| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Adell, R Trullas, E Gelp. Time course of changes in serotonin and noradrenaline in rat brain after predictable or unpredictable shock. Brain research. vol 459. issue 1. 1988-11-21. PMID:2458804. |
the activation of serotonergic metabolism following each type of shock is different according to the nucleus in which the 5-ht nerve endings originate. |
1988-11-21 |
2023-08-11 |
rat |
| I Reisert, V Han, E Lieth, D Toran-Allerand, C Pilgrim, J Laude. Sex steroids promote neurite growth in mesencephalic tyrosine hydroxylase immunoreactive neurons in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 5. issue 2. 1988-11-21. PMID:2902739. |
the influence of steroid hormones on the differentiation of catecholaminergic and serotonergic (5-ht) neurons was studied in dissociated cell cultures from embryonic day 14 (e14) rat diencephalon, mesencephalon and metencephalon treated for 6 days with 17 beta-estradiol (e), testosterone (t), 5 alpha-dihydrostestosterone (dht), progesterone (p), dexamethasone (dex), or e + t. the effects of these hormones on morphologic differentiation were determined by morphometric measurements of total length of neurites of immunocytochemically identified neurons in culture, which were stained with antisera against tyrosine hydroxylase (th) or 5-ht. |
1988-11-21 |
2023-08-11 |
rat |
| F G Szele, D L Murphy, N A Garric. Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates. Life sciences. vol 43. issue 16. 1988-11-16. PMID:3172981. |
fenfluramine's effects were blocked by the 5-ht2 antagonists, ritanserin and metergoline, while m-cpp's effects were not blocked by the peripheral 5-ht antagonist, xylamidine, indicating that tumescence can be elicited by serotonergic agents which act at non-5-ht1a sites in the central nervous system. |
1988-11-16 |
2023-08-11 |
monkey |
| L Lima, C Ayala, R Walder, B Druja. Behavioural effects produced in mice infected with venezuelan equine encephalomyelitis virus. Physiology & behavior. vol 43. issue 3. 1988-11-16. PMID:3174841. |
in order to study the functional state of serotonergic systems a series of tests susceptible to modifications by serotonin activity were carried out. |
1988-11-16 |
2023-08-11 |
mouse |
| Y Tille. Early ontogeny of serotonin-immunoreactivity in the sheep brain. An immunohistochemical study. Anatomy and embryology. vol 178. issue 5. 1988-10-31. PMID:3052174. |
compared with other species such as rodents or primates, serotonin appears early in the sheep nervous system, and the development of the serotonergic system is even more rapid. |
1988-10-31 |
2023-08-11 |
Not clear |
| L A Matsuda, C J Schmidt, J W Gibb, G R Hanso. Effects of methamphetamine on central monoaminergic systems in normal and ascorbic acid-deficient guinea pigs. Biochemical pharmacology. vol 37. issue 18. 1988-10-24. PMID:2458731. |
the ascorbic acid-deficient condition differentially influenced the meth-induced responses of dopaminergic and serotonergic variables in the striatum: drug-induced changes in dopaminergic variables were identical in normal and scorbutic animals; meth-induced decreases in serotonergic variables [tryptophan hydroxylase activity, serotonin (5-ht) and 5-hydroxyindoleacetic acid concentrations], however, were prevented in scorbutic animals. |
1988-10-24 |
2023-08-11 |
Not clear |
| L A Matsuda, C J Schmidt, J W Gibb, G R Hanso. Effects of methamphetamine on central monoaminergic systems in normal and ascorbic acid-deficient guinea pigs. Biochemical pharmacology. vol 37. issue 18. 1988-10-24. PMID:2458731. |
in vitro, ascorbic acid increased significantly da-mediated [3h]5-ht release from striatal slices, thus suggesting a potential role for ascorbate in da-mediated actions of meth on serotonergic systems. |
1988-10-24 |
2023-08-11 |
Not clear |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
conversely, using identical ejection parameters, ipsapirone and ly 165163 (previously reported) and 8-oh-dpat were as effective as 5-ht in inhibiting markedly the baseline activity of serotonergic dorsal raphe neurons; mcpp and tfmpp (previously reported) were only weakly active. |
1988-10-24 |
2023-08-11 |
rat |
| J P Zak, J A Miller, D V Sheehan, B S Fanou. The potential role of serotonin reuptake inhibitors in the treatment of obsessive compulsive disorder. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045108. |
the authors examine the role of the serotonergic system in the modulation or genesis of obsessive compulsive disorder and the potential for the use of the new serotonin (5-ht) reuptake inhibitors in its treatment. |
1988-10-13 |
2023-08-11 |
human |
| D V Sheehan, J P Zak, J A Miller, B S Fanou. Panic disorder: the potential role of serotonin reuptake inhibitors. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045109. |
