| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G F Koo. Hedonic valence, dopamine and motivation. Molecular psychiatry. vol 1. issue 3. 1997-04-22. PMID:9118342. |
appetitive events and not aversive events activated dopamine neurons in the mesolimbic dopamine system of primates. |
1997-04-22 |
2023-08-12 |
Not clear |
| G F Koo. Hedonic valence, dopamine and motivation. Molecular psychiatry. vol 1. issue 3. 1997-04-22. PMID:9118342. |
modelling studies show that dopamine neurons may be responsible for initiating action associated with significant changes in the value of incentives in the environment and neuropharmacological data show that the activation associated with approach to incentives is abolished by removal to the mesolimbic dopamine system. |
1997-04-22 |
2023-08-12 |
Not clear |
| A A Grace, B S Bunney, H Moore, C L Tod. Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends in neurosciences. vol 20. issue 1. 1997-03-31. PMID:9004417. |
furthermore, the therapeutic efficacy of antipsychotic drugs in humans correlates with their ability to induce depolarization block of mesolimbic dopamine neurons, whereas their potential to produce extrapyramidal side effects correlates with their propensity for inducing depolarization block in the nigrostriatal dopamine system. |
1997-03-31 |
2023-08-12 |
rat |
| J M Mathé, G G Nomikos, B E Hildebrand, P Hertel, T H Svensso. Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens. European journal of pharmacology. vol 309. issue 1. 1997-01-31. PMID:8864686. |
since most antipsychotic drugs exhibit both dopamine d2 receptor and alpha 1-adrenoceptor antagonistic properties, they may alleviate psychosis not only through blockade of postsynaptic dopamine receptors, but also presynaptically on the mesolimbic dopamine system, through their alpha 1-adrenoceptor antagonistic action. |
1997-01-31 |
2023-08-12 |
rat |
| J Stewart, H Rajab. Initial increases in extracellular dopamine in the ventral tegmental area provide a mechanism for the development of desipramine-induced sensitization within the midbrain dopamine system. Synapse (New York, N.Y.). vol 23. issue 4. 1997-01-07. PMID:8855510. |
initial increases in extracellular dopamine in the ventral tegmental area provide a mechanism for the development of desipramine-induced sensitization within the midbrain dopamine system. |
1997-01-07 |
2023-08-12 |
rat |
| J Stewart, H Rajab. Initial increases in extracellular dopamine in the ventral tegmental area provide a mechanism for the development of desipramine-induced sensitization within the midbrain dopamine system. Synapse (New York, N.Y.). vol 23. issue 4. 1997-01-07. PMID:8855510. |
in an attempt to understand the basis of the changes in the mesolimbic dopamine system that occur in response to chronic treatment with the antidepressant drug, desipramine hcl (dmi), we monitored changes in extracellular dopamine in ventral tegmental area (vta) and nucleus accumbens septi (nas) using in vivo microdialysis in freely moving animals. |
1997-01-07 |
2023-08-12 |
rat |
| J Stewart, H Rajab. Initial increases in extracellular dopamine in the ventral tegmental area provide a mechanism for the development of desipramine-induced sensitization within the midbrain dopamine system. Synapse (New York, N.Y.). vol 23. issue 4. 1997-01-07. PMID:8855510. |
early in treatment at a time before changes in the responsiveness of the dopamine system are observed, basal levels of dopamine, dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) were found to be increased in the vta of rats treated with 5.0 mg/kg dmi twice daily for 6 days compared to those of saline-treated animals. |
1997-01-07 |
2023-08-12 |
rat |
| N D Volkow, J S Fowler, S J Gatley, J Logan, G J Wang, Y S Ding, S Dewe. PET evaluation of the dopamine system of the human brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 7. 1996-12-26. PMID:8965206. |
it has also been used in psychopharmacological research to investigate dopamine drugs used in the treatment of parkinson's disease and of schizophrenia as well as to investigate the effects of drugs of abuse on the dopamine system. |
1996-12-26 |
2023-08-12 |
human |
| N D Volkow, J S Fowler, S J Gatley, J Logan, G J Wang, Y S Ding, S Dewe. PET evaluation of the dopamine system of the human brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 7. 1996-12-26. PMID:8965206. |
since various functional and neurological parameters can be studied in the same subject, pet enables investigation of the functional integrity of the dopamine system in the human brain and investigation of the interactions of dopamine with other neurotransmitters. |
1996-12-26 |
2023-08-12 |
human |
| R Y Wang, C R Ashby, J Y Zhan. Modulation of the A10 dopamine system: electrophysiological studies of the role of 5-HT3-like receptors. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788469. |
