| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Bradbury, J G Cannon, B Costall, R J Naylo. A comparison of dopamine agonist action to inhibit locomotor activity and to induce stereotyped behaviour in the mouse. European journal of pharmacology. vol 105. issue 1-2. 1984-12-20. PMID:6541588. |
it is concluded that whilst there exists clear potency differences to inhibit locomotor activity and to induce stereotyped behaviour, it is difficult to demonstrate unequivocally an absolute selectivity of dopamine agonist action for the motor inhibitory dopamine system. |
1984-12-20 |
2023-08-12 |
mouse |
| C D Kilts, D L Knight, R B Mailman, E Widerlöv, G R Brees. Effects of thioridazine and its metabolites on dopaminergic function: drug metabolism as a determinant of the antidopaminergic actions of thioridazine. The Journal of pharmacology and experimental therapeutics. vol 231. issue 2. 1984-12-19. PMID:6491985. |
intraperitoneally administered thd antagonized amphetamine-induced locomotion and also increased the concentration of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in terminals of the nigrostriatal dopamine system. |
1984-12-19 |
2023-08-12 |
rat |
| G F Koob, H Simon, J P Herman, M Le Moa. Neuroleptic-like disruption of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal dopamine systems. Brain research. vol 303. issue 2. 1984-08-30. PMID:6430466. |
results also suggest that both the mesolimbic and nigrostriatal dopamine systems act in concert to produce response enabling to important environmental events, and that the severe response enabling deficits observed in parkinson's disease involves not only degeneration of the nigrostriatal dopamine system, but of the mesolimbic dopamine system as well. |
1984-08-30 |
2023-08-12 |
rat |
| P W Kalivas, C B Nemeroff, A J Prang. Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing. Neuroscience. vol 11. issue 4. 1984-08-01. PMID:6738859. |
since dopamine acts on postsynaptic dopamine receptors in the nucleus accumbens, neurotensin is acting, not on dopamine terminals, but on neurons or neuronal systems which are modulated by the mesolimbic dopamine system. |
1984-08-01 |
2023-08-12 |
Not clear |
| M Miyamoto, S Narumi, Y Nagai, Y Saji, Y Nagaw. A TRH analog (DN-1417): motor stimulation with rearing related to catecholaminergic mechanisms in rats. Neuropharmacology. vol 23. issue 1. 1984-06-07. PMID:6425711. |
these findings indicate that the motor stimulatory action of dn-1417 appears to be mediated primarily via a dopaminergic mechanism by enhancing the release of dopamine from nerve terminals, including the nucleus accumbens in the mesolimbic dopamine system, and, in turn, the rearing may be mediated via noradrenergic mechanism. |
1984-06-07 |
2023-08-12 |
rat |
| T Tsutsumi, H Kojima, S Anraku, K Inanag. The short- and long-term effects of haloperidol on rat central dopamine turnover. Brain research. vol 232. issue 2. 1984-05-15. PMID:7188034. |
this suggests that tolerance is established after long-term treatment with haloperidol in both mesolimbic and nigrostriatal dopamine systems, whereas tolerance is not observed in the tuberoinfundibular dopamine system. |
1984-05-15 |
2023-08-12 |
rat |
| E M Joyce, L Stinus, S D Iverse. Effect of injections of 6-OHDA into either nucleus accumbens septi or frontal cortex on spontaneous and drug-induced activity. Neuropharmacology. vol 22. issue 9. 1983-12-21. PMID:6415508. |
biochemical assay data revealed that dopamine levels were significantly reduced both in nucleus accumbens septi (nas) and olfactory tubercle (ot) but not neostriatum; thus it was concluded that amphetamine- and apomorphine-induced locomotor activity is mediated by the mesolimbic dopamine system. |
1983-12-21 |
2023-08-12 |
rat |
| L F Agnati, K Fuxe, K Andersson, F Benfenati, P Cortelli, R D'Alessandr. The mesolimbic dopamine system: evidence for a high amine turnover and for a heterogeneity of the dopamine neuron population. Neuroscience letters. vol 18. issue 1. 1983-06-10. PMID:7052480. |
the mesolimbic dopamine system: evidence for a high amine turnover and for a heterogeneity of the dopamine neuron population. |
1983-06-10 |
2023-08-12 |
Not clear |
| T C Westfall, L Naes, C Pau. Relative potency of dopamine agonists on autoreceptor function in various brain regions of the rat. The Journal of pharmacology and experimental therapeutics. vol 224. issue 1. 1983-02-14. PMID:6848743. |
it is concluded that autoreceptor regulation of dopamine synthesis is more active in the mesolimbic compared with the nigrostriatal dopamine pathway while autoreceptors may be absent in the median eminence. |
1983-02-14 |