the authors review the role of the serotonergic system in panic disorder and the potential for use of the new serotonin (5-ht) reuptake inhibitors in treating panic disorder. |
1988-10-13 |
2023-08-11 |
Not clear |
| J Heym, B K Ko. Pharmacology of sertraline: a review. The Journal of clinical psychiatry. vol 49 Suppl. 1988-10-13. PMID:3045112. |
animal studies have demonstrated that inhibition of serotonin reuptake leads to enhanced serotonergic neurotransmission and indirectly results in a down-regulation of beta-adrenoceptors. |
1988-10-13 |
2023-08-11 |
Not clear |
| D A Morgan, P Thoren, E A Wilczynski, R G Victor, A L Mar. Serotonergic mechanisms mediate renal sympathoinhibition during severe hemorrhage in rats. The American journal of physiology. vol 255. issue 3 Pt 2. 1988-10-12. PMID:2843055. |
because serotonergic antagonists attenuate hemorrhage-induced vagal-mediated bradycardia, we determined whether blockade of serotonin synthesis by p-chlorophenylalanine (pcpa) or of serotonin receptors with methysergide would also abolish the renal sympathoinhibition. |
1988-10-12 |
2023-08-11 |
rat |
| T Miyauchi, S I Dworkin, C Co, J E Smit. Specific effects of punishment on biogenic monoamine turnover in discrete rat brain regions. Brain research. vol 454. issue 1-2. 1988-10-11. PMID:3409023. |
these results and reported effects of drugs which act on serotonergic systems on the punished behavior suggest that the increase in 5-ht neuronal activity in the frontal cortex is involved in the behavioral suppression induced by the punishment. |
1988-10-11 |
2023-08-11 |
rat |
| P J White, K A Cybulski, R Primus, D F Johnson, G H Collier, G C Wagne. Changes in macronutrient selection as a function of dietary tryptophan. Physiology & behavior. vol 43. issue 1. 1988-10-11. PMID:3413253. |
hypothalamic concentrations of serotonin and 5-hydroxyindole acetic acid indicated increased activity of the serotonergic system. |
1988-10-11 |
2023-08-11 |
rat |
| E O'Hearn, G Battaglia, E B De Souza, M J Kuhar, M E Mollive. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 8. 1988-10-07. PMID:2457659. |
two weeks after systemic administration of mda or mdma (20 mg/kg, s.c., twice daily for 4 d), there is profound loss of serotonergic (5-ht) axons throughout the forebrain; catecholamine axons are completely spared. |
1988-10-07 |
2023-08-11 |
rat |
| P A Kelly, C J Davis, G M Goodwi. Differential patterns of local cerebral glucose utilization in response to 5-hydroxytryptamine agonists. Neuroscience. vol 25. issue 3. 1988-09-22. PMID:2970017. |
the complexity of these results contrasts with previous 2-deoxyglucose investigations where less specific 5-hydroxytryptamine receptor ligands were used, and suggests that certain aspects of brain function may be selectively targeted by systemic pharmacological manipulation of endogenous serotonergic systems. |
1988-09-22 |
2023-08-11 |
rat |
| L H Price, D S Charney, G R Heninge. Effects of trazodone treatment on serotonergic function in depressed patients. Psychiatry research. vol 24. issue 2. 1988-09-22. PMID:3406237. |
changes in serotonergic (5ht) neurotransmission may mediate the therapeutic actions of some antidepressant drugs. |
1988-09-22 |
2023-08-11 |
Not clear |
| K Satoh, T Kushiro, N Kajiwar. [Effects of ketanserin on hemodynamic changes after intracerebroventricular corticotropin releasing factor administration in rats]. Nihon Naibunpi Gakkai zasshi. vol 64. issue 4. 1988-09-20. PMID:3261263. |
in order to elucidate the relation between the serotonergic nervous system and the hypothalamus-pituitary system in hemodynamic regulation, the effects of a serotonin s2 receptor antagonist, ketanserin, on hemodynamic changes after intracerebroventricularly (i.c.v.) |
1988-09-20 |
2023-08-11 |
rat |
| J S Soblosky, C Dills, G DuMontier, I Jen. Evidence for 5-HT1A binding sites in chick embryo brain and discrimination by 5-methoxytryptamine. Biochemistry international. vol 14. issue 5. 1988-09-15. PMID:2970262. |
the displacement characteristics of [3h]5-hydroxytryptamine (5-ht1) binding by several serotonergic ligands were studied in the chick embryo brain. |
1988-09-15 |
2023-08-11 |
chicken |
| F C Zhou, S B Auerbach, E C Azmiti. Transplanted raphe and hippocampal fetal neurons do not displace afferent inputs to the dorsal hippocampus from serotonergic neurons in the median raphe nucleus of the rat. Brain research. vol 450. issue 1-2. 1988-09-15. PMID:3401722. |
to determine if fetal transplants can substitute for or suppress intrinsic serotonergic (5-ht) innervation, we studied the relationship between transplanted and the endogenous raphe neurons projecting to the hippocampus. |
1988-09-15 |
2023-08-11 |
rat |