we hypothesize that the ability of clozapine to antagonize both 5-ht3-like and dopamine receptors may account for its preferential interaction with the mesocorticolimbic dopamine system and the higher efficacy in treating the schizophrenic symptoms. |
1996-12-04 |
2023-08-12 |
Not clear |
| G J Kilpatrick, R M Hagan, J D Gal. 5-HT3 and 5-HT4 receptors in terminal regions of the mesolimbic system. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788470. |
a range of studies show good evidence that 5-ht3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-ht3 receptors in terminal parts of the mesolimbic dopamine system. |
1996-12-04 |
2023-08-12 |
Not clear |
| M Leyton, J Stewar. Acute and repeated activation of male sexual behavior by tail pinch: opioid and dopaminergic mechanisms. Physiology & behavior. vol 60. issue 1. 1996-12-04. PMID:8804646. |
these acute and sensitized behavioral increases might result from tail pinch-induced activation of the midbrain dopamine system via an opioid mechanism; either preventing tail pinch-induced dopamine activation (by an opioid antagonist) or blocking the effects of dopamine activation (by a dopamine antagonist) attenuated the long-term facilitation of sexual behavior seen after pairing the female with tail pinch. |
1996-12-04 |
2023-08-12 |
rat |
| D S Hartman, O Civell. Molecular attributes of dopamine receptors: new potential for antipsychotic drug development. Annals of medicine. vol 28. issue 3. 1996-12-04. PMID:8811164. |
the discovery that schizophrenic symptoms can be alleviated by neuroleptic drugs and the finding that these drugs interact at dopamine receptors has indicated involvement of the dopamine system in schizophrenia. |
1996-12-04 |
2023-08-12 |
Not clear |
| M F Egan, S J Chrapusta, F Karoum, R J Wyat. The effects of acute and chronic haloperidol treatment on dopamine release mediated by the medial forebrain bundle in the striatum and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866705. |
alternatively, di could reduce psychotic symptoms by changing the responsiveness of the dopamine system to external stimuli or by reducing synaptic dopamine levels that have been hypothesized to be elevated in psychotic patients. |
1996-12-03 |
2023-08-12 |
rat |
| F J Lichtigfeld, M A Gillma. Role of dopamine mesolimbic system in opioid action of psychotropic analgesic nitrous oxide in alcohol and drug withdrawal. Clinical neuropharmacology. vol 19. issue 3. 1996-11-27. PMID:8726543. |
we thus infer that a probable major therapeutic effect of pan is in modulating this dopamine system, thereby correcting the severe deficit in dopamine release found in withdrawal states. |
1996-11-27 |
2023-08-12 |
Not clear |
| J W Tidey, K A Micze. Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain research. vol 721. issue 1-2. 1996-11-27. PMID:8793094. |
exposure to various aversive stimuli ('stressors') as well as positively-reinforcing stimuli has been shown to increase extracellular dopamine concentrations in terminal areas of the mesocorticolimbic dopamine system. |
1996-11-27 |
2023-08-12 |
rat |
| L V Metman, P J Blanchet, D de Jong, M M Mouradian, T N Chas. Effect of the putative dopamine D1 agonist and D2 antagonist FCE 23884 on Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 11. issue 3. 1996-11-07. PMID:8723141. |
the ergoline derivative fce 23,884 acts as a dopamine d1 agonist in untreated parkinsonian animals and as a d2 antagonist in animals whose dopamine system is intact or levodopa treated. |
1996-11-07 |
2023-08-12 |
Not clear |
| D M Gash, Z Zhang, W A Cass, A Ovadia, L Simmerman, D Martin, D Russell, F Collins, B J Hoffer, G A Gerhard. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. The Journal of comparative neurology. vol 363. issue 3. 1996-10-24. PMID:8847404. |
the studies included evaluating whole animal behavior, electrochemical recordings of striatal dopamine release, neurochemical determinations of basal ganglia and nigral monoamine levels, and immunohistochemical staining of the nigrostriatal dopamine system. |
1996-10-24 |
2023-08-12 |
human |
| V Bassareo, G Tanda, G Di Chiar. Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinence. Psychopharmacology. vol 122. issue 2. 1996-10-24. PMID:8848538. |
the results show that dopamine neurotransmission in the medial prefrontal cortex responds to opiate withdrawal in a manner opposite to dopamine transmission in the nucleus accumbens and indicate that the dopamine system is affected by abstinence in a topographically specific manner, consistent with a different functional role of mesocortical as compared to mesolimbic dopamine systems. |
1996-10-24 |
2023-08-12 |
rat |
| C Pifl, O Hornykiewicz, B Giros, M G Caro. Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 277. issue 3. 1996-08-06. PMID:8667208. |
we conclude that the toxic effect of mptp at the striatal dopamine system in the mptp primate model of parkinson's disease is not correlated with the affinity profile of mpp+ for catecholamine transporters, but rather with the higher turnover number of mpp+ at the dopamine transporter. |
1996-08-06 |
2023-08-12 |
human |