2023-08-12 |
rat |
| H Herlitz, S Lundin, M Henning, M Aurell, B E Karlberg, G Berglun. Hormonal pattern during development of hypertension in spontaneously hypertensive rats (SHR). Clinical and experimental hypertension. Part A, Theory and practice. vol 4. issue 6. 1982-09-24. PMID:7047004. |
urinary dopamine excretion was also increased probably mirroring a higher activity in a renal natriuretic dopamine system. |
1982-09-24 |
2023-08-12 |
rat |
| C Y Yim, G J Mogenso. Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine. Brain research. vol 239. issue 2. 1982-09-10. PMID:6284305. |
it is suggested as a working hypothesis that this inhibitory effect of dopamine may be an important function of the mesolimbic dopamine pathway in modulating the extent to which limbic structures can exert an influence on the motor system through the accumbens. |
1982-09-10 |
2023-08-12 |
rat |
| M Takigawa, G J Mogenso. [Intracranial self-stimulation of the nucleus accumbens of the rat and its associated behavior (author's transl)]. No to shinkei = Brain and nerve. vol 32. issue 3. 1980-07-28. PMID:7370136. |
the nas receives strong projections from dopamine of the ventral tegmemtal area (vta) which form the meso-limbic dopamine pathway (a10). |
1980-07-28 |
2023-08-12 |
rat |
| T A James, G L Collingridg. Rapid behavioural and biochemical effects of tetanus toxin microinjected into the substantia nigra: a dual role for GABA? Neuroscience letters. vol 11. issue 2. 1979-09-27. PMID:460688. |
raised ipsilateral striatal levels of the dopamine (da) metabolite, homovanillic acid (hva), indicated that this turning was due to activation of the nigro-striatal dopamine system. |
1979-09-27 |
2023-08-11 |
mouse |
| O Svendse. Long term effect of teflutixol on apomorphine-induced stereotypy and vomiting in dogs. European journal of pharmacology. vol 53. issue 4. 1979-05-16. PMID:570504. |
the results suggest that the nigro-neostriatal dopamine system in dogs became hypersensitive after prolonged teflutixol treatment, while the dopamine receptors of the emetic chemotrigger zone did not. |
1979-05-16 |
2023-08-11 |
Not clear |
| J L Waddingto. Behavioural evidence for GABAergic activity of the benzodiazepine flurazepam. European journal of pharmacology. vol 51. issue 4. 1979-01-26. PMID:30639. |
this response was anatomically associated with the gaba-rich zona reticulata of the substantia nigra and was attenuated by the gaba antagonist picrotoxin but not by the dopamine antagonist haloperidol or by destruction of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine. |
1979-01-26 |
2023-08-11 |
rat |
| K Kiianma. Decreased intoxicating effect of ethanol in rats after 6-hydroxydopamine-induced degeneration of ascending dopamine pathways. Pharmacology, biochemistry, and behavior. vol 9. issue 3. 1979-01-15. PMID:568806. |
selective lesion of ascending dopamine pathways was made by injecting the neurotoxin 6-ohda (8 microgram/4 microliter) bilaterally close to the nigro-striatal dopamine pathway of 18 male long evans rats. |
1979-01-15 |
2023-08-11 |
rat |
| M Tohyama, K Yamamoto, K Satoh, T Sakumoto, N Shimiz. Catecholamine innervation of the forebrain in the bull frog, Rana catesbiana. Journal fur Hirnforschung. vol 18. issue 3. 1978-01-27. PMID:303652. |
judging from their anatomical aspects it seems that the structure homologous to mammalian nigro-neostriatal dopamine or mesolimbic dopamine system is not present in amphibian brain. |
1978-01-27 |
2023-08-11 |
Not clear |
| I Creese, D R Burt, S H Snyde. Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science (New York, N.Y.). vol 197. issue 4303. 1977-09-02. PMID:877576. |
the binding of [3h]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. |
1977-09-02 |
2023-08-11 |
rat |
| M Palkovits, M Fekete, G B Makara, J P Herma. Total and partial hypothalamic deafferentations for topographical identification of catecholaminergic innervations of certain preoptic and hypothalamic nuclei. Brain research. vol 127. issue 1. 1977-07-18. PMID:861746. |
after posterior deafferentation, which destroys the fibres of the incertohypothalamic dopamine system, dopamine concentration in the nucleus dorsomedialis decreases. |
1977-07-18 |
2023-08-11 |
rat |
| T J Crow, E C Johnstone, J F Deakin, A Longde. Dopamine and schizophrenia. Lancet (London, England). vol 2. issue 7985. 1976-10-29. PMID:60635. |
it remains to be excluded that the receptors, particularly in the mesolimbic dopamine areas, become supersensitive, or that there is a deficit in a system which normally acts in antiagonism to the to the mesolimbic dopamine system. |
1976-10-29 |
2023-08-11 |
Not clear |