-12 |
2023-08-12 |
mouse |
| T Sander, H Harms, J Podschus, U Finckh, B Nickel, A Rolfs, H Rommelspacher, L G Schmid. Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biological psychiatry. vol 41. issue 3. 1997-04-29. PMID:9024952. |
alcohol mediates its reinforcing effects by enhancing dopamine activity in the mesolimbic dopamine system. |
1997-04-29 |
2023-08-12 |
Not clear |
| G F Koo. Hedonic valence, dopamine and motivation. Molecular psychiatry. vol 1. issue 3. 1997-04-22. PMID:9118342. |
dopamine neurons in the dopamine system that originate in the ventral tegmental area and project to the nucleus accumbens, olfactory tubercle and frontal cortex have long been implicated in reward and motivational processes. |
1997-04-22 |
2023-08-12 |
Not clear |